1. Comparative evaluation of the antifungal susceptibility of Candida isolates from blood specimens: results of a study in a tertiary care hospital in Bursa, Turkey
- Author
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SEVİM AKÇAĞLAR, GÜHER GÖRAL, BEYZA ENER, CANAN EVCİ, Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı., Evci, Canan, Ener, Beyza, Göral, Güher, Akçağlar, Sevim, and AAG-8523-2021
- Subjects
Candidemia ,Invasive Candidiasis ,Candida Parapsilosis ,Broth dilution ,Candida parapsilosis ,Blood sampling ,Antifungal susceptibility tests ,Candida glabrata ,Clinical practice ,Albicans ,Turkey (bird) ,Candida albicans ,Candida krusei ,Kluyveromyces marxianus ,Fluconazole ,Antifungal susceptibility testing ,Fungicides ,Candida ,Fungus culture ,Minimum inhibitory concentration ,Candida zeylanoides ,General Medicine ,Medicine, general & internal ,Antimicrobial surveillance program ,Tertiary health care ,Broth microdilution ,Pichia anomala ,Amphotericin-B ,Article ,Incubation time ,Blood specimens ,Amphotericin B ,Key words: Candida species,antifungal susceptibility tests ,Candida species ,Clinical evaluation ,Candida tropicalis ,Antifungal agents ,Susceptibility tests ,Stream infections ,Kefyr ,National-committee ,Comparative evaluations ,Antifungal resistance ,Nonhuman ,bacterial infections and mycoses ,Etest method ,Clinical practices ,Candida türleri ,Fungus isolation ,Voriconazole ,Macrodilution ,Comparative study ,Trends ,General & internal medicine ,Antifungal duyarlılık testleri ,Antifungal susceptibility - Abstract
Aim: Antifungal susceptibility testing may be an important aid in the treatment of patients with life threatening yeast infections. The aim of this study was to determine the susceptibility of Candida isolates obtained from clinical specimens to the antifungal agents amphotericin B and fluconazole, which are frequently used in our clinical practice. Materials and methods: Susceptibility to antifungal agents was investigated using the Etest (AB Biodisk, Solna, Sweden) and the reference broth macrodilution susceptibility test (CLSI M27-A2). The MICs obtained with each of the methods were read after 24 h and 48 h of incubation. Results: Overall agreement rates within +/- 1 dilution between the 2 methods were 86.7% (24 h) and 94.1% (48 h) for amphotericin B, and 85.5% (24 h) and 73.3% (48 h) for fluconazole. All C. albicans, C. pelliculosa, C. glabrata, and C. kefyr isolates were inhibited by
- Published
- 2014