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'Smart' bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery.

Cyberbullying is a social phenomenon that takes place with the help of technology and that causes suffering to victims. Children being attracted to it and not having enough knowledge about the safe use of technological devices have become potential victims of this phenomenon. In order to prevent and reduce this phenomenon, most researchers have turned their attention to combating online bullying among teenagers. But, they lose sight of the fact that cyberbullying does not take into account gender, age or status and neglect the teachers. According to the few studies on online aggression against teachers, the effects of this phenomenon are similar to those experienced by children, such as: anxiety, depression, low self-esteem, frustration, weight loss, insomnia, somatization, low motivation, and low professional performance. In order to identify the level of victimization among teachers, we conducted a focus group with 12 teachers from primary, secondary and high school education. The analysis of the answers revealed that online aggression against teachers is generally present in middle and high school education and is influenced by digital skills. This article aims to highlight the need to create a positive school climate that helps teachers, students and parents to communicate assertively and develop harmonious relationships. Keywords. cyberbullying, students, teachers, parents, aggression

Multiparent Advanced Generation Inter-Cross (MAGIC) populations are ideal genetic and breeding materials for quantitative trait locus (QTL) mapping and molecular breeding. In this study, a MAGIC population derived from eight tobacco parents was developed. Eight parents and 560 homozygous lines were genotyped by a 430K single-nucleotide polymorphism (SNP) chip assay and phenotyped for nicotine content under different conditions. Four QTLs associated with nicotine content were detected by genome-wide association mapping (GWAS), and one major QTL, named qNIC5-1, was mapped repeatedly under different conditions. Furthermore, by combining forward mapping, bioinformatics analysis and gene editing, we identified an ethylene responsive factor (ERF) transcription factor as a candidate gene underlying the major QTL qNIC5-1 for nicotine content in tobacco. A presence/absence variation (PAV) at qNIC5-1 confers changes in nicotine content. Overall, the large size of this MAGIC population, diverse genetic composition, balanced parental contributions and high levels of recombination all contribute to its value as a genetic and breeding resource. The application of the tobacco MAGIC population for QTL mapping and detecting rare allelic variation was demonstrated using nicotine content as a proof of principle.