Search

Your search keyword '"Kayembe, Clarisse"' showing total 12 results
Start Over Author "Kayembe, Clarisse"
12 results on '"Kayembe, Clarisse"'

1. Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities

Author

Cappelli, Luca Vincenzo, Fiore, Danilo, Phillip, Jude M., Yoffe, Liron, Di Giacomo, Filomena, Chiu, William, Hu, Yang, Kayembe, Clarisse, Ginsberg, Michael, Consolino, Lorena, Barcia Duran, Jose Gabriel, Zamponi, Nahuel, Melnick, Ari M., Boccalatte, Francesco, Tam, Wayne, Elemento, Olivier, Chiaretti, Sabina, Guarini, Anna, Foà, Robin, Cerchietti, Leandro, Rafii, Shahin, and Inghirami, Giorgio

Published
2023
Full Text
View/download PDF

2. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

Author

Aranda-Orgilles, Beatriz, Saldaña-Meyer, Ricardo, Wang, Eric, Trompouki, Eirini, Fassl, Anne, Lau, Stephanie, Mullenders, Jasper, Rocha, Pedro P., Raviram, Ramya, Guillamot, María, Sánchez-Díaz, María, Wang, Kun, Kayembe, Clarisse, Zhang, Nan, Amoasii, Leonela, Choudhuri, Avik, Skok, Jane A., Schober, Markus, Reinberg, Danny, Sicinski, Piotr, Schrewe, Heinrich, Tsirigos, Aristotelis, Zon, Leonard I., and Aifantis, Iannis

Published
2016
Full Text
View/download PDF

3. A Patient-Derived T-Cell Lymphoma Biorepository Uncovers New Pathogenetic Mechanisms and Host-Related Therapeutic Vulnerabilities

Author

Fiore, Danilo, primary, Cappelli, Luca Vincenzo, additional, Zhaoqi, Liu, additional, Kotlov, Nikita, additional, Sorokina, Maria, additional, Phillip, Jude, additional, Zumbo, Paul, additional, Yoffe, Liron, additional, Ghione, Paola, additional, Wang, Anqi, additional, Han, Xueshuai, additional, Chiu, William, additional, Fragliasso, Valentina, additional, Tabbò, Fabrizio, additional, Zamponi, Nahuel, additional, Kayembe, Clarisse, additional, Gaudiano, Marcello, additional, Machiorlatti, Rodolfo, additional, Astone, Giuseppina, additional, Cacciapuoti, Maria Teresa, additional, Patel, Sanjay, additional, Zammarchi, Francesca, additional, Zanettini, Claudio, additional, Queiroz, Lucio, additional, Nikitina, Anastasia, additional, Kudryashova, Olga, additional, Karelin, Anton, additional, Nikitin, Daniil, additional, Tychinin, Dmitry, additional, Postovalova, Ekaterina, additional, Bagaev, Alexander, additional, Svekolkin, Viktor, additional, Belova, Ekaterina, additional, Tikhonova, Katerina, additional, Degryse, Sandrine, additional, Novero, Domenico, additional, Ponzoni, Maurilio, additional, Tiacci, Enrico, additional, Falini, Brunangelo, additional, Song, Joo Y., additional, Khodos, Inna, additional, De Stanchina, Elisa, additional, Macari, Gabriele, additional, Cafforio, Luciana, additional, Gardini, Simone, additional, Piva, Roberto, additional, Medico, Enzo, additional, NG, Samuel Y., additional, Moskowitz, Allison, additional, Epstein, Zachary, additional, Intlekofer, Andrew M., additional, Ahmed, Dogan, additional, Martin, Peter, additional, Ruan, Jia, additional, Bertoni, Francesco, additional, Foà, Robin, additional, Brody, Joshua, additional, Osan, Jaspreet, additional, Santambrogio, Laura, additional, Betel, Doron, additional, Chan, John C., additional, Tam, Wayne, additional, Weinstock, David M., additional, Cerchietti, Leandro, additional, Rabadan, Raul, additional, Horwitz, Steven, additional, and Inghirami, Giorgio G.A., additional

Published
2023
Full Text
View/download PDF

4. A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Author

Cappelli, Luca Vincenzo, primary, Fiore, Danilo, additional, Phillip, Jude M, additional, Yoffe, Liron, additional, Di Giacomo, Filomena, additional, Hu, Yang, additional, Kayembe, Clarisse, additional, Ginsberg, Michael, additional, Consolino, Lorena, additional, Barcia Durán, José Gabriel, additional, Zamponi, Nahuel, additional, Melnick, Ari, additional, Boccalatte, Francesco, additional, Tam, Wayne, additional, Elemento, Olivier, additional, Chiaretti, Sabina, additional, Guarini, Anna, additional, Foa, Robin, additional, Cerchietti, Leandro, additional, Rafii, Shahin, additional, and Inghirami, Giorgio, additional

Published
2021
Full Text
View/download PDF

5. Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens

Author

Astone, Giuseppina, primary, Cappelli, Luca Vincenzo, additional, Chiu, William, additional, Kayembe, Clarisse, additional, Wang, Rui, additional, Yang, Bin, additional, Sharma, Kirti, additional, Dey, Joyoti, additional, Karnik, Rahul, additional, Brambilla, Lara, additional, Levy, David, additional, Yoffe, Liron, additional, Boccalatte, Francesco, additional, Hernaez, Javier Rodriguez, additional, Tsirigos, Aristotelis, additional, Zumbo, Paul, additional, Betel, Doron, additional, Verma, Akanksha, additional, Elemento, Olivier, additional, Cumerlato, Michela, additional, Piva, Roberto, additional, Horwitz, Steven M., additional, Epstein-Peterson, Zachary D., additional, Gollob, Jared, additional, DeSavi, Chris, additional, Liu, Phillip CC, additional, and Inghirami, Giorgio, additional

Published
2021
Full Text
View/download PDF

6. Diffuse Large B Cell Pdtx in Humanized Mice Are Valuable Models to Study Host-Lymphoma Interactions and Immune-Modulating Agents

Author

Zanetti, Giorgia, primary, Astone, Giuseppina, additional, Cappelli, Luca, additional, Chiu, William, additional, Cacciapuoti, Maria Teresa, additional, Kayembe, Clarisse, additional, Fiore, Danilo, additional, Tam, Wayne, additional, Scandura, Joseph, additional, Di Giandomenico, Silvana, additional, Galluzzi, Lorenzo, additional, Roth, Lisa Giulino, additional, and Inghirami, Giorgio, additional

Published
2021
Full Text
View/download PDF

8. A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries

Author

Fiore, Danilo, primary, Cappelli, Luca Vincenzo, additional, Zumbo, Paul, additional, Phillips, Jude M., additional, Liu, Zhaoqi, additional, Cheng, Shuhua, additional, Yoffe, Liron, additional, Ghione, Paola, additional, Di Maggio, Federica, additional, Dogan, Ahmet, additional, Khodos, Inna, additional, de Stanchina, Elisa, additional, Casano, Joseph, additional, Kayembe, Clarisse, additional, Tam, Wayne, additional, Betel, Doron, additional, Foa’, Robin, additional, Cerchietti, Leandro, additional, Rabadan, Raul, additional, Horwitz, Steven, additional, Weinstock, David M., additional, and Inghirami, Giorgio, additional

Published
2020
Full Text
View/download PDF

9. CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies

Author

Qin, Hong, primary, Dong, Zhenyuan, additional, Wang, Xiuli, additional, Cheng, Wesley A., additional, Wen, Feng, additional, Xue, Weili, additional, Sun, Han, additional, Walter, Miriam, additional, Wei, Guowei, additional, Smith, D. Lynne, additional, Sun, Xiuhua, additional, Fei, Fan, additional, Xie, Jianming, additional, Panagopoulou, Theano I., additional, Chen, Chun-Wei, additional, Song, Joo Y., additional, Aldoss, Ibrahim, additional, Kayembe, Clarisse, additional, Sarno, Luisa, additional, Müschen, Markus, additional, Inghirami, Giorgio G., additional, Forman, Stephen J., additional, and Kwak, Larry W., additional

Published
2019
Full Text
View/download PDF

11. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

Author

Mullenders, Jasper, primary, Aranda-Orgilles, Beatriz, additional, Lhoumaud, Priscillia, additional, Keller, Matthew, additional, Pae, Juhee, additional, Wang, Kun, additional, Kayembe, Clarisse, additional, Rocha, Pedro P., additional, Raviram, Ramya, additional, Gong, Yixiao, additional, Premsrirut, Prem K., additional, Tsirigos, Aristotelis, additional, Bonneau, Richard, additional, Skok, Jane A., additional, Cimmino, Luisa, additional, Hoehn, Daniela, additional, and Aifantis, Iannis, additional

Published
2015
Full Text
View/download PDF

12. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

Author

Mullenders, Jasper, Aranda-Orgilles, Beatriz, Lhoumaud, Priscillia, Keller, Matthew, Pae, Juhee, Wang, Kun, Kayembe, Clarisse, Rocha, Pedro P., Raviram, Ramya, Gong, Yixiao, Premsrirut, Prem K., Tsirigos, Aristotelis, Bonneau, Richard, Skok, Jane A., Cimmino, Luisa, Hoehn, Daniela, and Aifantis, Iannis

Abstract

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in a variety of human malignancies including acute myeloid leukemia (AML). To address the potential tumor-suppressive function of cohesin in vivo, we generated a series of shRNA mouse models in which endogenous cohesin can be silenced inducibly. Notably, silencing of cohesin complex members did not have a deleterious effect on cell viability. Furthermore, knockdown of cohesin led to gain of replating capacity of mouse hematopoietic progenitor cells. However, cohesin silencing in vivo rapidly altered stem cells homeostasis and myelopoiesis. Likewise, we found widespread changes in chromatin accessibility and expression of genes involved in myelomonocytic maturation and differentiation. Finally, aged cohesin knockdown mice developed a clinical picture closely resembling myeloproliferative disorders/neoplasms (MPNs), including varying degrees of extramedullary hematopoiesis (myeloid metaplasia) and splenomegaly. Our results represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results