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361 results on '"Keane, Robert W."'

7. Association of region‐specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's disease

Author

Vontell, Regina T., primary, Gober, Ryan, additional, Dallmeier, Julian, additional, Brzostowicki, Daniel, additional, Barreda, Ayled, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Kvartsberg, Hlin, additional, Gultekin, Sakir Humayun, additional, de Rivero Vaccari, Juan Pablo, additional, Bramlett, Helen M., additional, Dietrich, W. Dalton, additional, Keane, Robert W., additional, Davis, David A., additional, Rundek, Tatjana, additional, and Sun, Xiaoyan, additional

Published
2024
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12. Prognostic and Diagnostic Utility of Serum Biomarkers in Pediatric Traumatic Brain Injury

Author

Munoz Pareja, Jennifer Christine, primary, De Rivero Vaccari, Juan Pablo, additional, Mateo Chavez, Maria, additional, Kerrigan, Maria, additional, Pringle, Charlene, additional, Guthrie, Kourtney K, additional, Swaby, Kathryn, additional, Coto, Jennifer, additional, Kobeissy, Firas H, additional, Avery, K Leslie, additional, Ghosh, Suman, additional, Rajderkar, Dhanashree, additional, shanmugham, Prashanth, additional, Lautenslager, Lauren A, additional, Faulkinberry, Shannon, additional, Pareja Zabala, Maria Camila, additional, Governale, Lance, additional, Blatt, Jason, additional, Alfakhri, Nora, additional, Gober, Joslyn, additional, Perez, Paula Karina, additional, McCrea, Heather, additional, Thorson, Chad, additional, O'Phelan, Kristine, additional, Solano, Juan, additional, Loor Torres, Ricardo, additional, Keane, Robert W, additional, Dietrich, W. Dalton, additional, and Wang, Kevin K.W., additional

Published
2023
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20. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease.

Author

Vontell, Regina T., de Rivero Vaccari, Juan Pablo, Sun, Xiaoyan, Gultekin, Sakir Humayun, Bramlett, Helen M., Dietrich, W. Dalton, and Keane, Robert W.

Subjects
ALZHEIMER'S disease, INFLAMMASOMES, IMMUNOGLOBULINS, MONOCLONAL antibodies, NEURONS, PATHOLOGICAL physiology, ENTORHINAL cortex, POSTMORTEM changes
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that destroys memory and cognitive function. Inflammasome activation has been suggested to play a critical role in the neuroinflammatory response in AD progression, but the cell‐type expression of inflammasome proteins in the brain has not been fully characterized. In this study, we used samples from the hippocampus formation, the subiculum, and the entorhinal cortex brain from 17 donors with low‐level AD pathology and 17 intermediate AD donors to assess the expression of inflammasome proteins. We performed analysis of hippocampal thickness, β‐amyloid plaques, and hyperphosphorylated tau to ascertain the cellular pathological changes that occur between low and intermediate AD pathology. Next, we determined changes in the cells that express the inflammasome sensor proteins NOD‐like receptor proteins (NLRP) 1 and 3, and caspase‐1. In addition, we stained section with IC100, a humanized monoclonal antibody directed against the inflammasome adaptor protein apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC), and a commercially available anti‐ASC antibody. Our results indicate that hippocampal cortical thickness did not significantly change between low and intermediate AD pathology, but there was an increase in pTau and β‐amyloid clusters in intermediate AD cases. NLRP3 was identified mainly in microglial populations, whereas NLRP1 was seen in neuronal cytoplasmic regions. There was a significant increase of ASC in neurons labeled by IC100, whereas microglia in the hippocampus and subiculum were labeled with the commercial anti‐ASC antibody. Caspase‐1 was present in the parenchyma in the CA regions where amyloid and pTau were identified. Together, our results indicate increased inflammasome protein expression in the early pathological stages of AD, that IC100 identifies neurons in early stages of AD and that ASC expression correlates with Aβ and pTau in postmortem AD brains. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Inflammatory Biomarkers of Traumatic Brain Injury

Author

Johnson, Nathan H., primary, Hadad, Roey, additional, Taylor, Ruby Rose, additional, Rodríguez Pilar, Javier, additional, Salazar, Osman, additional, Llompart-Pou, Juan Antonio, additional, Dietrich, W. Dalton, additional, Keane, Robert W., additional, Pérez-Bárcena, Jon, additional, and de Rivero Vaccari, Juan Pablo, additional

Published
2022
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24. N

Author

Cohen, Daniel A., Hornung, David E., Mays, Lawrence, Douglas, Rodney, Kennedy, Henry, Knoblauch, Kenneth, Martin, Kevan, Abramov, Valery V., Gontova, Irina A., Abramova, Tatjana Ya., Kozlov, Vladimir A., Kusnecov, Alexander, Benchenane, Karim, Zugaro, Michaël, Wiener, Sidney, Witt, Martin, Moschovakis, Adonis, Braun, Anna Katharina, Kuratani, Shigeru, Murakami, Fujio, Starkweather, Angela, Dalezios, Yannis, Aihara, Kazuyuki, Okada, Masato, Adachi, Masaharu, Watanabe, Masataka, Rokni, Uri, Smith, Peter G., Richter, Diethelm W., Müller, Michael, Griffiths, M., Neal, J. W, Gasque, P., Bernhardi, Rommy von, Guillemin, Gilles J., Buijs, Ruud M., Kalsbeek, Andries, Darlington, Cynthia L., Swaab, Dick F., Lucassen, Paul J., Huitinga, Inge, Bao, Ai-Min, Ladwig, Bernd, Ohl, Frank W., Schnitzler, Hans-Ulrich, Denzinger, Annette, Takahashi, Terry, Warzecha, Anne-Kathrin, Kern, Roland, Oishi, Koji, Nakajima, Kazunori, Bernardino, Liliana, Agasse, Fabienne, Malva, João O., Bird, Thomas D., Alonso, Mariana, Dubayle, David, Menetrey, D., Haddad, John J., Lobell, Anna, Stahel, Philip F., Felderhoff-Mueser, Ursula, Barnum, Scott R., Jafarian-Tehrani, Mehrnaz, Mizuno, Tetsuya, Dietrich, W. Dalton, Keane, Robert W., Han, Jung-Soo, Dhaini, Hassan R., Spain, William J., Mandairon, Nathalie, Didier, Anne, Rich, Mark M., Kudo, Yoshihisa, Ruangkittisakul, Araya, Ballanyi, Klaus, Syed, Naweed I., Petzold, Axel, Rumbaugh, Jeffrey A., Nath, Avindra, Aldskogius, Håkan, Delgado-García, José M., Kengaku, Mineko, Kim, Joanne SM, Zhen, Mei, Mathie, Alistair, Veale, Emma L., Stengel, Maike, Baron, Ralf, Samson, Willis K., Chee, Melissa J. S., Colmers, William F., Smith, Paul F., Pauen, Michael, Elliott, Stacy L., Northoff, Georg, Jorna, René J., Inoue, Kazuhide, Kawabe, Hiroshi, Varoqueaux, Frederique, Brose, Nils, Tanaka, Kohichi, Whelan, Patrick J., Petralia, Ronald S., Wenthold, Robert J., Ramer, Matt S., McPhail, Lowell T., Mullaney, Ian, Widera, Darius, Kaltschmidt, Christian, Kaltschmidt, Barbara, Pennypacker, Keith R., Pollock, Glen, Saporta, Samuel, Koerber, H. Richard, Handwerker, Herrmann O., Smale, Laura, Nunez, Antonio A., Shimkin, Nahum, Tse, Frederick W., Wang, Nan, Yan, Lei, Tse, Amy, Covey, Ellen, Travagli, R. Alberto, Binder, Marc D., editor, Hirokawa, Nobutaka, editor, and Windhorst, Uwe, editor

Published
2009
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28. Author Correction: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats

Author

Ali, Anum, primary, Zambrano, Ronald, additional, Duncan, Matthew R., additional, Chen, Shaoyi, additional, Luo, Shihua, additional, Yuan, Huijun, additional, Chen, Pingping, additional, Benny, Merline, additional, Schmidt, Augusto, additional, Young, Karen, additional, Kerr, Nadine, additional, de Rivero Vaccari, Juan Pablo, additional, Keane, Robert W., additional, Dietrich, W. Dalton, additional, and Wu, Shu, additional

Published
2021
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37. Netosis and Inflammasomes in Large Vessel Occlusion Thrombi

Author

Chen, Stephanie H., primary, Scott, Xavier O., additional, Ferrer Marcelo, Yoandy, additional, Almeida, Vania W., additional, Blackwelder, Patricia L., additional, Yavagal, Dileep R., additional, Peterson, Eric C., additional, Starke, Robert M., additional, Dietrich, W. Dalton, additional, Keane, Robert W., additional, and de Rivero Vaccari, Juan Pablo, additional

Published
2021
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38. Inflammasomes in Large Vessel Occlusion Stroke Thrombi

Author

Chen, Stephanie H, primary, Scott, Xavier, additional, Peterson, Eric, additional, Yavagal, Dileep R, additional, Starke, Robert M, additional, Dietrich, Dalton, additional, Keane, Robert W, additional, and Vaccari, Juan Pablo de Rivero, additional

Published
2020
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42. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters

Author

Wang, Junjie, Ma, Meiyun, Locovei, Silviu, Keane, Robert W., and Dahl, Gerhard

Subjects
Cellular control mechanisms -- Research, Biological transport -- Research, Ion channels -- Research, Cell research, Biological sciences
Abstract

Connexin mimetic peptides are widely used to assess the contribution of nonjunctional connexin channels in several processes, including ATP release. These peptides are derived from various connexin sequences and have been shown to attenuate processes downstream of the putative channel activity. Yet so far, no documentation of effects of peptides on connexin channels has been presented. We tested several connexin and pannexin mimetic peptides and observed attenuation of channel currents that is not compatible with sequence specific actions of the peptides. Connexin mimetic peptides inhibited pannexin channel currents but not the currents of the channel formed by connexins from which the sequence was derived. Pannexin mimetic peptides did inhibit pannexin channel currents but also the channels formed by connexin 46. The same pattern of effects was observed for dye transfer, except that the inhibition levels were more pronounced than for the currents. The channel inhibition by peptides shares commonalities with channel effects of polyethylene glycol (PEG), suggesting a steric block as a mechanism. PEG accessibility is in the size range expected for the pore of innexin gap junction channels, consistent with a functional relatedness of innexin and pannexin channels. mimetic peptide; polyethylene glycol; calcium wave

Published
2007

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