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Abstract Background Gentamicin is a commonly used antibiotic with synergistic effects that is administered once or multiple times daily. However, the influence of the daily administration frequency on renal function has not yet been identified. This study aimed to investigate the effect of the daily dosing frequency on worsening renal function in patients receiving gentamicin. Methods This study included 35 patients undergoing gentamicin treatment who had at least one serum trough level measured and underwent therapeutic drug monitoring (TDM). We evaluated the influence of daily dosing frequency on gentamicin trough concentration and the risk of acute kidney injury (AKI). Results Compared to patients who received gentamicin once-daily dosing (n = 22), patients who received multiple-daily dosing (n = 13) had significantly higher initial and minimum trough concentrations after TDM. The proportion of patients with trough concentrations lower than 1.0 µg/mL was significantly higher in the once-daily dosing group at the initial trough concentration, whereas there was no significant difference at the minimum trough concentration after TDM. AKI developed in nine patients; however, there was no significant difference in the incidence of AKI according to the frequency of daily gentamicin dosing. In contrast, a higher minimum trough concentration after TDM was found to be a risk factor for AKI development with an odds ratio of 9.2 (95% confidence intervals; 1.3–65.5). Conclusion A higher trough concentration of gentamicin correlated with a higher incidence of AKI. The risk of developing AKI may be reduced by choosing a once-daily dosing regimen or implementing TDM.

Abstract This study proposes a system for estimating individual emotions based on collected indoor environment data for human participants. At the first step, we develop wireless sensor nodes, which collect indoor environment data regarding human perception, for monitoring working environments. The developed system collects indoor environment data obtained from the developed sensor nodes and the emotions data obtained from pulse and skin temperatures as big data. Then, the proposed system estimates individual emotions from collected indoor environment data. This study also investigates whether sensory data are effective for estimating individual emotions. Indoor environmental data obtained by developed sensors and emotions data obtained from vital data were logged over a period of 60 days. Emotions were estimated from indoor environmental data by machine learning method. The experimental results show that the proposed system achieves about 80% or more estimation correspondence by using multiple types of sensors, thereby demonstrating the effectiveness of the proposed system. Our obtained result that emotions can be determined with high accuracy from environmental data is a useful finding for future research approaches.

Cross-spectral iris recognition represents the ability of the system to identify the iris images acquired in different electromagnetic spectrums. An iris captured in the near-infrared spectrum (NIR) is matched with an iris obtained in the visual light spectrum (VIS) to boost the recognition performance. In cross-spectral iris recognition, the illumination factor between NIR and VIS images significantly degrades the recognition performance. Therefore, the existing method only achieved recognition performance with an equal error rate (EER) larger than 5%, and it is a challenging issue for cross-spectral performance to have EER below 5%. In this paper, we improve iris recognition performance by concatenating the Gradientfaces-based normalization technique (GRF) to a standard (conventional) iris recognition method to alleviate the illumination effect. In addition, we integrate the GRF with a Gabor filter, a difference of Gaussian (DoG) filter, and texture descriptors, namely a binary statistical image feature (BSIF) and a local binary pattern (LBP). The experimental results show that the GRF can boost the cross-spectral iris recognition performance with an EER equals to 1.69%. In addition, the best cross-spectral iris recognition performance is achieved when the GRF is integrated with the Gabor filter and the BSIF.

To investigate the influence of intrinsically photosensitive retinal ganglion cells (ipRGCs) on color discrimination, it is necessary to create two metameric light stimuli (metameric ipRGC stimuli) with the same amount of cone and rod stimulation, but different amounts of ipRGC stimulation. However, since the spectral sensitivity functions of cones and rods overlap with those of ipRGCs in a wavelength band, it has been difficult to independently control the amount of stimulation of ipRGCs only. In this study, we first propose a method for calculating metameric ipRGC stimulation based on the orthogonal basis functions of human photoreceptor cells. Then, we clarify the controllable range of metameric ipRGC stimulation within a color gamut. Finally, to investigate the color discrimination by metameric ipRGC stimuli, we conduct subjective evaluation experiments on 24 chromaticity coordinates using a multispectral projector. The results reveal a correlation between differences in the amount of ipRGC stimulation and differences in color appearance, indicating that ipRGCs may influence color discrimination.

In this paper, we propose a pipeline that reproduces human skin mockups using a UV printer by obtaining the spatial concentration map of pigments from an RGB image of human skin. The pigment concentration distributions were obtained by a separating method of skin pigment components with independent component analysis from the skin image. This method can extract the concentration of melanin and hemoglobin components, which are the main pigments that make up skin tone. Based on this concentration, we developed a procedure to reproduce a skin mockup with a multi-layered structure that is determined by mapping the absorbance of melanin and hemoglobin to CMYK (Cyan, Magenta, Yellow, Black) subtractive color mixing. In our proposed method, the multi-layered structure with different pigments in each layer contributes greatly to the accurate reproduction of skin tones. We use a UV printer because the printer is capable of layered fabrication by using UV-curable inks. As the result, subjective evaluation showed that the artificial skin reproduced by our method has a more skin-like appearance than that produced using conventional printing.

In cross-spectral iris recognition, different spectral bands are used to obtain rich information of the human iris. Previous studies on cross-spectral iris recognition are based primarily on feature-based approaches, which are prone to the changes in parameters in the feature extraction process, such as spatial position and iris image acquisition conditions. These parameters can degrade iris recognition performance. In this paper, we present a phase-based approach for cross-spectral iris recognition using phase-only correlation (POC) and band-limited phase-only correlation (BLPOC). A phase-based iris recognition system recognizes an iris using the phase information contained in the iris image; therefore, its performance is not affected by feature extraction parameters. However, the performance of a phase-based cross-spectral iris recognition is strongly influenced by specular reflection. Different illumination conditions may produce different iris images from the same subject. To overcome this challenge, we integrate a photometric normalization technique –homomorphic filtering– with phase-based cross-spectral iris recognition. The experimental results reveal that the proposed technique achieved an excellent matching performance with an equal error rate of 0.59% and a genuine acceptance rate of 95%.