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The Ni0.5Zn0.5Fe2O4 magnetic nanoparticles (MNPs) were synthesised using Plantago major seed extract through an environment-friendly, economic, and easy procedure. The nanoparticles were characterised by FTIR, XRD, SEM, TEM, EDX, BET surface area analysis, and VSM. The Ni0.5Zn0.5Fe2O4 MNPs were investigated as a nanoadsorbent for removal of reactive blue 21 (RB 21) and the results showed that the nanoparticles were effective for adsorption of RB 21. More than 93% of RB 21 was removed by the nanoadsorbent after a short time of 10 min (60 mg of nanoadsorbent dosage at concentration of 20 ppm for RB 21). The effect of initial concentration of RB 21 and nanoparticle dosage on dye adsorption were investigated. The Langmuir and Freundlich isotherm models used for adsorption equilibrium of RB 21 on Ni0.5Zn0.5Fe2O4 MNPs. The isotherm studies showed that the Langmuir model (KL = 2.76 L/mg, qmax = 18.08 mg/g) provides more compatible than the Freundlich model and thus RB 21 adsorb on the surface of Ni0.5Zn0.5Fe2O4 MNPs by a mono layer adsorption. The adsorption kinetics studies for the adsorption of RB 21 on Ni0.5Zn0.5Fe2O4 MNPs were conducted using the pseudo first-order, the pseudo second-order, and the intraparticle diffusion models and the results indicated that the pseudo second-order model (qe = 15.19 mg/g) provides more compatible than the other models for the adsorption of RB 21 on Ni0.5Zn0.5Fe2O4 MNPs. The maximum adsorption capacity was determined as 16.65 mg/g. [ABSTRACT FROM AUTHOR]

In this study, syntheses of [2-amino-3-(ethoxycarbonyl)-1,4-dihydro-1-phenyl-4-pyridinyl]ferrocene derivatives from reaction of ferrocenecarboxaldehyde, ethyl cyanoacetate, aniline, and acetylenic esters in the presence of piperidine were reported in good yields. The reaction proceeded smoothly and cleanly under mild reaction conditions and no side reactions were observed. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Then, structure, electronic and spectroscopic properties of the synthesized molecules were computed at the CAM-B3LYP/jorge-DZP (H,C,N,O) and Def2-TZVPPD (Fe) level of theory. First hyperpolarizability value were calculated to describe the nonlinear optical (NLO) properties of these molecules. The HOMO-LUMO study to find the band gap of the prepared molecules was extended to calculate global hardness, chemical potential and global electrophilicity for the investigation of the chemical behavior of the compounds. The energies of iron d-orbitals and formal electron configurations of iron atom were calculated by natural bond orbital (NBO) analysis. [ABSTRACT FROM AUTHOR]

A four-component reaction between , ( N-isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde and dibenzylamine is reported. This approach is an efficient, simple and high-yield procedure for the synthesis of 1,3,4-oxadiazole derivatives containing a ferrocene unit. The antimicrobial activities of the products were investigated against Staphylococcus aureus and Pseudomonas aeruginosa in in vitro and in vivo assays. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The three-component reaction of benzoic acid derivatives, (N-isocyanimino)triphenylphosphorane, and trichloroacetyl isocyanate in a 1:1:1 ratio in CH3CN occurred at room temperature, and the 5-aryl-N-(trichloroacetyl)-1,3,4-oxadiazole-2-carboxamide derivatives produced were formed in high yields. The reaction proceeded smoothly and cleanly under mild reaction conditions and no side reactions were observed. The structures of the products were confirmed by IR, ¹H NMR, 13C NMR, mass spectroscopy, and elemental analysis. [ABSTRACT FROM AUTHOR]

Even though the therapeutic efficacy of numerous antimicrobial drugs has been well established, inefficient delivery can result in an inadequate therapeutic index. Gold nanoparticles have unique physicochemical properties such as large surface area to mass ratio and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. In this study, gold nanospheres were used as a drug carrier system for gentamicin delivery to Staphylococcal infected foci. Conjugation of gentamicin with gold nanospheres was performed in HEPES buffer. The attachment of gentamicin to gold nanospheres was confirmed by UV/Vis spectroscopy. The HPLC and atomic absorption spectrometer analyses showed that 347 gentamicin molecules were attached to each gold nanosphere. Minimum inhibitory concentration and minimum bactericidal concentration studies showed the enhanced antibacterial effect of gentamicin-gold nanospheres complex in comparison with free gentamicin. The biodistribution study showed the localization of the complex at the site of Staphylococcal infection foci with high sensitivity in mouse model. [ABSTRACT FROM AUTHOR]

The four-component reaction of cyclobutanone, dibenzylamine and (isocyanoimino)triphenylphosphorane in the presence of aromatic carboxylic acids proceeds smoothly at room temperature under neutral conditions to afford N,N-dibenzyl-1-(5-aryl-1,3,4-oxadiazol-2-yl)cyclobutylamine derivatives in high yields. [ABSTRACT FROM AUTHOR]

The three-component reaction of isocyanides 1, carbodiimides 2, and trimethylsilyl azide ( 3) occurs at room temperature, and the produced 1,5-disubstituted 1 H-tetrazole derivatives 4 are formed in 81-98% yields ( Scheme 1, Table). The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions are observed. [ABSTRACT FROM AUTHOR]

Selenourea reacts with dialkyl acetylenedicarboxylates in acetone to form 1:1 adducts, which undergo a cyclization reaction to produce alkyl Z-2-(2-amino-4-oxo-1,3-selenazol-5(4 H )-yliden) acetates in fairly good yields. The reaction is completely stereoselective. [ABSTRACT FROM AUTHOR]

Potassium dihydrogen phosphate powder and sodium dihydrogen phosphate powder were found to catalyze stereoselective conversion of dialkyl 2-(imido-N-yl)- 3-(triphenylphosphoranylidene)butanedioates to electron-poor (Z)-N-vinylimides in solvent-free conditions under microwave irradiation in 5-6 minutes in high conversions. [ABSTRACT FROM AUTHOR]