852 results on '"Kazuo OGAWA"'
Search Results
2. Blunted increase in plasma BNP during acute coronary syndrome attacks in obese patients
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Toraaki Okuyama, Tomohisa Nagoshi, Nana Hiraki, Toshikazu D. Tanaka, Yuhei Oi, Haruka Kimura, Yusuke Kashiwagi, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
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Acute coronary syndrome ,Natriuretic peptides ,Obesity ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Unexpectedly low natriuretic peptide (NP) levels in proportion to heart failure severity are often observed in obese individuals. However, the magnitude of NP elevation in response to acute cardiac stress in obesity has not yet been extensively studied. This study aimed to determine the impact of obesity on the increase in plasma NP in response to cardiac hemodynamic stress during acute coronary syndrome (ACS) attacks. Methods and Results: The study population included 557 consecutive patients with ACS for whom data were collected during emergency cardiac catheterization. To determine the possible impact of body mass index (BMI) on the relationship between left ventricular ejection fraction (LVEF) and plasma B-type NP (BNP) levels, the study population was divided into two groups (Group 1: BMI
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- 2024
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3. Effects of angiotensin receptor‐neprilysin inhibitor on insulin resistance in patients with heart failure
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Yusuke Kashiwagi, Tomohisa Nagoshi, Haruka Kimura, Yoshiro Tanaka, Yuhei Oi, Yasunori Inoue, Kazuo Ogawa, Makoto Kawai, and Michihiro Yoshimura
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Angiotensin receptor‐neprilysin inhibitor ,Heart failure ,Insulin resistance ,Uric acid ,Structural equation model analysis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Although the haemodynamic effects of angiotensin receptor‐neprilysin inhibitor (ARNI) on patients with heart failure have been demonstrated, the effect on glucose metabolism has not been fully elucidated. We retrospectively investigated the effect of ARNI on abnormal glucose metabolism in patients with stable chronic heart failure using an additional structural equation model (SEM) analysis. Methods We analysed 34 patients who regularly visited to the outpatient department of our institute with heart failure from October 2021 and July 2022 and who were taking angiotensin‐converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). Seventeen patients switched from ACE inhibitors or ARBs to an ARNI (ARNI group), and the other 17 patients continued treatment with ACE inhibitors or ARBs (control group). Results At baseline, although the ARNI group included fewer patients with heart failure with preserved ejection fraction in comparison with the control group (P = 0.004), patients with heart failure with mildly reduced ejection fraction, and heart failure with reduced ejection fraction were mostly biased towards the ARNI group (although not statistically significant). The baseline insulin resistance in the ARNI group was already significantly higher in comparison with the control group [fasting blood insulin, 9.7 (7.4, 11.6) vs. 7.8 (5.2, 9.2) μU/mL, P = 0.033; homoeostasis model assessment of insulin resistance (HOMA‐IR), 3.10 (1.95, 4.19) vs. 2.02 (1.56, 2.42), P = 0.014]. Three months later, the fasting blood insulin and the HOMA‐IR levels were both found to have decreased in comparison with the baseline values [baseline to 3 months: insulin, 9.7 (7.4, 11.6) to 7.3 (4.6, 9.4) μU/mL, P
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- 2023
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4. The beneficial effects of balloon pulmonary angioplasty for patients with chronic thromboembolic pulmonary hypertension are accompanied by increased body mass index and improved nutritional status
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Shinya Fujii, Shinya Nagayoshi, Takashi Miyamoto, Kazuo Ogawa, and Michihiro Yoshimura
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appetite ,body mass index ,chronic thromboembolic pulmonary hypertension ,nutritional status ,oxygenation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Although balloon pulmonary angioplasty (BPA) improves pulmonary hypertension and the prognosis of patients with chronic thromboembolic pulmonary hypertension (CTEPH), subsequent changes in body mass index (BMI), nutritional status, and appetite have not been fully investigated. This retrospective study aimed to clarify changes in BMI, nutritional status, and appetite after BPA. Fifty‐two consecutive patients with CTEPH who underwent complete revascularization with BPA between July 2014 and July 2023 and were available for follow‐up were evaluated. We compared the presence or absence of increased appetite, BMI change, and nutritional status before and after BPA treatment. BPA significantly improved the mean pulmonary artery pressure from 37.4 ± 8.7 mmHg to 18.7 ± 2.8 mmHg and the partial pressure of oxygen from 61.6 ± 9.3 mmHg to 82.8 ± 9.9 mmHg (both p
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- 2024
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5. Relationship between haemodynamic indicators and haemogram in patients with heart failure
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Takuya Oh, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
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Left ventricular end‐diastolic pressure ,Platelet count ,Haemodynamic indicators ,Cardiac index ,Haemogram ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Pulmonary congestion, reduced cardiac output, neurohumoral factor activation, and decreased renal function associated with decreased cardiac function may have various effects on haemograms. The relationship between these factors and haemograms in patients with heart failure has not been sufficiently investigated. Recently, it was suggested that the lungs are an important site for platelet (Plt) biosynthesis and that it is necessary to study the relationship between pulmonary congestion and Plt count in heart failure in detail. In this study, we examined the relationship between various haemodynamic indicators and haemograms in detail using statistical analyses. Methods and results A total of 345 patients who underwent cardiac catheterization for the evaluation of cardiac function between 1 January 2015 and 31 December 2020 were included in the study. Haemodynamic indices, including left ventricular end‐diastolic pressure (LVEDP) and cardiac index (CI), were measured. Plasma noradrenaline (Nor) concentration, estimated glomerular filtration rate (eGFR), white blood cell (WBC) count, haemoglobin (Hb) level, and Plt count were measured using blood samples collected at the same time. Structural equation modelling (SEM) was used to examine the relationship between LVEDP, CI, plasma Nor concentration, eGFR, WBC count, Hb level, and Plt count. Bayesian inference using SEM was performed for Plt count. A total of 345 patients (mean age: 66.0 ± 13.2 years) were included in this study, and 251 (73%) patients were men. After simple and multiple regression analyses, path diagrams were drawn and analysed using SEM. LVEDP showed a significant negative relationship with Plt count (standardized estimate: −0.129, P = 0.015), and CI showed a significant negative relationship with Hb level (standardized estimate: −0.263, P
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- 2023
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6. Technical inefficiency and firm behavior: A panel study of small and medium Japanese manufacturing firms
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Kazuo Ogawa
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D22 ,E22 ,E23 ,J24 ,History of scholarship and learning. The humanities ,AZ20-999 ,Social sciences (General) ,H1-99 - Abstract
This study examines the technical inefficiency of small and medium Japanese manufacturing firms by using panel data from the Basic Survey on Small and Medium Enterprises (2009–2018). We estimate the stochastic frontier production function with four production factors (regular workers, nonregular workers, capital stock and materials) and calculate the technical inefficiency of individual firms by applying a true random effects model that can distinguish technical inefficiency from firm heterogeneity.We find that inefficient firms are smaller, rely more on nonregular workers, exhibit poorer firm performance, have a higher debt-asset ratio, pay a lower interest rate and are inactive in capital investment and R&D investment. We also find that inactive capital investment and a high debt-asset ratio are mainly responsible for causing technical inefficiency.
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- 2023
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7. Sex-inducing effects toward planarians widely present among parasitic flatworms
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Kiyono Sekii, Soichiro Miyashita, Kentaro Yamaguchi, Ikuma Saito, Yuria Saito, Sayaka Manta, Masaki Ishikawa, Miyu Narita, Taro Watanabe, Riku Ito, Mizuki Taguchi, Ryohei Furukawa, Aoi Ikeuchi, Kayoko Matsuo, Goro Kurita, Takashi Kumagai, Sho Shirakashi, Kazuo Ogawa, Kimitoshi Sakamoto, Ryo Koyanagi, Noriyuki Satoh, Mizuki Sasaki, Takanobu Maezawa, Madoka Ichikawa-Seki, and Kazuya Kobayashi
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Parasitology ,Developmental genetics ,Science - Abstract
Summary: Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti-parasitic drug design, little is known regarding bioactive compounds controlling flatworm sexual maturation. Using the planarian Dugesia ryukyuensis, we observed that sex-inducing substances found in planarians are also widespread in parasitic flatworms, such as monogeneans and flukes (but not in tapeworms). Reverse-phase HPLC analysis revealed the sex-inducing substance(s) eluting around the tryptophan retention time in the fluke Calicophoron calicophorum, consistent with previous studies on the planarian Bipalium nobile, suggesting that the substance(s) is likely conserved among flatworms. Moreover, six of the 18 ovary-inducing substances identified via transcriptome and metabolome analyses are involved in purine metabolism. Our findings provide a basis for understanding and modifying the life cycles of various parasitic flatworms.
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- 2023
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8. Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid
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Takashi Sakurai, Kengo Ito, Koichi Kozaki, Kenji Toba, Hiroshige Fujishiro, Masanori Nakagawa, Kazuo Ogawa, Hiroshi Yamauchi, Chio Okuyama, Hiroshi Ito, Daisuke Watanabe, Satoshi Koyama, Ryosuke Takahashi, Kazunori Terasaki, Harushi Mori, Tetsuya Maeda, Masaru Suzuki, Masatoyo Nishizawa, Mikio Shoji, Mineo Yamazaki, Etsuro Matsubara, Shuichi Ikeda, Hidehiro Mizusawa, Kenji Nakashima, Jun Takeuchi, Hiroyuki Shimada, Takashi Kudo, Nobuyuki Saito, Hiroyuki Arai, Takashi Yamazaki, Mitsutoshi Okazaki, Takeshi Iwatsubo, Nobuo Sanjo, Masaki Takao, Shigeo Murayama, Masahito Yamada, Yuichi Sato, Satoshi Takahashi, Harumasa Takano, Masuhiro Sakata, Shunji Mugikura, Shun Shimohama, Takashi Kato, Toshiki Mizuno, Yukiko Yamada, Daisuke Yamamoto, Makoto Higuchi, Yu Nakamura, Yu Hayasaka, Yoshiko Fukushima, Takayuki Obata, Kimiko Yoshimaru, Shinichi Sakamoto, Kaori Watanabe, Masashi Tsujimoto, Osamu Yokota, Seishi Terada, Atsushi Watanabe, Akinori Miyashita, Ryozo Kuwano, Daisuke Yamaguchi, Tetsuaki Arai, Rieko Okada, Hiroshi Matsuda, Kyoko Ito, Kenji Ishii, Yukio Miki, Yuka Yamamoto, Toru Takahashi, Makoto Sasaki, Ken Nagata, Hajime Sato, Miwako Takahashi, Toshimitsu Momose, Isao Ito, Masakazu Yamagishi, Mayumi Watanabe, Hitoshi Shibuya, Shin-ichi Urayama, Hidenao Fukuyama, Toshio Kawamata, Yasuji Yamamoto, Kiyoshi Maeda, Manabu Ikeda, Mamoru Hashimoto, Takeshi Kawarabayashi, Masaki Ikeda, Eizo Iseki, Kazunari Ishii, Yuko Saito, Miharu Samuraki, Heii Arai, Takashi Asada, Haruo Hanyu, Katsuyoshi Mizukami, Takahiko Tokuda, Yukihiko Washimi, Mitsuhiro Yoshita, Hitoshi Shimada, Fumitoshi Niwa, Hitoshi Shinotoh, Tetsuya Suhara, Masatoshi Takeda, YOKO KONAGAYA, Takaaki Mori, Kensaku Kasuga, Takayoshi Tokutake, Takeshi Ikeuchi, Hiroaki Kazui, Noriko Sato, Takeshi Tamaru, Masanobu Takahashi, Yasuhiro Nakata, Yasumasa Yoshiyama, Hisatomo Kowa, Shuichi Ono, Takuya Ohkubo, Yasuo Kuwabara, Tomoko Nakazawa, Kazutomi Kanemaru, Toshiaki Taoka, Nobuyuki Okamura, Hiroki Hayashi, Shin Tanaka, Kayoko Kikuchi, Masataka Kikuchi, Tamao Tsukie, Kazushi Suzuki, Ryoko Ihara, Atsushi Iwata, Norikazu Hara, Morihiro Sugishita, Michio Senda, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Chiyoko Takanami, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Yoshihiro Takai, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Masayuki Takeda, Toshiaki Sasaki, Koichiro Sera, Yoshihiro Saitoh, Shoko Goto, Kuniko Ueno, Hiromi Sakashita, Kuniko Watanabe, Yasushi Kondoh, Daiki Takano, Mio Miyata, Hiromi Komatsu, Tomomi Sinoda, Rena Muraoka, Hitomi Ito, Aki Sato, Toshibumi Kinoshita, Hideyo Toyoshima, Kaoru Sato, Shigeki Sugawara, Fumiko Kumagai, Katsutoshi Furukawa, Masaaki Waragai, Naoki Tomita, Mari Ootsuki, Katsumi Sugawara, Satomi Sugawara, Atsushi Umetsu, Takanori Murata, Tatsuo Nagasaka, Yukitsuka Kudo, Manabu Tashiro, Shoichi Watanuki, Saeri Ishikawa, Emiko Kishida, Nozomi Sato, Mieko Hagiwara, Kumi Yamanaka, Takeyuki Watanabe, Taeko Takasugi, Shoichi Inagawa, Kenichi Naito, Masanori Awaji, Tsutomu Kanazawa, Kouiti Okamoto, Tsuneo Yamazaki, Yuiti Tasiro, Syunn Nagamine, Shiori Katsuyama, Sathiko Kurose, Sayuri Fukushima, Etsuko Koya, Makoto Amanuma, Noboru Oriuti, Kouiti Ujita, Kazuhiro Kishi, Kazuhisa Tuda, Etsuko Nakajima, Katsumi Miyamoto, Kousaku Saotome, Tomoya Kobayashi, Saori Itoya, Jun Ookubo, Toshiya Akatsu, Yoshiko Anzai, Junya Ikegaki, Yuuichi Katou, Kaori Kimura, Ryou Kuchii, Hajime Saitou, Kazuya Shinoda, Satoka Someya, Hiroko Taguchi, Kazuya Tashiro, Masaya Tanaka, Tatsuya Nemoto, Ryou Wakabayashi, Hitoshi Shinoto, Kazuko Suzuki, Izumi Izumida, Katsuyuki Tanimoto, Takahiro Shiraishi, Junko Shiba, Hiroaki Yano, Miki Satake, Aimi Nakui, Yae Ebihara, Tomomi Hasegawa, Mami Kato, Yuki Ogata, Hiroyuki Fujikawa, Nobuo Araki, Yoshihiko Nakazato, Takahiro Sasaki, Tomokazu Shimadu, Etsuko Imabayashi, Asako Yasuda, Etuko Yamamoto, Natsumi Nakamata, Noriko Miyauchi, Keiko Ozawa, Rieko Hashimoto, Taishi Unezawa, Takafumi Ichikawa, Tunemichi Mihara, Masaya Hirano, Shinichi Watanabe, Junichiro Fukuhara, Hajime Matsudo, Toshihiro Hayashi, Toji Miyagawa, Mizuho Yoshida, Yuri Koide, Eriko Samura, Kurumi Fujii, Nagae Orihara, Akira Kunimatsu, Takuya Arai, Yoshiki Kojima, Masami Goto, Takeo Sarashina, Syuichi Uzuki, Seiji Katou, Yoshiharu Sekine, Yukihiro Takauchi, Chiine Kagami, Yasushi Nishina, Maria Sakaibara, Yumiko Okazaki, Maki Obata, Yuko Iwata, Mizuho Minami, Yasuko Hanabusa, Hanae Shingyouji, Kyoko Tottori, Aya Tokumaru, Makoto Ichinose, Kazuya Kume, Syunsuke Kahashi, Kunimasa Arima, Tadashi Tukamoto, Yuko Nagahusa, Maki Yamada, Tiine Kodama, Tomoko Takeuchi, Keiichiro Ozawa, Yoshiko Kawaji, Kyouko Tottori, Satoshi Sawada, Makoto Mimatsu, Daisuke Nakkamura, Shunichirou Horiuchi, Tsuneyoshi Ota, Aiko Kodaka, Yuko Tagata, Tomoko Nakada, Kiyoshi Sato, Norio Murayama, Satoshi Kimura, Hirofumi Sakurai, Takahiko Umahara, Hidekazu Kanetaka, Kaori Arashino, Mikako Murakami, Ai Kito, Seiko Miyagi, Kaori Doi, Kazuyoshi Sasaki, Akiko Ishiwata, Yasushi Arai, Akane Nogami, Sumiko Fukuda, Sayaka Kimura, Ayako Machida, Kuninori Kobayashi, Mutsufusa Watanabe, Hiromi Utashiro, Yukiko Matsumoto, Kumiko Hagiya, Yoshiko Miyama, Takako Shinozaki, Haruko Hiraki, Isamu Ohashi, Akira Toriihara, Shinichi Ohtani, Toshifumi Matsui, Tomomi Toyama, Hideki Sakurai, Kumiko Sugiura, Hirofumi Taguchi, Shizuo Hatashita, Akari Imuta, Akiko Matsudo, Daichi Wakebe, Hideki Hayakawa, Mitsuhiro Ono, Takayoshi Ohara, Yutaka Arahata, Akinori Takeda, Akiko Yamaoka, Hideyuki Hattori, Miura Hisayuki, Hidetoshi Endou, Syousuke Satake, Young Jae Hong, Katsunari Iwai, Kenji Yoshiyama, Masaki Suenaga, Sumiko Morita, Teruhiko Kachi, Rina Miura, Takiko Kawai, Ai Honda, Kengo Itou, Ken Fujiwara, Rikio Katou, Mariko Koyama, Naohiko Fukaya, Akira Tsuji, Hitomi Shimizu, Hiroyuki Fujisawa, Takanori Sakata, Kenjiro Ono, Moeko Shinohara, Yuki Soshi, Kozue Niwa, Chiaki Doumoto, Mariko Hata, Miyuki Matsushita, Mai Tsukiyama, Nozomi Takeda, Sachiko Yonezawa, Ichiro Matsunari, Osamu Matsui, Fumiaki Ueda, Yasuji Ryu, Masanobu Sakamoto, Yasuomi Ouchi, Madoka Chita, Yumiko Fujita, Rika Majima, Hiromi Tsubota, Umeo Shirasawa, Masashi Sugimori, Wataru Ariya, Yuuzou Hagiwara, Yasuo Tanizaki, Hajime Takechi, Chihiro Namiki, Kengo Uemura, Takeshi Kihara, Shizuko Tanaka-Urayama, Emiko Maeda, Natsu Saito, Shiho Satomi, Konomi Kabata, Tomohisa Okada, Koichi Ishizu, Shigeto Kawase, Satoshi Fukumoto, Masaki Kondo, Yoko Oishi, Mariko Yamazaki, Yoku Asano, Chizuru Hamaguchi, Kei Yamada, Kentaro Akazawa, Shigenori Matsushima, Takamasa Matsuo, Toshiaki Nakagawa, Takeshi Nii, Takuji Nishida, Kuniaki Kiuchi, Masami Fukusumi, Hideyuki Watanabe, Akihiro Nogi, Toshihisa Tanaka, Naoyuki Sato, Masayasu Okochi, Takashi Morihara, Shinji Tagami, Noriyuki Hayashi, Masahiko Takaya, Tamiki Wada, Mikiko Yokokoji, Hiromichi Sugiyama, Shuko Takeda, Keiko Nomura, Mutsumi Tomioka, Eiichi Uchida, Yoshiyuki Ikeda, Mineto Murakami, Takami Miki, Suzuka Ataka, Motokatsu Kanemoto, Akitoshi Takeda, Rie Azuma, Yuki Iwamoto, Naomi Tagawa, Junko Masao, Yuka Matsumoto, Yuko Kikukawa, Hisako Fujii, Junko Matsumura, Susumu Shiomi, Joji Kawabe, Yoshihiro Shimonishi, Mitsuji Higashida, Tomohiro Sahara, Takashi Yamanaga, Hiroyuki Tsushima, Kazuo Sakai, Haruhiko Oda, Taichi Akisaki, Mizuho Adachi, Masako Kuranaga, Sachi Takegawa, Yoshihiko Tahara, Takeshi Ishihara, Hajime Honda, Yuki Kishimoto, Naoya Takeda, Nao Imai, Mayumi Yabe, Kentaro Ida, Daigo Anami, Seiji Inoue, Toshi Matsushita, Reiko Wada, Shinsuke Hiramatsu, Hiromi Tonbara, Reiko Yamamoto, Kenji Wada-Isoe, Saori Yamasaki, Eijiro Yamashita, Ichiro Ishikawa, Sonoko Danjo, Tomomi Shinohara, Miyuki Ueno, Yuka Kashimoto, Yoshihiro Nishiyama, Narihide Kimura, Yasuhiro Sasakawa, Takashi Ishimori, Yukito Maeda, Tatsuo Yamada, Shinji Ouma, Aika Fukuhara-Kaneumi, Nami Sakamoto, Rie Nagao, Kengo Yoshimitsu, Ryuji Nakamuta, Minoru Tanaka, Keiichirou Kaneda, Yuusuke Yatabe, Kazuki Honda, Naoko Ichimi, Fumi Akatuka, Mariko Morinaga, Miyako Noda, Mika Kitajima, Toshinori Hirai, Shinya Shiraishi, Naoji Amano, Shinsuke Washizuka, Shin Inuzuka, Tetsuya Hagiwara, Nobuhiro Sugiyama, Yatsuka Okada, Tomomi Ogihara, Takehiko Yasaki, Minori Kitayama, Tomonori Owa, Akiko Ryokawa, Rie Takeuchi, Satoe Goto, Keiko Yamauchi, Mie Ito, Tomoki Kaneko, Hitoshi Ueda, Ban Mihara, Hirofumi Kubo, Akiko Takano, Gou Yasui, Masami Akuzawa, Kaori Yamaguchi, Toshinari Odawara, Megumi Shimamura, Mikiko Sugiyama, Naomi Oota, Shigeo Takebayashi, Yoshigazu Hayakawa, Mitsuhiro Idegawa, and Noriko Toya
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population.Methods We stratified 177 individuals who participated in the Japanese Alzheimer’s Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)tau and AT(N)NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles.Results We found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive impairment, and 61% of patients with Alzheimer’s disease (AD) dementia had the biological AD profile (ie, A+T+) in the cohort. The frequency of AT(N) profiles substantially differed between the AT(N)tau and AT(N)NfL classifications. When we used t-tau as the N marker (AT(N)tau), those who had T− were more frequently assigned to (N)−, whereas those who had T+were more frequently assigned to (N)+ than when we used NfL as the N marker (AT(N)NfL). During a follow-up, the AD continuum group progressed clinically and biologically compared with the normal biomarker group in both the AT(N)tau and AT(N)NfL classifications. More frequent conversion to dementia was observed in the non-AD pathological change group in the AT(N)tau classification, but not in the AT(N)NfL classification.Conclusions AT(N)tau and AT(N)NfL in CSF may capture different aspects of neurodegeneration and provide a different prognostic value. The AT(N) classification aids in understanding the AD continuum biology in various populations.
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- 2022
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9. Possible diverse contribution of coronary risk factors to left ventricular systolic and diastolic cavity sizes
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Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
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Medicine ,Science - Abstract
Abstract It is generally believed that risk factors damage the coronary arteries, cause myocardial ischemia, and consequently change the shape of the heart. On the other hand, each of the risk factors may also have a negative effect on the heart. However, it is very difficult to examine the effects of each of these risk factors independently. Therefore, it is necessary to select an appropriate statistical method and apply it efficiently. In this study, the effects of coronary risk factors on left ventricular size and cardiac function were investigated using structure equation modeling (SEM), and were shown as Bayesian SEM-based frequency polygons using selected two-dimensional contours. This study showed that each risk factor directly affected the shape of the heart. Because vascular risk and heart failure risk are likely to evolve at the same time, managing risk factors is very important in reducing the heart failure pandemic.
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- 2021
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10. A pilot cohort study assessing the feasibility of complete revascularization with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.
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Shinya Fujii, Shinya Nagayoshi, Kazuo Ogawa, Makoto Muto, Toshikazu D Tanaka, Kosuke Minai, Makoto Kawai, and Michihiro Yoshimura
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Medicine ,Science - Abstract
Balloon pulmonary angioplasty improves prognosis by alleviating pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension, even with incomplete revascularization. However, hypoxia or the requirement for pulmonary vasodilators often remain even after pulmonary hypertension relief. With this cohort study, we aimed to examine whether complete revascularization by additional balloon pulmonary angioplasty on residual lesions, even after pulmonary hypertension relief, could resolve hypoxia or the requirement for pulmonary vasodilators. During complete revascularization with balloon pulmonary angioplasty in 42 patients with chronic thromboembolic pulmonary hypertension, we investigated therapeutic effects at baseline (T1), pulmonary hypertension relief phase (T2), and at 6 months post-final balloon pulmonary angioplasty (T3). The pulmonary hypertension relief phase was defined as the first time that a mean pulmonary artery pressure ≤ 25 mmHg or pulmonary vascular resistance ≤ 240 dyn-s/cm5 was reached in right heart catheterization before balloon pulmonary angioplasty. The partial pressure of oxygen increased progressively over T1, T2, and T3 (59.2±8.5, 69.0±9.7, and 80.0±9.5 mmHg, respectively; P
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- 2021
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11. Associations between Left Ventricular Cavity Size and Cardiac Function and Overload Determined by Natriuretic Peptide Levels and a Covariance Structure Analysis
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Jun Yoshida, Makoto Kawai, Kosuke Minai, Kazuo Ogawa, Takayuki Ogawa, and Michihiro Yoshimura
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Medicine ,Science - Abstract
Abstract The effects of left ventricular (LV) cavity size on cardiac function and overload have not yet been fully elucidated. We performed a covariance structure analysis and drew theoretical path models to clarify the effects of hemodynamic parameters on the stroke volume index (SVI) as a marker of cardiac function and on the plasma B-type natriuretic peptide (BNP) level as a marker of cardiac overload. We simultaneously measured various hemodynamic parameters and the BNP levels during cardiac catheterization in 1,715 inpatients of our institution. The current path models tested the validity of the Frank-Starling law in patients with heart failure using the SVI, the LV end-systolic volume index (LVESVI) and the LV end-diastolic volume index (LVEDVI). Using the BNP levels, the path models clearly demonstrated that LVESVI substantially augmented cardiac overload, whereas LVEDVI palliated this parameter. These volume indices exerted opposite effects on cardiac function and overload. These results advance the understanding of the relationships between LV cavity size and both cardiac function and overload and indicate the increasing importance of LV diastolic volume in heart failure and the utility of LVESVI as an important marker of cardiac remodeling for further relevant studies.
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- 2017
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12. Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
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Yoshiro Tanaka, Tomohisa Nagoshi, Makoto Kawai, Goki Uno, Satoshi Ito, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D. Tanaka, Kosuke Minai, Takayuki Ogawa, and Michihiro Yoshimura
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Medicine ,Science - Abstract
Abstract High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure analyses were performed to elucidate the cause-and-effect relationship between UA level and LV ejection fraction (LVEF). A path model exploring the factors contributing to LVEF showed that high UA was a significant cause of reduced LVEF (P = 0.004), independent of other significant factors. The degree of atherosclerosis, as estimated by the number of diseased coronary vessels, was significantly affected by high UA (P = 0.005); and the number of diseased coronary vessels subsequently led to reduced LVEF (P
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- 2017
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13. Parallel comparison of risk factors between progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome by covariance structure analysis.
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Kazuo Ogawa, Kosuke Minai, Makoto Kawai, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, and Michihiro Yoshimura
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Medicine ,Science - Abstract
It is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated.We investigated the differences in risk factors between these conditions using a statistical procedure.The study population consisted of 1,029 patients with ischemic heart disease (IHD). We divided the study population into two groups (ACS and non-ACS) and by diseased vessels (organic stenosis). Covariance structure analysis was simultaneously performed in one equation model for determination and comparison of the risk factors for organic stenosis and ACS.The analysis revealed that age (standardized regression coefficient, β: 0.206, P < 0.001), male gender (β: 0.126, P < 0.001), HbA1c level (β: 0.109, P < 0.001), HDL level (β: -0.109, P < 0.001) and LDL level (β: 0.127, P = 0.002) were significant for the advancement of organic stenosis. HDL level (β: 0100, P = 0.002) and MDA-LDL level (β: 0.335, P < 0.001) were significant for the onset of ACS, but age, HbA1c and LDL (P = NS or β < 0.1, respectively) were not. Among the risk factors, age, HbA1c and LDL were significantly more strongly associated with organic stenosis than ACS, while MDA-LDL was significantly more strongly associated with ACS than organic stenosis.The current statistical analysis revealed clear differences among the risk factors between the progression of organic stenosis and the onset of ACS. Among them, the MDA-LDL level should be considered to indicate a substantial risk of ACS.
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- 2017
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14. Conflicting relationship between age-dependent disorders, valvular heart disease and coronary artery disease by covariance structure analysis: Possible contribution of natriuretic peptide.
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Risa Fukumoto, Makoto Kawai, Kosuke Minai, Kazuo Ogawa, Jun Yoshida, Yasunori Inoue, Satoshi Morimoto, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, and Michihiro Yoshimura
- Subjects
Medicine ,Science - Abstract
It is conceivable that contemporary valvular heart disease (VHD) is affected largely by an age-dependent atherosclerotic process, which is similar to that observed in coronary artery disease (CAD). However, a comorbid condition of VHD and CAD has not been precisely examined. The first objective of this study was to examine a possible comorbid condition. Provided that there is no comorbidity, the second objective was to search for the possible reasons by using conventional risk factors and plasma B-type natriuretic peptide (BNP) because BNP has a potentiality to suppress atherosclerotic development.The study population consisted of 3,457 patients consecutively admitted to our institution. The possible comorbid condition of VHD and CAD and the factors that influence the comorbidity were examined by covariance structure analysis and multivariate analysis.The distribution of the patients with VHD and those with CAD in the histograms showed that the incidence of VHD and the severity of CAD rose with seniority in appearance. The real statistical analysis was planned by covariance structure analysis. The current path model revealed that aging was associated with VHD and CAD severity (P < 0.001 for each); however, as a notable result, there was an inverse association regarding the comorbid condition between VHD and CAD (Correlation coefficient [β]: -0.121, P < 0.001). As the second objective, to clarify the factors leading to this inverse association, the contribution of conventional risk factors, such as age, gender, hypertension, smoking, diabetes, obesity and dyslipidemia, to VHD and CAD were examined by multivariate analysis. However, these factors did not exert an opposing effect on VHD and CAD, and the inverse association defied explanation. Since different pathological mechanisms may contribute to the formation of VHD and CAD, a differentially proposed path model using plasma BNP revealed that an increase in plasma BNP being drawn by VHD suppressed the progression of CAD (β: -0.465, P < 0.001).The incidence of VHD and CAD showed a significant conflicting relationship. This result supported the likely presence of unknown diverse mechanisms on top of the common cascade of atherosclerosis. Among them, the continuous elevation of plasma BNP due to VHD might be one of the explicable factors suppressing the progression of CAD.
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- 2017
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15. Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis.
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Satoshi Ito, Tomohisa Nagoshi, Kosuke Minai, Yusuke Kashiwagi, Hiroshi Sekiyama, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D Tanaka, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
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Medicine ,Science - Abstract
OBJECTIVE:Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether "insulin resistance" is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure. METHODS AND RESULTS:We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). During ACS, homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly increased (P
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- 2017
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16. Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor.
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Joshi Tsutsumi, Kosuke Minai, Makoto Kawai, Kazuo Ogawa, Yasunori Inoue, Satoshi Morimoto, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, and Michihiro Yoshimura
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Medicine ,Science - Abstract
Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients.The study patients consisted of 1252 subjects (IHD: n = 970; non-IHD: n = 282). Multiple logistic regression analysis revealed that dyslipidemia, hypertension, diabetes, and the low reactivity of BNP were significant risk factors for IHD, but body mass index (BMI) was not. A theoretical path model was proposed by positioning BMI at the top of the hierarchical model. Exploratory factor analysis revealed that BMI did not play a causative role in IHD (P = NS). BMI was causatively linked to other risk factors (P
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- 2017
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17. Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.
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Katsuya Ohbuchi, Yoshikazu Mori, Kazuo Ogawa, Eiji Warabi, Masahiro Yamamoto, and Takatsugu Hirokawa
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Medicine ,Science - Abstract
Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. In this study, mutational analysis of human TRPV1 was performed, and four agonists (capsaicin, RTX, [6]-shogaol and [6]-gingerol) were used to identify amino acid residues involved in ligand binding and/or modulation of proton sensitivity. The detailed binding mode of each ligand was then simulated by computational analysis. As a result, three amino acids (L518, F591 and L670) were newly identified as being involved in ligand binding and/or modulation of proton sensitivity. In addition, in silico docking simulation and a subsequent mutational study suggested that [6]-gingerol might bind to and activate TRPV1 in a unique manner. These results provide novel insights into the binding mode of various vanilloids to the channel and will be helpful in developing a TRPV1 modulator.
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- 2016
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18. The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.
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Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Kimiaki Komukai, Toshikazu Tanaka, Kazuo Ogawa, Tomohisa Nagoshi, Satoshi Arase, Satoshi Morimoto, Yasunori Inoue, Hiroshi Sekiyama, Akihiro Urabe, Seiichiro Matsuo, Kenichi Hongo, and Michihiro Yoshimura
- Subjects
Medicine ,Science - Abstract
OBJECTIVE: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD. METHODS: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed. RESULTS: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p
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- 2014
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19. Effects of platelet-to-lymphocyte ratio on renal function following acute myocardial infarction: A retrospective observational study.
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Keisuke Shirasaki, Kosuke Minai, Satoshi Morimoto, Tanaka, Toshikazu D., Kazuo Ogawa, Tomohisa Nagoshi, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
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- 2024
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20. Establishment of the Life Cycle of Philometroides seriolae (Nematoda: Philometridae) Using Surrogate Copepod Intermediate Host
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Kazuo Ogawa, Naoya Sata, Yukitaka Sugihara, Haruki Miyazaki, Mutsuki Ueno, Sora Kuramochi, and Sho Shirakashi
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Animal Science and Zoology ,Aquatic Science - Published
- 2023
21. Relationship between haemodynamic indicators and haemogram in patients with heart failure
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Takuya, Oh, Kazuo, Ogawa, Tomohisa, Nagoshi, Kosuke, Minai, Takayuki, Ogawa, Makoto, Kawai, and Michihiro, Yoshimura
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Cardiology and Cardiovascular Medicine - Abstract
Pulmonary congestion, reduced cardiac output, neurohumoral factor activation, and decreased renal function associated with decreased cardiac function may have various effects on haemograms. The relationship between these factors and haemograms in patients with heart failure has not been sufficiently investigated. Recently, it was suggested that the lungs are an important site for platelet (Plt) biosynthesis and that it is necessary to study the relationship between pulmonary congestion and Plt count in heart failure in detail. In this study, we examined the relationship between various haemodynamic indicators and haemograms in detail using statistical analyses.A total of 345 patients who underwent cardiac catheterization for the evaluation of cardiac function between 1 January 2015 and 31 December 2020 were included in the study. Haemodynamic indices, including left ventricular end-diastolic pressure (LVEDP) and cardiac index (CI), were measured. Plasma noradrenaline (Nor) concentration, estimated glomerular filtration rate (eGFR), white blood cell (WBC) count, haemoglobin (Hb) level, and Plt count were measured using blood samples collected at the same time. Structural equation modelling (SEM) was used to examine the relationship between LVEDP, CI, plasma Nor concentration, eGFR, WBC count, Hb level, and Plt count. Bayesian inference using SEM was performed for Plt count. A total of 345 patients (mean age: 66.0 ± 13.2 years) were included in this study, and 251 (73%) patients were men. After simple and multiple regression analyses, path diagrams were drawn and analysed using SEM. LVEDP showed a significant negative relationship with Plt count (standardized estimate: -0.129, P = 0.015), and CI showed a significant negative relationship with Hb level (standardized estimate: -0.263, P 0.001). Plasma Nor concentration showed a significant positive relationship with WBC count (standardized estimate: 0.165, P = 0.003) and Plt count (standardized estimate: 0.198, P 0.001). The eGFR had a significant positive relationship with Hb level (standardized estimate: 0.274, P 0.001). Bayesian inference using SEM revealed no relationship between LVEDP and Hb level or WBC count but a significant negative relationship between LVEDP and Plt count.LVEDP, CI, plasma Nor concentration, and eGFR were related to WBC count, Hb level, and Plt count in patients with heart failure. There was a strong relationship between elevated LVEDP and decreased Plt count, suggesting that pressure overload on the lungs may interfere with the function of the lung as a site of Plt biosynthesis.
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- 2022
22. Digenean Larva Migrans in Cultured Seriola spp. Caused by Hirudinella ventricosa (Trematoda: Hirudinellidae)
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Soetsu Yanagi, Tohru Mekata, Yoshiaki Imaoka, and Kazuo Ogawa
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Animal Science and Zoology ,Aquatic Science - Published
- 2022
23. Pulmonary Vein Angioplasty for Pulmonary Vein Stenosis After Ablation Therapy for Atrial Fibrillation ― A Report of 7 Cases ―
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Takayuki, Ogawa, Seigo, Yamashita, Hirotsuna, Oseto, Masaaki, Yokoyama, Ryosuke, Itakura, Ryeonshi, Kang, Kenichi, Tokutake, Takatoku, Aizawa, Yasunori, Inoue, Satoshi, Morimoto, Kazuo, Ogawa, Tomohisa, Nagoshi, Makoto, Kawai, Teiichi, Yamane, and Michihiro, Yoshimura
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Treatment Outcome ,Stenosis, Pulmonary Vein ,Pulmonary Veins ,Angioplasty ,Atrial Fibrillation ,Catheter Ablation ,Humans ,Constriction, Pathologic ,General Medicine ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Pulmonary vein (PV) stenosis after atrial fibrillation (AF) ablation is rare; however, it remains a serious complication. PV angioplasty is reportedly an effective therapy; however, a dedicated device for PV angioplasty has not been developed, and the detailed procedural methods remain undetermined. This study describes the symptoms, indications, treatment strategies, and long-term outcomes for PV stenosis after AF ablation.Methods and Results: This study retrospectively analyzed 7 patients with PV stenosis after catheter ablation for AF and who had undergone PV angioplasty at our hospital during 2015-2021. PV stenosis occurred in the left superior (5 patients) and left inferior (2 patients) PV. Six patients had hemoptysis, chest pain, and dyspnea. Seven de novo lesions were treated using balloon angioplasty (BA) (3 patients), a bare metal stent (BMS) (3 patients), and a drug-coated balloon (DCB) (1 patient). The restenosis rate was 42.9% (n=3; 2 patients in the BA group and 1 patient in the DCB group). The repeat treatment rate was 28.6% (2 patients in the BA group). Stenting was performed as repeat treatment. One patient with subsequent repeat restenosis development underwent BA. Ten PV angioplasties were performed; there were no major complications.Regarding PV angioplasty after ablation therapy for AF, stenting showed superior long-term PV patency than BA alone; therefore, it should be considered as a standard first-line approach.
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- 2022
24. The safety and feasibility of retrograde balloon aortic valvuloplasty using the INOUE-BALLOON with severe aortic stenosis
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Naoko Yuzawa-Tsukada, Yusuke Kashiwagi, Akira Nonoue, Goki Uno, Shinya Fujii, Akimichi Murakami, Kazuo Ogawa, Makoto Kawai, Makoto Muto, Michihiro Yoshimura, and Takashi Miyamoto
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Balloon Valvuloplasty ,Transcatheter Aortic Valve Replacement ,Treatment Outcome ,Aortic Valve ,Humans ,Feasibility Studies ,Aortic Valve Stenosis ,Cardiology and Cardiovascular Medicine ,Aged ,Retrospective Studies - Abstract
In the transcatheter aortic valve implantation (TAVI) era, the indications for balloon aortic valvuloplasty (BAV) are increasing. Previously, the INOUE-BALLOON® (IB) was used only for antegrade BAV, but recently, it has also been used for retrograde BAV. However, the safety and feasibility of retrograde BAV using an IB are not fully understood. In this study, we investigated the safety and feasibility of retrograde BAV using an IB in elderly Japanese patients with severe aortic stenosis (AS). We compared 39 cases of retrograde BAV using an IB performed from June 2018 to September 2020 and 34 cases of antegrade BAV using an IB performed from August 2013 to May 2018. The total number of complications was lower in retrograde BAV than in antegrade BAV (p = 0.020). The procedure time was significantly shorter in retrograde BAV than in antegrade BAV (p 0.001), and the maximum balloon size and number of balloon inflations were smaller in retrograde BAV than in antegrade BAV (p = 0.002 and p 0.001, respectively). There was no significant difference in the degree of improvement in the aortic valve area or ejection fraction between retrograde and antegrade BAV. In conclusion, the present study showed the safety and feasibility of retrograde BAV using an IB in elderly Japanese patients with severe AS compared with antegrade BAV using an IB.
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- 2022
25. Polyopisthocotylid Monogenean Infections of Amberjacks Seriola spp. in Japan
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Kazuo Ogawa, Sho Shirakashi, and Yutaka Fukuda
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Animal Science and Zoology ,Aquatic Science - Published
- 2022
26. Investigation of the small-balloon technique as a method for retrieving dislodged stents
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Takayuki Ogawa, Yasunori Inoue, Takatoku Aizawa, Satoshi Morimoto, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Makoto Kawai, and Michihiro Yoshimura
- Subjects
Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
27. Redescription of Zeuxapta seriolae (Meserve, 1938) and Zeuxapta australica Lebedev, 1968 (Monogenea: Heteraxinidae)
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Kazuo Ogawa
- Subjects
Fish Diseases ,Species Specificity ,Fishes ,Animals ,Female ,Parasitology ,Trematoda ,Trematode Infections ,Perciformes - Abstract
Redescription is given of heteraxinid monogeneans Zeuxapta seriolae (Meserve, 1938), type species of the genus, and Zeuxapta australica Lebedev, 1968 (formerly Z. seriolae australica). Type specimens of Z. seriolae from Seriola dorsalis from Galápagos Islands were differentiated from Z. australica specimens collected by Lebedev from Seriola glandis (now Seriola lalandi) from Tasman Sea, the type locality, by the shape of the vagina, which consisted of the transversely oval central body and horizontally extended paired tubes in the former, and the transversely oval central body and short, obliquely posteriad paired extensions in the latter. Zeuxapta japonica (Yamaguti, 1940) and Zeuxapta kahala (Yamaguti, 1968) were synonymized with Z. seriolae. Hitherto undescribed Zeuxapta specimens were also examined; those from Seriola aureovittata from Japan and China, and specimens from Seriola dumerili from Japan and Spain were identified as Z. seriolae, while those from Seriola lalandi from Chile and New Zealand were identified as Z. australica. Specimens from S. lalandi (as Seriola glandis) from Heron Island, Australia described by Rohde in 1978 as Z. seriolae consisted of Z. seriolae and Z. australica.
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- 2022
28. Inhibitory action of B-type natriuretic peptide on adrenocorticotropic hormone in patients with acute coronary syndrome.
- Author
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Nana Hiraki, Tomohisa Nagoshi, Toraaki Okuyama, Tanaka, Toshikazu D., Yuhei Oi, Yusuke Kashiwagi, Yasunori Inoue, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura
- Abstract
In addition to the classical actions of hemodynamic regulation, natriuretic peptides (NPs) interact with various neurohumoral factors that are deeply involved in the pathophysiology of cardiovascular diseases. However, their effects on the hypothalamic-pituitary-adrenal (HPA) axis, which is activated under acute high-stress conditions in acute coronary syndrome (ACS), remain largely unknown. We investigated the impact of plasma B-type NP (BNP) on plasma adrenocorticotropic hormone (ACTH)-cortisol levels during the acute phase of ACS ischemic attacks. The study population included 436 consecutive patients with ACS for whom data were collected during emergency cardiac catheterization. Among them, biochemical data after acute-phase treatment were available in 320 cases, defined as the ACS-remission phase (ACS-rem). Multiple regression analyses revealed that plasma BNP levels were significantly negatively associated with plasma ACTH levels only during ACS attacks (P < 0.001), but not in ACSrem, whereas plasma BNP levels were not significantly associated with plasma cortisol levels at any point. Accordingly, covariance structure analyses were performed to clarify the direct contribution of BNP to ACTH by excluding other confounding factors, confirming that BNP level was negatively correlated with ACTH level only during ACS attacks (β = -0.152, P = 0.002), whereas BNP did not significantly affect ACTH in ACS-rem. In conclusion, despite the lack of a significant direct association with cortisol levels, BNP negatively regulated ACTH levels during the acute phase of an ACS attack in which the HPA axis ought to be activated. NP may alleviate the acute stress response induced by severe ischemic attacks in patients with ACS. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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29. Influence of the Imaging Method on Regional Cerebral Blood Flow Value in Arterial Spin Labeling (ASL): Comparison of Pulsed-ASL with Two-dimensional Acquisition and Pseudo-continuous-ASL with 3D Spiral Acquisition
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Takuya, Kobata, Tatsuya, Yamasaki, Keigo, Omori, and Kazuo, Ogawa
- Subjects
Cerebrovascular Circulation ,Humans ,Reproducibility of Results ,Spin Labels ,Arteries ,General Medicine ,Magnetic Resonance Imaging - Abstract
The purposes of this study were to compare regional cerebral blood flow (rCBF) images acquired by the pulsed arterial spin labeling with two-dimensional acquisition (PASL-2D) and the pseudo-continuous-ASL with three-dimensional spiral acquisition (pCASL-3D spiral), and to clarify the characteristics of rCBF values in both ASL methods.PASL-2D and pCASL-3D spiral were performed in five healthy volunteers with no history of brain disease using 3T scanners from two venders in the same center. 3D TIn all sessions, mean values of rCBF were the highest at PCA for PASL-2D and at MCA for pCASL-3D spiral. RIs of pCASL-3D spiral were lower than those of PASL-2D in all arterial territories.In the PASL-2D and the pCASL-3D spiral, we confirmed the characteristics of the mean and reproducibility of rCBF values in each arterial territory.
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- 2022
30. Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine
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Tomoaki Ishida, Kohei Jobu, Kei Kawada, Shumpei Morisawa, Tetsushi Kawazoe, Hisashi Shiraishi, Hiroko Fujita, Satomi Nishimura, Hitomi Kanno, Mitsue Nishiyama, Kazuo Ogawa, Yasuyo Morita, Kazuhiro Hanazaki, and Mitsuhiko Miyamura
- Subjects
Pharmacology ,Mice ,Animals ,Humans ,Pharmaceutical Science ,Medicine, Kampo ,General Medicine ,Glycyrrhizic Acid ,Drugs, Chinese Herbal ,Gastrointestinal Microbiome - Abstract
Individual differences in gut microbiota can affect the pharmacokinetics of drugs. Yokukansan is a traditional Japanese kampo medicine used to treat peripheral symptoms of dementia and delirium. A study examining the pharmacokinetics of the components of yokukansan reported large individual differences in the pharmacokinetics of glycyrrhizic acid (GL). It is known that GL is metabolized by intestinal bacteria to glycyrrhetinic acid (GA), which is absorbed in the gastrointestinal tract. Thus, the gut microbiota may affect GL pharmacokinetics. We aimed to clarify the relationship between the gut microbiota composition and pharmacokinetics of GL in yokukansan. Mice were orally administered yokukansan, following the administration of various antibiotics, and the plasma concentration of GA and composition of gut microbiota were measured. The GA plasma concentration was low in mice treated with amoxicillin and vancomycin. The composition of gut microbiota revealed a different pattern from that of the control group. Mice with low plasma levels of GA had lower levels of the phylum Bacteroides and Firmicutes. Additionally, bacteria, such as those belonging to the genera Parabaceroides, Bacteroides, Ruminococcus and an unknown genus in families Lachnospiraceae and Ruminococcaceae, exerted positive correlations between the gene copies and plasma GA levels. These bacteria may contribute to the absorption of GA in the gastrointestinal tract, and multiple bacteria may be involved in GL pharmacokinetics. The pharmacokinetics of GL may be predicted by evaluating the composition of gut bacteria, rather than by evaluating the amount of a single bacterium.
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- 2022
31. Cut-off values of geriatric nutritional risk index for cardiovascular events in acute myocardial infarction patients
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Satoshi Ito, Yasunori Inoue, Tomohisa Nagoshi, Takatoku Aizawa, Yusuke Kashiwagi, Satoshi Morimoto, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa, and Michihiro Yoshimura
- Abstract
Low Geriatric Nutritional Risk Index (GNRI) in patients with heart failure is associated with poor prognosis. However, the usefulness of GNRI for patients with acute myocardial infarction (AMI) remains controversial. We evaluated the optimal cut-off values of GNRI for cardiovascular events in AMI patients by time-dependent receiver operating characteristic (ROC) analysis to examine its usefulness. We retrospectively investigated the optimal cut-off values for two endpoints of all-cause death and major adverse cardiac events (MACE: all-cause death, non-fatal myocardial infarction, hospitalization for heart failure, stroke) over 48 months in 360 patients with AMI who required emergency admission to our hospital between January 2012 and February 2020. The cumulative incidence of MACE over 48 months was 11.6%. The cut-off value of GNRI for all-cause death was 82.7 (AUC 0.834) at 3 months, 89.3 (AUC 0.861) at 12 months, and 90.3 (AUC 0.854) at 48 months. The cut-off value of GNRI for MACE was 83.0 (AUC 0.841) at 3 months, 95.7 (AUC 0.863) at 12 months, and 95.3 (AUC 0.821) at 48 months. Time-dependent ROC analysis showed that the optimal cut-off value of GNRI varied over time. The optimal cut-off value of GNRI is a useful predictor for prognosis in patients with AMI.
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- 2023
32. Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
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Keisuke Shirasaki, Kosuke Minai, Makoto Kawai, Toshikazu D. Tanaka, Kazuo Ogawa, Yasunori Inoue, Satoshi Morimoto, Tomohisa Nagoshi, Takayuki Ogawa, Kimiaki Komukai, and Michihiro Yoshimura
- Subjects
General Medicine - Abstract
In the pathophysiology of acute coronary syndrome (ACS), platelet (PLT) and neutrophil (Neu) crosstalk may be important for activating coagulation and inflammation. It has been speculated that PLTs and Neu may affect each other's cell counts; however, few studies have investigated this hypothesis. In this study, we measured changes in blood cell counts in 245 patients with ACS during treatment and investigated the mutual effects of each blood cell type. Path diagrams were drawn using structural equation modeling, and temporal changes in the count of each blood cell type and the relevance of these changes were analyzed. Throughout the treatment period, the numbers of all blood cell types (red blood cells [RBCs], leukocytes, and PLTs) were associated with each other before and after treatment. A detailed examination of the different cell types revealed that the PLT count at admission had a significant positive effect on the leukocyte (especially Neu) count after treatment. Conversely, the leukocyte (especially Neu) count at admission had a significant positive effect on the PLT count after treatment. During ACS, PLTs and leukocytes, especially Neu, stimulate each other to increase their numbers. The formation of a PLT-leukocyte complex may increase coagulation activity and inflammation, which can lead to a further increase in the counts of both blood cell types.
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- 2023
33. Infection of a Species of Digenean in Common Octopus Octopus sinensis in Japan
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Shotaro Izumi, Nobuhiko Akiyama, Yuta Suzumura, and Kazuo Ogawa
- Subjects
Animal Science and Zoology ,Aquatic Science - Published
- 2021
34. Biology and Pathogenicity of Benedenia akajin Infecting Hatchery-reared Plectropomus leopardus Juveniles
- Author
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Yutaro Fujiwara, Kazuo Ogawa, Sho Shirakashi, Yuji Fujikura, and Hirotaka Mizuochi
- Subjects
Leopardus ,biology ,Plectropomus ,media_common.quotation_subject ,Zoology ,Aquatic Science ,biology.organism_classification ,Pathogenicity ,Site specificity ,Hatchery ,Capsalidae ,Animal Science and Zoology ,Grouper ,Reproduction ,media_common - Published
- 2021
35. Emendation of the genus Neoheterobothrium and a proposal of a new genus Paraheterobothrium (Monogenea: Diclidophoridae) for five species of diclidophorids from Pleuronectiform fishes
- Author
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Marcelo E. Oliva, Naoki Itoh, and Kazuo Ogawa
- Subjects
biology ,Neoheterobothrium ,Zoology ,biology.organism_classification ,Type species ,Type (biology) ,Species Specificity ,Genus ,Animal ecology ,Flatfishes ,Animals ,Female ,Parasitology ,Type locality ,Trematoda ,Chile ,Internal transcribed spacer ,Monogenea - Abstract
Neoheterobothrium chilense Gonzalez, Oliva & Acuna, 2002 is redescribed based on newly collected specimens from the type host, Hippoglossina macrops and type locality (Coquimbo, Northern Chile). Type specimens of Neoheterobothrium hippoglossini Piasecki, Wierzbicka & Kempter, 2000 and Choricotyle exilis Crane, 1972 are also redescribed. These three diclidophorid monogeneans infecting pleuronectiform flatfishes have pre-ovarian seminal receptacle, ootype inside the semicircle of ovary and elongated pharynx, differentiated from the most similar Orbocotyle Euzet & Suriano, 1975 in that members of the latter genus possess post-ovarian seminal receptacle, post-ovarian ootype and cylindrical or pyriform pharynx. Paraheterobothrium n. g. is proposed for P. chilense n. comb. (type), P. hippoglossini n. comb., P. exilis n. comb., P. papillosum n. comb. and P. syacii n. comb. A redescription of Neoheterobothrium affine (Linton, 1898), the type species of the genus, based on voucher specimens confirmed differences from the new genus in the presence of lamellate plate in the anterior jaw of clamps, absence of seminal receptacle and ovoid pharynx. The genus Neoheterobothrium was emended and N. cynoscioni (MacCallum, 1917) and N. mcdonaldi Payne, 1987 were removed from the genus. Neoheterobothrium now comprises N. affine (type), N. insulare Oliva & Luque, 1995, N. hirame Ogawa, 1999, and N. paralichthyi Suriano & Labriola, 1999, all of them parasites of flatfishes of the genus Paralichthys. Molecular analyses with the internal transcribed spacer 1 distinguished the clade for Paraheterobothrium spp. (P. chilense n. comb. and P. papillosum n. comb.) and Neoheterobothrium spp. (N. hirame, N. affine and N. paralichthyi), supporting this taxonomic emendation.
- Published
- 2021
36. 'Seikatsu Rinsho' – a values-based approach to supporting recovery in Japan
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Kenichi Hasegawa, Takashi Iseda, Geoff Shepherd, Syudo Yamasaki, Kazuo Ogawa, and Atsushi Nishida
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050103 clinical psychology ,Health (social science) ,Seikatsu ,Process (engineering) ,business.industry ,05 social sciences ,Context (language use) ,Public relations ,Mental health ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Full recovery ,Life course approach ,0501 psychology and cognitive sciences ,Service user ,Pshychiatric Mental Health ,Family history ,business ,Psychology - Abstract
Purpose This paper aims to introduce Seikatsu Rinsho, a values-based approach to supporting recovery based on identifying service user values and aspirations that have been developed since 1958 in Japan where mental health services are still hospital-based and user involvement is not well-developed. This paper believes this will be of great implications for future practices around the world. Design/methodology/approach Hope is essential to recovery and that hope is dependent on identifying what service users really want for themselves (aspirations) and then ensuring that these are communicated to – and supported by – professionals and carers. This is achieved through examining the life events, which are likely to trigger relapse for a specific individual, the important choices that the person has made throughout his/her life course and the reasons behind them. Through a process of “co-production”, an attempt is made to understand the values expressed in these choices in the context of family history over several generations. Findings The attempt to examine both life events throughout the life course and family history over generations was found to be an effective way to understand a service user and his/her family and then support recovery. The cases where even people with severe and persistent mental health problems have successfully achieved full recovery have been accumulated. Research limitations/implications The limitations of the approach in the context of Japanese mental health services, and the necessity of additional evidence are acknowledged and some thoughts shall be given to future development. Originality/value Seikatsu Rinsho approach can provide a new angle to understand service users and family and a new way to support recovery.
- Published
- 2021
37. Ceratothoa verrucosa (Isopoda: Cymothoidae) Infection in the Buccal Cavity of Red Seabream Caught in Iyo-Nada, Western Japan, with Some Notes on Its Co-infection with Choricotyle elongata (Monogenea: Diclidophoridae)
- Author
-
Tomomichi Ohtani, Noriyuki Kurono, Kazuo Ogawa, Masamitsu Chiba, Satoru Matsuoka, and Izumi Kawamoto
- Subjects
Pagrus major ,Cymothoidae ,Isopoda ,biology ,Ceratothoa ,Diclidophoridae ,Zoology ,Animal Science and Zoology ,Choricotyle ,Aquatic Science ,biology.organism_classification ,Monogenea ,Co infection - Published
- 2021
38. Real estate market and consumption: macro and micro evidence of Japan
- Author
-
Kazuo Ogawa
- Published
- 2022
39. A Pilot Evaluation Study of Diffuse Coronary Arterial Contraction Causing Ischemia by Double Measurement of Left Ventriculography Before and After Intracoronary Administration of Nitrates
- Author
-
Kimiaki Komukai, Makoto Kawai, Takayuki Ogawa, Toshikazu D. Tanaka, Satoshi Morimoto, Michihiro Yoshimura, Kosuke Minai, Tomohisa Nagoshi, Yasunori Inoue, and Kazuo Ogawa
- Subjects
medicine.medical_specialty ,Ejection fraction ,Contraction (grammar) ,Receiver operating characteristic ,business.industry ,Provocation test ,Original article ,Ischemia ,Lumen (anatomy) ,Coronary artery spasm ,General Medicine ,medicine.disease ,Ischemic Heart Disease ,Double left ventriculography ,New approach ,medicine.anatomical_structure ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,Isosorbide dinitrate ,business ,medicine.drug ,Artery - Abstract
Background: Abnormal diffuse coronary artery contraction is not easily diagnosed. In order to evaluate its true risk, we performed double left ventriculography (LVG) before and after intracoronary administration of isosorbide dinitrate (ISDN). We also investigated the relationship between changes in coronary lumen area and changes in left ventricular ejection fraction (LVEF) after ISDN. Methods and Results: The study included 53 patients who underwent an acetylcholine (ACh) provocation test after coronary angiogram and LVG. The second LVG was performed after intracoronary ISDN administration. Coronary lumen area was measured by quantitative coronary arteriography (QCA). Simple and multiple regression analyses showed a significant correlation between changes in total QCA area before and after ISDN administration (pre-and post-total QCA area, respectively) and changes in LVEF. Using structural equation modeling, we observed a negative effect of pre-total QCA area and a positive effect of post-total QCA area on LVEF improvement. Importantly, LVEF improvement was similar between the ACh-positive and -negative groups on the coronary artery spasm test. Receiver operating characteristic curves indicated that the cut-off value at which changes in total QCA area affected changes in LVEF was 5%. Conclusions: Performing double LVG tests before and after ISDN administration may detect myocardial ischemia caused by diffuse coronary artery contraction. The addition of this method to the conventional ACh provocation test may detect the presence of local and/or global myocardial ischemia.
- Published
- 2021
40. Benedenia akajin n. sp. (Monogenea: Capsalidae) from Leopard Coral Grouper Plectropomus leopardus Reared in Okinawa Prefecture, Japan
- Author
-
Sho Shirakashi, Nanami Asai, Kazuo Ogawa, Yasuo Agawa, Tomofumi Yamaguchi, and Hirotaka Mizuochi
- Subjects
Leopardus ,Plectropomus ,biology.animal ,Coral ,Leopard ,Zoology ,Animal Science and Zoology ,Grouper ,Aquatic Science ,Biology ,biology.organism_classification ,Monogenea ,Capsalidae - Published
- 2021
41. Larval Cucullanid Nematode Infection in the Liver of Ayu
- Author
-
Kazuo Ogawa, Akira Okino, Mitsuru Okamoto, and Mark A. Freeman
- Subjects
Larva ,Nematode infection ,medicine ,Zoology ,Animal Science and Zoology ,Aquatic Science ,Biology ,medicine.disease - Published
- 2021
42. Possible diverse contribution of coronary risk factors to left ventricular systolic and diastolic cavity sizes
- Author
-
Michihiro Yoshimura, Tomohisa Nagoshi, Kazuo Ogawa, Makoto Kawai, Yasunori Inoue, Kosuke Minai, Kenichiro Suzuki, and Takayuki Ogawa
- Subjects
Male ,0301 basic medicine ,Cardiac function curve ,medicine.medical_specialty ,Myocardial ischemia ,Systole ,Heart Ventricles ,Science ,Cardiology ,Myocardial Ischemia ,Diastole ,Coronary Disease ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Vascular risk ,Article ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Risk factor ,Aged ,Heart Failure ,Models, Statistical ,Multidisciplinary ,business.industry ,Coronary risk factors ,Bayes Theorem ,Heart ,Middle Aged ,medicine.disease ,Coronary arteries ,030104 developmental biology ,medicine.anatomical_structure ,Risk factors ,Heart Disease Risk Factors ,Heart failure ,Medicine ,Female ,Anatomy ,business ,Biomarkers - Abstract
It is generally believed that risk factors damage the coronary arteries, cause myocardial ischemia, and consequently change the shape of the heart. On the other hand, each of the risk factors may also have a negative effect on the heart. However, it is very difficult to examine the effects of each of these risk factors independently. Therefore, it is necessary to select an appropriate statistical method and apply it efficiently. In this study, the effects of coronary risk factors on left ventricular size and cardiac function were investigated using structure equation modeling (SEM), and were shown as Bayesian SEM-based frequency polygons using selected two-dimensional contours. This study showed that each risk factor directly affected the shape of the heart. Because vascular risk and heart failure risk are likely to evolve at the same time, managing risk factors is very important in reducing the heart failure pandemic.
- Published
- 2021
43. Metazoan Parasite Life Cycles: Significance for Fish Mariculture
- Author
-
Sho Shirakashi, Kazuo Ogawa, Barbara F. Nowak, and Daniel C. Huston
- Subjects
0301 basic medicine ,Life Cycle Stages ,Animal Welfare (journal) ,business.industry ,Chemical treatment ,Parasitic Diseases, Animal ,030231 tropical medicine ,Fisheries ,Fishes ,Marine fish ,Biology ,Fishery ,Life History Characteristics ,Fish Diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Infectious Diseases ,Aquaculture ,Animals ,%22">Fish ,Parasitology ,Mariculture ,business ,Metazoan parasite - Abstract
Marine fish are a nutritious and high-value food commodity, but many wild-capture fisheries are in decline. Thus, marine fish culture is expected to expand greatly in coming years. Management of disease is a major problem in this industry, and metazoan parasites are among the most significant disease agents in terms of economic loss and animal welfare. Current methods for controlling metazoan parasites are mostly reactionary and rely on chemical treatment. Such methods are ultimately unsustainable. Here, we summarise the life cycles of marine metazoan parasites and how this knowledge can be used for nonchemical management and control. To aid the sustainable growth of marine fish culture, we advocate for a renewed research focus on the basic life history characteristics of parasites.
- Published
- 2020
44. Heart Failure Treatments Such As Angiotensin Receptor/Neprilysin Inhibitor Improve Heart Failure Status and Glucose Metabolism
- Author
-
Yusuke Kashiwagi, Tomohisa Nagoshi, Kazuo Ogawa, Makoto Kawai, and Michihiro Yoshimura
- Subjects
General Engineering - Published
- 2022
45. Heavy Metacercarial Infection in the Abdominal Cavity of Hatchery-reared Japanese Dace Tribolodon hakonensis
- Author
-
Kazuo Ogawa, Norihiko Komatsu, and Naoki Itoh
- Subjects
medicine.anatomical_structure ,medicine ,Zoology ,Animal Science and Zoology ,Abdominal cavity ,Tribolodon hakonensis ,Aquatic Science ,Biology ,Hatchery - Published
- 2020
46. Bucephalid Metacercarial Infection in Wild Larval and Juvenile Ayu Plecoglossus altivelis
- Author
-
Sho Shirakashi, Tsukasa Waki, and Kazuo Ogawa
- Subjects
Larva ,Phylogenetics ,Fish farming ,Zoology ,Helminths ,Juvenile ,Animal Science and Zoology ,Aquatic animal ,Aquatic Science ,Biology ,Plecoglossus altivelis ,Ribosomal DNA - Published
- 2020
47. Technical Inefficiency and Firm Behavior a Panel Study of Small and Medium Japanese Manufacturing Firms
- Author
-
Kazuo Ogawa
- Subjects
General Medicine - Published
- 2022
48. Five new and two known species of Heterobothrium (Monogenea: Diclidophoridae) infecting puffers of the genus Takifugu from Japanese waters
- Author
-
Kazuo Ogawa and Naoki Itoh
- Subjects
Gills ,Fish Diseases ,Japan ,Species Specificity ,Animals ,Parasitology ,Trematoda ,Trematode Infections ,DNA, Ribosomal ,Takifugu - Abstract
Seven species of puffers of the genus Takifugu caught in Japanese waters were examined for monogeneans on the gills. Five new species of Heterobothrium (H. gotoi n. sp. from T. porphyreus, H. tabetai n. sp. from T. vermicularis, H. aljufailiae n. sp. and H. iwatai n. sp. from T. snyderi, H. matsubarai n. sp. from T. stictonotus) and two known species (H. praeorchis Bychowsky, MamaevNagibina, 1976 from T. pardalis, T. chrysops and T. flavipterus and H. bychowskyi Ogawa, 1991 from T. flavipterus) were found and described. Heterobothrium tetrodonis of Iwata (1991) was synonymized with H. bychowskyi. Currently, a total of 11 species of Heterobothrium, including the seven species in this study, were recorded from nine species of Japanese Takifugu spp. Ten species excluding H. praeorchis were found from a single host species, suggesting that they are highly host-specific and have co-evolved with the host Takifugu spp. Tagia Sproston, 1946 is synonymized with Heterobothrium. Earlier divergence of Heterobothrium of tetraodontid puffers in Diclidophoridae was suggested by the large subunit ribosomal DNA (rDNA) analyses, and interspecific relationships in this genus inferred from the internal transcribed spacer region of rDNA well corresponded to those inferred from their morphology and adhesive mode to the gills. Including the five new species and synonymization of Tagia with Heterobothrium, the genus Heterobothrium now comprises 19 species.
- Published
- 2021
49. Public Debt, Economic Growth and the Real Interest Rate: A Panel VAR Approach to EU and OECD Countries
- Author
-
Ichiro Tokutsu, Elmer Sterken, Kazuo Ogawa, and Research programme EEF
- Subjects
Macroeconomics ,Economics and Econometrics ,media_common.quotation_subject ,education ,Debt-to-GDP ratio ,Government debt ,Monetary economics ,CAUSALITY ,Vector autoregression ,GOVERNMENT DEBT ,SUSTAINABILITY ,Panel VAR ,Granger causality ,Debt ,0502 economics and business ,Economics ,050207 economics ,Real interest rate ,Debt levels and flows ,health care economics and organizations ,Economic growth ,media_common ,050208 finance ,Bond ,05 social sciences ,Oecd countries ,External debt ,humanities ,Interest rate ,Publict debt ,Real gross domestic product ,Internal debt - Abstract
We investigate the causal relationship between the public debt to GDP ratio and economic growth for 31 EU and OECD countries from 1995 to 2013. A number of studies have tackled this problem, but very few make the transmission mechanism explicit in their analysis. We estimate a panel VAR model that incorporates the long-term real interest rate on government bonds as a vehicle to transmit shocks in both the public debt to GDP ratio and economic growth. We find no causal link from the public debt to GDP ratio to the GDP growth rate, irrespective of the levels of public debt. Rather, we find a causal relation from the GDP growth rate to the public debt to GDP ratio. In high-debt countries, the direct negative impact of economic growth on public debt is enhanced by a rise in the long-term real interest rate, which in turn decreases interest-sensitive demand and leads to a further increase in the public debt to GDP ratio.
- Published
- 2019
50. Skin Injuries Contribute to Nocardiosis in Japanese Amberjack Seriola quinqueradiata
- Author
-
Yutaka Fukuda, Kazuo Ogawa, and Yasuyuki Miyoshi
- Subjects
Benedenia seriolae ,biology ,Nocardiosis ,Zoology ,Aquatic animal ,Aquatic Science ,medicine.disease ,medicine.disease_cause ,biology.organism_classification ,food.food ,Aquatic organisms ,food ,Infestation ,medicine ,Animal Science and Zoology ,Nocardia seriolae ,Seriola quinqueradiata ,Amberjack - Published
- 2019
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