Search

Integrated assessment of the water environment has become widespread in many rivers, lakes, and reservoirs; however, aquatic organisms in freshwater are often overlooked in this process. Zooplankton, as primary consumers, are sensitive and responsive to changes in the water environment. Water and zooplankton samples were collected on-site at Shanxi Reservoir quarterly to determine 12 water environmental indicators and to quantify the abundance of zooplankton of Cladocera, Copepoda and Rotifera by using the ZooScan zooplankton image-scanning analysis system, combined with OLYMPUS BX51 using machine learning recognition classification. The aim was to explore the relationship between water environmental factors and zooplankton through their spatial and temporal heterogeneity. Through principal component analysis, redundancy analysis and cluster analysis, variations in the factors driving zooplankton population growth in different seasons could be identified. At the same time, different taxa of zooplankton can form clusters with related water environmental factors during the abundant water period in summer and the dry water period in winter. Based on long-term monitoring, zooplankton can be used as a comprehensive indicator for water environment and water ecological health evaluation, as well as providing scientific support for regional water resources deployment and management.

Composite supercapacitive materials can combine two different kinds of electrode materials with different energy storage mechanisms, as well as present enhanced supercapacitive performance. In this paper, a reduced graphene oxide aerogel (GA) was prepared with an adjustable pore structure and used as a matrix for loading of secondary active material (MnO2) through an electrochemical deposition method. The influences of the deposition time and deposition voltage on the electrochemical behaviors and specific capacitances of MnO2/GA composites were studied. The unique three-dimensional porous structure of GA can act as a good matrix for MnO2. The results show that when the deposition time is 30 s and deposition voltage is 1.0 V, the MnO2/GA composite has the highest specific capacitance of 664 F/g at a current density of 1 A/g. Compared with neat GA, the specific capacitance of the MnO2/GA composite is enhanced by 190%, which can be assigned to the co-contribution of two kinds of active materials, a facile ion diffusion path through the porous structure, and good electron conductivity of the GA.

Ovarian cancer (OVCA) is a common gynecological malignant tumor and the fourth most common female tumor, following breast cancer, cervical cancer and endometrial cancer. Spindle Assembly checkpoint (SAC) can finely control the dynamic balance between kinetosomes and microtubules during mitosis. MAD2L2 is a chromatin binding protein and selective shear body of MAD2, one part of SAC. However, the expression and prognostic values of MAD2L2 in OVCA have not been clarified. GEPIA, UALCAN, cBioPortal, GeneMANIA, DAVID 6.8, Metascape, TIMER, Kaplan-Meier and in vito cell experiments were utilized in this study. MAD2L2 was over expression in OVCA patients and accompanied with poor survival time, especially in grade four patients. MAD2L2’s mRNA alteration way was amplification and ubiquitination was the mainly regulation way. Significant GO term analysis showed that MAD2L2 were located mainly in the organellar ribosome, where they participate primarily in NADH dehydrogenase activity. They also acted as structural constituents in mitochondrial translation elongation. KEGG pathway analysis showed enrichment in the sulfur relay system and ribosome. Four types of immune module were used and the results showed that MAD2L was relate to CD4, CD8, B cell, NK cell and Myeloid dendritic cell. At last, high level of MAD2L2 promoted cell proliferation and migration of OVCA and upregulation of MAD2L2 suppressing ferroptosis process and accompanied by mTOR signaling in OVCA cells. Therefore, suppressing MAD2L2 might be a next choice of treatment of OVCA patients. In addition to the common strategies, like chemotherapy, preventing mTOR signaling might also be a better treatment method in the future.

Background miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective This study aimed to analyze the expression profile of miR-486-5p in tumor tissues and serum samples of patients with EC and explore the target prediction, function analysis and validation in immortal cell lines. Patients and methods A total of 42 freshly paired EC tissues, the corresponding adjacent non-neoplastic tissues and serum samples were also collected from patients with EC, and 42 matched normal serum samples were included as control group. The level of miR-486-5p expression was tested by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was determined by colony formation assay and CCK-8 assay. Furthermore, functional evaluation of miR-486-5p on migration was performed by wound-healing assay and invasion was estimated by transwell invasion assay. qRT-PCR, luciferase reporter assay and Western blotting (WB) were performed to verify the targeting of MARK1 by miR-486-5p. Results miR-486-5p was significantly up-regulated in EC tissues and serum samples, promoting the proliferation, migration and invasive activities of EC cells by targeting MARK1. Conclusion These data indicated miR-486-5p as a novel molecular biomarker for diagnosing and treating EC, and MARK1 might act as a critical and functional target of miR-486-5p with the implications on cell proliferation, migration and invasiveness of EC tumor cells.

OBJECTIVES: To determine the impact of coronavirus disease 2019 on burnout syndrome in the multiprofessional ICU team and to identify factors associated with burnout syndrome. DESIGN: Longitudinal, cross-sectional survey. SETTING: All adult ICUs within an academic health system. SUBJECTS: Critical care nurses, advanced practice providers, physicians, respiratory therapists, pharmacists, social workers, and spiritual health workers were surveyed on burnout in 2017 and during the coronavirus disease 2019 pandemic in 2020. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Burnout syndrome and contributing factors were measured using the Maslach Burnout Inventory of Health and Human Service and Areas of Worklife Survey. Response rates were 46.5% (572 respondents) in 2017 and 49.9% (710 respondents) in 2020. The prevalence of burnout increased from 59% to 69% (p < 0.001). Nurses were disproportionately impacted, with the highest increase during the pandemic (58-72%; p < 0.0001) with increases in emotional exhaustion and depersonalization, and personal achievement decreases. In contrast, although burnout was high before and during coronavirus disease 2019 in all specialties, most professions had similar or lower burnout in 2020 as they had in 2017. Physicians had the lowest rates of burnout, measured at 51% and 58%, respectively. There was no difference in burnout between clinicians working in ICUs who treated coronavirus disease 2019 than those who did not (71% vs 67%; p = 0.26). Burnout significantly increased in females (71% vs 60%; p = 0.001) and was higher than in males during the pandemic (71% vs 60%; p = 0.01). CONCLUSIONS: Burnout syndrome was common in all multiprofessional ICU team members prior to and increased substantially during the pandemic, independent of whether one treated coronavirus disease 2019 patients. Nurses had the highest prevalence of burnout during coronavirus disease 2019 and had the highest increase in burnout from the prepandemic baseline. Female clinicians were significantly more impacted by burnout than males. Different susceptibility to burnout syndrome may require profession-specific interventions as well as work system improvements.

The present study was designed to evaluate the anticancer effects of withaferin A against the human endometrial cancer via modulation of transforming growth factor-β (TGF-β) signalling. The results of the present study revealed that withaferin A exerts a dose and time-dependent antiproliferative effects against the human KLE endometrial cancer cells with comparatively lower toxicity against the THESCs normal cells. The IC(50) of withaferin A against the KLE endometrial cancer cells was found to 10 μM. The results showed that withaferin A induced apoptosis and G(2)/M cell cycle arrest of the KLE cells which was associated with alteration of the apoptosis and cell cycle related proteins. In addition, the transwell assays showed that the migration and invasion of the KLE cells were inhibited by 53 and 40%, respectively. Finally, the effects of withaferin A were also examined on the TGF-β signalling pathway. The results showed that withaferin A blocked TGF-β-dependent Smad2 phosphorylation and expression of other TGF-β-related proteins in KLE cells. Summing up, the results suggest that withaferin A inhibits the proliferation of the human endometrial carcinoma via TGF-β signalling.

Significance Fermi surface (FS) topology is a fundamental property of metals and superconductors. In electron-doped cuprate Nd 2− x Ce x CuO 4 , an unexpected FS reconstruction has been observed in optimal- and overdoped regime ( x = 0.15 − 0.17) by quantum oscillation measurements (QOM). This is puzzling because neutron scattering suggests that the antiferromagnetic long-range order, which is believed to reconstruct the FS, vanishes before x = 0.14. Here, we report angle-resolved photoemission evidence of FS reconstruction. The observed FSs are in quantitative agreement with QOM, suggesting an intrinsic FS reconstruction without field. Furthermore, the energy gap of the reconstruction decreases rapidly near x = 0.17 like an order parameter, echoing the quantum critical doping in transport. The totality of the data points to a mysterious order between x = 0.14 and 0.17.

The present study executed iron pentacarbonyl pyrolysis to synthesize one-dimensional structured carbonyl iron fibers (CIFs) via carrier gas induced flow. The obtained CIFs with a diameter of 100–300 nm and length–diameter ratio of more than 20, are actually composed of a large number of nanocrystalline aggregates. We investigated the dependence of the structure, morphology, and static magnetic and electromagnetic properties of the CIFs on the pyrolysis temperatures. CIFs synthesized at 300 °C (denoted as CIF-300) exhibited optimal microwave absorption properties dependent on the fiber structure and well-matched impedance. An optimal reflection loss of −58.1 dB was observed at 13.8 GHz with a matching thickness of 1.43 mm. Furthermore, CIF-300 presented a broad effective absorption bandwidth (RL ≤ −10 dB) of 5.66 GHz with a thickness of 1.44 mm, indicating that it could be applied in practical applications from 3.74 GHz to 18.0 GHz by tuning its thickness from 1.0 mm to 4.0 mm. This paper not only reveals that the CIFs synthesized at 300 °C have great potential application in microwave absorbing materials (MAMs) with thin thicknesses, wide absorption bandwidths, and strong absorption intensities, but also provides a simple approach to prepare metal fibers.

Construction of thin thickness and broadband microwave absorption materials (MAMs) is challenging but important. One important and relatively successful strategy involves the reduction of quarter-wavelength resonance thickness by increasing permittivity ( e r ) and permeability ( μ r ). In this study, MOFs-derived core-shell structured flaky carbonyl iron/Co@C (FCI/Co@C) composites were synthesized via self-polymerization and in-situ pyrolysis to enhance e r . The effects of Co content in the porous carbon shell on the microstructure and electromagnetic performance of the FCI/Co@C composites were investigated. The FCI/Co@C composite with a Co-to-Zn molar ratio of 1:0 and 3:1 in its precursor and 70 wt% of filler exhibited excellent microwave absorption performance. The effective absorption bandwidth (EAB, corresponding to a reflection loss of less than −10 dB) of FCI/Co@C-1 reached 5.7 GHz (12.3–18 GHz) with a thickness of 1.28 mm, while the EAB of FCI/Co@C-3/1 reached 5.2 GHz (12.8–18 GHz) with a thickness of 1.19 mm, and both samples demonstrated broadband absorption in the Ku band. Thus, core-shell structured FCI/Co@C composites can be used as thin broadband MAMs in the Ku band. Furthermore, this work not only provides a simple method for constructing FCI-based core-shell structured MAMs, but also offers a novel strategy for reducing thickness while maintaining good microwave absorption performance.

A sharp boundary in the cuprates Many physicists working on cuprate superconductors believe that the so-called strange metal phase in the cuprate phase diagram is associated with a quantum critical point. Within this picture, the quantum critical point gives rise to a V-shaped region in the doping-temperature phase diagram of the cuprates: the strange metal phase. Chen et al. used angle-resolved photoemission spectroscopy in the cuprate family Bi2212 to challenge this view. By taking comprehensive measurements as a function of doping and temperature—and making sure that the signal was not affected by environmental conditions—they found an incoherent strange metal phase that was sharply separated from a conventional phase by a temperature-independent vertical line in the phase diagram. Science , this issue p. 1099

This paper proposes a convolution neural network based fault diagnosis for rolling bearings. Analysis about why convolution networks fit for vibration signals is first introduced. Then, an end to end network that reflects the raw vibration signals to fault types is built. Hyper parameters are tuned guided by the similarities and differences between images and vibration signals. Some conclusions about hyper parameters are drawn from hyper parameters tuning process, which helps us get a deeper understanding of convolution network’s application to vibration signals. The experiment is taken using Case Western Reserve University bearings dataset and 101 categories including different motor speeds are divided from the raw data. The result shows that our model achieves about 99% accuracy. What’s more, even the frequency differences among motor speeds are very small (about 20 RPM, less than 0.5 Hz), our model can also classify them with high accuracy.

Linyan Zhu,* Xiaojiao Zheng,* Yongming Du, Yan Xing, Kejun Xu, Lining Cui Department of Obstetrics and Gynaecology, Ningbo First Hospital, Ningbo, Zhejiang, People’s Republic of China *These authors contributed equally to this work Background: The biological and clinical significance of matrix metalloproteinase-7 (MMP-7) in cervical cancer remains unknown. Here, we investigated the function of MMP-7 in cervical cancer cells and evaluated its clinical significance in both tissues and serum from cervical cancer patients.Methods: First, we analyzed the expression of MMP-7 in cervical cancer using Oncomine microarray data and examined its expression in cervical tissues by quantitative real-time polymerase chain reaction and Western blotting. Second, we utilized gene silencing to explore the role of MMP-7 in cells. Finally, we examined the MMP-7 levels in patients with cervical cancer and normal serum by enzyme-linked immunosorbent assay. Moreover, we further investigated the relationship between MMP-7 expression and pathological features.Results: The mRNA and protein MMP-7 levels were higher in cervical cancer tissues than in healthy controls. Silencing of MMP-7 significantly decreased cervical cancer cell proliferation, migration, and invasion. The serum MMP-7 levels were significantly higher in cervical cancer patients than in healthy subjects (P

"Cross-Cultural Communication" is a collection of essays that examines how practitioners can improve the acceptance of their documentation when communicating to cultures other than their own. The essays begin by examining the cross-cultural issues relating to quality in documentation. From there, the essays look at examples of common documents, analysing them from several perspectives. Specifically, the author uses communication theories (such as Bernstein's Elaborated and Restricted Code theory and Marwell and Schmidt's Compliance-Gaining theory) to show how documents used by readers who are not native speakers of English can be written and organized to increase their effectiveness. The principal assumption about how practitioners create their documents is that, while large organizations can afford to write, translate, and then localize, small- to medium-size organizations produce many documents that are used directly by people in other cultures-often without translating and localizing. The advantage the writer gains from these essays is in understanding the strategies and knowing the kinds of strategies to apply in specific situations. In addition, the essays can serve as a valuable resource for students and teachers alike as they determine ways to understand how cross-cultural communication is different and why it makes a difference. Not only do students need to be aware of the various strategies they may apply when creating documents for cross-cultural settings, they also need to see how research can apply theories from different areas-in the case of these essays, communication and rhetorical theories. Another value of the essays is to show the students the role standards play in cross-cultural communication; standards are written by committees that follow style rules developed by the International Standardization Organization in Geneva. Thus, both students and practitioners can find valuable cross-cultural communication advice in these essays.

Here we report that TiSe2 thin films can be epitaxially grown on TiO2 substrates despite different lattice symmetry between the two materials. The TiSe2 thin films can be prepared on TiO2 via molecular beam epitaxy (MBE) in two ways: by conventional co-deposition using selenium and titanium sources, and by evaporating just selenium on reconstructed surfaces of TiO2. Both growth methods yield crystalline thin films with similar electronic band structures. TiSe2 films on TiO2 substrates exhibit large electron doping and a lack of charge density wave (CDW) order, which is different from both bulk single crystal TiSe2 and TiSe2 thin films on graphene. These phenomena can be explained by selenium vacancies in the TiSe2 films, which naturally occur when these films are grown on TiO2 substrates. Our successful growth of transition metal dichalcogenide (TMDC) films on a transition metal oxide (TMO) substrate provides a platform to further tune the electrical and optical properties of TMDC thin films.

Many patients with diabetes and their care providers are unaware of the presence of the disease. Dysglycemia encompassing hyperglycemia, hypoglycemia, and glucose variability is common in the ICU in patients with and without diabetes. The purpose of this study was to determine the impact of unknown diabetes on glycemic control in the ICU.Prospective observational study.Nine ICUs in an academic, tertiary hospital and a hybrid academic/community hospital.Hemoglobin A1c levels were ordered at all ICU admissions from March 1, 2011 to September 30, 2013. Electronic medical records were examined for a history of antihyperglycemic medications or International Classification of Diseases, 9th Edition diagnosis of diabetes. Patients were categorized as having unknown diabetes (hemoglobin A1c6.5%, without history of diabetes), no diabetes (hemoglobin A1c6.5%, without history of diabetes), controlled known diabetes (hemoglobin A1c6.5%, with documented history of diabetes), and uncontrolled known diabetes (hemoglobin A1c6.5%, with documented history of diabetes).None.A total of 15,737 patients had an hemoglobin A1c and medical record evaluable for the history of diabetes, and 5,635 patients had diabetes diagnosed by either medical history or an elevated hemoglobin A1c in the ICU. Of these, 1,460 patients had unknown diabetes, accounting for 26.0% of all patients with diabetes. This represented 41.0% of patients with an hemoglobin A1c6.5% and 9.3% of all ICU patients. Compared with patients without diabetes, patients with unknown diabetes had a higher likelihood of requiring an insulin infusion (44.3% vs 29.3%; p0.0001), a higher average blood glucose (172 vs 126 mg/dL; p0.0001), an increased percentage of hyperglycemia (19.7% vs 7.0%; blood glucose180 mg/dL; p0.0001) and hypoglycemia (8.9% vs 2.5%; blood glucose70 mg/dL; p0.0001), higher glycemic variability (55.6 vs 28.8, average of patient SD of glucose; p0.0001), and increased mortality (13.8% vs 11.4%; p = 0.01).Patients with unknown diabetes represent a significant percentage of ICU admissions. Measurement of hemoglobin A1c at admission can prospectively identify a population that are not known to have diabetes but have significant challenges in glycemic control in the ICU.

In this paper, a semiparametric regression model in which errors are i. i. d random variables from an unknown density f(·) is considered. Based on Hall et al. (1995), a nonlinear wavelet estimation of f(·) without restrictions of continuity everywhere on f(·) is given, and the convergence rate of the estimators in L 2 is obtained.

This book addresses a wide spectrum of issues in technical communication, ranging from specific visual elements to the entire research process, from brief memos to formal proposals. Part I, "Communication in the Workplace," starts with how to prepare an effective technical document and deliver the essential information. In Part II, "The Research Process," the author outlines both the procedural and the inquiry stages of the research. Part III, "Structural and Style Elements," focuses on strategies for organizing and conveying messages that users can follow and understand: partitioning and classifying, outlining, storyboarding, paragraphing, sequencing, chunking, and creating an overview. Part IV, "Visual, Design, and Usability Elements," further enhances the discussion in Part II about technical documents. The author talks about the rhetorical implications of graphics and page design so that readers can learn to enhance a document's access, appeal, and visual impact for audiences. Part V, "Specific Documents and Applications," is a rich "think tank" of applications in technical communications. The author offers instructions on almost all the writing styles you can think of - from memos, instant messages, and webpages, to resumes, letters, and proposals. The last part, "A Brief Handbook with Addition Sample Documents," has three appendices that once again address the writing process, editing, and research findings documentation. Readers can also find a wealth of resources on the book's companion website: www.alongman.com/lannonweb. This book presents a panorama of technical communication, providing readers with a look at every aspect of this profession. It is not only a comprehensive textbook for classroom teaching, but also a valuable reference book for instructors and working professionals.