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273 results on '"Kawaguchi, Naoki"'

2. Taste disorders and alopecia in myasthenia gravis

Author

Uzawa, Akiyuki, Suzuki, Shigeaki, Kuwabara, Satoshi, Akamine, Hiroyuki, Onishi, Yosuke, Yasuda, Manato, Ozawa, Yukiko, Kawaguchi, Naoki, Kubota, Tomoya, Takahashi, Masanori P., Suzuki, Yasushi, Watanabe, Genya, Kimura, Takashi, Sugimoto, Takamichi, Samukawa, Makoto, Minami, Naoya, Masuda, Masayuki, Konno, Shingo, Nagane, Yuriko, and Utsugisawa, Kimiaki

Published
2024
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5. Worsening of myasthenic symptoms associated with statins

Author

Sugimoto, Takamichi, Suzuki, Shigeaki, Uzawa, Akiyuki, Yamawaki, Takemori, Masuda, Masayuki, Minami, Naoya, Kawaguchi, Naoki, Kubota, Tomoya, Takahashi, Masanori P., Suzuki, Yasushi, Watanabe, Genya, Konno, Shingo, Kimura, Takashi, Samukawa, Makoto, Ishizuchi, Kei, Akamine, Hiroyuki, Onishi, Yosuke, Yasuda, Manato, Nagane, Yuriko, Maruyama, Hirofumi, Murai, Hiroyuki, and Utsugisawa, Kimiaki

Published
2024
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6. Clinical features and outcomes of patients with muscle-specific kinase antibody-positive myasthenia gravis in Japan

Author

Yasuda, Manato, Uzawa, Akiyuki, Kuwabara, Satoshi, Suzuki, Shigeaki, Akamine, Hiroyuki, Onishi, Yosuke, Ozawa, Yukiko, Kawaguchi, Naoki, Kubota, Tomoya, Takahashi, Masanori P., Suzuki, Yasushi, Watanabe, Genya, Kimura, Takashi, Sugimoto, Takamichi, Samukawa, Makoto, Minami, Naoya, Masuda, Masayuki, Konno, Shingo, Nagane, Yuriko, and Utsugisawa, Kimiaki

Published
2023
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7. Impact of Early Treatment with Intravenous High-Dose Methylprednisolone for Ocular Myasthenia Gravis

Author

Uzawa, Akiyuki, Suzuki, Shigeaki, Kuwabara, Satoshi, Akamine, Hiroyuki, Onishi, Yosuke, Yasuda, Manato, Ozawa, Yukiko, Kawaguchi, Naoki, Kubota, Tomoya, Takahashi, Masanori P., Suzuki, Yasushi, Watanabe, Genya, Kimura, Takashi, Sugimoto, Takamichi, Samukawa, Makoto, Minami, Naoya, Masuda, Masayuki, Konno, Shingo, Nagane, Yuriko, and Utsugisawa, Kimiaki

Published
2023
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8. Preliminary study of discrimination of human vocal commands in walrus (Odobenus rosmarus divergens)

Author

Endo, Shiho, Kawaguchi, Naoki, Shimizu, Yusuke, Imagawa, Asuka, Suzuki, Tomohiro, Ashikari, Harumasa, Wakai, Yoshihito, and Murayama, Tsukasa

Subjects
human vocal command, walrus
Abstract

Walruses seem to use various acoustic signals in social context. So, the auditory faculty is seems to be important for walruses. Can walruses understand another animals' vocal information using auditory sense? This study tested whether a male walrus could discriminate human vocal words and perform different actions corresponding to each one under various conditions. The subject, a male walrus (Odobenus rosmarus) named Pou, was set on the ground, and the experimenter spoke one of the ten words to the subject under the following conditions; (1) The experimenter stood close to the subject and spoke each vocal stimulus wearing a black cloak and goggles so that the experimenter's eye and body movements would not influence the subject's behavior, (2) A wooden board was placed between the experimenter and the subject so that the subject could not see the experimenter, (3) A wooden board was placed between the experimenter and the subject so that the subject could not to see the experimenter, and the experimenter uttered each vocal stimulus through an audio speaker. Under each condition, when the subject performed the correct action corresponding to the vocal stimulus, he was rewarded with a piece of fish. As a result, the subject responded correctly to almost all the human vocal stimuli in every condition, including when the speaker was not visible. This means that he was indeed responding to the vocal words and not the experimenter's cues. This study demonstrated that walruses can hear and identify human vocal words using their auditory sense and can form correspondence between vocal words and their meanings.

Published
2020

11. Cutoffs on severity metrics for minimal manifestations or better status in patients with generalized myasthenia gravis.

Author

Watanabe, Genya, Takai, Yoshiki, Nagane, Yuriko, Kubota, Tomoya, Yasuda, Manato, Akamine, Hiroyuki, Onishi, Yosuke, Uzawa, Akiyuki, Kawaguchi, Naoki, Masuda, Masayuki, Konno, Shingo, Amino, Itaru, Minami, Naoya, Kimura, Takashi, Samukawa, Makoto, Sugimoto, Takamichi, Suzuki, Yasushi, Takahashi, Masanori P., Suzuki, Shigeaki, and Murai, Hiroyuki

Subjects
MYASTHENIA gravis, RECEIVER operating characteristic curves, CLINICAL trials, TRIAL practice, QUALITY of life
Abstract

International consensus guidance and Japanese clinical guidelines for myasthenia gravis (MG) recommend achieving minimal manifestations or better status (MM-or-better) as the severity component of the treatment goal. However, the subjective nature of determining MM can result in ambiguity regarding this category in clinical practice and clinical trials. This study analyzed severity metrics in a large number of MG patients to propose criteria for MM-or-better. We utilized data obtained from 3800 MG patients who participated in nationwide cross-sectional surveys in Japan. Among these, 2784 patients with generalized MG were divided into two groups based on MG Foundation of America postintervention status: MM-or-better status (n = 1432); and improved-or-worse (I-or-worse) status (n = 1352). We compared severity metrics (MG-activities of daily living scale [MG-ADL], quantitative MG score [QMG], and MG composite scale [MGC]) between groups and calculated cutoff values to separate the two groups. Using these cutoffs, patients subjectively assigned as MM-or-better were classified into strict MM-or-better (below a cutoff) or optimistic MM-or-better (above a cutoff) groups, and clinical characteristics were then compared. Cutoff values for strict MM-or-better were MG-ADL ≤2, QMG ≤7, and MGC ≤4 (sensitivity 82.0%, 88.7%, and 87.4%; specificity 85.0%, 70.0%, and 77.9%; and accuracy 91.2%, 88.7%, and 90.7%, respectively). Mean values of the revised 15-item MG quality of life scale were significantly lower in the strict MM-or-better group than in the optimistic MM-or-better group. Quantitative criteria for MM-or-better appear likely to be useful in the context of rigorous clinical trials and also as reference information in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2025
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13. Congenital Pulmonary Lymphangiectasia Masked by Postoperative Pulmonary Venous Obstruction in an Infant with Total Anomalous Pulmonary Venous Connection

Author

Nawata, Yoshiko, primary, Toyomura, Daisuke, additional, Okada, Seigo, additional, Suzuki, Yasuo, additional, Honda-Nakada, Narumi, additional, Ohnishi, Yuji, additional, Sugitani, Yuichiro, additional, Kawaguchi, Naoki, additional, Tokitaka-Okada, Rui, additional, Masaki, Naoki, additional, Ikeda, Eiji, additional, and Hasegawa, Shunji, additional

Published
2024
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14. Corrigendum to “Clinical features and outcomes of patients with muscle-specific kinase antibody-positive myasthenia gravis in Japan” [Journal of Neuroimmunology 385 (2023) 578241].

Author

Yasuda, Manato, Uzawa, Akiyuki, Kuwabara, Satoshi, Suzuki, Shigeaki, Akamine, Hiroyuki, Onishi, Yosuke, Ozawa, Yukiko, Kawaguchi, Naoki, Kubota, Tomoya, Takahashi, Masanori P., Suzuki, Yasushi, Watanabe, Genya, Kimura, Takashi, Sugimoto, Takamichi, Samukawa, Makoto, Minami, Naoya, Masuda, Masayuki, Konno, Shingo, Nagane, Yuriko, and Utsugisawa, Kimiaki

Published
2024
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15. Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study

Author

Mazia, Claudio Gabriel, Wilken, Miguel, Barroso, Fabio, Saba, Juliet, Rugiero, Marcelo, Bettini, Mariela, Chaves, Marcelo, Vidal, Gonzalo, Garcia, Alejandra Dalila, De Bleecker, Jan, Van den Abeele, Guy, de Koning, Kathy, De Mey, Katrien, Mercelis, Rudy, Mahieu, Délphine, Wagemaekers, Linda, Van Damme, Philip, Depreitere, Annelies, Schotte, Caroline, Smetcoren, Charlotte, Stevens, Olivier, Van Daele, Sien, Vandenbussche, Nicolas, Vanhee, Annelies, Verjans, Sarah, Vynckier, Jan, D'Hondt, Ann, Tilkin, Petra, Alves de Siqueira Carvalho, Alzira, Dias Brockhausen, Igor, Feder, David, Ambrosio, Daniel, César, Pamela, Melo, Ana Paula, Martins Ribeiro, Renata, Rocha, Rosana, Bezerra Rosa, Bruno, Veiga, Thabata, da Silva, Luiz Augusto, Santos Engel, Murilo, Gonçalves Geraldo, Jordana, Ananias Morita, Maria da Penha, Nogueira Coelho, Erica, Paiva, Gabriel, Pozo, Marina, Prando, Natalia, Martineli Torres, Debora Dada, Butinhao, Cristiani Fernanda, Duran, Gustavo, Gomes da Silva, Tamires Cristina, Otavio Maia Gonçalves, Luiz, Pazetto, Lucas Eduardo, Fialho, Tomás Augusto Suriane, Renata Cubas Volpe, Luciana, Souza Duca, Luciana, Souza Bulle Oliveira, Acary, Amaral Andrade, Ana Carolina, Annes, Marcelo, Duarte Silva, Liene, Cavalcante Lino, Valeria, Pinto, Wladimir, Assis, Natália, Carrara, Fernanda, Miranda, Carolina, Souza, Iandra, Fernandes, Patricia, Siddiqi, Zaeem, Phan, Cecile, Narayan, Jeffrey, Blackmore, Derrick, Mallon, Ashley, Roderus, Rikki, Watt, Elizabeth, Junkerova, Jana, Kurkova, Barbora, Reguliova, Katarina, Zapletalova, Olga, Pitha, Jiri, Novakova, Iveta, Tyblova, Michaela, Jurajdova, Ivana, Wolfova, Marcela, Andersen, Henning, Harbo, Thomas, Vinge, Lotte, Krogh, Susanne, Mogensen, Anita, Vissing, John, Højgaard, Joan, Witting, Nanna, Mette Ostergaard Autzen, Anne, Pedersen, Jane, Eralinna, Juha-Pekka, Laaksonen, Mikko, Oksaranta, Olli, Harrison, Tuula, Eriksson, Jaana, Rozsa, Csilla, Horvath, Melinda, Lovas, Gabor, Matolcsi, Judit, Szabo, Gyorgyi, Jakab, Gedeonne, Szabadosne, Brigitta, Antonini, Giovanni, Di Pasquale, Antonella, Garibaldi, Matteo, Morino, Stefania, Troili, Fernanda, Fionda, Laura, Filla, Allessandro, Costabile, Teresa, Marano, Enrico, Saccà, Francesco, Fasanaro, Angiola, Marsili, Angela, Puorro, Giorgia, Mantegazza, Renato, Antozzi, Carlo, Bonanno, Silvia, Camera, Giorgia, Locatelli, Alberta, Maggi, Lorenzo, Pasanisi, Maria, Campanella, Angela, Evoli, Amelia, Alboini, Paolo Emilio, D'Amato, Valentina, Iorio, Raffaele, Kanai, Tetsuya, Kawaguchi, Naoki, Mori, Masahiro, Kaneko, Yoko, Kanzaki, Akiko, Kobayashi, Eri, Masaki, Katsuhisa, Matsuse, Dai, Matsushita, Takuya, Uehara, Taira, Shimpo, Misa, Jingu, Maki, Kikutake, Keiko, Nakamura, Yumiko, Sano, Yoshiko, Nagane, Yuriko, Kamegamori, Ikuko, Tsuda, Tomoko, Fujii, Yuko, Futono, Kazumi, Ozawa, Yukiko, Mizugami, Aya, Saito, Yuka, Morikawa, Miyuki, Samukawa, Makoto, Kamakura, Sachiko, Miyawaki, Eriko, Mitazaki, Teiichiro, Motomura, Masakatsu, Mukaino, Akihiro, Yoshimura, Shunsuke, Asada, Shizuka, Yoshida, Seiko, Amamoto, Shoko, Kobashikawa, Tomomi, Koga, Megumi, Maeda, Yasuko, Takada, Kazumi, Takada, Mihoko, Tsurumaru, Masako, Yamashita, Yumi, Akiyama, Tetsuya, Narikawa, Koichi, Tano, Ohito, Tsukita, Kenichi, Kurihara, Rikako, Meguro, Fumie, Fukuda, Yusuke, Sato, Miwako, Funaka, Soichiro, Kawamura, Tomohiro, Makamori, Masayuki, Takahashi, Masanori, Taichi, Namie, Hasuike, Tomoya, Higuchi, Eriko, Kobayashi, Hisako, Osakada, Kaori, Tsuda, Emiko, Shimohama, Shun, Hayashi, Takashi, Hisahara, Shin, Kawamata, Jun, Murahara, Takashi, Saitoh, Masaki, Suzuki, Shuichiro, Yamamoto, Daisuke, Ishiyama, Yoko, Ishiyama, Naoko, Noshiro, Mayuko, Takeyama, Rumi, Uwasa, Kaori, Yasuda, Ikuko, van der Kooi, Anneke, de Visser, Marianne, Gibson, Tamar, Casasnovas, Carlos, Alberti Aguilo, Maria Antonia, Homedes-Pedret, Christian, Julia Palacios, Natalia, Diez Porras, Laura, Velez Santamaria, Valentina, Lazaro, Ana, Diez Tejedor, Exuperio, Gomez Salcedo, Pilar, Fernandez-Fournier, Mireya, Lopez Ruiz, Pedro, Rodriguez de Rivera, Francisco Javier, Sastre, Maria, Gamez, Josep, Sune, Pilar, Salvado, Maria, Gili, Gisela, Mazuela, Gonzalo, Illa, Isabel, Cortes Vicente, Elena, Diaz-Manera, Jordi, Querol Gutierrez, Luis Antonio, Rojas Garcia, Ricardo, Vidal, Nuria, Arribas-Ibar, Elisabet, Piehl, Fredrik, Hietala, Albert, Bjarbo, Lena, Sengun, Ihsan, Meherremova, Arzu, Ozcelik, Pinar, Balkan, Bengu, Tuga, Celal, Ugur, Muzeyyen, Erdem-Ozdamar, Sevim, Bekircan-Kurt, Can Ebru, Acar, Nazire Pinar, Yilmaz, Ezgi, Caliskan, Yagmur, Orsel, Gulsah, Efendi, Husnu, Aydinlik, Seda, Cavus, Hakan, Kutlu, Ayse, Becerikli, Gulsah, Semiz, Cansu, Tun, Ozlem, Terzi, Murat, Dogan, Baki, Onar, Musa Kazim, Sen, Sedat, Kirbas Cavdar, Tugce, Veske, Adife, Norwood, Fiona, Dimitriou, Aikaterini, Gollogly, Jakit, Mahdi-Rogers, Mohamed, Seddigh, Arshira, Sokratous, Giannis, Maier, Gal, Sohail, Faisal, Jacob, Saiju, Sadalage, Girija, Torane, Pravin, Brown, Claire, Shah, Amna, Sathasivam, Sivakumar, Arndt, Heike, Davies, Debbie, Watling, Dave, Amato, Anthony, Cochrane, Thomas, Salajegheh, Mohammed, Roe, Kristen, Amato, Katherine, Toska, Shirli, Wolfe, Gil, Silvestri, Nicholas, Patrick, Kara, Zakalik, Karen, Katz, Jonathan, Miller, Robert, Engel, Marguerite, Forshew, Dallas, Bravver, Elena, Brooks, Benjamin, Plevka, Sarah, Burdette, Maryanne, Cunningham, Scott, Sanjak, Mohammad, Kramer, Megan, Nemeth, Joanne, Schommer, Clara, Tierney, Scott, Juel, Vern, Guptill, Jeffrey, Hobson-Webb, Lisa, Massey, Janice, Beck, Kate, Carnes, Donna, Loor, John, Anderson, Amanda, Pascuzzi, Robert, Bodkin, Cynthia, Kincaid, John, Snook, Riley, Guingrich, Sandra, Micheels, Angela, Chaudhry, Vinay, Corse, Andrea, Mosmiller, Betsy, Kelley, Andrea, Ho, Doreen, Srinivasan, Jayashri, Vytopil, Michal, Jara, Jordan, Ventura, Nicholas, Scala, Stephanie, Carter, Cynthia, Donahue, Craig, Herbert, Carol, Weiner, Elaine, Alam, Sharmeen, McKinnon, Jonathan, Haar, Laura, McKinnon, Naya, Alcon, Karan, McKenna, Kaitlyn, Sattar, Nadia, Daniels, Kevin, Jeffery, Dennis, Freimer, Miriam, Hoyle, Joseph Chad, Kissel, John, Agriesti, Julie, Chelnick, Sharon, Mezache, Louisa, Pineda, Colleen, Muharrem, Filiz, Karam, Chafic, Khoury, Julie, Marburger, Tessa, Kaur, Harpreet, Dimitrova, Diana, Gilchrist, James, Agrawal, Brajesh, Elsayed, Mona, Kohlrus, Stephanie, Andoin, Angela, Darnell, Taylor, Golden, Laura, Lokaitis, Barbara, Seelback, Jenna, Muppidi, Srikanth, Goyal, Neelam, Sakamuri, Sarada, So, Yuen T., Paulose, Shirley, Pol, Sabrina, Welsh, Lesly, Bhavaraju-Sanka, Ratna, Tobon Gonzales, Alejandro, Dishman, Lorraine, Jones, Floyd, Gonzalez, Anna, Padilla, Patricia, Saklad, Amy, Silva, Marcela, Kazamel, Mohamed, Alsharabati, Mohammad, Lu, Liang, Nozaki, Kenkichi, Mumfrey-Thomas, Sandi, Woodall, Amy, Mozaffar, Tahseen, Cash, Tiyonnoh, Goyal, Namita, Roy, Gulmohor, Mathew, Veena, Maqsood, Fatima, Minton, Brian, Jones, H. James, Rosenfeld, Jeffrey, Garcia, Rebekah, Echevarria, Laura, Garcia, Sonia, Pulley, Michael, Aranke, Shachie, Berger, Alan Ross, Shah, Jaimin, Shabbir, Yasmeen, Smith, Lisa, Varghese, Mary, Gutmann, Laurie, Gutmann, Ludwig, Jerath, Nivedita, Nance, Christopher, Swenson, Andrea, Olalde, Heena, Kressin, Nicole, Sieren, Jeri, Barohn, Richard, Dimachkie, Mazen, Glenn, Melanie, McVey, April, Pasnoor, Mamatha, Statland, Jeffery, Wang, Yunxia, Liu, Tina, Emmons, Kelley, Jenci, Nicole, Locheke, Jerry, Fondaw, Alex, Johns, Kathryn, Rico, Gabrielle, Walsh, Maureen, Herbelin, Laura, Hafer-Macko, Charlene, Kwan, Justin, Zilliox, Lindsay, Callison, Karen, Young, Valerie, DiSanzo, Beth, Naunton, Kerry, Benatar, Michael, Bilsker, Martin, Sharma, Khema, Cooley, Anne, Reyes, Eliana, Michon, Sara-Claude, Sheldon, Danielle, Steele, Julie, Howard Jr, James, Chopra, Manisha, Traub, Rebecca, Vu, Tuan, Katzin, Lara, McClain, Terry, Harvey, Brittany, Hart, Adam, Huynh, Kristin, Beydoun, Said, Chilingaryan, Amaiak, Doan, Victor, Droker, Brian, Gong, Hui, Karimi, Sanaz, Lin, Frank, Pokala, Krishna, Shah, Akshay, Tran, Anh, Akhter, Salma, Malekniazi, Ali, Tandan, Rup, Hehir, Michael, Waheed, Waqar, Lucy, Shannon, Weiss, Michael, Distad, Jane, Strom, Susan, Downing, Sharon, Kim, Bryan, Nowak, Richard, Dicapua, Daniel, Keung, Benison, Kumar, Aditya, Patwa, Huned, Robeson, Kimberly, Yang, Irene, Nye, Joan, Vu, Hong, Murai, Hiroyuki, Uzawa, Akiyuki, Suzuki, Yasushi, Imai, Tomihiro, Shiraishi, Hirokazu, Suzuki, Hidekazu, Okumura, Meinoshin, O’Brien, Fanny, Wang, Jing-Jing, Fujita, Kenji P., and Utsugisawa, Kimiaki

Published
2019
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20. Pretransplant ribavirin and interferon-α therapy for rhinovirus interstitial pneumonia in a RAG1-deficient infant

Author

Harada, Nobutaka, primary, Sonoda, Motoshi, additional, Ishimura, Masataka, additional, Eguchi, Katsuhide, additional, Kinoshita, Keishiro, additional, Matsuoka, Wakato, additional, Motomura, Yoshitomo, additional, Kaku, Noriyuki, additional, Kawaguchi, Naoki, additional, Takeuchi, Takami, additional, and Ohga, Shouichi, additional

Published
2023
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21. Performance evaluation of the EUROIMMUN anti‐acetylcholine receptor enzyme‐linked immunoassay.

Author

Kawaguchi, Naoki, Imafuku, Asami, Fujii, Satoshi, and Sohn, Ji‐Hoon

Subjects
*IMMUNOASSAY, *ENZYME-linked immunosorbent assay, *MYASTHENIA gravis, *RECEPTOR antibodies, *RADIOIMMUNOASSAY, *DESMOGLEINS
Abstract

Objectives: Anti‐acetylcholine receptor antibodies (AChR Ab) are one of the pathogenic autoantibodies in myasthenia gravis (MG), and they are specifically mentioned in the Japanese clinical guidelines for MG. In the serological diagnosis and measurement of autoantibodies as an adjunct marker for MG, the radioimmunoassay (RIA) method has been conventionally used as the gold standard. However, there have been several worldwide concerns regarding the use of radioisotopes. In this study, we evaluated the performance of the EUROIMMUN AChR Ab enzyme‐linked immunosorbent assay (ELISA) in comparison with RIA. Methods: ELISA reproducibility and dilution linearity were analyzed using AChR Ab‐positive samples. Sera from 50 patients with suspected MG and 50 healthy donors were used to assess the correlation and qualitative agreement between the two methods. Results: The ELISA showed good interassay precision and dilution linearity. The correlation coefficient, sensitivity, specificity and overall agreement of the ELISA in comparison with the conventional RIA amounted to 0.87, 98%, 92% and 95% (kappa = 0.895), respectively. Analysis of the discordant results suggested that the ELISA might be more capable of detecting low AChR Ab reactivity in patients with suspected MG. Conclusions: The AchR Ab ELISA provides a reliable tool for the quantification of AchR Ab, supporting the diagnosis of MG. As a non‐isotopic assay with good precision, shorter handling time and high correlation with the conventional RIA, the AChR ELISA could be a useful alternative in the laboratory routine. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Real‐world experience with eculizumab and switching to ravulizumab for generalized myasthenia gravis.

Author

Tokuyasu, Daiki, Suzuki, Shigeaki, Uzawa, Akiyuki, Nagane, Yuriko, Masuda, Masayuki, Konno, Shingo, Kubota, Tomoya, Samukawa, Makoto, Sugimoto, Takamichi, Ishizuchi, Kei, Oyama, Munenori, Yasuda, Manato, Akamine, Hiroyuki, Onishi, Yosuke, Suzuki, Yasushi, Kawaguchi, Naoki, Minami, Naoya, Kimura, Takashi, Takahashi, Masanori P., and Murai, Hiroyuki

Subjects
MYASTHENIA gravis, ECULIZUMAB, CLINICAL trials, PATIENTS' attitudes
Abstract

Objective: Eculizumab and ravulizumab are complement protein C5 inhibitors, showing efficacy and tolerability for patients with anti‐acetylcholine receptor‐positive (AChR+) generalized myasthenia gravis (gMG) in phase 3 clinical trials and subsequent analyses. The purpose of the present study was to evaluate the clinical significance of eculizumab and switching to ravulizumab for refractory AChR+ gMG patients in the real‐world experience. Methods: Among the database of Japan MG registry survey 2021, we studied AChR+ gMG patients who received eculizumab. We also evaluated these patients who switched from eculizumab to ravulizumab. Responder was defined as an improvement of at least 3 points in MG‐ADL. We performed a questionnaire of preference between eculizumab and ravulizumab. Results: Among 1,106 patients with AChR+ gMG, 36 patients (3%) received eculizumab (female 78%, mean age 56.0 years). Eculizumab was preferentially used in severe and refractory MG patients. The duration of eculizumab treatment was 35 months on average. MG‐ADL improved from 9.4 ± 4.9 to 5.9 ± 5.1, and 25 (70%) of the 36 gMG patients were responders. Postintervention status was markedly improved after the eculizumab treatment. Of 13 patients who did not continue eculizumab, 6 showed insufficiencies. Early onset MG was most effective. However, 15 patients switching from eculizumab to ravulizumab kept favorable response and tolerability. Questionnaire surveys showed preference for ravulizumab over eculizumab. Interpretation: Eculizumab and switching to ravulizumab showed to be effective for refractory AChR+ gMG patients in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis

Author

Mori, Shuuichi, primary, Suzuki, Shigeaki, additional, Konishi, Tetsuro, additional, Kawaguchi, Naoki, additional, Kishi, Masahiko, additional, Kuwabara, Satoshi, additional, Ishizuchi, Kei, additional, Zhou, Heying, additional, Shibasaki, Futoshi, additional, Tsumoto, Hiroki, additional, Omura, Takuya, additional, Miura, Yuri, additional, Mori, Seijiro, additional, Higashihara, Mana, additional, Murayama, Shigeo, additional, and Shigemoto, Kazuhiro, additional

Published
2023
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27. 非協力的ターゲット捕獲・把持機構の検討

Author

NAKANISHI, Hiroki, TAKAHASHI, Kenichiro, KAWAGUCHI, Naoki, HASHIMOTO, Takuya, and TOKUYASU, Akihiro

Abstract

第10回スペースデブリワークショップ (2022年11月28-30日. 主催: 宇宙航空研究開発機構研究開発部門(JAXA), 宇宙航空研究開発機構調布航空宇宙センター(JAXA)(CAC)), 調布市, 東京, The 10th Space Debris Workshop (November 28-30, 2022. Organizer: Research and Development Directorate, Japan Aerospace Exploration Agency (JAXA), Chofu Aerospace Center, Japan Aerospace Exploration Agency (JAXA)(CAC)), Chofu, Tokyo, Japan, 能動的スペースデブリ除去（ADR）作業において，ターゲットの把持および，スラスタやEDT，デオービット膜といったデオービットデバイスの取付は重要なキーテクノロジーの一つである．これまでに確立されている軌道上サービス技術は全て，専用の被把持機構を備え，姿勢が安定化している「協力的」な作業ターゲットを前提している．一方ADR の対象は「非協力的」なターゲットとなるため，これに対応できる捕獲・把持をできるだけ簡易な機構・制御で実現することが必要である．筆者らは，衛星やロケット上段の構造を利用する・または全体を包み込むことにより把持をした後，直ちにサービス衛星から切り離されることによりデオービットデバイス固定機構としても機能するデブリ把持機構について様々な方式について検討を進めている．本発表では，これまでの取り組みおよび最新の成果について報告する．, In active space debris removal (ADR) operations, target grasping and attachment of deorbit devices such as thrusters, EDTs, and deorbit membranes is one of the key technologies. All on-orbit service technologies established so far assume a "cooperative" working target with a dedicated grasping mechanism and stabilized attitude. On the other hand, ADR targets are "non-cooperative" targets, so it is necessary to realize capture and grasping with simple mechanisms and control. The authors have been studying various methods of debris grasping mechanisms that can also function as a deorbit device fixation mechanism by being immediately detached from the service satellite after grasping by utilizing the structure of the satellite or rocket upper stage or by encasing the entire debris. In this presentation, we will report on our past efforts and latest results., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA2230027058

Published
2023

28. Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis

Author

Uzawa, Akiyuki, primary, Suzuki, Shigeaki, additional, Kuwabara, Satoshi, additional, Akamine, Hiroyuki, additional, Onishi, Yosuke, additional, Yasuda, Manato, additional, Ozawa, Yukiko, additional, Kawaguchi, Naoki, additional, Kubota, Tomoya, additional, Takahashi, Masanori P, additional, Suzuki, Yasushi, additional, Watanabe, Genya, additional, Kimura, Takashi, additional, Sugimoto, Takamichi, additional, Samukawa, Makoto, additional, Minami, Naoya, additional, Masuda, Masayuki, additional, Konno, Shingo, additional, Nagane, Yuriko, additional, and Utsugisawa, Kimiaki, additional

Published
2023
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29. Immunotherapy for ocular myasthenia gravis: an observational study in Japan

Author

Narita, Tomoko, primary, Nakane, Shunya, additional, Nagaishi, Akiko, additional, Minami, Naoya, additional, Niino, Masaaki, additional, Kawaguchi, Naoki, additional, Murai, Hiroyuki, additional, Kira, Jun-ichi, additional, Shimizu, Jun, additional, Iwasa, Kazuo, additional, Yoshikawa, Hiroaki, additional, Hatanaka, Yuki, additional, Sonoo, Masahiro, additional, Shimizu, Yuko, additional, and Matsuo, Hidenori, additional

Published
2023
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30. New Era’s J.LEAGUE : Future of J.LEAGUE after COVID-19

Author

KAWAGUCHI, Naoki

Subjects
デジタル応援, New Corona, Community Contribution Activities, 地域貢献活動, J League, コロナ禍, リモートマッチ, Jリーグ, Digital support, Remote match
Abstract

text, 紀要論文 / Departmental Bulletin Paper

Published
2021

32. ADR作業の為の非協力的ターゲット捕獲・把持機構の検討

Author

NAKANISHI, Hiroki, KAWAGUCHI, Naoki, HAYASHI, Teruaki, WASHI, Yuki, HASHIMOTO, Takuya, MASUDA, Yuto, and TAGA, Keisuke

Abstract

第9回スペースデブリワークショップ (2021年2月24-26日. 宇宙航空研究開発機構調布航空宇宙センター(JAXA)(CAC), オンライン会議), 調布市, 東京, The 9th Space Debris Workshop (February 24-26, 2021. Chofu Aerospace Center, Japan Aerospace Exploration Agency (JAXA)(CAC), Online meeting), Chofu, Tokyo, Japan, 能動的スペースデブリ除去（ADR）作業において，ターゲットの把持および，スラスタやEDT，デオービット膜といったデオービットデバイスの取付は重要なキーテクノロジーの一つである．これまでに確立されている軌道上サービス技術は全て，専用の被把持機構を備え，姿勢が安定化している「協力的」な作業ターゲットを前提している．一方ADR の対象は「非協力的」なターゲットとなるため，これに対応できる捕獲・把持をできるだけ簡易な機構・制御で実現することが必要である．筆者らは，衛星やロケット上段の構造を利用する・または全体を包み込むことにより把持をした後，直ちにサービス衛星から切り離されることによりデオービットデバイス固定機構としても機能するデブリ把持機構について検討を進めている．本発表では，これまでの取り組みおよび最新の成果について報告する．, In order to realize the active debris removal (ADR), capturing debris and attaching a debris removal device (ex. micro thruster, EDT, and deorbit membrane) to debris is a key technology. Any space robot hands in existence cannot capture debris because they require their dedicated fixtures on the capture target. It is essential to establish a simple grasping system for the uncooperative target without such fixtures. The authors study such a grasping system that can grasp the original structure on debris or grasp its whole body. The system can also become a fixing mechanism for debris deorbit devices after separating from the service satellite (robot). In this presentation, the overview of our gripping systems and the latest issues are introduced., 形態: カラー図版あり, Physical characteristics: Original contains color illustrations, 資料番号: AA2130003035, レポート番号: JAXA-SP-21-001

Published
2021

33. Japan MG registry: Chronological surveys over 10 years

Author

Suzuki, Shigeaki, primary, Masuda, Masayuki, additional, Uzawa, Akiyuki, additional, Nagane, Yuriko, additional, Konno, Shingo, additional, Suzuki, Yasushi, additional, Kubota, Tomoya, additional, Sugimoto, Takamichi, additional, Samukawa, Makoto, additional, Watanabe, Genya, additional, Ishizuchi, Kei, additional, Akamine, Hiroyuki, additional, Onishi, Yosuke, additional, Yoshizumi, Kazuki, additional, Uchi, Takafumi, additional, Amino, Itaru, additional, Ueta, Yuki, additional, Minami, Naoya, additional, Kawaguchi, Naoki, additional, Kimura, Takashi, additional, Takahashi, Masanori P., additional, Murai, Hiroyuki, additional, and Utsugisawa, Kimiaki, additional

Published
2022
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34. Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets

Author

Muta, Kanako, primary, Hata, Junichi, additional, Kawaguchi, Naoki, additional, Haga, Yawara, additional, Yoshimaru, Daisuke, additional, Hagiya, Kei, additional, Kaneko, Takaaki, additional, Miyabe-Nishiwaki, Takako, additional, Komaki, Yuji, additional, Seki, Fumiko, additional, Okano, Hirotaka James, additional, and Okano, Hideyuki, additional

Published
2022
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36. Initial In-Orbit Operation Result of Microsatellite HIBARI: Attitude Control by Driving Solar Array Paddles

Author

Watanabe, Kei, Kobayashi, Hiroyuki, Kawaguchi, Naoki, Nerome, Shogo, Amaki, Yuki, Sagawa, Fumitaka, Sato, Soichi, Takahashi, Kenichiro, Sasagawa, Yuta, Miyamoto, Kiyona, Yatsu, Yoichi, Chujo, Toshihiro, and Matunaga, Saburo

Subjects
microsatellite, VSAC, HIBARI
Abstract

We have developed a 50kg class microsatellite "HIBARI". The mission of this satellite is to demonstrate a novel attitude control method for microsatellites which is called “Variable Shape Attitude Control (VSAC).” VSAC is a method using anti-torque by driving variable shape structures. HIBARI has four drivable solar array paddles, and will demonstrate VSAC. The development of HIBARI began in 2019, and it was injected into orbit in November 2021 under the Innovative Satellite Technology Demonstration Program led by JAXA. Currently, HIBARI has completed its critical phase and paddle deployment phase, and is conducting paddle drive experiments in orbit. In paddle drive experiments, the paddles are driven according to the command values, and the accompanying attitude change is confirmed. These results indicate that the satellite can generate angular velocities of 4 deg/s or more and achieve the target agile maneuver of 30deg in 10seconds, which is comparable to that of CMG for microsatellite.

Published
2022

37. 押し付け動作のみでの把持を実現するトラス構造把持エンドエフェクタの研究

Author

NAKANISHI, Hiroki, KAWAGUCHI, Naoki, and TAGA, Keisuke

Abstract

第32回アストロダイナミクスシンポジウム (2022年7月25-26日. ハイブリッド開催（JAXA相模原キャンパス& オンライン)), The 32th Workshop on JAXA Astrodynamics and Flight Mechanics 2022 (July 25-26, 2022. Hybrid(in-person & online) Conference (Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), 資料番号: SA6000181056, レポート番号: ASTRO-2022-C007

Published
2022

38. A clinical predictive score for postoperative myasthenic crisis

Author

Kanai, Tetsuya, Uzawa, Akiyuki, Sato, Yasunori, Suzuki, Shigeaki, Kawaguchi, Naoki, Himuro, Keiichi, Oda, Fumiko, Ozawa, Yukiko, Nakahara, Jin, Suzuki, Norihiro, Takahashi, Yuko K., Ishibashi, Satoru, Yokota, Takanori, Ogawa, Takashi, Yokoyama, Kazumasa, Hattori, Nobutaka, Izaki, Shoko, Oji, Satoru, Nomura, Kyoichi, Kaneko, Juntaro, Nishiyama, Kazutoshi, Yoshino, Ichiro, and Kuwabara, Satoshi

Published
2017
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47. Flight Model Development and Operation Plan of Micro-Satellite HIBARI for Variable Shape Attitude Control Demonstration

Author

WATANABE, Kei, primary, KOBAYASHI, Hiroyuki, additional, KAWAGUCHI, Naoki, additional, SATO, Soich, additional, NEROME, Shogo, additional, AMAKI, Yuki, additional, SAGAWA, Fumitaka, additional, SASAGAWA, Yuta, additional, TAKAHASHI, Kenichiro, additional, MIYAMOTO, Kiyona, additional, CHUJO, Toshihiro, additional, YATSU, Yoichi, additional, and MATUNAGA, Saburo, additional

Published
2022
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