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14 results on '"Ke, Yamin"'

4. Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride–glucose index with arterial stiffness risk

Author

Zhang, Wenkai, Huo, Weifeng, Hu, Huifang, Li, Tianze, Yuan, Lijun, Zhang, Jinli, Feng, Yifei, Wu, Yuying, Fu, Xueru, Ke, Yamin, Wang, Mengmeng, Wang, Longkang, Chen, Yaobing, Gao, Yajuan, Li, Xi, Sun, Liang, Pang, Jinyuan, Zheng, Zeqiang, Hu, Fulan, Zhang, Ming, Liu, Yu, Hu, Dongsheng, and Zhao, Yang

Published
2024
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10. Obesity and risk of depressive disorder in children and adolescents: A meta‐analysis of observational studies

Author

Chen, Yaobing, primary, Zhang, Jinli, additional, Yuan, Lijun, additional, Hu, Huifang, additional, Li, Tianze, additional, Zhao, Yang, additional, Wu, Yuying, additional, Wang, Mengmeng, additional, Huo, Weifeng, additional, Gao, Yajuan, additional, Ke, Yamin, additional, Wang, Longkang, additional, Zhang, Wenkai, additional, Fu, Xueru, additional, Li, Xi, additional, Hu, Fulan, additional, Zhang, Ming, additional, Sun, Liang, additional, and Hu, Dongsheng, additional

Published
2024
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12. Association of methylation risk score with incident type 2 diabetes mellitus: A nested case–control study

Author

Huo, Weifeng, primary, Hu, Huifang, additional, Li, Tianze, additional, Yuan, Lijun, additional, Zhang, Jinli, additional, Feng, Yifei, additional, Wu, Yuying, additional, Fu, Xueru, additional, Ke, Yamin, additional, Wang, Mengmeng, additional, Zhang, Wenkai, additional, Wang, Longkang, additional, Chen, Yaobing, additional, Gao, Yajuan, additional, Li, Xi, additional, Liu, Jiong, additional, Huang, Zelin, additional, Hu, Fulan, additional, Zhang, Ming, additional, Sun, Liang, additional, Hu, Dongsheng, additional, and Zhao, Yang, additional

Published
2023
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13. Association of methylation risk score with incident type 2 diabetes mellitus: A nested case–control study.

Author

Huo, Weifeng, Hu, Huifang, Li, Tianze, Yuan, Lijun, Zhang, Jinli, Feng, Yifei, Wu, Yuying, Fu, Xueru, Ke, Yamin, Wang, Mengmeng, Zhang, Wenkai, Wang, Longkang, Chen, Yaobing, Gao, Yajuan, Li, Xi, Liu, Jiong, Huang, Zelin, Hu, Fulan, Zhang, Ming, and Sun, Liang

Abstract

Aims: To investigate the association of methylation risk score (MRS) and its interactions with environmental factors with type 2 diabetes mellitus (T2DM) risk. Methods: We conducted a nested case–control study with 241 onset cases and 241 matched controls. Conditional logistic regression models were employed to identify risk CpG sites. Simple and weighted MRSs were constructed based on the methylation levels of ATP‐binding cassette G1 gene, fat mass and obesity associated gene, potassium voltage‐gated channel member 1 gene, and thioredoxin‐interacting protein gene previously associated with T2DM to estimate the association of MRS with T2DM risk. Stratified analyses were used to investigate interactions between MRS and environmental factors. Results: A total of 10 CpG loci were identified from the aforementioned genes to calculate MRS. After controlling for potential confounding factors, taking tertile 1 as reference, the odds ratios (ORs) and 95% confidence intervals (CIs) for T2DM of tertile 3 was 2.39 (1.36–4.20) for simple MRS and 2.59 (1.45–4.63) for weighted MRS. With per SD score increment in MRS, the OR (95% CI) was 1.66 (1.29–2.14) and 1.60 (1.24–2.08) for simple and weighted MRSs, respectively. J‐curved associations were observed between both simple and weighted MRSs and T2DM risks. Additionally, multiplication interactions for smoking and hypertension with simple MRS on the risk of T2DM were found, similarly for smoking and obesity with weighted MRS on the risk of T2DM (all Pinteraction <.05). Conclusion: Elevated simple and weighted MRSs were associated with increased risk of T2DM. Environmental risk factors may influence the association between MRS and T2DM. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Visit to visit transition in TXNIPgene methylation and the risk of type 2 diabetes mellitus: a nested case-control study

Author

Wu, Yuying, Chen, Weiling, Zhao, Yang, Gu, Minqi, Gao, Yajuan, Ke, Yamin, Wang, Longkang, Wang, Mengmeng, Zhang, Wenkai, Chen, Yaobing, Huo, Weifeng, Fu, Xueru, Li, Xi, Zhang, Dongdong, Qin, Pei, Hu, Fulan, Liu, Yu, Sun, Xizhuo, Zhang, Ming, and Hu, Dongsheng

Abstract

Our study aimed to investigate the association between the transition of the TXNIPgene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1–5; chr1:145441102-145442001) on the TXNIPgene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels. Compared with individuals whose methylation level of CpG2–5 at the TXNIPgene was maintained low, individuals with maintained high methylation levels showed a 61–87% reduction in T2DM risk (66% for CpG2 [OR: 0.34, 95% CI: 0.14, 0.80]; 77% for CpG3 [OR: 0.23, 95% CI: 0.07, 0.78]; 87% for CpG4 [OR: 0.13, 95% CI: 0.03, 0.56]; and 61% for CpG5 [OR: 0.39, 95% CI: 0.16, 0.92]). Maintained high methylation levels of four loci of the TXNIPgene are associated with a reduction of T2DM incident risk in the current study. Our study suggests that preserving hypermethylation levels of the TXNIPgene may hold promise as a potential preventive measure against the onset of T2DM.

Published
2024
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