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1. Use of strips of rapid diagnostic tests as a source of ribonucleic acid for genomic surveillance of viruses: an example of SARS-CoV-2

Author

Keita, Alpha Kabiné, Mbaye, Aminata, Soumah, Abdoul Karim, Kadio, Kadio Jean Jacques Olivier, Diallo, Haby, Gnimadi, Thibaut Armel Chérif, Koivogui, Joel Balla, Povogui, Moriba Kowa, Monemou, Jean Louis, Traore, Baba, Vidal, Nicole, Guichet, Emilande, Ayouba, Ahidjo, Delaporte, Eric, Peeters, Martine, Toure, Abdoulaye, and Keita, Alpha Kabinet

Published
2024
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3. Ebola Virus Circulation in a Non-Epidemic Guinean Rural Area: Virological and Anthropological Approaches

Author

Hounmenou, Castro Gbêmêmali, primary, Le Marcis, Fréderic, additional, Kaba, Djiba, additional, Diaby, Maladho, additional, Soumah, Abdoul-Karim, additional, Diallo, Haby, additional, Thaurignac, Guillaume, additional, Camara, Saidouba Cherif, additional, Ayouba, Ahidjo, additional, Peeters, Martine, additional, Keita, Alpha-Kabinet, additional, Delaporte, Eric, additional, and Touré, Abdoulaye, additional

Published
2024
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4. Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

Author

Keita, Alpha Kabinet, Koundouno, Fara R., Faye, Martin, Düx, Ariane, Hinzmann, Julia, Diallo, Haby, Ayouba, Ahidjo, Le Marcis, Frederic, Soropogui, Barre, Ifono, Kekoura, Diagne, Moussa M., Sow, Mamadou S., Bore, Joseph A., Calvignac-Spencer, Sebastien, Vidal, Nicole, Camara, Jacob, and Keita, Mamadou B.

Subjects
Ebola virus infections -- Distribution -- Forecasts and trends, Market trend/market analysis, Company distribution practices, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak--between 14 February and 19 June 2021--near the epicentre of the previous epidemic.sup.1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization. The viral lineage responsible for the February 2021 outbreak of Ebola virus disease in Guinea is nested within a clade that predominantly consists of genomes sampled during the 2013-2016 epidemic, suggesting that the virus might have re-emerged after a long period of latency within a previously infected individual., Author(s): Alpha Kabinet Keita [sup.1] [sup.2] , Fara R. Koundouno [sup.3] [sup.4] , Martin Faye [sup.5] , Ariane Düx [sup.6] , Julia Hinzmann [sup.4] [sup.7] [sup.8] , Haby Diallo [sup.1] [...]

Published
2021
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5. Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea: a retrospective, cross-sectional observational study

Author

ABOUBACAR, Diaby, BALDE, Alseny, BALDE, Ibrahima, BAMBA, Amara, CAMARA, Amadou, CONTE, Aboubacar Mamy, DELFRAISSY, Jean-François, DIALLO, Amadou Bailo, DOUMBOUYA, Saran, KAMANO, Emile Souro, KOIVOGUI, Joel Balle, LANIECE-DELAUNAY, Charlotte, LEVY, Yves, MONEMOU, Jean Louis, POVOGUI, Moriba, SAKOUVOGUI, Maou, SOUMAH, Abdoul Karim, SUBTIL, Fabien, SYLLA, Aboubacar Hawa, TAVERNE, Bernard, YAZDANPANAH, Yazdan, Diallo, Mamadou Saliou Kalifa, Rabilloud, Muriel, Ayouba, Ahidjo, Touré, Abdoulaye, Thaurignac, Guillaume, Keita, Alpha Kabinet, Butel, Christelle, Kpamou, Cécé, Barry, Thierno Alimou, Sall, Mariama Djouldé, Camara, Ibrahima, Leroy, Sandrine, Msellati, Philippe, Ecochard, René, Peeters, Martine, Sow, Mamadou Saliou, Delaporte, Eric, and Etard, Jean-François

Published
2019
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6. Extensive Survey and Analysis of Factors Associated with Presence of Antibodies to Orthoebolaviruses in Bats from West and Central Africa

Author

Peeters, Martine, primary, Champagne, Maëliss, additional, Ndong Bass, Innocent, additional, Goumou, Souana, additional, Ndimbo Kumugo, Simon-Pierre, additional, Lacroix, Audrey, additional, Esteban, Amandine, additional, Meta Djomsi, Dowbiss, additional, Soumah, Abdoul Karim, additional, Mbala Kingebeni, Placide, additional, Mba Djonzo, Flaubert Auguste, additional, Lempu, Guy, additional, Thaurignac, Guillaume, additional, Mpoudi Ngole, Eitel, additional, Kouanfack, Charles, additional, Mukadi Bamuleka, Daniel, additional, Likofata, Jacques, additional, Muyembe Tamfum, Jean-Jacques, additional, De Nys, Helene, additional, Capelle, Julien, additional, Toure, Abdoulaye, additional, Delaporte, Eric, additional, Keita, Alpha Kabinet, additional, Ahuka Mundeke, Steve, additional, and Ayouba, Ahidjo, additional

Published
2023
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7. Effects of biological and environmental factors on filovirus serology in bats in Guinea

Author

Champagne, Maeliss, primary, Cappelle, Julien, additional, Caron, Alexandre, additional, Pouliquen, Thibault, additional, Samoura, Aboubacar, additional, Doumbouya, Mohamed Idriss, additional, Thaurignac, Guillaume, additional, Ayouba, Ahidjo, additional, Keita, Alpha Kabinet, additional, Peeters, Martine, additional, Bourgarel, Mathieu, additional, and De Nys, Helene Marie, additional

Published
2023
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8. Survey of Ebola Viruses in Frugivorous and Insectivorous Bats in Guinea, Cameroon, and the Democratic Republic of the Congo, 2015-2017

Author

De Nys, Helene M., Kingebeni, Placide Mbala, Keita, Alpha K., Butel, Christelle, Thaurignac, Guillaume, Villabona-Arenas, Christian-Julian, Lemarcis, Thomas, Geraerts, Mare, Vidal, Nicole, Esteban, Amandine, Bourgarel, Mathieu, Roger, Francois, Leendertz, Fabian, Diallo, Ramadan, Ndimbo-Kumugo, Simon-Pierre, Nsio-Mbeta, Justus, Tagg, Nikki, Koivogui, Lamine, Toure, Abdoulaye, Delaporte, Eric, Ahuka-Mundeke, Steve, Tamfum, Jean-Jacques Muyembe, Mpoudi-Ngole, Eitel, Ayouba, Ahidjo, and Peeters, Martine

Subjects
Ebola hemorrhagic fever -- Risk factors, Bats (Animals) -- Research, Health
Abstract

Since the first outbreak of Ebola virus disease (EVD) in 1976 in the northern part of the Democratic Republic of the Congo (DRC), 26 recognized outbreaks have occurred in humans [...]

Published
2018
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10. Large diffusion of SARS-CoV-2 after the successive epidemiological waves, including Omicron, in Guinea and Cameroon: implications for vaccine strategies

Author

Diallo, Mamadou Saliou Kalifa, primary, Amougou-Atsama, Marie, additional, Ayouba, Ahidjo, additional, Kpamou, Cece, additional, Taze, Eric Donald Mimbe, additional, Thaurignac, Guillaume, additional, Diallo, Haby, additional, Lamare, Nadine Boutgam, additional, Bouillin, Julie, additional, Soumah, Abdoul Karim, additional, Noah, Sébastien Awono, additional, Guichet, Emilande, additional, Keita, Alpha Kabinet, additional, Varloteaux, Marie, additional, Peeters, Martine, additional, Bissek, Anne-Cécile Zoung-Kanyi, additional, Toure, Abdoulaye, additional, Delaporte, Eric, additional, and Kouanfack, Charles, additional

Published
2023
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11. Multidisciplinary assessment of post-Ebola sequelae in Guinea (Postebogui): an observational cohort study

Author

Ayouba, Ahidjo, Baize, Sylvain, Bangoura, Kaba, Barry, Alimou, Barry, Moumié, Cissé, Mamoudou, Cissé, Mohammed, Delaporte, Eric, Delfraissy, Jean-François, Delmas, Christelle, Desclaux, Alice, Diallo, Saliou Bella, Diallo, Mamadou Safiatou, Diallo, Mariama Sadjo, Étard, Jean François, Etienne, Cécile, Faye, Ousmane, Fofana, Ibrahima, Granouillac, Bruno, Hébert, Esther Hereth, Izard, Suzanne, Kassé, Djenaba, Keita, Alpha Kabinet, Keita, Sakoba, Koivogui, Lamine, Kpamou, Cécé, Lacarabaratz, Christine, Leroy, Sandrine, Marchal, Claire Levy, Levy, Yves, Magassouba, N'Fally, March, Laura, Mendiboure, Vincent, Msellati, Philippe, Niane, Harissatou, Peeters, Martine, Pers, Yves-Marie, Raoul, Hervé, Sacko, Sidi Lamine, Savané, Ibrahima, Sow, Mamadou Saliou, Taverne, Bernard, Touré, Abdoulaye, Traoré, Fodé Amara, Traoré, Falaye, Youla, Yamoussa, Yazdanpanah, Yazdan, Etard, Jean-François, and Savane, Ibrahima

Published
2017
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12. Exploratory analysis of the knowledge, attitudes and perceptions of healthcare workers about arboviruses in the context of surveillance in the Republic of Guinea.

Author

Bangoura, Salifou Talassone, Hounmènou, Castro Gbêmêmali, Sidibé, Sidikiba, Camara, Saidouba Cherif, Mbaye, Aminata, Olive, Marie-Marie, Camara, Alioune, Delamou, Alexandre, Keita, Alpha-Kabinet, Delaporte, Eric, Khanafer, Nagham, and Touré, Abdoulaye

Subjects
MEDICAL personnel, DENGUE hemorrhagic fever, RIFT Valley fever, ARBOVIRUSES, ARBOVIRUS diseases, YELLOW fever
Abstract

Background: The escalating risk and contemporary occurrences of arbovirus infections prompt a critical inquiry into the ability of nations to execute efficient surveillance systems capable to detect, prevent and respond to arbovirus outbreaks. Healthcare workers (HCWs) are the major actors in the surveillance of infectious diseases with epidemic potential. The objective of this study was to evaluate the knowledge, attitudes and perceptions of HCWs regarding arboviruses in the public health facilities of Conakry, Guinea. Methods: A cross-sectional survey was conducted during the from December 27, 2022, to January 31, 2023, encompassing from public health facilities in Conakry. The data collection process encompassed various aspects, including the characteristics of health facilities, socio-demographic and professional attributes of HCWs, the information received concerning arboviruses and the sources of information, as well as a series of inquiries designed to evaluate their knowledge, attitudes and perceptions. Subsequently, scores were computed for knowledge, attitude and perception. To identify the factors influencing the knowledge, attitudes, and perceptions of HCWs regarding arboviruses, Decision Tree and Inference Conditional Tree models were used. Results: A total of 352 HCWs participated in the study, comprising 219 from national hospitals, 72 from municipal hospitals and 61 from primary health centers. More than half of the respondents (54.3%) had never received information on arboviruses. Only 1% of the respondents had good knowledge about arboviruses, 95.7% had a negative attitude about arboviruses. Moreover, nearly 60% of the respondents had a moderate perception and 24.1% had a good perception. The analysis revealed significant associations between the knowledge and attitudes of respondents concerning arboviruses and their years of professional experience and age. Conclusion: This study highlights the imperative requirement for comprehensive training targeting HCWs to enhance their capacity for early case detection within healthcare facilities. Additionally, there is a crucial need for analogous studies adopting a mixed-methods approach across all healthcare regions in Guinea. Author summary: Arboviruses, including yellow fever, dengue, Zika, chikungunya, and Rift Valley fever, constitute viral diseases transmitted by blood-sucking arthropod vectors, such as mosquitoes, ticks, and biting midges, to vertebrate hosts. In many countries, particularly within Africa, the prevalence of these arboviruses remains widely underestimated due to the absence of effective surveillance systems, often resulting in the conflation of arboviral infections with other infectious diseases. Nevertheless, sub-Saharan Africa is prone to periodic arbovirus-linked epidemics, propelled by factors such as the expansion of vector habitats, viral genetic mutations, anthropogenic influences, inadequate healthcare services, commercial transportation, and climate fluctuations. While Guinea has predominantly reported suspected cases of yellow fever, widespread arbovirus-related epidemics have yet to be documented. Nevertheless, it is imperative for healthcare workers to be well-informed and prepared for prospective epidemics. The assessment of the knowledge, attitudes, and perceptions of healthcare workers can serve as a catalyst to heighten awareness, bolster surveillance mechanisms, and enhance the capabilities of public health facilities in the prevention and mitigation of potential epidemics. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses

Author

Meta Djomsi, Dowbiss Meta, primary, Lacroix, Audrey, additional, Soumah, Abdoul Karim, additional, Kinganda Lusamaki, Eddy Kinganda, additional, Mesdour, Asma, additional, Raulino, Raisa, additional, Esteban, Amandine, additional, Ndong Bass, Innocent Ndong, additional, Mba Djonzo, Flaubert Auguste Mba, additional, Goumou, Souana, additional, Ndimbo-Kimugu, Simon Pierre, additional, Lempu, Guy, additional, Mbala Kingebeni, Placide Mbala, additional, Bamuleka, Daniel Mukadi, additional, Likofata, Jacques, additional, Muyembe Tamfum, Jean-Jacques Muyembe, additional, Toure, Abdoulaye, additional, Mpoudi Ngole, Eitel Mpoudi, additional, Kouanfack, Charles, additional, Delaporte, Eric, additional, Keita, Alpha Kabinet, additional, Ahuka-Mundeke, Steve, additional, Ayouba, Ahidjo, additional, and Peeters, Martine, additional

Published
2023
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14. Analyse comparative des initiatives One Health en Guinée et en République Démocratique du Congo : Un appel à l’opérationnalisation/ Comparative analysis of One Health initiatives in Guinea and the Democratic Republic of Congo: A call for operationalization

Author

Maltais, Stéphanie, primary, Bangoura, Salifou Talassone, additional, Paku, Rolly Nzau, additional, Mambote, Marlène Metena, additional, Hounmenou, Castro, additional, Rüegg, Simon, additional, Masumu, Justin Mulumbu, additional, Tchialeu, Rodrigue Deuboué, additional, Makiala, Sheila, additional, Touré, Abdoulaye, additional, Camara, Alioune, additional, Keita, Alpha-Kabinet, additional, and Yaya, Sanni, additional

Published
2022
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15. Analyse comparative des initiatives One Health en Guinée et en République Démocratique du Congo: Un appel à l’opérationnalisation

Author

Maltais, Stéphanie, Bangoura, Salifou Talassone, Paku, Rolly Nzau, Mambote, Marlène Metena, Hounmenou, Castro, Rüegg, Simon R, Masumu, Justin Mulumbu, Tchialeu, Rodrigue Deuboué, Makiala, Sheila, Touré, Abdoulaye, Camara, Alioune, Keita, Alpha-Kabinet, Yaya, Sanni, and University of Zurich

Subjects
General Engineering, 570 Life sciences, biology, General Earth and Planetary Sciences, 610 Medicine & health, 10599 Chair in Veterinary Epidemiology, General Environmental Science
Published
2022

17. Self-medication against COVID-19 in health workers in Conakry, Guinea

Author

Toure, Abdoulaye, primary, Camara, Saidouba Cherif, additional, Camara, Alioune, additional, Conde, Mamoudou, additional, Delamou, Alexandre, additional, Camara, Ibrahima, additional, Bangoura, Salifou Talassone, additional, Camara, Alimou, additional, Diallo, Mamadou Bobo, additional, Keita, Mamadou Bhoye, additional, Kourouma, Kaba, additional, Camara, Robert, additional, Etard, Jean-François, additional, and Keita, Alpha-Kabinet, additional

Published
2022
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18. Large Diffusion of Severe Acute Respiratory Syndrome Coronavirus 2 After the Successive Epidemiological Waves, Including Omicron, in Guinea and Cameroon: Implications for Vaccine Strategies.

Author

Diallo, Mamadou Saliou Kalifa, Amougou-Atsama, Marie, Ayouba, Ahidjo, Kpamou, Cece, Taze, Eric Donald Mimbe, Thaurignac, Guillaume, Diallo, Haby, Lamare, Nadine Boutgam, Bouillin, Julie, Soumah, Abdoul Karim, Noah, Sébastien Awono, Guichet, Emilande, Keita, Alpha Kabinet, Varloteaux, Marie, Peeters, Martine, Bissek, Anne-Cécile Zoung-Kanyi, Toure, Abdoulaye, Delaporte, Eric, and Kouanfack, Charles

Abstract

Background We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among the general population in Conakry, Guinea and Yaounde, Cameroon after the coronavirus disease 2019 Omicron wave. Methods We conducted population-based, age-stratified seroprevalence surveys in Conakry and Yaounde (May and June 2022). We collected demographic and epidemiologic information and dried blood spot samples that were tested for SARS-CoV-2 immunoglobulin G (IgG) antibodies using recombinant nucleocapsid and spike proteins with Luminex technology. Results Samples were obtained from 1386 and 1425 participants in Guinea and Cameroon, respectively. The overall age-standardized SARS-CoV-2 IgG seroprevalence against spike and nucleocapsid proteins was 71.57% (95% confidence interval [CI], 67.48%–75.33%) in Guinea and 74.71% (95% CI, 71.99%–77.25%) in Cameroon. Seroprevalence increased significantly with age categories. Female participants were more likely than male participants to be seropositive. The seroprevalence in unvaccinated participants was 69.6% (95% CI, 65.5%–73.41%) in Guinea and 74.8% (95% CI, 72.04%–77.38%) in Cameroon. In multivariate analysis, only age, sex, and education were independently associated with seropositivity. Conclusions These findings show a high community transmission after the different epidemiological waves including Omicron, especially among people aged >40 years. In addition, our results suggest that the spread of SARS-CoV-2 has been underestimated as a significant proportion of the population has already contracted the virus and that vaccine strategies should focus on vulnerable populations. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Tropheryma whipplei as a cause of epidemic fever, Senegal, 2010-2012

Author

Bassene, Hubert, Mediannikov, Oleg, Socolovschi, Cristina, Ratmanov, Pavel, Keita, Alpha K., Sokhna, Cheikh, Raoult, Didier, and Fenollar, Florence

Subjects
Actinomycetales -- Health aspects, Epidemics -- Causes of -- Senegal, Fever -- Causes of, Hyperthermia -- Causes of, Health
Abstract

Determining the etiologic causes of febrile illness in tropical settings provides public health and local community benefits. In the context of a decline in malaria cases in many parts of [...]

Published
2016
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20. The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Author

Tegally, Houriiyah, primary, San, James E., additional, Cotten, Matthew, additional, Tegomoh, Bryan, additional, Mboowa, Gerald, additional, Martin, Darren P., additional, Baxter, Cheryl, additional, Moir, Monika, additional, Lambisia, Arnold, additional, Diallo, Amadou, additional, Amoako, Daniel G., additional, Diagne, Moussa M., additional, Sisay, Abay, additional, Zekri, Abdel-Rahman N., additional, Barakat, Abdelhamid, additional, Gueye, Abdou Salam, additional, Sangare, Abdoul K., additional, Ouedraogo, Abdoul-Salam, additional, Sow, Abdourahmane, additional, Musa, Abdualmoniem O., additional, Sesay, Abdul K., additional, Lagare, Adamou, additional, Kemi, Adedotun-Sulaiman, additional, Abar, Aden Elmi, additional, Johnson, Adeniji A., additional, Fowotade, Adeola, additional, Olubusuyi, Adewumi M., additional, Oluwapelumi, Adeyemi O., additional, Amuri, Adrienne A., additional, Juru, Agnes, additional, Ramadan, Ahmad Mabrouk, additional, Kandeil, Ahmed, additional, Mostafa, Ahmed, additional, Rebai, Ahmed, additional, Sayed, Ahmed, additional, Kazeem, Akano, additional, Balde, Aladje, additional, Christoffels, Alan, additional, Trotter, Alexander J., additional, Campbell, Allan, additional, Keita, Alpha Kabinet, additional, Kone, Amadou, additional, Bouzid, Amal, additional, Souissi, Amal, additional, Agweyu, Ambrose, additional, Gutierrez, Ana V., additional, Page, Andrew J., additional, Yadouleton, Anges, additional, Vinze, Anika, additional, Happi, Anise N., additional, Chouikha, Anissa, additional, Iranzadeh, Arash, additional, Maharaj, Arisha, additional, Batchi-Bouyou, Armel Landry, additional, Ismail, Arshad, additional, Sylverken, Augustina, additional, Goba, Augustine, additional, Femi, Ayoade, additional, Sijuwola, Ayotunde Elijah, additional, Ibrahimi, Azeddine, additional, Marycelin, Baba, additional, Salako, Babatunde Lawal, additional, Oderinde, Bamidele S., additional, Bolajoko, Bankole, additional, Dhaala, Beatrice, additional, Herring, Belinda L., additional, Tsofa, Benjamin, additional, Mvula, Bernard, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Marondera, Blessing T., additional, Khaireh, Bouh Abdi, additional, Kouriba, Bourema, additional, Adu, Bright, additional, Pool, Brigitte, additional, McInnis, Bronwyn, additional, Brook, Cara, additional, Williamson, Carolyn, additional, Anscombe, Catherine, additional, Pratt, Catherine B., additional, Scheepers, Cathrine, additional, Akoua-Koffi, Chantal G., additional, Agoti, Charles N., additional, Loucoubar, Cheikh, additional, Onwuamah, Chika Kingsley, additional, Ihekweazu, Chikwe, additional, Malaka, Christian Noël, additional, Peyrefitte, Christophe, additional, Omoruyi, Chukwuma Ewean, additional, Rafaï, Clotaire Donatien, additional, Morang’a, Collins M., additional, Nokes, D. James, additional, Lule, Daniel Bugembe, additional, Bridges, Daniel J., additional, Mukadi-Bamuleka, Daniel, additional, Park, Danny, additional, Baker, David, additional, Doolabh, Deelan, additional, Ssemwanga, Deogratius, additional, Tshiabuila, Derek, additional, Bassirou, Diarra, additional, Amuzu, Dominic S.Y., additional, Goedhals, Dominique, additional, Grant, Donald S., additional, Omuoyo, Donwilliams O., additional, Maruapula, Dorcas, additional, Wanjohi, Dorcas Waruguru, additional, Foster-Nyarko, Ebenezer, additional, Lusamaki, Eddy K., additional, Simulundu, Edgar, additional, Ong’era, Edidah M., additional, Ngabana, Edith N., additional, Abworo, Edward O., additional, Otieno, Edward, additional, Shumba, Edwin, additional, Barasa, Edwine, additional, Ahmed, El Bara, additional, Kampira, Elizabeth, additional, Fahime, Elmostafa El, additional, Lokilo, Emmanuel, additional, Mukantwari, Enatha, additional, Cyril, Erameh, additional, Philomena, Eromon, additional, Belarbi, Essia, additional, Simon-Loriere, Etienne, additional, Anoh, Etilé A., additional, Leendertz, Fabian, additional, Taweh, Fahn M., additional, Wasfi, Fares, additional, Abdelmoula, Fatma, additional, Takawira, Faustinos T., additional, Derrar, Fawzi, additional, Ajogbasile, Fehintola V, additional, Treurnicht, Florette, additional, Onikepe, Folarin, additional, Ntoumi, Francine, additional, Muyembe, Francisca M., additional, Ngiambudulu, Francisco, additional, Zongo Ragomzingba, Frank Edgard, additional, Dratibi, Fred Athanasius, additional, Iyanu, Fred-Akintunwa, additional, Mbunsu, Gabriel K., additional, Thilliez, Gaetan, additional, Kay, Gemma L., additional, Akpede, George O., additional, George, Uwem E., additional, van Zyl, Gert, additional, Awandare, Gordon A., additional, Schubert, Grit, additional, Maphalala, Gugu P., additional, Ranaivoson, Hafaliana C., additional, Lemriss, Hajar, additional, Omunakwe, Hannah E, additional, Onywera, Harris, additional, Abe, Haruka, additional, Karray, Hela, additional, Nansumba, Hellen, additional, Triki, Henda, additional, Adje Kadjo, Herve Albéric, additional, Elgahzaly, Hesham, additional, Gumbo, Hlanai, additional, mathieu, Hota, additional, Kavunga-Membo, Hugo, additional, Smeti, Ibtihel, additional, Olawoye, Idowu B., additional, Adetifa, Ifedayo, additional, Odia, Ikponmwosa, additional, Boubaker, Ilhem Boutiba-Ben, additional, Ssewanyana, Isaac, additional, Wurie, Isatta, additional, Konstantinus, Iyaloo S, additional, Afiwa Halatoko, Jacqueline Wemboo, additional, Ayei, James, additional, Sonoo, Janaki, additional, Lekana-Douki, Jean Bernard, additional, Makangara, Jean-Claude C., additional, Tamfum, Jean-Jacques M., additional, Heraud, Jean-Michel, additional, Shaffer, Jeffrey G., additional, Giandhari, Jennifer, additional, Musyoki, Jennifer, additional, Uwanibe, Jessica N., additional, Bhiman, Jinal N., additional, Yasuda, Jiro, additional, Morais, Joana, additional, Mends, Joana Q., additional, Kiconco, Jocelyn, additional, Sandi, John Demby, additional, Huddleston, John, additional, Odoom, John Kofi, additional, Morobe, John M., additional, Gyapong, John O., additional, Kayiwa, John T., additional, Okolie, Johnson C., additional, Xavier, Joicymara Santos, additional, Gyamfi, Jones, additional, Kofi Bonney, Joseph Humphrey, additional, Nyandwi, Joseph, additional, Everatt, Josie, additional, Farah, Jouali, additional, Nakaseegu, Joweria, additional, Ngoi, Joyce M., additional, Namulondo, Joyce, additional, Oguzie, Judith U., additional, Andeko, Julia C., additional, Lutwama, Julius J., additional, O’Grady, Justin, additional, Siddle, Katherine J, additional, Victoir, Kathleen, additional, Adeyemi, Kayode T., additional, Tumedi, Kefentse A., additional, Carvalho, Kevin Sanders, additional, Mohammed, Khadija Said, additional, Musonda, Kunda G., additional, Duedu, Kwabena O., additional, Belyamani, Lahcen, additional, Fki-Berrajah, Lamia, additional, Singh, Lavanya, additional, Biscornet, Leon, additional, de Oliveira Martins, Leonardo, additional, Chabuka, Lucious, additional, Olubayo, Luicer, additional, Deng, Lul Lojok, additional, Ochola-Oyier, Lynette Isabella, additional, Mine, Madisa, additional, Ramuth, Magalutcheemee, additional, Mastouri, Maha, additional, ElHefnawi, Mahmoud, additional, Mbanne, Maimouna, additional, Matsheka, Maitshwarelo I., additional, Kebabonye, Malebogo, additional, Diop, Mamadou, additional, Momoh, Mambu, additional, Lima Mendonça, Maria da Luz, additional, Venter, Marietjie, additional, Paye, Marietou F, additional, Faye, Martin, additional, Nyaga, Martin M., additional, Mareka, Mathabo, additional, Damaris, Matoke-Muhia, additional, Mburu, Maureen W., additional, Mpina, Maximillian, additional, Claujens Chastel, Mfoutou Mapanguy, additional, Owusu, Michael, additional, Wiley, Michael R., additional, Tatfeng, Mirabeau Youtchou, additional, Ayekaba, Mitoha Ondo’o, additional, Abouelhoda, Mohamed, additional, Beloufa, Mohamed Amine, additional, Seadawy, Mohamed G, additional, Khalifa, Mohamed K., additional, Dellagi, Mohammed Koussai, additional, Matobo, Mooko Marethabile, additional, Kane, Mouhamed, additional, Ouadghiri, Mouna, additional, Salou, Mounerou, additional, Mbulawa, Mphaphi B., additional, Saibu, Mudashiru Femi, additional, Mwenda, Mulenga, additional, Kaba, Muluken, additional, Phan, My V.T., additional, Abid, Nabil, additional, Touil, Nadia, additional, Rujeni, Nadine, additional, Ismael, Nalia, additional, Top, Ndeye Marieme, additional, Dia, Ndongo, additional, Mabunda, Nédio, additional, Hsiao, Nei-yuan, additional, Silochi, Nelson Boricó, additional, Saasa, Ngonda, additional, Bbosa, Nicholas, additional, Murunga, Nickson, additional, Gumede, Nicksy, additional, Wolter, Nicole, additional, Sitharam, Nikita, additional, Ndodo, Nnaemeka, additional, Ajayi, Nnennaya A., additional, Tordo, Noël, additional, Mbhele, Nokuzola, additional, Razanajatovo, Norosoa H, additional, Iguosadolo, Nosamiefan, additional, Mba, Nwando, additional, Kingsley, Ojide C., additional, Sylvanus, Okogbenin, additional, Peter, Okokhere, additional, Femi, Oladiji, additional, Testimony, Olumade, additional, Ogunsanya, Olusola Akinola, additional, Fakayode, Oluwatosin, additional, Ogah, Onwe E., additional, Faye, Ousmane, additional, Smith-Lawrence, Pamela, additional, Ondoa, Pascale, additional, Combe, Patrice, additional, Nabisubi, Patricia, additional, Semanda, Patrick, additional, Oluniyi, Paul E., additional, Arnaldo, Paulo, additional, Quashie, Peter Kojo, additional, Bejon, Philip, additional, Dussart, Philippe, additional, Bester, Phillip A., additional, Mbala, Placide K., additional, Kaleebu, Pontiano, additional, Abechi, Priscilla, additional, El-Shesheny, Rabeh, additional, Joseph, Rageema, additional, Aziz, Ramy Karam, additional, Essomba, René Ghislain, additional, Ayivor-Djanie, Reuben, additional, Njouom, Richard, additional, Phillips, Richard O., additional, Gorman, Richmond, additional, Kingsley, Robert A., additional, Audu, Rosemary, additional, Carr, Rosina A.A., additional, Kabbaj, Saâd El, additional, Gargouri, Saba, additional, Masmoudi, Saber, additional, Sankhe, Safietou, additional, Mohamed, Sahra Isse, additional, Mhalla, Salma, additional, Hosch, Salome, additional, Kassim, Samar Kamal, additional, Metha, Samar, additional, Trabelsi, Sameh, additional, Lemriss, Sanaâ, additional, Agwa, Sara Hassan, additional, Mwangi, Sarah Wambui, additional, Doumbia, Seydou, additional, Makiala-Mandanda, Sheila, additional, Aryeetey, Sherihane, additional, Ahmed, Shymaa S., additional, Ahmed, Sidi Mohamed, additional, Elhamoumi, Siham, additional, Moyo, Sikhulile, additional, Lutucuta, Silvia, additional, Gaseitsiwe, Simani, additional, Jalloh, Simbirie, additional, Andriamandimby, Soafy, additional, Oguntope, Sobajo, additional, Grayo, Solène, additional, Lekana-Douki, Sonia, additional, Prosolek, Sophie, additional, Ouangraoua, Soumeya, additional, van Wyk, Stephanie, additional, Schaffner, Stephen F., additional, Kanyerezi, Stephen, additional, Ahuka-Mundeke, Steve, additional, Rudder, Steven, additional, Pillay, Sureshnee, additional, Nabadda, Susan, additional, Behillil, Sylvie, additional, Budiaki, Sylvie L., additional, van der Werf, Sylvie, additional, Mashe, Tapfumanei, additional, Aanniz, Tarik, additional, Mohale, Thabo, additional, Le-Viet, Thanh, additional, Velavan, Thirumalaisamy P., additional, Schindler, Tobias, additional, Maponga, Tongai, additional, Bedford, Trevor, additional, Anyaneji, Ugochukwu J., additional, Chinedu, Ugwu, additional, Ramphal, Upasana, additional, Enouf, Vincent, additional, Nene, Vishvanath, additional, Gorova, Vivianne, additional, Roshdy, Wael H., additional, Karim, Wasim Abdul, additional, Ampofo, William K., additional, Preiser, Wolfgang, additional, Choga, Wonderful T., additional, Ahmed, Yahaya Ali, additional, Ramphal, Yajna, additional, Bediako, Yaw, additional, Naidoo, Yeshnee, additional, Butera, Yvan, additional, de Laurent, Zaydah R., additional, Ouma, Ahmed E.O., additional, von Gottberg, Anne, additional, Githinji, George, additional, Moeti, Matshidiso, additional, Tomori, Oyewale, additional, Sabeti, Pardis C., additional, Sall, Amadou A., additional, Oyola, Samuel O., additional, Tebeje, Yenew K., additional, Tessema, Sofonias K., additional, de Oliveira, Tulio, additional, Happi, Christian, additional, Lessells, Richard, additional, Nkengasong, John, additional, and Wilkinson, Eduan, additional

Published
2022
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21. Seroprevalence of IgG Antibodies Against Multiple Arboviruses in Bats from Cameroon, Guinea, and the Democratic Republic of Congo

Author

Raulino, Raisa, primary, Thaurignac, Guillaume, additional, Keita, Alpha K., additional, Esteban, Amandine, additional, Goumou, Souana, additional, Diallo, Ramadan, additional, Ndimbo-Kumugo, Simon-Pierre, additional, Ndong Bass, Innocent, additional, Mbala Kingebeni, Placide, additional, Toure, Abdoulaye, additional, Delaporte, Eric, additional, Ahuka-Mundeke, Steve, additional, Muyembe Tamfum, Jean-Jacques, additional, Mpoudi-Ngole, Eitel, additional, Peeters, Martine, additional, and Ayouba, Ahidjo, additional

Published
2022
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22. High and Rapid Increase in Seroprevalence for SARS-CoV-2 in Conakry, Guinea: Results From 3 Successive Cross-Sectional Surveys (ANRS COV16-ARIACOV)

Author

Soumah, Abou Aissata, primary, Diallo, Mamadou Saliou Kalifa, additional, Guichet, Emilande, additional, Maman, David, additional, Thaurignac, Guillaume, additional, Keita, Alpha Kabinet, additional, Bouillin, Julie, additional, Diallo, Haby, additional, Pelloquin, Raphael, additional, Ayouba, Ahidjo, additional, Kpamou, Cece, additional, Peeters, Martine, additional, Delaporte, Eric, additional, Etard, Jean-Francois, additional, and Toure, Abdoulaye, additional

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2022
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23. Knowledge and Practice of Acetaminophen Use in Conakry Before the Onset of COVID-19 Epidemic: A Cross-Sectional Study in the Private Pharmacies

Author

Touré, Abdoulaye, primary, Jean-Jacques Olivier Kadio, Kadio, additional, Fofana, Lunceny, additional, Talassone Bangoura, Salifou, additional, Cherif Camara, Saidouba, additional, Diaby, Maladho, additional, Fapeingou Tounkara, Adrien, additional, Niouma Leno, Nestor, additional, Keita, Alpha-Kabinet, additional, Delamou, Alexandre, additional, and Camara, Alioune, additional

Published
2022
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24. VARIATION SAISONNIERE DES ARTHROPODES DINTERET MEDICAL, VETERINAIRE ET AGRICOLE DANS DIFFERENTES ZONES ECO-CLIMATIQUES DU MALI

Author

Alassane Dit Assitoun , Youssouf Faya Keita , Alpha Seydou Yaro , Adama Dao , Josue Poudiougo, Makan Camara , Sanou Makan Konate , Fily Dabo , Dougoufana Samake, and Moussa Diallo , Djibril Samake and Bernard Sodio

Subjects
Arthropodes Medical Veterinaire Agricole Zones Eco-Climatiques Mali
Abstract

Introduction:Les Arthropodes sont vecteurs de nombreuses maladies chez les hommes, les animaux et les plantes. Cest pourquoi lidentification des vecteurs devient necessaire afin de mener une lutte a travers des programmes nationaux de lutte. Methodes:Cette etude a ete conduite dans trois differentes zones eco-climatiques du Mali afin de voir la variation saisonniere des Arthropodes dinteret medical, veterinaire et Agricole au Mali. La collecte des arthropodes a ete faite a laide de deux types de piege (Piege demergence et piege en T) dans les villages de Bia, de Kenieroba et de Thierola. Les identifications ont ete faites a la loupe pour les Arthropodes, et par PCR pour les moustiques. Limportance des Arthropodes collectes a ete evaluee a travers leur dominance et leur frequence en fonction des zones et des saisons. Resultats:Letude des arthropodes des trois zones a permis davoir un apercu de lensemble de variations qualitatives et quantitatives des differents Arthropodes. Un total de 20 especes dArthropodes appartenant a trois classes a ete identifie (Arachnides, Insectes Myriapodes), 13 ordres (Araneides, Coleopteres, Dermapteres, Dictyopteres, Dipteres, Hemipteres, Hymenopteres, Lepidopteres, Nevropteres, Odonates, Orthopteres, Plecopteres, Trichopteres). Les Dipteres sont mieux representes a Bia et a Thierola et les Coleopteres frequents a Kenieroba. Conclusion:Il ressort de cette etude que les Arthropodes etaient plus frequents pendant la saison des pluies sur les sites. Les Arthropodes dinteret agricole constituaient le groupe dominant sur chacun des sites, suivi de ceux dinteret medical.

Published
2021
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25. Temporal evolution of the humoral antibody response after Ebola virus disease in Guinea: a 60-month observational prospective cohort study

Author

Diallo, Mamadou Saliou Kalifa, primary, Ayouba, Ahidjo, additional, Keita, Alpha Kabinet, additional, Thaurignac, Guillaume, additional, Sow, Mamadou Saliou, additional, Kpamou, Cécé, additional, Barry, Thierno Alimou, additional, Msellati, Philippe, additional, Etard, Jean-François, additional, Peeters, Martine, additional, Ecochard, René, additional, Delaporte, Eric, additional, Toure, Abdoulaye, additional, Baize, Sylvain, additional, Bangoura, Kaba, additional, Barry, Alimou, additional, Barry, Moumié, additional, Cissé, Mamoudou, additional, Cissé, Mohammed, additional, Delfraissy, Jean-François, additional, Delmas, Christelle, additional, Desclaux, Alice, additional, Diallo, Saliou Bella, additional, Diallo, Mamadou Safiatou, additional, Diallo, Mariama Sadjo, additional, Étard, Jean-François, additional, Etienne, Cécile, additional, Faye, Ousmane, additional, Fofana, Ibrahima, additional, Granouillac, Bruno, additional, Izard, Suzanne, additional, Kassé, Djenaba, additional, Keita, Sakoba, additional, Koivogui, Lamine, additional, Lacarabaratz, Christine, additional, Leroy, Sandrine, additional, Marchal, Claire Levy, additional, Levy, Yves, additional, Magassouba, N'Fally, additional, March, Laura, additional, Mendiboure, Vincent, additional, Niane, Harissatou, additional, Pers, Yves-Marie, additional, Raoul, Hervé, additional, Sacko, Sidi Lamine, additional, Savané, Ibrahima, additional, Taverne, Bernard, additional, Touré, Abdoulaye, additional, Traoré, Fodé Amara, additional, Traoré, Falaye, additional, Youla, Yamoussa, additional, and Yazdanpanah, Yazdan, additional

Published
2021
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27. A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

Author

Wilkinson, Eduan, primary, Giovanetti, Marta, additional, Tegally, Houriiyah, additional, San, James E., additional, Lessells, Richard, additional, Cuadros, Diego, additional, Martin, Darren P., additional, Rasmussen, David A., additional, Zekri, Abdel-Rahman N., additional, Sangare, Abdoul K., additional, Ouedraogo, Abdoul-Salam, additional, Sesay, Abdul K., additional, Priscilla, Abechi, additional, Kemi, Adedotun-Sulaiman, additional, Olubusuyi, Adewunmi M., additional, Oluwapelumi, Adeyemi O. O., additional, Hammami, Adnène, additional, Amuri, Adrienne A., additional, Sayed, Ahmad, additional, Ouma, Ahmed E. O., additional, Elargoubi, Aida, additional, Ajayi, Nnennaya A., additional, Victoria, Ajogbasile F., additional, Kazeem, Akano, additional, George, Akpede, additional, Trotter, Alexander J., additional, Yahaya, Ali A., additional, Keita, Alpha K., additional, Diallo, Amadou, additional, Kone, Amadou, additional, Souissi, Amal, additional, Chtourou, Amel, additional, Gutierrez, Ana V., additional, Page, Andrew J., additional, Vinze, Anika, additional, Iranzadeh, Arash, additional, Lambisia, Arnold, additional, Ismail, Arshad, additional, Rosemary, Audu, additional, Sylverken, Augustina, additional, Femi, Ayoade, additional, Ibrahimi, Azeddine, additional, Marycelin, Baba, additional, Oderinde, Bamidele S., additional, Bolajoko, Bankole, additional, Dhaala, Beatrice, additional, Herring, Belinda L., additional, Njanpop-Lafourcade, Berthe-Marie, additional, Kleinhans, Bronwyn, additional, McInnis, Bronwyn, additional, Tegomoh, Bryan, additional, Brook, Cara, additional, Pratt, Catherine B., additional, Scheepers, Cathrine, additional, Akoua-Koffi, Chantal G., additional, Agoti, Charles N., additional, Peyrefitte, Christophe, additional, Daubenberger, Claudia, additional, Morang’a, Collins M., additional, Nokes, D. James, additional, Amoako, Daniel G., additional, Bugembe, Daniel L., additional, Park, Danny, additional, Baker, David, additional, Doolabh, Deelan, additional, Ssemwanga, Deogratius, additional, Tshiabuila, Derek, additional, Bassirou, Diarra, additional, Amuzu, Dominic S. Y., additional, Goedhals, Dominique, additional, Omuoyo, Donwilliams O., additional, Maruapula, Dorcas, additional, Foster-Nyarko, Ebenezer, additional, Lusamaki, Eddy K., additional, Simulundu, Edgar, additional, Ong’era, Edidah M., additional, Ngabana, Edith N., additional, Shumba, Edwin, additional, El Fahime, Elmostafa, additional, Lokilo, Emmanuel, additional, Mukantwari, Enatha, additional, Philomena, Eromon, additional, Belarbi, Essia, additional, Simon-Loriere, Etienne, additional, Anoh, Etilé A., additional, Leendertz, Fabian, additional, Ajili, Faida, additional, Enoch, Fakayode O., additional, Wasfi, Fares, additional, Abdelmoula, Fatma, additional, Mosha, Fausta S., additional, Takawira, Faustinos T., additional, Derrar, Fawzi, additional, Bouzid, Feriel, additional, Onikepe, Folarin, additional, Adeola, Fowotade, additional, Muyembe, Francisca M., additional, Tanser, Frank, additional, Dratibi, Fred A., additional, Mbunsu, Gabriel K., additional, Thilliez, Gaetan, additional, Kay, Gemma L., additional, Githinji, George, additional, van Zyl, Gert, additional, Awandare, Gordon A., additional, Schubert, Grit, additional, Maphalala, Gugu P., additional, Ranaivoson, Hafaliana C., additional, Lemriss, Hajar, additional, Anise, Happi, additional, Abe, Haruka, additional, Karray, Hela H., additional, Nansumba, Hellen, additional, Elgahzaly, Hesham A., additional, Gumbo, Hlanai, additional, Smeti, Ibtihel, additional, Ayed, Ikhlas B., additional, Odia, Ikponmwosa, additional, Ben Boubaker, Ilhem Boutiba, additional, Gaaloul, Imed, additional, Gazy, Inbal, additional, Mudau, Innocent, additional, Ssewanyana, Isaac, additional, Konstantinus, Iyaloo, additional, Lekana-Douk, Jean B., additional, Makangara, Jean-Claude C., additional, Tamfum, Jean-Jacques M., additional, Heraud, Jean-Michel, additional, Shaffer, Jeffrey G., additional, Giandhari, Jennifer, additional, Li, Jingjing, additional, Yasuda, Jiro, additional, Mends, Joana Q., additional, Kiconco, Jocelyn, additional, Morobe, John M., additional, Gyapong, John O., additional, Okolie, Johnson C., additional, Kayiwa, John T., additional, Edwards, Johnathan A., additional, Gyamfi, Jones, additional, Farah, Jouali, additional, Nakaseegu, Joweria, additional, Ngoi, Joyce M., additional, Namulondo, Joyce, additional, Andeko, Julia C., additional, Lutwama, Julius J., additional, O’Grady, Justin, additional, Siddle, Katherine, additional, Adeyemi, Kayode T., additional, Tumedi, Kefentse A., additional, Said, Khadija M., additional, Hae-Young, Kim, additional, Duedu, Kwabena O., additional, Belyamani, Lahcen, additional, Fki-Berrajah, Lamia, additional, Singh, Lavanya, additional, Martins, Leonardo de O., additional, Tyers, Lynn, additional, Ramuth, Magalutcheemee, additional, Mastouri, Maha, additional, Aouni, Mahjoub, additional, el Hefnawi, Mahmoud, additional, Matsheka, Maitshwarelo I., additional, Kebabonye, Malebogo, additional, Diop, Mamadou, additional, Turki, Manel, additional, Paye, Marietou, additional, Nyaga, Martin M., additional, Mareka, Mathabo, additional, Damaris, Matoke-Muhia, additional, Mburu, Maureen W., additional, Mpina, Maximillian, additional, Nwando, Mba, additional, Owusu, Michael, additional, Wiley, Michael R., additional, Youtchou, Mirabeau T., additional, Ayekaba, Mitoha O., additional, Abouelhoda, Mohamed, additional, Seadawy, Mohamed G., additional, Khalifa, Mohamed K., additional, Sekhele, Mooko, additional, Ouadghiri, Mouna, additional, Diagne, Moussa M., additional, Mwenda, Mulenga, additional, Allam, Mushal, additional, Phan, My V. T., additional, Abid, Nabil, additional, Touil, Nadia, additional, Rujeni, Nadine, additional, Kharrat, Najla, additional, Ismael, Nalia, additional, Dia, Ndongo, additional, Mabunda, Nedio, additional, Hsiao, Nei-yuan, additional, Silochi, Nelson B., additional, Nsenga, Ngoy, additional, Gumede, Nicksy, additional, Mulder, Nicola, additional, Ndodo, Nnaemeka, additional, Razanajatovo, Norosoa H, additional, Iguosadolo, Nosamiefan, additional, Judith, Oguzie, additional, Kingsley, Ojide C., additional, Sylvanus, Okogbenin, additional, Peter, Okokhere, additional, Femi, Oladiji, additional, Idowu, Olawoye, additional, Testimony, Olumade, additional, Chukwuma, Omoruyi E., additional, Ogah, Onwe E., additional, Onwuamah, Chika K., additional, Cyril, Oshomah, additional, Faye, Ousmane, additional, Tomori, Oyewale, additional, Ondoa, Pascale, additional, Combe, Patrice, additional, Semanda, Patrick, additional, Oluniyi, Paul E., additional, Arnaldo, Paulo, additional, Quashie, Peter K., additional, Dussart, Philippe, additional, Bester, Phillip A., additional, Mbala, Placide K., additional, Ayivor-Djanie, Reuben, additional, Njouom, Richard, additional, Phillips, Richard O., additional, Gorman, Richmond, additional, Kingsley, Robert A., additional, Carr, Rosina A. A., additional, El Kabbaj, Saâd, additional, Gargouri, Saba, additional, Masmoudi, Saber, additional, Sankhe, Safietou, additional, Lawal, Salako B., additional, Kassim, Samar, additional, Trabelsi, Sameh, additional, Metha, Samar, additional, Kammoun, Sami, additional, Lemriss, Sanaâ, additional, Agwa, Sara H. A., additional, Calvignac-Spencer, Sébastien, additional, Schaffner, Stephen F., additional, Doumbia, Seydou, additional, Mandanda, Sheila M., additional, Aryeetey, Sherihane, additional, Ahmed, Shymaa S., additional, Elhamoumi, Siham, additional, Andriamandimby, Soafy, additional, Tope, Sobajo, additional, Lekana-Douki, Sonia, additional, Prosolek, Sophie, additional, Ouangraoua, Soumeya, additional, Mundeke, Steve A., additional, Rudder, Steven, additional, Panji, Sumir, additional, Pillay, Sureshnee, additional, Engelbrecht, Susan, additional, Nabadda, Susan, additional, Behillil, Sylvie, additional, Budiaki, Sylvie L., additional, van der Werf, Sylvie, additional, Mashe, Tapfumanei, additional, Aanniz, Tarik, additional, Mohale, Thabo, additional, Le-Viet, Thanh, additional, Schindler, Tobias, additional, Anyaneji, Ugochukwu J., additional, Chinedu, Ugwu, additional, Ramphal, Upasana, additional, Jessica, Uwanibe, additional, George, Uwem, additional, Fonseca, Vagner, additional, Enouf, Vincent, additional, Gorova, Vivianne, additional, Roshdy, Wael H., additional, Ampofo, William K., additional, Preiser, Wolfgang, additional, Choga, Wonderful T., additional, Bediako, Yaw, additional, Naidoo, Yeshnee, additional, Butera, Yvan, additional, de Laurent, Zaydah R., additional, Sall, Amadou A., additional, Rebai, Ahmed, additional, von Gottberg, Anne, additional, Kouriba, Bourema, additional, Williamson, Carolyn, additional, Bridges, Daniel J., additional, Chikwe, Ihekweazu, additional, Bhiman, Jinal N., additional, Mine, Madisa, additional, Cotten, Matthew, additional, Moyo, Sikhulile, additional, Gaseitsiwe, Simani, additional, Saasa, Ngonda, additional, Sabeti, Pardis C., additional, Kaleebu, Pontiano, additional, Tebeje, Yenew K., additional, Tessema, Sofonias K., additional, Happi, Christian, additional, Nkengasong, John, additional, and de Oliveira, Tulio, additional

Published
2021
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28. Factors Associated With Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea

Author

camara, Alimou, primary, Diallo, Penda Maladho, additional, Diallo, Mamadou Bobo, additional, Nioké, Talla, additional, Cissé, Adama, additional, Sylla, Mamadou Alpha, additional, Lamah, Gobounet, additional, Diakité, Mamady, additional, Bah, Amadou Sadio, additional, Keita, Mamadou Bhoye, additional, Keita, Alpha Kabinet, additional, Conde, Mamoudou, additional, Kourouma, Kaba, additional, camara, Robert, additional, Koita, Youssouf, additional, Magassouba, Fode Bangaly, additional, camara, Alioune, additional, and TOURE, Abdoulaye Abdoulaye, additional

Published
2021
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31. Numerical analysis of the failure mechanisms of sill mats made of cemented backfill.

Author

Keita, Alpha Mamoudou Talibe, Jahanbakhshzadeh, Abtin, and Li, Li

Abstract

Sill mat (SM) made with cemented backfill is an important structure in underground mining with backfill. Determining its minimum required strength is key to ensure economic and safe design. In 1991, Mitchell proposed a model with immobile walls. Four failure modes were possible. Recently, Pagé and co-workers showed that the failure mode of SM in a narrow stope is crushing when the entire underlying excavation is realized in one step. In this paper, the influences of stope width and sequence of underling excavation on the failure modes of SM are numerically analyzed. The results show that crushing remains the main failure mode for narrow stopes. Failure by flexure becomes possible when SM is wide enough with underlying excavation in several thin layers. Failures by rotation and caving are also possible, depending on the wall inclination and SM span Stronger SM is necessary when mine depth and, SM thickness, and stiffness increase. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Intrafamilial Circulation of Tropheryma whipplei, France

Author

Fenollar, Florence, Keita, Alpha K., Buffet, Sylvain, and Raoult, Didier

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Infection -- Health aspects, Disease transmission -- Health aspects, Health
Abstract

Whipple disease, a rare sporadic disease, was first considered a metabolic disease (1) and later suspected to be an infectious disease caused by a rare bacterium, Tropheryma whipplei (2). However, [...]

Published
2012
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35. Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa

Author

Lacroix, Audrey, Vidal, Nicole, Keita, Alpha Kabinet, Thaurignac, G., Esteban, Amandine, De nys, Hélène, Diallo, R., Toure, A., Goumou, S., Soumah, A. K., Povogui, M., Koivogui, J., Monemou, J. L., Raulino, R., Nkuba, A., Foulongne, V., Delaporte, E., Ayouba, Ahidjo, Peeters, Martine, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] (CERFIG), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Ministère de L'Elevage et des Productions Animales [Conakry, Guinée], Institut National de Santé Publique [Conakry, Guinée] (INSP), Ministère de la Santé [Conakry, Guinea], Cliniques Universitaires de Kinshasa [Congo], Pathogénèse et contrôle des infections chroniques (PCCI), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), This work was supported in part by grants from Institut National de la Sante et de la Recherche Medicale (INSERM)/the Ebola Task Force/REACTing, EBO-SURSY project funded by the European Union, Institut de Recherche pour le Developpement (IRD) and Agence Nationale de Recherches sur le SIDA (Grant Number ANRS-COVID10). A.K.K. was supported by fellowships from IRD and the University of Montpellier (MUSE, ANR-16-IDEX-0006). Raisa Raulino was supported by a PhD grant from INSERM and University of Montpellier and Antoine Nkuba was supported by a doctoral fellowship from the French foreign office., ANR-16-IDEX-0006,MUSE,MUSE(2016), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), LESUR, Hélène, and Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)

Subjects
Male, viruses, [SDV]Life Sciences [q-bio], Pneumonia, Viral, lcsh:QR1-502, coronavirus, virus diversity, Pilot Projects, bat, Genome, Viral, lcsh:Microbiology, Article, Betacoronavirus, Chiroptera, Zoonoses, Animals, Humans, Pandemics, Phylogeny, ComputingMilieux_MISCELLANEOUS, SARS-CoV-2, COVID-19, virus diseases, Biodiversity, [SDV] Life Sciences [q-bio], Africa, Female, Guinea, Coronavirus Infections
Abstract

Zoonoses can constitute a threat for public health that can have a global importance, as seen with the current COVID-19 pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV2). Bats have been recognized as an important reservoir of zoonotic coronaviruses (CoVs). In West Africa, where there is a high diversity of bat species, little is known on the circulation of CoVs in these hosts, especially at the interface with human populations. In this study, in Guinea, we tested a total of 319 bats belonging to 14 genera and six families of insectivorous and frugivorous bats across the country, for the presence of coronaviruses. We found CoVs in 35 (11%) of the tested bats&mdash, in three insectivorous bat species and five fruit bat species that were mostly captured close to human habitat. Positivity rates varied from 5.7% to 100%, depending on bat species. A wide diversity of alpha and beta coronaviruses was found across the country, including three sequences belonging to SarbeCoVs and MerbeCoVs subgenera known to harbor highly pathogenic human coronaviruses. Our findings suggest that CoVs are widely spread in West Africa and their circulation should be assessed to evaluate the risk of exposure of potential zoonotic CoVs to humans.

Published
2020

36. Long-lasting severe immune dysfunction in Ebola virus disease survivors

Author

Wiedemann, Aurélie, Foucat, Emile, Hocini, Hakim, Lefebvre, Cécile, Hejblum, Boris P., Durand, Mélany, Krüger, Miriam, Keita, Alpha Kabinet, Ayouba, Ahidjo, Mély, Stéphane, Fernandez, José-Carlos, Touré, Abdoulaye, Fourati, Slim, Lévy-Marchal, Claire, Raoul, Hervé, Delaporte, Eric, Koivogui, Lamine, Thiébaut, Rodolphe, Lacabaratz, Christine, Lévy, Yves, Vaccine Research Institute (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Gamal Abdel Nasser de Conakry, Laboratoire P4 - Jean Mérieux, Centre Européen de Virologie/Immunologie-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Santé Publique [Conakry, Guinée] (INSP), Ministère de la Santé [Conakry, Guinea], CHU Henri Mondor, Pôle de Recherche Clinique [Paris] (PRC), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Bordeaux [Bordeaux], This work was supported by INSERM and by the Investissements d’Avenir program, Vaccine Research Institute (VRI), managed by the ANR under reference ANR-10-LABX-77-01., PostEboGui Study Group, ANR-10-LABX-0077,VRI,Initiative for the creation of a Vaccine Research Institute(2010), Bodescot, Myriam, Laboratoires d'excellence - Initiative for the creation of a Vaccine Research Institute - - VRI2010 - ANR-10-LABX-0077 - LABX - VALID, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), ANR-10-LABX-0077/10-LABX-0077,VRI,Initiative for the creation of a Vaccine Research Institute(2010), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université de Bordeaux (UB), Laboratoire P4 Jean Mérieux-Inserm [Lyon] (Unité de service 3), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Européen de Recherche en Virologie et Immunologie [Lyon] (Tour Inserm CERVI), Groupe Henri Mondor-Albert Chenevier, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Universtié Yaoundé 1 [Cameroun]-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut national de la santé publique (INSP), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), and CHU Henri Mondor [Créteil]

Subjects
Adult, Genetic Markers, Male, [SDV.IMM] Life Sciences [q-bio]/Immunology, T-Lymphocytes, Immunology, Antibodies, Viral, Lymphocyte Activation, Antiviral Agents, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Article, Young Adult, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, Survivors, Immunological disorders, Inflammation, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, B-Lymphocytes, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Hemorrhagic Fever, Ebola, Ebolavirus, SISTM, Immune System Diseases, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Immunoglobulin G, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Infection, Transcriptome
Abstract

Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18–25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in ‘inflammation’ and ‘antiviral’ pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of “chronic Ebola virus disease (CEVD)”., Patients who have recovered from Ebola virus can have ongoing health problems. Here, the authors show that 35 Guinean survivors of the last West African Ebola epidemic have a chronic disease with high inflammatory cytokine expression and other markers of immune activation as well as evidence of intestinal tissue damage nearly two years after their release from hospital.

Published
2020

37. Preparing for the COVID-19 Pandemic Response in a Country Emerging from an Ebola Epidemic: Assessment of Health Workers Knowledge, Attitudes and Practices on Coronavirus (COVID-19) in Guinea

Author

Camara, Ibrahima, Touré, Abdoulaye, Camara, Alioune, Le Marcis, Frédéric, Talassone Bangoura, Salifou, Kpamou, Cécé, Sow, Mamadou Saliou, Keita, Alpha Kabinet, Université Gamal Abdel Nasser de Conakry, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre de Recherche et de Formation en Infectiologie de Guinée [Conakry, Guinée] (CERFIG), Institut National de Santé Publique [Conakry, Guinée] (INSP), Ministère de la Santé [Conakry, Guinea], Triangle : action, discours, pensée politique et économique (TRIANGLE), Centre National de la Recherche Scientifique (CNRS)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Hôpital National Donka, Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Universtié Yaoundé 1 [Cameroun]-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
knowledge, attitudes, 030503 health policy & services, [SDV]Life Sciences [q-bio], COVID-19, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, professional practice, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, health facilities, Guinea, 030212 general & internal medicine, 0305 other medical science
Abstract

Background: On January 30, 2020, the World Health Organization designated the outbreak as a Public Health Emergency of International Scope (USPPI). Underdeveloped countries, such as the Republic of Guinea, where the health system has been severely impacted by the Ebola virus epidemic between 2013 and 2014, will therefore find it difficult to respond effectively to the predicted epidemic. The purpose of this study was to assess the knowledge, attitudes and practices of medical personnel on the prevention of Covid-2019.Methods:This was a cross-sectional study with an analytical aim carried out from 1st to 29th February 2020 among front-line health workers in the health structures of the city of Conakry. Data were collected using the Kobocollect application by administration of a standardized questionnaire. The knowledge and attitude score was categorized in 2: Good if ≥ at the average score and bad if < 50%. Logistic regression models were conducted to identify factors associated with knowledge and attitude. Odds ratios (OR) with their confidence intervals were calculated.Results :548 health workers surveyed, the mean score for knowledge on the prevention of Covid-19 was 54.81 SD = 9.71, [95% CI: [ 53.9-55.6]. 70.6% had a good knowledge of Covid-19. However, 99.6% of the staff did not know the emergency number in case of a suspected case and about 50% did not know the incubation period of Covid-19.Among the health personnel interviewed, 57.7% had a good attitude towards a suspected case of Covid-19.Although the majority (57.5%) of the health workers had received training in infection prevention and control, infection prevention and control (IPC) practices were not routinely implemented, as the implementation rate was not even 80% for every action.Variables associated with poor knowledge of Covid-19 prevention were sex, health facility, and staff grade. As for poor attitude, the associated variables were knowledge of Ebola cases reported in the facility and the rank of the health staff.Conclusion:This study underlines the difficulties of the appropriation of prevention and protection measures against Covid-19 by health personnel for whom the risk appears remote and limited to a transnational or foreign elite.

Published
2020

39. A 40-Month Follow-Up of Ebola Virus Disease Survivors in Guinea (PostEbogui) Reveals Long-Term Detection of Ebola Viral Ribonucleic Acid in Semen and Breast Milk

Author

Keita, Alpha Kabinet, Vidal, Nicole, Toure, Abdoulaye, Diallo, Mamadou Saliou Kalifa, Magassouba, N’fally, Baize, Sylvain, Mateo, Mathieu, Raoul, Herve, Mely, Stephane, Subtil, Fabien, Kpamou, Cécé, Koivogui, Lamine, Traore, Falaye, Sow, Mamadou Saliou, Ayouba, Ahidjo, Etard, Jean Francois, Delaporte, Eric, Peeters, Martine, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Institut de Recherche pour le Développement (IRD [France-Sud]), Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abdel Nasser de Conakry, Institut National de Santé Publique [Conakry, Guinée] (INSP), Ministère de la Santé [Conakry, Guinea], Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire P4 Jean Mérieux-Inserm [Lyon] (Unité de service 3), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Européen de Recherche en Virologie et Immunologie [Lyon] (Tour Inserm CERVI), Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital National Donka, This work was funded in part by grants from the Institut National de la Santé et de la Recherche Médicale/Ebola Task Force, REACTing (REsearch and ACTion targeting emerging infectious diseases) and the Institut de Recherche pour le Développement and Montpellier Université d’Excellence (EBOHEALTH, I-Site MUSE, ANR-16-IDEX-0006). A. K. K. was supported by a postdoctoral fellowship from Montpellier Université d’Excellence (I-Site MUSE, ANR-16-IDEX-0006)., We thank the PostEbogui team for their daily work, all of the survivors, the Guinean survivors’ associations for their help in identifying and tracing survivors, the laboratory staff of Institut National de Santé Publique and Centre de Recherche et de Formation en Infectiologie (CERFIG) (Moriba Povogui, Jean-louis Monemou, Joel Ballè Koivogui, Abdoul Karim Soumah, Amara Bamba, and Saran Doumbouya), the laboratory facility from Macenta (Guillain Mikaty), and European West African Mobile Laboratory (Brunel Joanna, Belarbi Essia, Martinez Prudencio, Pannetier Delphine, Picard Caroline, Escudero Beatriz, Mengardi Chloe, Nguyen Xuan-Nhi, Tracqui Elodie, Hamied Lola, Olausson Mikaela, Verner-Carlsson Jenny, Godard Sabine, Moroso Marie, Thomas Damien, Ottmann Michele, Bernard Sandra, Yonga Wansi Gide Martial, Sylla Yahaya, Bocquin Anne, Sautter Carmen-Alexandra, Rittaud Adeline, Carbonnelle Caroline, Mundweiler Stephanie, Calland Noemie, Chevillard Eve, and Juven Fabienne)., PostEbogui Study Group, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-16-IDEX-0006,MUSE,MUSE(2016), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Donka National Hospital

Subjects
Editor's Choice, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, viruses, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Ebola, Major Article, breast milk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Guinea, semen, body fluids
Abstract

Background With the increasing frequency and impact of Ebola virus disease (EVD) outbreaks illustrated by recent epidemics, a good understanding of the extent of viral persistance or ribonucleic acid (RNA) detection in body fluids from survivors is urgently needed. Methods Ebola viral RNA shedding was studied with molecular assays in semen (n = 1368), urine (n = 1875), cervicovaginal fluid (n = 549), saliva (n = 900), breast milk (n = 168), and feces (n = 558) from EVD survivors in Guinea (PostEbogui cohort, n = 802) at a regular base period until 40 months after inclusion. Results Twenty-seven of 277 (9.8%) male survivors tested positive for Ebola RNA in at least 1 semen sample. The probability of remaining positive for Ebola RNA in semen was estimated at 93.02% and 60.12% after 3 and 6 months. Viral RNA in semen was more frequent in patients with eye pain (P = .036), joint pain (P = .047), and higher antibody levels to Ebola virus antigens (nucleoprotein [P = .001], glycoprotein [P = .05], and viral protein-40 [P = .05]). Ebola RNA was only rarely detected in the following body fluids from EVD survivors: saliva (1 of 454), urine (2 of 593), breast milk (2 of 168), cervicovaginal secretions (0 of 273), and feces (0 of 330). Ribonucleic acid was detected in breast milk 1 month after delivery but 500 days after discharge of Ebola treatment unit (ETU) in 1 woman who became pregnant 7 months after discharge from the ETU. Conclusions The frequency and potential long-term presence of viral RNA in semen confirmed that systematic prevention measures in male survivors are required. Our observation in breast milk suggests that our knowledge on viral reservoir in immune-privileged sites and its impact are still incomplete., On 5,400 body fluid samples from Ebola Virus Disease (EVD) survivors, during 40 months follow-up in Guinea, RNA was observed in semen and breast milk for up to 500 days, illustrating the complexity of the viral reservoir and management of survivors.

Published
2019

43. Understanding Long-term Evolution and Predictors of Sequelae of Ebola Virus Disease Survivors in Guinea: A 48-Month Prospective, Longitudinal Cohort Study (PostEboGui).

Author

Diallo, Mamadou Saliou Kalifa, Toure, Abdoulaye, Sow, Mamadou Saliou, Kpamou, Cécé, Keita, Alpha Kabinet, Taverne, Bernard, Peeters, Martine, Msellati, Philippe, Barry, Thierno Alimou, Etard, Jean-Francois, Ecochard, René, Delaporte, Eric, and Group, PostEboGui Study

Subjects
EBOLA virus disease, CONFIDENCE intervals, CHRONIC diseases, GUINEANS, DISEASE incidence, RISK assessment, DISEASE duration, DISEASE prevalence, LONGITUDINAL method, DISEASE complications
Abstract

Background Longitudinal analyses are needed to better understand long-term Ebola virus disease (EVD) sequelae. We aimed to estimate the prevalence, incidence, and duration of sequelae and to identify risk factors associated with symptom occurrence among EVD survivors in Guinea. Methods We followed 802 EVD survivors over 48 months and recorded clinical symptoms with their start/end dates. Prevalence, incidence, and duration of sequelae were calculated. Risk factors associated with symptom occurrence were assessed using an extended Cox model for recurrent events. Results Overall, the prevalence and incidence of all symptoms decreased significantly over time, but sequelae remained present 48 months after Ebola treatment center discharge with a prevalence of 30.68% (95% confidence interval [CI] 21.40–39.96) for abdominal, 30.55% (95% CI 20.68–40.41) for neurologic, 5.80% (95% CI 1.96–9.65) for musculoskeletal, and 4.24% (95% CI 2.26–6.23) for ocular sequelae. Half of all patients (50.70%; 95% CI 47.26–54.14) complained of general symptoms 2 years' postdischarge and 25.35% (95% CI 23.63–27.07) 4 years' post-discharge. Hemorrhage (hazard ratio [HR], 2.70; P =.007), neurologic (HR 2.63; P =.021), and general symptoms (HR 0.34; P =.003) in the EVD acute phase were significantly associated with the further occurrence of ocular sequelae, whereas hemorrhage (HR 1.91; P =.046) and abdominal (HR 2.21; P =.033) symptoms were significantly associated with musculoskeletal sequelae. Conclusions Our findings provide new insight into the long-term clinical complications of EVD and their significant association with symptoms in the acute phase, thus reinforcing the importance of regular, long-term follow-up for EVD survivors. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Extensive serological survey of multiple African non-human primate species reveals low prevalence of Immunoglobulin G antibodies to four Ebola virus species

Author

Ayouba, Ahidjo, Ahuka-Mundeke, Steve, Butel, Christelle, Mbala Kingebeni, Placide, Loul, Severin, Tagg, Nikki, Villabona-Arenas, Christian Julián, Lacroix, Audrey, Ndimbo-Kumugo, Simon-Pierre, Keita, Alpha, Touré, Abdoulaye, Couacy-Hymann, Emmanuel, Calvignac-Spencer, Sebastien, Leendertz, Fabian, Formenty, Pierre, Delaporte, Eric, Muyembe-Tamfum, Jean-Jacques, Peeters, Martine, Mpoudi Ngole, Eitel, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Recherche Biomédicale [Kinshasa] (INRB), Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abdel Nasser de Conakry, Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute [Berlin] (RKI), and Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)

Subjects
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, viruses, Ebola, Africa, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, virus diseases, ape, monkey
Abstract

International audience; Bats are considered a reservoir species for Ebola viruses, but nonhuman primates (NHPs) have represented a source of infection in several outbreaks in humans. Here we report serological screening of blood or fecal samples from monkeys (n = 2322) and apes (n = 2327). Thirty-six NHP species from Cameroon, Democratic Republic of the Congo, and Ivory Coast were tested with a sensitive and specific Luminex-based assay for immunoglobulin G antibodies to 4 Ebola virus species. Using the simultaneous presence of antibodies to nucleoproteins and glycoproteins to define positivity, we showed that specific Ebola virus antibodies are not widespread among NHPs. Only 1 mustached monkey (Cercopithecus cephus) from Cameroon was positive for Sudan ebolavirus. These observations support that NHPs are most likely intermediate hosts for Ebola viruses. With the increasing frequency of Ebola outbreaks, it is crucial to identify the animal reservoir and understand the ecology of Ebola viruses to inform disease control.

Published
2019

45. Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea : a retrospective, cross-sectional observational study

Author

Diallo, M. S. K., Rabilloud, M., Ayouba, Ahidjo, Toure, A., Thaurignac, Guillaume, Keita, Alpha Kabinet, Butel, Christelle, Kpamou, C., Barry, T. A., Sall, M. D., Camara, I., Leroy, S., Msellati, Philippe, Ecochard, R., Peeters, Martine, Sow, M. S., Delaporte, E., Etard, Jean-François, Taverne, Bernard (collab.), and Contactebogui Study Group

Subjects
viruses
Abstract

Background The prevalence of Ebola virus infection among people who have been in contact with patients with Ebola virus disease remains unclear, but is essential to understand the dynamics of transmission. This study aimed to identify risk factors for seropositivity and to estimate the prevalence of Ebola virus infection in unvaccinated contact persons. Methods In this retrospective, cross-sectional observational study, we recruited individuals between May 12, 2016, and Sept 8, 2017, who had been in physical contact with a patient with Ebola virus disease, from four medical centres in Guinea (Conakry, Macenta, N'zerekore, and Forecariah). Contact persons had to be 7 years or older and not diagnosed with Ebola virus disease. Participants were selected through the Postebogui survivors' cohort. We collected self-reported information on exposure and occurrence of symptoms after exposure using a questionnaire, and tested antibody response against glycoprotein, nucleoprotein, and 40-kDa viral protein of Zaire Ebola virus by taking a blood sample. The prevalence of Ebola virus infection was estimated with a latent class model. Findings 1721 contact persons were interviewed and given blood tests, 331 of whom reported a history of vaccination so were excluded, resulting in a study population of 1390. Symptoms were reported by 216 (16%) contact persons. The median age of participants was 26 years (range 7-88) and 682 (49%) were male. Seropositivity was identified in 18 (8.33%, 95% CI 5.01-12.80) of 216 paucisymptomatic contact persons and 39 (3.32%, 5.01-12.80) of 1174 (2-4) asymptomatic individuals (p=0.0021). Seropositivity increased with participation in burial rituals (adjusted odds ratio [aOR] 2.30, 95% CI 1.21-4.17; p=0.0079) and exposure to blood or vomit (aOR 2.15, 1.23-3.91; p=0.0090). Frequency of Ebola virus infection varied from 3.06% (95% CI 1.84-5.05) in asymptomatic contact persons who did not participate in burial rituals to 5.98% (2.81-8.18) in those who did, and from 7.17% (3.94-9.09) in paucisymptomatic contact persons who did not participate in burial rituals to 17.16% (12.42-22.31) among those who did. Interpretation This study provides a new assessment of the prevalence of Ebola virus infection among contact persons according to exposure, provides evidence for the occurrence of paucisymptomatic cases, and reinforces the importance of closely monitoring at-risk contact persons.

Published
2019

46. Long-lasting severe immune dysfunction in Ebola virus disease survivors

Author

Wiedemann, Aurélie, primary, Foucat, M.Sc. Emile, additional, Hocini, Hakim, additional, Lefebvre, M.Sc. Cécile, additional, Keita, Alpha Kabinet, additional, Ayouba, Ahidjo, additional, Mély, M.Sc. Stéphane, additional, Fernandez, M.Sc. José-Carlos, additional, Tou, Abdoulaye, additional, Lévy-Marchal, Claire, additional, Raoul, Hervé, additional, Delaporte, Eric, additional, Koivogui, Lamine, additional, Lacabaratz, Christine, additional, and Lévy, Yves, additional

Published
2019
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47. Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea: a retrospective, cross-sectional observational study

Author

Diallo, Mamadou Saliou Kalifa, primary, Rabilloud, Muriel, additional, Ayouba, Ahidjo, additional, Touré, Abdoulaye, additional, Thaurignac, Guillaume, additional, Keita, Alpha Kabinet, additional, Butel, Christelle, additional, Kpamou, Cécé, additional, Barry, Thierno Alimou, additional, Sall, Mariama Djouldé, additional, Camara, Ibrahima, additional, Leroy, Sandrine, additional, Msellati, Philippe, additional, Ecochard, René, additional, Peeters, Martine, additional, Sow, Mamadou Saliou, additional, Delaporte, Eric, additional, Etard, Jean-François, additional, ABOUBACAR, Diaby, additional, BALDE, Alseny, additional, BALDE, Ibrahima, additional, BAMBA, Amara, additional, CAMARA, Amadou, additional, CONTE, Aboubacar Mamy, additional, DELFRAISSY, Jean-François, additional, DIALLO, Amadou Bailo, additional, DOUMBOUYA, Saran, additional, KAMANO, Emile Souro, additional, KOIVOGUI, Joel Balle, additional, LANIECE-DELAUNAY, Charlotte, additional, LEVY, Yves, additional, MONEMOU, Jean Louis, additional, POVOGUI, Moriba, additional, SAKOUVOGUI, Maou, additional, SOUMAH, Abdoul Karim, additional, SUBTIL, Fabien, additional, SYLLA, Aboubacar Hawa, additional, TAVERNE, Bernard, additional, and YAZDANPANAH, Yazdan, additional

Published
2019
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48. Extensive Serological Survey of Multiple African Nonhuman Primate Species Reveals Low Prevalence of Immunoglobulin G Antibodies to 4 Ebola Virus Species

Author

Ayouba, Ahidjo, primary, Ahuka-Mundeke, Steve, additional, Butel, Christelle, additional, Mbala Kingebeni, Placide, additional, Loul, Severin, additional, Tagg, Nikki, additional, Villabona-Arenas, Christian-Julian, additional, Lacroix, Audrey, additional, Ndimbo-Kumugo, Simon-Pierre, additional, Keita, Alpha K, additional, Toure, Abdoulaye, additional, Couacy-Hymann, Emmanuel, additional, Calvignac-Spencer, Sebastien, additional, Leendertz, Fabian H, additional, Formenty, Pierre, additional, Delaporte, Eric, additional, Muyembe-Tamfum, Jean-Jacques, additional, Mpoudi Ngole, Eitel, additional, and Peeters, Martine, additional

Published
2019
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