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338 results on '"Kazan, S."'

22. The effect of non-albumin proteinuria on renal outcomes in patients with biopsy proven diabetic nephropathy

Author

Kazan, S., Tunca, O., and Kazan, Sinan

Subjects
Proteinuria, Diabetes Mellitus, Microalbuminuria
Abstract

Objective: We aimed at investigating the effect of non-albumin proteinuria on renal outcomes in patients with biopsy-proven diabetic nephropathy. Patients and methods: The files of all patients who underwent kidney biopsy between January 2010 and January 2020 were reviewed retrospectively. Non-albumin proteinuria was calculated by subtracting albumin from total protein in 24-hour urine samples. The patients were divided into 2 groups, according to the presence of composite kidney outcomes. Results: The study included 23 patients with diabetic nephropathy. The kidney endpoint was achieved in 34.8% (n=8) of the patients. Hypertension, duration of diabetes mellitus, creatinine level at the date of biopsy, microalbuminuria and non-albumin proteinuria were found to be independent predictors for composite kidney outcome (p=0.002, p=0.007, p=0.004, p=0.006, and p=0.001, respectively). Conclusions: NAP was found to be an independent risk factor for doubling the serum creatinine level from the date of biopsy, for starting hemodialysis or peritoneal dialysis, for kidney transplantation, and kidney-related death.

Published
2022

25. Systemic immune inflammation index and pan-immune inflammation value as prognostic markers in patients with idiopathic low and moderate risk membranous nephropathy.

Author

KAZAN, D. E. and KAZAN, S.

Abstract

OBJECTIVE: We aimed to investigate the prognostic values of systemic immune inflammation index and pan-immune inflammation value in patients with idiopathic low and moderate risk membranous nephropathy. PATIENTS AND METHODS: All membranous nephropathy patients diagnosed in the nephrology clinic between January 2015 and January 2022 were reviewed retrospectively. Patients with idiopathic membranous nephropathy were included. The patients were divided into two groups; the complete remission group: whose proteinuria decreased below 0.3 g/day and serum albumin level above 3.5 g/dL after 6 months of conservative treatment, and the non-remission group: all other patients. Groups were compared in terms of systemic immune inflammation index and pan-immune inflammation value. RESULTS: Patients in the non-remission group had significantly higher systemic immune-in- flammation index (SII) and pan-immune-inflammation value (PIV) than patients in the complete remission group (p<0.05). An SII of 1,056.2 was found to have 63.6% sensitivity and 100% specificity in predicting non-remission, and a PIV of 447.4 was found to have 100% sensitivity and 70.6% specificity in predicting non-remission. CONCLUSIONS: SII and PIV are reliable markers for predicting non-remission in patients with low and moderate risk idiopathic MN. [ABSTRACT FROM AUTHOR]

Published
2023

29. The effect of lymphocyte blood levels on mortality of COVID-19 patients under intensive care unit follow-up.

Author

DIZEN KAZAN, E., ORHAN, S., KORKMAZ, D., SARI, A., and KAZAN, S.

Abstract

OBJECTIVE: Lymphocytes are the most important cells in defending the human body against viral pathogens. In this study, we aimed at investigating the relationship between lymphocyte blood levels and patient survival in COVID-19 patients hospitalized in the intensive care unit. PATIENTS AND METHODS: We retrospectively evaluated patients hospitalized with COVID-19 pneumonia in the intensive care unit. Patients were divided into two groups in terms of blood lymphocyte levels; increased lymphocyte and decreased lymphocyte groups on the 5th day of hospitalization. Mortality rates were compared between groups. RESULTS: Two groups were similar in terms of laboratory tests and comorbidities. Overall survival was 63.8% (n=102) in patients with increased lymphocytes and 33.2% (n=68) in patients with decreased lymphocytes. Mortality rates were significantly higher in decreased lymphocyte group than in increased lymphocyte group (p=0.003). CONCLUSIONS: Our study reveals that mortality is higher in patients with a lower lymphocyte count on the 5th day compared to the day of hospitalization. [ABSTRACT FROM AUTHOR]

Published
2022

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