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Approximately 660,000 women are diagnosed with cervical cancer annually. Current screening options such as cytology or human papillomavirus testing have limitations, creating a need to identify more effective ancillary biomarkers for triage. Here, we evaluated whether metabolomic analysis of cervical mucus metabolism could be used to identify biomarkers of cervical intraepithelial neoplasia (CIN) and cervical cancer. The case–control group consisted of 181 CIN, 69 squamous cell carcinoma (SCC) patients, and 48 healthy controls in the primary cohort. We undertook metabolomic analyses using ultra‐HPLC–tandem mass spectrometry. Univariate and multivariate analyses were carried out to profile metabolite characteristics, and receiver operating characteristic (ROC) analysis identified biomarker candidates. Five metabolites conferred the highest discriminatory power for SCC: oxidized glutathione (GSSG) (area under the ROC curve, 0.924; 95% confidence interval, 0.877–0.971), malic acid (0.914, 0.859–0.968), kynurenine (0.884, 0.823–0.945), GSSG/glutathione (GSH) (0.936, 0.892–0.979), and kynurenine/tryptophan (0.909, 0.856–0.961). Malic acid was the best marker for detection of CIN2 or worse (0.858, 0.793–0.922) and was a clinically useful metabolite. We confirmed the reproducibility of the results by validation cohort. Additionally, metabolomic analyses revealed eight pathways strongly associated with cervical neoplasia. Of these, only the tricarboxylic acid cycle was strongly associated with all CINs and cancer, indicating active energy production. Aberrant arginine metabolism by decreasing arginine and increasing citrulline might reduce tumor immunity. Changes in cysteine‐methionine and GSH pathways might drive the initiation and progression of cervical cancer. These results suggest that metabolic analysis can identify ancillary biomarkers and could improve our understanding of the pathophysiological mechanisms underlying cervical neoplasia. [ABSTRACT FROM AUTHOR]

The purpose of this study is to understand the fluidity of survivors' narratives and to clarify the changes such narratives undergo after time has elapsed. Nineteen survivors of the landslide disaster that occurred on August 20, 2014 in Hiroshima City were interviewed twice-three years after the disaster and five years after the disaster-and the changes in the content of their narratives were analyzed. In addition, by analyzing the titles of newspaper articles that were published within one month of the disaster, the characteristics of narrative transformation were quantitatively identified. The narratives of disaster victims that were once accepted as "dominant stories" become "personalized" as "alternative stories" with the elapse of time, even though they are told by the same person. Comparisons of two interviews conducted at different times show that the word "evacuation" undergoes a significant change in context over time elapse, while the word "disaster" appears in a new context in the fifth-year interview. While social or community groups are the bearers of "socialized" memories, individuals are the bearers of "personalized" memories which are expected to continue to change as time elapses. It is necessary to examine what should be shared in order to utilize disaster victims' memories to prevent and mitigate disasters, and how to such memories should be shared. [ABSTRACT FROM AUTHOR]