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16 results on '"Kazemi Ashtiani, Mohammad"'

8. 10th Royan Institute's International Summer School on “Molecular Biomedicine: From Diagnostics to Therapeutics”

Author

Moradi, Sharif, primary, Torabi, Parisa, additional, Mohebbi, Saeed, additional, Amjadian, Sara, additional, Bosma, Piter, additional, Faridbod, Farnoush, additional, Khoddami, Vahid, additional, Hosseini, Morteza, additional, Babashah, Sadegh, additional, Ghotbaddini, Maryam, additional, Rasti, Arezoo, additional, Shekari, Faezeh, additional, Sadeghi‐Abandansari, Hamid, additional, Kiani, Jafar, additional, Shamsara, Mehdi, additional, Kazemi‐Ashtiani, Mohammad, additional, and Gholami, Samira, additional

Published
2020
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10. Chitosan surface modified hydrogel as a therapeutic contact lens.

Author

Kazemi Ashtiani, Mohammad, Zandi, Mojgan, Shokrollahi, Parvin, Ehsani, Morteza, and Baharvand, Hossein

Subjects
CONTACT lenses, SMALL molecules, BACTERIAL adhesion, BACTERIAL proteins, BACTERIAL colonies, HYDROGELS
Abstract

Therapeutic contact lenses have attracted significant attention during the last decades. In this study, we used chitosan‐conjugated poly(2‐hydroxyethyl methacrylate) (PHEMA) for contact lens application. We aimed to increase affinity of anionic drugs, which are used in treatment of eye diseases. In this regard, we evaluated delivery of the small molecule anionic drug, ascorbic acid from the chitosan‐conjugated PHEMA. Chitosan immobilization improves drug loading efficiency and induces sustained release of ascorbic acid. The chitosan modified hydrogel also reduces the biofouling of tear fluid components. Our results showed that surface modification by chitosan inhibits protein and bacterial deposition on the contact lens. Protein absorption analysis revealed that neat PHEMA adsorbed tear proteins at a density of 28.4 ± 4.4 μg/cm2, whereas the chitosan‐conjugated hydrogel adsorbed tear proteins at a density of 18.5 ± 1.8 μg/cm2. Moreover, the neat PHEMA bacterial adhesion had a mean CFU value of 273 ± 27. However, a significant decrease in the number of bacterial colonies was observed in the chitosan group with a CFU value of 9 ± 6. [ABSTRACT FROM AUTHOR]

Published
2020
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13. Islet transplantation for type 1 diabetes

Author

Khosravi-Maharlooei, Mohsen, Hajizadeh-Saffar, Ensiyeh, Tahamtani, Yaser, Basiri, Mohsen, Montazeri, Leila, Khalooghi, Keynoosh, Kazemi Ashtiani, Mohammad, Farrokhi, Ali, Aghdami, Nasser, Sadr Hashemi Nejad, Anavasadat, Larijani, Mohammad-Bagher, De Leu, Nico, Heimberg, Henry, Luo, Xunrong, Baharvand, Hossein, Pathology/molecular and cellular medicine, and Beta Cell Neogenesis

Subjects
endocrine system, beta cells, surgical procedures, operative, endocrine system diseases, diabetes, Review, transplantation
Abstract

Over the past decades, tremendous efforts were made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the five-year insulin independence rates for diabetic patients. Here, we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.

Published
2015

14. THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away

Author

Khosravi-Maharlooei, Mohsen, primary, Hajizadeh-Saffar, Ensiyeh, additional, Tahamtani, Yaser, additional, Basiri, Mohsen, additional, Montazeri, Leila, additional, Khalooghi, Keynoosh, additional, Kazemi Ashtiani, Mohammad, additional, Farrokhi, Ali, additional, Aghdami, Nasser, additional, Sadr Hashemi Nejad, Anavasadat, additional, Larijani, Mohammad-Bagher, additional, De Leu, Nico, additional, Heimberg, Harry, additional, Luo, Xunrong, additional, and Baharvand, Hossein, additional

Published
2015
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