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Introduction: soft tissue sarcomas (STSs) are a rare heterogeneous disease, Ki-67 is a nuclear protein highly expressed in the proliferative state of somatic cycle. We studied the prognostic value of Ki-67 expression and its primary tumor characteristics in adult patients with extremity STSs. Patients and Methods: We retrospectively collected the clinical data of 40 patients with extremity STSs treated at Ain Shams university hospital from January 2010 to December 2012 and we correlated between Ki-67 expression by immunohistochemistry and the clinico-pathological data. We used a cut-off value of 20% for Ki-67 in tumor cells. The differences among variables were calculated by Chi-square test. Results': High Ki-67 expression (>20%) was found in 20% of cases (8/40) of. High Ki- 67 was significantly correlated with age > 50 years old (p < 0.002), grade (p < 0.023), local recurrence (p < 0.009) and distant metastasis (p < 0.001). Multivariate analysis indicated that high Ki-67 expression was a significant independent prognostic factor for median DFS (12 months vs 4 months for low and high Ki-67 respectively with (P = <0.006, Cl 95% 7.87-14.13) and median OS was 28 months vs 10 months respectively (P = 0.001, Cl 95% 12.45-35.55). Conclusion: In our study we found that high expression of Ki-67 protein >20 % in extremity STSs, is frequently associated with poor prognosis, including the occurrence of distant metastases. [ABSTRACT FROM AUTHOR]

Background: Glioblastoma multiforme (GBM) is the most common and most malignant of the glial tumors. Optimum management consists of maximal safe surgical resection, followed by concurrent chemoradiotherapy treatment then adjuvant chemotherapy with temozolomide. A considerable part from the care of patients with GBM involves general medical management, containing corticosteroids. Despite steroids common use, there is experimental and clinical evidence that corticosteroids have direct effects on tumor cell proliferation and apoptosis. Aim of the Work: was to discuss the clinical relation between corticosteroids usage in Glioblastoma Multiforme (GBM) patients and quality of life as well as the disease progression free survival according to the recorded data from the joined hospitals. Patients and Methods: Retrospective analysis of 66 adult patients diagnosed with GBM by surgery or imaging criteria. In order to assess the relation between corticosteroid dependence and the survival, patients were recruited into two groups (arms) according to dependency. Arm (A) was steroid dependent(34 patients) and arm (B) was steroid non-dependent (32 patients). Results: Corticosteroids dependency was statistically significant correlated to both Overall Survival (OS)(median 2.5 in arm (A) vs. 13.1 months in the arm (B), p < 0.001), and Progression-free survival ratio (PFS)(median 2.3 in arm (A) vs. 9.4 months in arm (B), p = 0.035). Also, steroid dependency was independent prognostic factor by doing the COX regression analysis. Conclusion: Dependence on corticosteroids during course of treatment is identified as a poor prognostic factor. [ABSTRACT FROM AUTHOR]

Purpose: Discussing the clinical relation between corticosteroids usage in GBM patients and quality of life as well as the disease progression free survival according to the recorded data from the joined hospitals. Patients and Methods: Retrospective analysis of 66 adult patients diagnosed with GBM by surgery or imaging criteria. In order to assess the relation between corticosteroid dependence and the survival, patients were recruited into two groups (arms) according to dependency. Arm (A) was steroid dependant (34 patients) and arm (B) was steroid non-dependent (32 patients). Results: Corticosteroids dependency was statistically significant correlated to both OS (median 2.5 in arm (A) vs. 13.1 months in the arm (B), p < 0.001), and PFS (median 2.3 in arm (A) vs. 9.4 months in arm (B), p = 0.035). Also steroid dependency was independent prognostic factor by doing the COX regression analysis. Conclusion: Dependence on corticosteroids during course of treatment is identified as a poor prognostic factor. [ABSTRACT FROM AUTHOR]

Introduction: soft tissue sarcomas (STSs) are a rare heterogeneous disease, Ki-67 is a nuclear protein highly expressed in the proliferative state of somatic cycle. We studied the prognostic value of Ki-67 expression and its primary tumor characteristics in adult patients with extremity STSs. Patients and Methods: We retrospectively collected the clinical data of 40 patients with extremity STSs treated at Ain Shams university hospital from January 2010 to December 2012 and we correlated between Ki-67 expression by immunohistochemistry and the clinico-pathological data. We used a cut-off value of 20% for Ki-67 in tumor cells. The differences among variables were calculated by Chi-square test. Results': High Ki-67 expression (>20%) was found in 20% of cases (8/40) of. High Ki-67 was significantly correlated with age > 50 years old (p < 0.002), grade (p < 0.023), local recurrence (p < 0.009) and distant metastasis (p < 0.001). Multivariate analysis indicated that high Ki-67 expression was a significant independent prognostic factor for median DFS (12 months vs 4 months for low and high Ki-67 respectively with (P = <0.006, Cl 95% 7.87-14.13) and median OS was 28 months vs 10 months respectively (P = 0.001, Cl 95% 12.45-35.55). Conclusion: In our study we found that high expression of Ki-67 protein >20 % in extremity STSs, is frequently associated with poor prognosis, including the occurrence of distant metastases. [ABSTRACT FROM AUTHOR]