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9 results on '"Kehoe, Leanne"'

1. The kinetics and durability of antibody and T-cell responses to SARS-CoV-2 in children

Author

Files, Megan A, primary, Gentles, Lauren, additional, Kehoe, Leanne, additional, Adler, Amanda, additional, Lacombe, Kirsten, additional, Dickerson, Jane A, additional, Greninger, Alexander, additional, Waghmare, Alpana, additional, Fairlie, Tarayn, additional, Pringle, Kimberly, additional, Midgley, Claire M, additional, Hagen, Melissa Briggs, additional, Englund, Janet A, additional, and Seshadri, Chetan, additional

Published
2024
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2. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

Author

Williams, Leah M., Inge, Melissa M., Mansfield, Katelyn M., Rasmussen, Anna, Afghani, Jamie, Agrba, Mikhail, Albert, Colleen, Andersson, Cecilia, Babaei, Milad, Babaei, Mohammad, Bagdasaryants, Abigail, Bonilla, Arianna, Browne, Amanda, Carpenter, Sheldon, Chen, Tiffany, Christie, Blake, Cyr, Andrew, Dam, Katie, Dulock, Nicholas, Erdene, Galbadrakh, Esau, Lindsie, Esonwune, Stephanie, Hanchate, Anvita, Huang, Xinli, Jennings, Timothy, Kasabwala, Aarti, Kehoe, Leanne, Kobayashi, Ryan, Lee, Migi, LeVan, Andre, Liu, Yuekun, Murphy, Emily, Nambiar, Avanti, Olive, Meagan, Patel, Devansh, Pavesi, Flaminio, Petty, Christopher A., Samofalova, Yelena, Sanchez, Selma, Stejskal, Camilla, Tang, Yinian, Yapo, Alia, Cleary, John P., Jr., Yunes, Sarah A., Siggers, Trevor, and Gilmore, Thomas D.

Published
2020
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4. Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time

Author

Gentles, Lauren E., primary, Kehoe, Leanne, additional, Crawford, Katharine H.D., additional, Lacombe, Kirsten, additional, Dickerson, Jane, additional, Wolf, Caitlin, additional, Yuan, Joanna, additional, Schuler, Susanna, additional, Watson, John T., additional, Nyanseor, Sankan, additional, Briggs-Hagen, Melissa, additional, Saydah, Sharon, additional, Midgley, Claire M., additional, Pringle, Kimberly, additional, Chu, Helen, additional, Bloom, Jesse D., additional, and Englund, Janet A., additional

Published
2022
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5. LB9. Longitudinal antibody dynamics in children infected with SARS-CoV-2 through 6 months post-infection

Author

Gentles, Lauren E, primary, Kehoe, Leanne P, additional, Crawford, Katharine D, additional, Lacombe, Kirsten, additional, Dickerson, Jane, additional, Yuan, Joanna H, additional, Schuler, Susanna L, additional, Nyanseor, Sankan, additional, Saydah, Sharon, additional, Midgley, Claire, additional, Pringle, Kimberly, additional, Bloom, Jesse, additional, and Englund, Janet A, additional

Published
2021
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7. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

Author

Williams, Leah M., primary, Inge, Melissa M., additional, Mansfield, Katelyn M., additional, Rasmussen, Anna, additional, Afghani, Jamie, additional, Agrba, Mikhail, additional, Albert, Colleen, additional, Andersson, Cecilia, additional, Babaei, Milad, additional, Babaei, Mohammad, additional, Bagdasaryants, Abigail, additional, Bonilla, Arianna, additional, Browne, Amanda, additional, Carpenter, Sheldon, additional, Chen, Tiffany, additional, Christie, Blake, additional, Cyr, Andrew, additional, Dam, Katie, additional, Dulock, Nicholas, additional, Erdene, Galbadrakh, additional, Esau, Lindsie, additional, Esonwune, Stephanie, additional, Hanchate, Anvita, additional, Huang, Xinli, additional, Jennings, Timothy, additional, Kasabwala, Aarti, additional, Kehoe, Leanne, additional, Kobayashi, Ryan, additional, Lee, Migi, additional, LeVan, Andre, additional, Liu, Yuekun, additional, Murphy, Emily, additional, Nambiar, Avanti, additional, Olive, Meagan, additional, Patel, Devansh, additional, Pavesi, Flaminio, additional, Petty, Christopher A., additional, Samofalova, Yelena, additional, Sanchez, Selma, additional, Stejskal, Camilla, additional, Tang, Yinian, additional, Yapo, Alia, additional, Cleary, John P., additional, Yunes, Sarah A., additional, Siggers, Trevor, additional, and Gilmore, Thomas D., additional

Published
2019
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9. Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time.

Author

Gentles LE, Kehoe L, Crawford KHD, Lacombe K, Dickerson J, Wolf C, Yuan J, Schuler S, Watson JT, Nyanseor S, Briggs-Hagen M, Saydah S, Midgley CM, Pringle K, Chu H, Bloom JD, and Englund JA

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicits an antibody response that targets several viral proteins including spike (S) and nucleocapsid (N); S is the major target of neutralizing antibodies. Here, we assess levels of anti-N binding antibodies and anti-S neutralizing antibodies in unvaccinated children compared with unvaccinated older adults following infection. Specifically, we examine neutralization and anti-N binding by sera collected up to 52 weeks following SARS-CoV-2 infection in children and compare these to a cohort of adults, including older adults, most of whom had mild infections that did not require hospitalization. Neutralizing antibody titers were lower in children than adults early after infection, but by 6 months titers were similar between age groups. The neutralizing activity of the children's sera decreased modestly from one to six months; a pattern that was not significantly different from that observed in adults. However, infection of children induced much lower levels of anti-N antibodies than in adults, and levels of these anti-N antibodies decreased more rapidly in children than in adults, including older adults. These results highlight age-related differences in the antibody responses to SARS-CoV-2 proteins and, as vaccines for children are introduced, may provide comparator data for the longevity of infection-elicited and vaccination-induced neutralizing antibody responses.

Published
2022
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