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1. Predicting Retention of Fuel Economy Benefits in Engine Oils Containing Soluble Molybdenum-Type Friction Modifiers

Author

Kumar, Sanjay, Chidambaram, C. T., Arivannoor, Jencen Mathai, Navinkiran, Kavirayani, Kumar, Duddu Vinod, Kumar, S. Vinith, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Sinha, Sujeet Kumar, editor, Kumar, Deepak, editor, Gosvami, Nitya Nand, editor, and Nalam, Prathima, editor

Published
2024
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2. Additive–Additive Interaction: Understanding Synergistic and Antagonistic Effects of Additives in Neat Cutting Oil Formulation

Author

Chidambaram, C. T., Kumar, Sanjay, Kumar, Duddu Vinod, Kumar, S. Vinith, Navinkiran, Kavirayani, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Sinha, Sujeet Kumar, editor, Kumar, Deepak, editor, Gosvami, Nitya Nand, editor, and Nalam, Prathima, editor

Published
2024
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4. Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline

Author

Cox, Miriam F, Mackenzie, Strachan, Low, Ryan, Brown, Michael, Sanchez, Emilie, Carr, Aisling, Carpenter, Ben, Bishton, Mark, Duncombe, Andrew, Akpabio, Akpabio, Kulasekararaj, Austin, Sin, Fang En, Jones, Alexis, Kavirayani, Akhila, Sen, Ethan S, Quick, Vanessa, Dulay, Gurdeep S, Clark, Sam, Bauchmuller, Kris, Tattersall, Rachel S, and Manson, Jessica J

Published
2024
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5. PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

Author

Cikes, Domagoj, Elsayad, Kareem, Sezgin, Erdinc, Koitai, Erika, Torma, Ferenc, Orthofer, Michael, Yarwood, Rebecca, Heinz, Leonhard X., Sedlyarov, Vitaly, Miranda, Nasser Darwish, Taylor, Adrian, Grapentine, Sophie, al-Murshedi, Fathiya, Abot, Anne, Weidinger, Adelheid, Kutchukian, Candice, Sanchez, Colline, Cronin, Shane J. F., Novatchkova, Maria, Kavirayani, Anoop, Schuetz, Thomas, Haubner, Bernhard, Haas, Lisa, Hagelkruys, Astrid, Jackowski, Suzanne, Kozlov, Andrey V., Jacquemond, Vincent, Knauf, Claude, Superti-Furga, Giulio, Rullman, Eric, Gustafsson, Thomas, McDermot, John, Lowe, Martin, Radak, Zsolt, Chamberlain, Jeffrey S., Bakovic, Marica, Banka, Siddharth, and Penninger, Josef M.

Published
2023
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6. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Agrimbau Vázquez, Jorge, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N., Burgner, David P., Carey, Emma, Crawford, Nigel W., Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Almeida Farias, Camila Giuliana, Almeida, Flávia Jacqueline, Alves Leal, Izabel, Araujo da Silva, André Ricardo, Araujo e Silva, Anna Esther, Barreiro, Sabrina T.A., Bomfim Prado da Silva, Daniella Gregória, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Henriques Teixeira, Cristiane, Jarovsky, Daniel, Martins Araujo, Julienne, Naaman Berezin, Eitan, Palazzi Sáfadi, Marco Aurélio, Paternina-de la Ossa, Rolando Andres, Souza Vieira, Cristina, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M., Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, Bustos B, Raul, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A., Valenzuela Galaz, Gonzalo, Camacho-Moreno, Germán, Avila-Aguero, María L., Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, Soriano-Fallas, Alejandra, Ulloa-Gutierrez, Rolando, Yock-Corrales, Adriana, Amer, Maysa Abbas, Abdelmeguid, Yasmine, Ahmed, Yomna H.H.Z., Badib, Adham, Badreldin, Karim, Elkhashab, Yara, Heshmat, Hassan, Hussein, Amna, Mohamed Hussein, Amna Hussein, Ibrahim, Sandra, Shoman, Walaa, Yakout, Radwa M, Heinonen, Santtu, Angoulvant, François, Belot, Alexandre, Ouldali, Naïm, Beske, Florian, Heep, Axel, Masjosthusmann, Katja, Reiter, Karl, van den Heuvel, Ingeborg, von Both, Ulrich, Agrafiotou, Aikaterini, Antachopoulos, Charalampos, Charisi, Konstantina, Eleftheriou, Irini, Farmaki, Evangelia, Fotis, Lampros, Kafetzis, Dimitrios, Koletsi, Patra, Kourtesi, Katerina, Lampidi, Stavroula, Liakopoulou, Theodota, Maritsi, Despoina, Michailidou, Elisa, Milioudi, Maria, Mparmpounaki, Ioanna, Papadimitriou, Eleni, Papaevangelou, Vassiliki, Roilides, Emmanuel, Tsiatsiou, Olga, Tsolas, Georgios, Tsolia, Maria, Vantsi, Petrina, Banegas Pineda, Linda Yajeira, Borjas Aguilar, Karla Leversia, Cantillano Quintero, Edwin Mauricio, Ip, Patrick, Kwan, Mike Yat Wah, Kwok, Janette, Lau, Yu Lung, To, Kelvin, Wong, Joshua Sung Chih, David, Mate, Farkas, David, Kalcakosz, Szofia, Szekeres, Klaudia, Zsigmond, Borbala, Aslam, Nadeem, Luder, Anthony, Andreozzi, Laura, Bianco, Francesco, Bucciarelli, Valentina, Buonsenso, Danilo, Cimaz, Rolando, De Luca, Maia, Dellepiane, Rosa Maria, Fabi, Marianna, Filice, Emanuele, Lanari, Marcello, Lo Vecchio, Andrea, Mastrolia, Maria Vincenza, Mauro, Angela, Mazza, Angelo, Papa, Mario Virgilio, Romani, Lorenza, Scarano, Sara Maria, Simonini, Gabriele, Tipo, Vincenzo, Verdoni, Lucio, Macharia, Anne-Marie, Musiime, Grace, Reel, Bhupi, Wangai, Frederick, Pace, David, Torpiano, Paul, Anaya-Enriquez, Nancy, Carreon-Guerrero, Juan Manuel, Chacon-Cruz, Enrique, Cheung López, Mariana, Faugier Fuentes, Enrique, Fonseca Flores, Marisol, García-Domínguez, Miguel, Giron Vargas, Ana Luisa, Lopez-Delgado, Ivan, Lopez Hernández, Liliana, Menchaca Aguayo, Hector F., Montaño-Duron, Jesus Gilberto, Pérez-Gaxiola, Giordano, Ramos Tiñini, Pamela, Tostado-Morales, Edgardo, Valadez, Julio, Inchley, Christopher, Klevberg, Sjur, Knudsen, Per Kristian, Måseide, Per Helge, Carrera, Jose Manuel, Castaño, Elizabeth, Daza Timana, Carlos Alberto, De Leon, Tirza, Estripeaut, Dora, Levy, Jacqueline, Norero, Ximena, Record, Javier, Rojas-Bonilla, Magda, Wong, Mayra, Iramain, Ricardo, Hernandez, Roger, Huamán, Gian, Munaico, Manuel, Peralta, Carlos, Seminario, Diego, Zapata Yarlequé, Elmer Hans, Gadzinska, Justyna, Ludwikowska, Kamila, Mandziuk, Joanna, Okarska-Napierała, Magdalena, Alacheva, Zalina A., Alexeeva, Ekaterina, Ananin, Petr V., Antsupova, Margarita, Bakradze, Maya D., Berbenyuk, Anna, Bobkova, Polina, Borzakova, Svetlana, Chashchina, Irina L., El-Taravi, Yasmin, Fisenko, Andrey P., Gautier, Marina S., Glazyrina, Anastasia, Gorlenko, Cyrill, Grosheva, Mariia, Kiselev, Herman, Kondrikova, Elena, Korobyants, Evgeniya, Korsunskiy, Anatoliy A., Kovygina, Karina, Krasnaya, Ekaterina, Kurbanova, Seda, Kurdup, Maria K., Mamutova, Anna V., Mazankova, Lyudmila, Mitushin, Ilya L., Munblit, Daniel, Nargizyan, Anzhelika, Orlova, Yanina O., Osmanov, Ismail M., Polyakova, Anastasia S., Pushkareva, Anna, Romanova, Olga, Samitova, Elmira, Shvedova, Anastasia, Sologub, Anna, Iakovleva, Ekaterina, Tepaev, Rustem F., Tkacheva, Anna A., Yegiyan, Margarita, Yusupova, Valeriya, Zholobova, Elena, Grasa, Carlos Daniel, Epalza, Cristina, Lopez Segura, Nuria, Martinon-Torres, Federico, Melendo, Susana, Mendez-Echevarria, Ana, Mesa Guzmán, Juan Miguel, Palacios Argueta, Jorge Roberto, Rivero-Calle, Irene, Rivière, Jacques, Rodríguez-González, Moisés, Rojo, Pablo, Sanchez Manubens, Judith, Soler-Palacin, Pere, Soriano-Arandes, Antoni, Tagarro, Alfredo, Villaverde, Serena, Altman, Maria, Brodin, Petter, Horne, AnnaCarin, Palmblad, Karin, Brotschi, Barbara, Meyer Sauteur, Patrick, Pachlopnik Schmid, Jana, Prader, Seraina, Relly, Christa, Schlapbach, Luregn J., Seiler, Michelle, Strasser, Sophie, Trück, Johannes, Weber, Kathrin, Wütz, Daniela, Hamdan, Alaa, Melhem, Ibrahim, Moussa, Ahmed, Dunk, Joke, Ketharanathan, Naomi, Vermont, Clementien, Akyüz Özkan, Esra, Cetin, Benhur Sirvan, Erdeniz, Emine Hafize, Şahin, Irfan Oğuz, Borisova, Galina, Boyarchuk, Oksana, Boychenko, Lidiya, Boyko, Yaryna, Diudenko, Nadiia, Dyvonyak, Olha, Kasiyan, Olexandr, Katerynych, Kostiantyn, Kostyuchenko, Larysa, Mamenko, Marina, Melnyk, Kateryna, Miagka, Nelia, Nazarenko, Liliya, Nezgoda, Iryna, Rykova, Stanislava, Svyst, Olga, Teslenko, Maria, Trykosh, Mykola, Vasilenko, Nataliya, Volokha, Alla, Adams, Charlotte, Akomolafe, Toju, Al-Abadi, Eslam, Alders, Nele, Alifieraki, Styliani, Ansumanu, Hareef, Aston, Emily, Avram, Paula, Bamford, Alasdair, Banks, Millie, Basu Roy, Robin, Beattie, Thomas, Boleti, Olga, Bracken, Abbey, Broad, Jonathan, Cai, James, Carrol, Enitan D., Carter, Michael, Chandran, Anchit, Charlesworth, James, Chawla, Jaya, Cooper, Hannah, Cooray, Samantha, Davies, Patrick, Davis, Francesca, Drysdale, Simon B., Dzora, Ella, Emonts, Marieke, Evans, Ceri, Fidler, Katy, Foster, Caroline, Gong, Chen, Gongrun, Berin, Gonzalez, Carmen, Gorgun, Berin, Grandjean, Louis, Grant, Karlie, Guo, Jonathan, Hacohen, Yael, Hall, Jack, Hamid, Hytham K.S., Hassell, Jane, Hesketh, Christine, Hewlett, Jessica, Hnieno, Ahmad, Holt-Davis, Hannah, Hossain, Aleena, Hu, Shiying, Hudson, Lee D., Jheeta, Sharon, Johnson, Mae, Johnson, Sarah, Jyothish, Deepthi, Kampmann, Beate, Kavirayani, Akhila, Kelly, Deborah, Kirubakaran, Arangan, Kucera, Filip, Langer, Daniel, Lawson, George, Lees, Emily A, Lenihan, Rebecca, Lillie, Jon, Longbottom, Katherine, Lyall, Hermione, Mackdermott, Niamh, Maltby, Sarah, Mclelland, Thomas, McMahon, Anne-Marie, Miller, Danielle, Miranda, Mariana, Mirza, Luwaiza, Morrison, Zoe, Moshal, Karyn, Muller, Jennifer, Musuka, Phoebe, Myttaraki, Evangelia, Nadel, Simon, Nair, Sreedevi, Nuttall, Luke, Oremakinde, Oyinkansola, Osaghae, Daniella, Osman, Fatima, Ostrzewska, Anna, Paccagnella, Davide, Panthula, Mrinalini, Papachatzi, Eleni, Papadopoulou, Charalampia, Patel, Fahim, Patel, Harsita, Payne, Helen, Penner, Justin, Polandi, Shervin, Prendergast, Andrew J., Ramnarayan, Padmanabhan, Ranasinghe, Lasith, Ravichandran, Muthukumaran, Rhys-Evans, Sophie, Riordan, Andrew, Rodrigues, Charlene M.C., Roe, Lauren, Romaine, Sam, Schobi, Nina, Seddon, James, Shingadia, Delane, Sikdar, Oishi, Srivastava, Anand, Struik, Siske, Sun, Thomas, Tan, Rachel Wei, Taylor, Alice, Taylor, Amanda, Taylor, Andrew, Tran, Steven, Tsagkaris, Stavros, Tudor-Williams, Gareth, van den Berg, Sarah, van der Velden, Fabian, Ventilacion, Lyn, Wellman, Paul A., Withers Green, Joseph, Yanney, Michael P., Yeung, Shunmay, Badheka, Aditya, Badran, Sarah, Bailey, Dwight M., Burch, Anna Kathryn, Burns, Jane C., Cichon, Catherine, Cirks, Blake, Dallman, Michael D., Delany, Dennis R., Fairchok, Mary, Friedman, Samantha, Geracht, Jennifer, Langs-Barlow, Allison, Mann, Kelly, Padhye, Amruta, Quade, Alexis, Ramirez, Kacy Alyne, Rockett, John, Sayed, Imran Ali, Santos, Roberto P., Shahin, Amr A., Tremoulet, Adriana, Umaru, Samuel, Widener, Rebecca, Mujuru, Hilda Angela, Kandawasvika, Gwendoline, Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Carter, Michael J, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, and Levin, Michael

Published
2023
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7. Cross-Modality Imaging of Murine Tumor Vasculature—a Feasibility Study

Author

Zopf, Lydia M., Heimel, Patrick, Geyer, Stefan H., Kavirayani, Anoop, Reier, Susanne, Fröhlich, Vanessa, Stiglbauer-Tscholakoff, Alexander, Chen, Zhe, Nics, Lukas, Zinnanti, Jelena, Drexler, Wolfgang, Mitterhauser, Markus, Helbich, Thomas, Weninger, Wolfgang J., Slezak, Paul, Obenauf, Anna, Bühler, Katja, and Walter, Andreas

Published
2021
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11. Stabilization at upright equilibrium position of a double inverted pendulum with unconstrained bat optimization

Author

Srikanth, Kavirayani and Kumar, Gundavarapu Nagesh

Subjects
Computer Science - Systems and Control
Abstract

A double inverted pendulum plant has been in the domain of control researchers as an established model for studies on stability. The stability of such as a system taking the linearized plant dynamics has yielded satisfactory results by many researchers using classical control techniques. The established model that is analyzed as part of this work was tested under the influence of time delay, where the controller was fine tuned using a BAT algorithm taking into considering the fitness function of square of error. This proposed method gave results which were better when compared without time delay wherein the calculated values indicated the issues when incorporating time delay., Comment: 15 Pages

Published
2015
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15. Fuzzy Granular Computing-Based Controller Design for Inverted Pendulum System with Delay

Author

Kavirayani, Srikanth, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Sharma, Renu, editor, Mishra, Manohar, editor, Nayak, Janmenjoy, editor, Naik, Bighnaraj, editor, and Pelusi, Danilo, editor

Published
2020
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16. Verification of Zener Voltage Regulation Phenomenon Using Remote Engineering

Author

Chakravarthy, Rayudu, Supriya, Sanku, Srikanth, Kavirayani, Uddandapu, Divya Sree, Rout, Ajit Kumar, Krishna, Asapu Mohan, Tangudu, Srinivasu, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Auer, Michael E., editor, and Ram B., Kalyan, editor

Published
2020
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18. The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope.

Author

Mercer, Louise, Abhishek, Abhishek, Kavirayani, Akhila, Ahmed, Alison, Davidson, Alan, Foulkes, Amy, Jones, Claire, Nash, Clare, Rose-Parfitt, Emily, Dhillon, Emmandeep, Zabate, Genevieve, Twohig, Helen, Vere, Hope De, Scott, Jennifer, Reynolds, John, Holmes, Julia, Hartley, Karen, Warrier, Kishore, Nowak, Kataryzna, and Parsons, Kate

Subjects
ANTIRHEUMATIC agents, RHEUMATOLOGY, RHEUMATISM, AUTOIMMUNE diseases, MEDICAL prescriptions
Abstract

This guideline will provide up-to-date, evidence-based recommendations on the safe use of non-biologic DMARDs, also called conventional synthetic DMARDs (csDMARD), across the full spectrum of autoimmune rheumatic diseases. The guideline will update the guideline published in 2017 and will be expanded to include people of all ages. Updated information on the monitoring of DMARDs and vaccinations will be included. The guideline will be developed using the methods and processes described in the British Society for Rheumatology's 'Creating clinical guidelines: our protocol', updated 2023. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

Author

Cikes, Domagoj, Elsayad, Kareem, Sezgin, Erdinc, Koitai, Erika, Torma, Ferenc, Orthofer, Michael, Yarwood, Rebecca, Heinz, Leonhard X., Sedlyarov, Vitaly, Miranda, Nasser Darwish, Taylor, Adrian, Grapentine, Sophie, al-Murshedi, Fathiya, Abot, Anne, Weidinger, Adelheid, Kutchukian, Candice, Sanchez, Colline, Cronin, Shane J. F., Novatchkova, Maria, Kavirayani, Anoop, Schuetz, Thomas, Haubner, Bernhard, Haas, Lisa, Hagelkruys, Astrid, Jackowski, Suzanne, Kozlov, Andrey V., Jacquemond, Vincent, Knauf, Claude, Superti-Furga, Giulio, Rullman, Eric, Gustafsson, Thomas, McDermot, John, Lowe, Martin, Radak, Zsolt, Chamberlain, Jeffrey S., Bakovic, Marica, Banka, Siddharth, and Penninger, Josef M.

Published
2023
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25. RANKL/RANK control Brca1 mutation-driven mammary tumors

Author

Sigl, Verena, Owusu-Boaitey, Kwadwo, Joshi, Purna A, Kavirayani, Anoop, Wirnsberger, Gerald, Novatchkova, Maria, Kozieradzki, Ivona, Schramek, Daniel, Edokobi, Nnamdi, Hersl, Jerome, Sampson, Aishia, Odai-Afotey, Ashley, Lazaro, Conxi, Gonzalez-Suarez, Eva, Pujana, Miguel A, CIMBA, for, Heyn, Holger, Vidal, Enrique, Cruickshank, Jennifer, Berman, Hal, Sarao, Renu, Ticevic, Melita, Uribesalgo, Iris, Tortola, Luigi, Rao, Shuan, Tan, Yen, Pfeiler, Georg, Lee, Eva YHP, Bago-Horvath, Zsuzsanna, Kenner, Lukas, Popper, Helmuth, Singer, Christian, Khokha, Rama, Jones, Laundette P, and Penninger, Josef M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Stem Cell Research, Cancer, Aging, Genetic Testing, Genetics, Prevention, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Cell Proliferation, Cells, Cultured, DNA Damage, Epithelial Cells, Estrogen Receptor alpha, Female, Genotype, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Progesterone, Recombinant Fusion Proteins, Stem Cells, Tumor Suppressor Protein p53, BRCA1, RANK, RANKL, inherited breast cancer, mammary progenitor cells, Clinical Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (BRCA1) or BRCA2 genes markedly increase the risk for the development of breast cancer. Here, using two different mouse models, we show that genetic inactivation of the key osteoclast differentiation factor RANK in the mammary epithelium markedly delayed onset, reduced incidence, and attenuated progression of Brca1;p53 mutation-driven mammary cancer. Long-term pharmacological inhibition of the RANK ligand RANKL in mice abolished the occurrence of Brca1 mutation-driven pre-neoplastic lesions. Mechanistically, genetic inactivation of Rank or RANKL/RANK blockade impaired proliferation and expansion of both murine Brca1;p53 mutant mammary stem cells and mammary progenitors from human BRCA1 mutation carriers. In addition, genome variations within the RANK locus were significantly associated with risk of developing breast cancer in women with BRCA1 mutations. Thus, RANKL/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer. These results present a viable strategy for the possible prevention of breast cancer in BRCA1 mutant patients.

Published
2016

26. Robotic Flexible Artificial Finger Design Using Nanosized DC Motors and Gears for Finger Injuries

Author

Kavirayani, Srikanth, Salma, Umme, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Panda, Ganapati, editor, Satapathy, Suresh Chandra, editor, Biswal, Birendra, editor, and Bansal, Ramesh, editor

Published
2019
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27. Fuzzy Granular Computing Controls Ill-Conditioned Matrix Definitions for Triple Inverted Pendulum

Author

Kavirayani, Srikanth, Salma, Umme, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Nayak, Janmenjoy, editor, Abraham, Ajith, editor, Krishna, B. Murali, editor, Chandra Sekhar, G. T., editor, and Das, Asit Kumar, editor

Published
2019
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30. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks

Author

Uras, Iris Z., Maurer, Barbara, Nivarthi, Harini, Jodl, Philipp, Kollmann, Karoline, Prchal-Murphy, Michaela, Milosevic Feenstra, Jelena D., Zojer, Markus, Lagger, Sabine, Grausenburger, Reinhard, Grabner, Beatrice, Holly, Raimund, Kavirayani, Anoop, Bock, Christoph, Gisslinger, Heinz, Valent, Peter, Kralovics, Robert, and Sexl, Veronika

Published
2019
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31. Multimodality imaging beyond CLEM: Showcases of combined in-vivo preclinical imaging and ex-vivo microscopy to detect murine mural vascular lesions

Author

Keuenhof, Katharina, primary, Heimel, Patrick, additional, Zopf, L.M., additional, Raigel, Martin, additional, Turyanskaya, Anna, additional, Kavirayani, Anoop, additional, Reier, Susanne, additional, Glösmann, Martin, additional, Schöfer, Christian, additional, Kralovics, Robert, additional, Streli, Christina, additional, Weninger, Wolfgang J., additional, Geyer, Stefan H., additional, Slezak, Paul, additional, Macfelda, Karin, additional, Jäger, Roland, additional, Wanek, Thomas, additional, and Walter, Andreas, additional

Published
2021
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32. Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy

Author

Iris Uribesalgo, David Hoffmann, Yin Zhang, Anoop Kavirayani, Jelena Lazovic, Judit Berta, Maria Novatchkova, Tsung‐Pin Pai, Reiner A Wimmer, Viktória László, Daniel Schramek, Rezaul Karim, Luigi Tortola, Sumit Deswal, Lisa Haas, Johannes Zuber, Miklós Szűcs, Keiji Kuba, Balazs Dome, Yihai Cao, Bernhard J Haubner, and Josef M Penninger

Subjects
anti‐angiogenic therapy, Apelin–Apelin receptor, therapy‐induced resistance, tumor angiogenesis, VEGF‐VEGFR, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Abstract Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy‐induced resistance. We show that Apelin inhibition potently remodels the tumor microenvironment, reducing angiogenesis, and effectively blunting tumor growth. Functionally, targeting Apelin improves vessel function and reduces polymorphonuclear myeloid‐derived suppressor cell infiltration. Importantly, in mammary and lung cancer, Apelin prevents resistance to anti‐angiogenic receptor tyrosine kinase (RTK) inhibitor therapy, reducing growth and angiogenesis in lung and breast cancer models without increased hypoxia in the tumor microenvironment. Apelin blockage also prevents RTK inhibitor‐induced metastases, and high Apelin levels correlate with poor prognosis of anti‐angiogenic therapy patients. These data identify a druggable anti‐angiogenic drug target that reduces tumor blood vessel densities and normalizes the tumor vasculature to decrease metastases.

Published
2019
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37. A Rare Case of Hypothenar Hammer Syndrome Triggering Guyon’s Canal Syndrome

Author

Guruprasad Rai, Ganesh Sevagur Kamath, Vaishnavi Kavirayani, Arvind Kumar Bishnoi, and Revanth Reddy

Subjects
bilobed pseudoaneurysm, ulnar artery, ulnar nerve, Medicine
Abstract

In certain occupations, injuries and microtrauma are commonly encountered by the soft tissues of the hand in the adult population, which may, however, less frequently lead to arterial occlusion. One such example is that of the Hypothenar Hammer Syndrome (HHS). It is a rare traumatic disease of the hand, caused by blunt traumas to the heel of the hand that may damage the ulnar artery at the level of hypothenar eminence. This results in occlusion or aneurysm of the vessel. It is of clinical importance due to the risk of loss of limb function following digital ischemia. The ulnar nerve barely gets compressed in the Guyon’s canal, which may in turn cause Guyon’s canal syndrome. This is a case of a 43-year-old male patient who presented with painful swelling of the right hand, which was diagnosed as a bizarre presentation of a bilobed and partially thrombosed pseudoaneurysm of the ulnar artery producing Guyon’s canal syndrome that had to be surgically excised. The objective of this case is to highlight the clinical presentation of HHS for early diagnosis and treatment.

Published
2021
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38. Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline

Author

Cox, Miriam F, primary, Mackenzie, Strachan, additional, Low, Ryan, additional, Brown, Michael, additional, Sanchez, Emilie, additional, Carr, Aisling, additional, Carpenter, Ben, additional, Bishton, Mark, additional, Duncombe, Andrew, additional, Akpabio, Akpabio, additional, Kulasekararaj, Austin, additional, Sin, Fang En, additional, Jones, Alexis, additional, Kavirayani, Akhila, additional, Sen, Ethan S, additional, Quick, Vanessa, additional, Dulay, Gurdeep S, additional, Clark, Sam, additional, Bauchmuller, Kris, additional, Tattersall, Rachel S, additional, and Manson, Jessica J, additional

Published
2023
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43. High-Resolution Episcopic Microscopy (HREM) in Multimodal Imaging Approaches

Author

Katharina S. Keuenhof, Anoop Kavirayani, Susanne Reier, Stefan H. Geyer, Wolfgang J. Weninger, and Andreas Walter

Subjects
high-resolution episcopic microscopy, correlated multimodal imaging (CMI), correlation, bioimaging, microscopy, preclinical imaging, Biology (General), QH301-705.5
Abstract

High-resolution episcopic microscopy (HREM) is a three-dimensional (3D) episcopic imaging modality based on the acquisition of two-dimensional (2D) images from the cut surface of a block of tissue embedded in resin. Such images, acquired serially through the entire length/depth of the tissue block, are aligned and stacked for 3D reconstruction. HREM has proven to be specifically advantageous when integrated in correlative multimodal imaging (CMI) pipelines. CMI creates a composite and zoomable view of exactly the same specimen and region of interest by (sequentially) correlating two or more modalities. CMI combines complementary modalities to gain holistic structural, functional, and chemical information of the entire sample and place molecular details into their overall spatiotemporal multiscale context. HREM has an advantage over in vivo 3D imaging techniques on account of better histomorphologic resolution while simultaneously providing volume data. HREM also has certain advantages over ex vivo light microscopy modalities. The latter can provide better cellular resolution but usually covers a limited area or volume of tissue, with limited 3D structural context. HREM has predominantly filled a niche in the phenotyping of embryos and characterisation of anatomic developmental abnormalities in various species. Under the umbrella of CMI, when combined with histopathology in a mutually complementary manner, HREM could find wider application in additional nonclinical and translational areas. HREM, being a modified histology technique, could also be incorporated into specialised preclinical pathology workflows. This review will highlight HREM as a versatile imaging platform in CMI approaches and present its benefits and limitations.

Published
2021
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44. Effects of Tulp4 deficiency on murine embryonic development and adult phenotype.

Author

Jäger, Roland, Geyer, Stefan H., Kavirayani, Anoop, Kiss, Máté G., Waltenberger, Elisabeth, Rülicke, Thomas, Binder, Christoph J., Weninger, Wolfgang J., and Kralovics, Robert

Abstract

Genetically engineered mouse models have the potential to unravel fundamental biological processes and provide mechanistic insights into the pathogenesis of human diseases. We have previously observed that germline genetic variation at the TULP4 locus influences clinical characteristics in patients with myeloproliferative neoplasms. To elucidate the role of TULP4 in pathological and physiological processes in vivo, we generated a Tulp4 knockout mouse model. Systemic Tulp4 deficiency exerted a strong impact on embryonic development in both Tulp4 homozygous null (Tulp4−/−) and heterozygous (Tulp4+/−) knockout mice, the former exhibiting perinatal lethality. High‐resolution episcopic microscopy (HREM) of day 14.5 embryos allowed for the identification of multiple developmental defects in Tulp4−/− mice, including severe heart defects. Moreover, in Tulp4+/− embryos HREM revealed abnormalities of several organ systems, which per se do not affect prenatal or postnatal survival. In adult Tulp4+/− mice, extensive examinations of hematopoietic and cardiovascular features, involving histopathological surveys of multiple tissues as well as blood counts and immunophenotyping, did not provide evidence for anomalies as observed in corresponding embryos. Finally, evaluating a potential obesity‐related phenotype as reported for other TULP family members revealed a trend for increased body weight of Tulp4+/− mice. Research Highlights: To study the role of the TULP4 gene in vivo, we generated a Tulp4 knockout mouse model.Correlative analyses involving HREM revealed a strong impact of Tulp4 deficiency on murine embryonic development. [ABSTRACT FROM AUTHOR]

Published
2024
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47. HACE1 deficiency leads to structural and functional neurodevelopmental defects

Author

Nagy, Vanja, Hollstein, Ronja, Pai, Tsung-Pin, Herde, Michel K., Buphamalai, Pisanu, Moeseneder, Paul, Lenartowicz, Ewelina, Kavirayani, Anoop, Korenke, Georg Christoph, Kozieradzki, Ivona, Nitsch, Roberto, Cicvaric, Ana, Monje Quiroga, Francisco J., Deardorff, Matthew A., Bedoukian, Emma C., Li, Yun, Yigit, Gökhan, Menche, Jörg, Perçin, E. Ferda, Wollnik, Bernd, Henneberger, Christian, Kaiser, Frank J., and Penninger, Josef M.

Published
2019
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48. Historical perspectives on personality – The past and current concept: The search is not yet over

Author

Krishnamurthy Kavirayani

Subjects
Character, personality, temperament, types, Medicine
Abstract

Personality is the way we think, feel, perceive, and react to the external world, which has been thought of by different workers since ancient times. The number of theories itself reflects that personality is not an homogenous entity and the development of personality is biopsychosocial as viewed by psychiatrists and psychologists of different times.

Published
2018
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