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844 results on '"Kawaguchi, Yoshiharu"'

1. Zones where reduced implant density leads to correction loss after scoliosis surgery for Lenke 1A adolescent idiopathic scoliosis: a multicenter study

Author

Yanagisawa, Kaho, Oba, Hiroki, Ohba, Tetsuro, Banno, Tomohiro, Seki, Shoji, Uehara, Masashi, Ikegami, Shota, Mimura, Tetsuhiko, Hatakenaka, Terue, Miyaoka, Yoshinari, Kurogochi, Daisuke, Fukuzawa, Takuma, Koseki, Michihiko, Kawaguchi, Yoshiharu, Haro, Hirotaka, Matsuyama, Yukihiro, and Takahashi, Jun

Published
2024
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3. Deep learning-based prediction model for postoperative complications of cervical posterior longitudinal ligament ossification

Author

Ito, Sadayuki, Nakashima, Hiroaki, Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Tsutui, Shinji, Hirai, Takashi, Matsukura, Yu, Wada, Kanichiro, Katsumi, Keiichi, Koda, Masao, Kimura, Atsushi, Furuya, Takeo, Maki, Satoshi, Nagoshi, Narihito, Nishida, Norihiro, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Miyagi, Masayuki, Kaito, Takashi, Yamada, Kei, Banno, Tomohiro, Kato, Satoshi, Ohba, Tetsuro, Inami, Satoshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Oda, Masahiro, Mori, Kensaku, Taneichi, Hiroshi, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Matsumoto, Morio, Yamazaki, Masashi, Okawa, Atsushi, and Imagama, Shiro

Published
2023
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4. Comparison of radiological characteristics between diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: a multicenter study

Author

Takahashi, Takuya, Yoshii, Toshitaka, Mori, Kanji, Kobayashi, Shigeto, Inoue, Hisashi, Tada, Kurisu, Tamura, Naoto, Hirai, Takashi, Sugimura, Nobuhiro, Nagoshi, Narihito, Maki, Satoshi, Katsumi, Keiichi, Koda, Masao, Murata, Kazuma, Takeuchi, Kazuhiro, Nakashima, Hiroaki, Imagama, Shiro, Kawaguchi, Yoshiharu, Yamazaki, Masashi, and Okawa, Atsushi

Published
2023
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8. Preoperative Symptom Duration Influences Neurological Recovery and Patient Reported Outcome Measures After Surgical Treatment of Cervical Ossification of the Posterior Longitudinal Ligament

Author

Matsukura, Yu, Egawa, Satoru, Inose, Hiroyuki, Sakai, Kenichiro, Kusano, Kazuo, Tsutsui, Shunji, Hirai, Takashi, Matsukura, Yu, Wada, Kanichiro, Katsumi, Keiichi, Koda, Masao, Kimura, Atsushi, Furuya, Takeo, Maki, Satoshi, Nagoshi, Narihito, Nishida, Norihiro, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Nakashima, Hiroaki, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Miyagi, Masayuki, Kaito, Takashi, Yamada, Kei, Banno, Tomohiro, Kato, Satoshi, Ohba, Tetsuro, Moridaira, Hiroshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Taneichi, Hiroshi, Imagama, Shiro, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Nakamura, Masaya, Matsumoto, Morio, Yamazaki, Masashi, Okawa, Atsushi, and Yoshii, Toshitaka

Published
2023
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15. Factors Associated With Loss of Cervical Lordosis After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: Data From a Prospective Multicenter Study

Author

Nakashima, Hiroaki, Imagama, Shiro, Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Tsutsui, Shinji, Hirai, Takashi, Matsukura, Yu, Wada, Kanichiro, Katsumi, Keiichi, Koda, Masao, Kimura, Atsushi, Furuya, Takeo, Maki, Satoshi, Nagoshi, Narihito, Nishida, Norihiro, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Miyagi, Masayuki, Kaito, Takashi, Yamada, Kei, Banno, Tomohiro, Kato, Satoshi, Ohba, Tetsuro, Moridaira, Hiroshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Taneichi, Hiroshi, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Nakamura, Masaya, Okawa, Atsushi, and Yamazaki, Masashi

Published
2023
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16. Usefulness of modified S-line for upper instrumented vertebra selection in adolescent idiopathic scoliosis Lenke type 2 curves

Author

Mimura, Tetsuhiko, Ikegami, Shota, Banno, Tomohiro, Seki, Shoji, Ohba, Tetsuro, Oba, Hiroki, Kuraishi, Shugo, Uehara, Masashi, Munakata, Ryo, Takizawa, Takashi, Hatakenaka, Terue, Kamanaka, Takayuki, Miyaoka, Yoshinari, Kurogochi, Daisuke, Fukuzawa, Takuma, Haro, Hirotaka, Kawaguchi, Yoshiharu, Matsuyama, Yukihiro, Koseki, Michihiko, and Takahashi, Jun

Published
2022
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18. Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament

Author

Nakashima, Hiroaki, Imagama, Shiro, Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Nakagawa, Yukihiro, Hirai, Takashi, Wada, Kanichiro, Katsumi, Keiichi, Fujii, Kengo, Kimura, Atsushi, Furuya, Takeo, Kanchiku, Tsukasa, Nagamoto, Yukitaka, Oshima, Yasushi, Nagoshi, Narihito, Ando, Kei, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Matsunaga, Shunji, Kaito, Takashi, Yamada, Kei, Kobayashi, Sho, Kato, Satoshi, Ohba, Tetsuro, Inami, Satoshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Li, Yuanying, Yatsuya, Hiroshi, Koda, Masao, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Matsumoto, Morio, Yamazaki, Masashi, and Okawa, Atsushi

Published
2022
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20. Impact of obesity on cervical ossification of the posterior longitudinal ligament: a nationwide prospective study

Author

Mori, Kanji, Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Tsutsui, Shunji, Hirai, Takashi, Matsukura, Yu, Wada, Kanichiro, Katsumi, Keiichi, Koda, Masao, Kimura, Atsushi, Furuya, Takeo, Maki, Satoshi, Nagoshi, Narihito, Nishida, Norihiro, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Nakashima, Hiroaki, Takahata, Masahiko, Nakajima, Hideaki, Murata, Kazuma, Miyagi, Masayuki, Kaito, Takashi, Yamada, Kei, Banno, Tomohiro, Kato, Satoshi, Ohba, Tetsuro, Inami, Satoshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Taneichi, Hiroshi, Imagama, Shiro, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Matsumoto, Morio, Yamazaki, Masashi, and Okawa, Atsushi

Published
2022
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21. Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation.

Author

Kamei, Katsuhiko, Yahara, Yasuhito, Kim, Jun-Dal, Tsuji, Mamiko, Iwasaki, Mami, Takemori, Hiroshi, Seki, Shoji, Makino, Hiroto, Futakawa, Hayato, Hirokawa, Tatsuro, Nguyen, Tran Canh Tung, Nakagawa, Takashi, and Kawaguchi, Yoshiharu

Abstract

Maintenance of bone homeostasis and the balance between bone resorption and formation are crucial for maintaining skeletal integrity. This study sought to investigate the role of salt-inducible kinase 3 (SIK3), a key regulator in cellular energy metabolism, during the differentiation of osteoclasts. Despite osteoclasts being high energy-consuming cells essential for breaking down mineralized bone tissue, the specific function of SIK3 in this process remains unclear. To address this issue, we generated osteoclast-specific SIK3 conditional knockout mice and assessed the impact of SIK3 deletion on bone homeostasis. Our findings revealed that SIK3 conditional knockout mice exhibited increased bone mass and an osteopetrosis phenotype, suggesting a pivotal role for SIK3 in bone resorption. Moreover, we assessed the impact of pterosin B, a SIK3 inhibitor, on osteoclast differentiation. The treatment with pterosin B inhibited osteoclast differentiation, reduced the numbers of multinucleated osteoclasts, and suppressed resorption activity in vitro. Gene expression analysis demonstrated that SIK3 deletion and pterosin B treatment influence a common set of genes involved in osteoclast differentiation and bone resorption. Furthermore, pterosin B treatment altered intracellular metabolism, particularly affecting key metabolic pathways, such as the tricarboxylic acid cycle and oxidative phosphorylation. These results provide valuable insights into the involvement of SIK3 in osteoclast differentiation and the molecular mechanisms underlying osteoclast function and bone diseases. Lay Summary: Osteoporosis is a disease that causes bones to become weak and fragile, increasing the risk of fractures especially in elderly. It is caused by an imbalance between the formation of new bone and the destruction of old bone. Cells called osteoclasts are responsible for breaking down old bone. Excessive osteoclast activity results in bone loss and osteoporosis. Our research has identified a LKB1-SIK3 pathway, which acts as an energy sensor in osteoclasts. We found that this pathway is activated when osteoclast activity is increased, and we were able to reduce osteoclast activity by genetically removing or inhibiting SIK3. These findings suggest that targeting the LKB1-SIK3 pathway may be a promising new approach for the treatment of osteoporosis. Developing drugs that inhibit SIK3 may slow bone loss and reduce the risk of fractures in osteoporotic patients. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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23. Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH.

Author

He, Zhongyuan, Tung, Nguyen Tran Canh, Yahara, Yasuhito, Makino, Hiroto, Yasuda, Taketoshi, Seki, Shoji, Suzuki, Kayo, Futakawa, Hayato, Kamei, Katsuhiko, and Kawaguchi, Yoshiharu

Subjects
LONGITUDINAL ligaments, RESEARCH funding, BONE growth, SEVERITY of illness index, SPINAL osteophytosis, DESCRIPTIVE statistics, METAPLASTIC ossification, EXOSTOSIS, LUMBAR vertebrae, INFLAMMATION, SACROILIAC joint, INTERLEUKINS, EVALUATION
Abstract

Objective To investigate the relationship between the severity and morphology of heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum interleukin-17 (IL-17) levels in patients with ossification of the posterior longitudinal ligament (OPLL) with or without diffuse idiopathic skeletal hyperostosis (DISH), as well as a non-OPLL group. Methods A total of 103 patients with OPLL [DISH (−), n  =   50; DISH (+), n  =   53] and 53 age- and gender-matched controls were included. The serum levels of IL-17 were analysed, and the severity of ectopic ossification and the morphology of ectopic bone formation were evaluated. The SI joint morphological variations were categorized into four types. Results No significant differences were found in serum IL-17 levels between the OPLL and control groups. However, the DISH (+) group showed higher IL-17 levels than the DISH (−) group, especially in female patients (P   =  0.003). Additionally, IL-17 levels were positively correlated with the number of flat vertebral units, this being one of the characteristic DISH ossification types (R 2 = 0.199, P   =  0.012). IL-17 levels in the type showing bridging osteophyte and bone fusion were significantly higher in the DISH (+) group than in the DISH (−) group. Conclusion The morphological characteristics of paravertebral bone formation in the entire spine, including the SI joint, are likely associated with serum IL-17 levels in OPLL. These findings provide pathological and serological evidence of local inflammation contributing to paravertebral ossification of OPLL patients. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Effectiveness And Safety Of Vertebral Body Stenting For Acute Spinal Compression Fractures Due To Primary Osteoporosis: A Multicenter Prospective Clinical Study

Author

Takemasa, Ryuichi, primary, Konishi, Hiroaki, additional, Minamide, Akito, additional, Kawasaki, Motohiro, additional, Kawaguchi, Yoshiharu, additional, Watanabe, Kenichi, additional, Shirasawa, Kenzo, additional, Ishii, Ken, additional, Yukawa, Yasutsugu, additional, Toyone, Tomoaki, additional, and Yoshida, Munehito, additional

Published
2024
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26. Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament

Author

Koda, Masao, Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Nakagawa, Yukihiro, Hirai, Takashi, Wada, Kanichiro, Katsumi, Keiichi, Kimura, Atsushi, Furuya, Takeo, Maki, Satoshi, Nagoshi, Narihito, Watanabe, Kota, Kanchiku, Tsukasa, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Nakashima, Hiroaki, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Matsunaga, Shunji, Kaito, Takashi, Yamada, Kei, Kobayashi, Sho, Kato, Satoshi, Ohba, Tetsuro, Inami, Satoshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Takahashi, Hiroshi, Fujii, Kengo, Miyagi, Masayuki, Inoue, Gen, Takaso, Masashi, Imagama, Shiro, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Nakamura, Masaya, Matsumoto, Morio, Okawa, Atsushi, and Yamazaki, Masashi

Published
2021
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27. The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament

Author

Katsumi, Keiichi, Hirai, Takashi, Yoshii, Toshitaka, Maki, Satoshi, Mori, Kanji, Nagoshi, Narihito, Nishimura, Soraya, Takeuchi, Kazuhiro, Ushio, Shuta, Furuya, Takeo, Watanabe, Kei, Nishida, Norihiro, Watanabe, Kota, Kaito, Takashi, Kato, Satoshi, Nagashima, Katsuya, Koda, Masao, Ito, Kenyu, Imagama, Shiro, Matsuoka, Yuji, Wada, Kanichiro, Kimura, Atsushi, Ohba, Tetsuro, Katoh, Hiroyuki, Matsuyama, Yukihiro, Ozawa, Hiroshi, Haro, Hirotaka, Takeshita, Katsushi, Watanabe, Masahiko, Matsumoto, Morio, Nakamura, Masaya, Yamazaki, Masashi, Okawa, Atsushi, and Kawaguchi, Yoshiharu

Published
2021
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28. Perioperative Complications in Posterior Surgeries for Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Investigation

Author

Yoshii, Toshitaka, Egawa, Satoru, Sakai, Kenichiro, Kusano, Kazuo, Nakagawa, Yukihiro, Hirai, Takashi, Wada, Kanichiro, Katsumi, Keiichi, Fujii, Kengo, Kimura, Atsushi, Furuya, Takeo, Nagoshi, Narihito, Kanchiku, Tsukasa, Nagamoto, Yukitaka, Oshima, Yasushi, Ando, Kei, Takahata, Masahiko, Mori, Kanji, Nakajima, Hideaki, Murata, Kazuma, Matsunaga, Shunji, Kaito, Takashi, Yamada, Kei, Kobayashi, Sho, Kato, Satoshi, Ohba, Tetsuro, Inami, Satoshi, Fujibayashi, Shunsuke, Katoh, Hiroyuki, Kanno, Haruo, Imagama, Shiro, Koda, Masao, Kawaguchi, Yoshiharu, Takeshita, Katsushi, Matsumoto, Morio, Yamazaki, Masashi, and Okawa, Atsushi

Published
2021
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32. Effect of small interference RNA for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle puncture model

Author

Seki, Shoji, Asanuma-Abe, Yumiko, Masuda, Koichi, Kawaguchi, Yoshiharu, Asanuma, Kunihiro, Muehleman, Carol, Iwai, Akiko, and Kimura, Tomoatsu

Abstract

Abstract Introduction The etiology of degenerative disc disease is unknown. Several investigators have reported the presence of proteolytic enzymes, such as the matrix metalloproteinase (MMP) and ADAMTS (a disintegrin and metalloprotease with thrombospondin-like repeats) families, in degenerated human discs. Glasson and colleagues recently reported that a significant reduction occurs in the severity of cartilage destruction in ADAMTS5 knockout mice compared with wild-type mice. The purpose of this study was to evaluate the suppressive effects of injections of ADAMTS5 small interference RNA (siRNA) oligonucleotide on intervertebral disc degeneration in the rabbit anular needle-puncture model. Methods Rabbit nucleus pulposus (NP) cells were transfected with siRNA oligonucleotides specific for ADAMTS5 or the control. The suppression of the ADAMTS5 gene by siRNA transfection was assessed by using real-time polymerase chain reaction (PCR), both in monolayer and alginate bead cultures with or without interleukin-1β (IL-1β) stimulation. The effect of siRNA was determined in vivo by using the rabbit anular needle-puncture model (control group: n = 8; ADAMTS5 group: n = 8). One week after the initial anular puncture, the animals received an injection of the control or anti-ADAMTS5 oligonucleotide (100 μg each at the L2/3 and L4/5 level; 16 discs/group). Disc height, magnetic resonance imaging (MRI) (Thompson classification and signal intensity), and safranin-O staining (histologic grade) were assessed. Results IL-1β treatment significantly increased the ADAMTS5 mRNA level in NP cells (P < 0.01). ADAMTS5 gene suppression was 70% compared with the control oligonucleotide in both monolayer and alginate bead culture with or without stimulation with IL-1β. The injection of anti-ADAMTS5 oligonucleotide in vivo resulted in improved MRI scores with increased signal intensity and improved histologic grade scores with statistical significance (P < 0.05). No significant change in disc height was observed. Conclusions A single injection of ADAMTS5 siRNA induced the suppression of degradation in NP tissues, as shown by significantly improved MRI and histologic grades. The mechanism of response to siRNA may be worthy of exploration for possible therapeutic purposes.

Published
2009

34. Assessment of Cervical Myelopathy Risk in Ossification of the Posterior Longitudinal Ligament Patients With Spinal Cord Compression Based on Segmental Dynamic Versus Static Factors

Author

He, Zhongyuan, primary, Tung, Nguyen Tran Canh, additional, Makino, Hiroto, additional, Yasuda, Taketoshi, additional, Seki, Shoji, additional, Suzuki, Kayo, additional, Watanabe, Kenta, additional, Futakawa, Hayato, additional, Kamei, Katsuhiko, additional, and Kawaguchi, Yoshiharu, additional

Published
2023
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36. Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study

Author

Hirai, Takashi, Yoshii, Toshitaka, Ushio, Shuta, Mori, Kanji, Maki, Satoshi, Katsumi, Keiichi, Nagoshi, Narihito, Takeuchi, Kazuhiro, Furuya, Takeo, Watanabe, Kei, Nishida, Norihiro, Watanabe, Kota, Kaito, Takashi, Kato, Satoshi, Nagashima, Katsuya, Koda, Masao, Ito, Kenyu, Imagama, Shiro, Matsuoka, Yuji, Wada, Kanichiro, Kimura, Atsushi, Ohba, Tetsuro, Katoh, Hiroyuki, Matsuyama, Yukihiro, Ozawa, Hiroshi, Haro, Hirotaka, Takeshita, Katsushi, Watanabe, Masahiko, Matsumoto, Morio, Nakamura, Masaya, Yamazaki, Masashi, Okawa, Atsushi, and Kawaguchi, Yoshiharu

Published
2020
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38. Outcomes of Surgery for Thoracic Myelopathy Owing to Thoracic Ossification of The Ligamentum Flavum in a Nationwide Multicenter Prospectively Collected Study in 223 Patients: Is Instrumented Fusion Necessary?

Author

Ando, Kei, Imagama, Shiro, Kaito, Takashi, Takenaka, Shota, Sakai, Kenichiro, Egawa, Satoru, Shindo, Shigeo, Watanabe, Kota, Fujita, Nobuyuki, Matsumoto, Morio, Nakashima, Hideaki, Wada, Kanichiro, Kimura, Atsushi, Takeshita, Katsushi, Kato, Satoshi, Murakami, Hideki, Takeuchi, Kazuhiro, Takahata, Masahiko, Koda, Masao, Yamazaki, Masashi, Watanabe, Masahiko, Fujibayashi, Shunsuke, Furuya, Takeo, Kawaguchi, Yoshiharu, Matsuyama, Yukihiro, Yoshii, Toshitaka, and Okawa, Atsushi

Published
2020
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43. Comparison of Surgical Outcomes of Anterior and Posterior Fusion Surgeries for K-line (−) Cervical Ossification of the Posterior Longitudinal Ligament

Author

Nagoshi, Narihito, primary, Yoshii, Toshitaka, additional, Egawa, Satoru, additional, Sakai, Kenichiro, additional, Kusano, Kazuo, additional, Tsutsui, Shunji, additional, Hirai, Takashi, additional, Matsukura, Yu, additional, Wada, Kanichiro, additional, Katsumi, Keiichi, additional, Koda, Masao, additional, Kimura, Atsushi, additional, Furuya, Takeo, additional, Sato, Yasunori, additional, Maki, Satoshi, additional, Nishida, Norihiro, additional, Nagamoto, Yukitaka, additional, Oshima, Yasushi, additional, Ando, Kei, additional, Nakashima, Hiroaki, additional, Takahata, Masahiko, additional, Mori, Kanji, additional, Nakajima, Hideaki, additional, Murata, Kazuma, additional, Miyagi, Masayuki, additional, Kaito, Takashi, additional, Yamada, Kei, additional, Banno, Tomohiro, additional, Kato, Satoshi, additional, Ohba, Tetsuro, additional, Moridaira, Hiroshi, additional, Fujibayashi, Shunsuke, additional, Katoh, Hiroyuki, additional, Kanno, Haruo, additional, Watanabe, Kota, additional, Taneichi, Hiroshi, additional, Imagama, Shiro, additional, Kawaguchi, Yoshiharu, additional, Takeshita, Katsushi, additional, Nakamura, Masaya, additional, Matsumoto, Morio, additional, and Yamazaki, Masashi, additional

Published
2023
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46. Rod Rotation with Outrigger Is Substantial for Correcting Apical Hypokyphosis in Patients with Adolescent Idiopathic Scoliosis: Novel Outrigger Device for Concave Rod Rotation.

Author

Seki, Shoji, Makino, Hiroto, Yahara, Yasuhito, Kamei, Katsuhiko, Futakawa, Hayato, Yasuda, Taketoshi, Suzuki, Kayo, Nakano, Masato, and Kawaguchi, Yoshiharu

Subjects
ADOLESCENT idiopathic scoliosis, PARAVERTEBRAL anesthesia, ROTATIONAL motion, SPINAL fusion, ORTHOPEDIC braces, LUNG volume measurements, SPINAL surgery
Abstract

The apical hypokyphosis of scoliotic patients is thought to lead to decreased lung capacity and cause shortness of breath. Additionally, concave rod curve reduction is a problem in the correction of apical hypokyphosis in posterior spinal fusion surgery in adolescent idiopathic scoliosis (AIS). We investigated the contributions of rod rotation (RR) with an outrigger device, followed by differential rod contouring (DRC) with the outrigger attached to the concave rod, designed to prevent concave rod curve-flattening. We analyzed and compared the results of segmental pedicle screw fixation without the outrigger in 41 AIS patients with thoracic curves (Lenke type I, 25; type II, 16) to those corrected using the outrigger in 36 patients (Lenke type I, 24; type II,12). The changes in the Cobb angle, apical kyphosis of five vertebrae, thoracic kyphosis (TK, T4–12), correction rate, correction angle of apical vertebral rotation, spinal penetration index (SPi), and rib hump index (RHi) before and after surgery were measured, and the contribution of the outrigger was analyzed. The mean scoliosis correction rates without and with the outrigger were 72.1° and 75.6°, respectively (p = 0.03). Kyphosis of the five apical vertebrae and TK were significantly greater in the surgery with the outrigger (p = 0.002). Significantly greater improvements in SPi and RHi were also noted in the surgery with the outrigger (p < 0.05). The use of concave RR and convex DRC with the outrigger appear to be advantageous for correcting apical hypokyphosis, followed by the subsequent formation of TK. As a result, breathing problems are less likely to occur during daily life because of improvements in SPi and RHi. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Residual Neuropathic Pain in Postoperative Patients With Cervical Ossification of Posterior Longitudinal Ligament

Author

Miyagi, Masayuki, primary, Inoue, Gen, additional, Yoshii, Toshitaka, additional, Egawa, Satoru, additional, Sakai, Kenichiro, additional, Kusano, Kazuo, additional, Nakagawa, Yukihiro, additional, Hirai, Takashi, additional, Wada, Kanichiro, additional, Katsumi, Keiichi, additional, Kimura, Atsushi, additional, Furuya, Takeo, additional, Nagoshi, Narihito, additional, Kanchiku, Tsukasa, additional, Nagamoto, Yukitaka, additional, Oshima, Yasushi, additional, Nakashima, Hiroaki, additional, Ando, Kei, additional, Takahata, Masahiko, additional, Mori, Kanji, additional, Nakajima, Hideaki, additional, Murata, Kazuma, additional, Matsunaga, Shunji, additional, Kaito, Takashi, additional, Yamada, Kei, additional, Kobayashi, Sho, additional, Kato, Satoshi, additional, Ohba, Tetsuro, additional, Inami, Satoshi, additional, Fujibayashi, Shunsuke, additional, Katoh, Hiroyuki, additional, Kanno, Haruo, additional, Koda, Masao, additional, Takahashi, Hiroshi, additional, Ikeda, Shinsuke, additional, Imagama, Shiro, additional, Kawaguchi, Yoshiharu, additional, Takeshita, Katsushi, additional, Matsumoto, Morio, additional, Takaso, Masashi, additional, Okawa, Atsushi, additional, and Yamazaki, Masashi, additional

Published
2023
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