366,118 results on '"Keller, A."'
Search Results
2. Leon Battista Alberti: Universal Man of the Renaissance by Joan Gadol (review)
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Keller, A. G.
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- 2023
3. Atti del primo convegno intermzionale di ricognizione delle fonti per la storia della scienza italiana. I. Secoli XIV-XVI . (Vol. 1) Domus Galilaeana, Pisa, September 14–16, 1966. Atti del convegno sui problemi metodologici di storia della scienza . (Vol. 2) Centro di Studi Methodologici, Turin, March 29–31, 1967 ed. by Carlo Maccagni (review)
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Keller, A.
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- 2023
4. John Rogers, Tudor Military Engineer by L. R. Shelby (review)
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Keller, A.
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- 2023
5. Long-range and dead-zone free dual-comb ranging for the interferometric tracking of moving targets
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Camenzind, Sandro L., Lang, Lukas, Willenberg, Benjamin, Pupeikis, Justinas, Soghomonyan, Hayk, Presl, Robert, Ray, Pabitro, Wieser, Andreas, Keller, Ursula, and Phillips, Christopher R.
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Physics - Optics - Abstract
Dual-comb ranging has emerged as an effective technology for long-distance metrology, providing absolute distance measurements with high speed, precision, and accuracy. Here, we demonstrate a dual-comb ranging method that utilizes a free-space transceiver unit, enabling dead-zone-free measurements and simultaneous ranging with interchanged comb roles to allow for long-distance measurements even when the target is moving. It includes a GPU-accelerated algorithm for real-time signal processing and a free-running single-cavity solid-state dual-comb laser with a carrier wavelength $\lambda_c \approx$ 1055 nm, a pulse repetition rate of 1 GHz and a repetition rate difference of 5.06 kHz. This combination offers a fast update rate and sufficient signal strength to reach a single-shot time-of-flight precision of around 0.1 $\mu$m (i.e. $< \lambda_c/4$) on a cooperative target placed at a distance of more than 40 m. The free-running laser is sufficiently stable to use the phase information for interferometric distance measurements, which improves the single-shot precision to $<$20 nm. To assess the ranging accuracy, we track the motion of the cooperative target when moved over 40 m and compare it to a reference interferometer. The residuals between the two measurements are below 3 $\mu$m. These results highlight the potential of this approach for accurate and dead-zone-free long-distance ranging, supporting real-time tracking with nm-level precision., Comment: Supplementary Information included
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- 2024
6. Diceplot: A package for high dimensional categorical data visualization
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Flotho, Matthias, Flotho, Philipp, and Keller, Andreas
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Quantitative Biology - Quantitative Methods - Abstract
Visualization of multidimensional, categorical data is a common challenge across scientific areas and, in particular, the life sciences. The goal is to create a comprehensive overview of the underlying data which allows to assess multiple variables intuitively. One application where such visualizations are particularly useful is pathway analysis, where we check for dysregulation in known biological regulatory mechanisms and functions across multiple conditions. Here, we propose a new visualization approach that codes such data in a comprehensive and intuitive representation: Dice plots visualize up to four distinct categorical classes in a single view that consist of multiple elements resembling the faces of dice, whereas domino plots add an additional layer of information for binary comparison. The code is available as the diceplot R package, as pydiceplot on pip and at https://github.com/maflot., Comment: 4 pages, 1 figure
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- 2024
7. $p$-converse theorems for elliptic curves of potentially good ordinary reduction at Eisenstein primes
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Keller, Timo and Yin, Mulun
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Mathematics - Number Theory ,11G40 (Primary) 11G05, 11G10, 14G10 (Secondary) - Abstract
Let $E/\mathbf{Q}$ be an elliptic curve and $p\geq 3$ be a prime. We prove the $p$-converse theorems for elliptic curves of potentially good ordinary reduction at Eisenstein primes (i.e., such that the residual representation $E[p]$ is reducible) when the $p$-Selmer rank is $0$ or $1$. The key step is to obtain the anticyclotomic Iwasawa Main Conjectures for an auxiliary imaginary quadratic field $K$ where $E$ does not have CM similar to those in [CGLS22] and descent to $\mathbf{Q}$. As an application we get improved proportions for the number of elliptic curves in quadratic twist families having rank $0$ or $1$., Comment: 34 pages. Comments welcome!
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- 2024
8. CCAT: LED Mapping and Characterization of the 280 GHz TiN KID Array
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Middleton, Alicia, Choi, Steve K., Walker, Samantha, Austermann, Jason, Burgoyne, James R., Butler, Victoria, Chapman, Scott C., Crites, Abigail T., Duell, Cody J., Freundt, Rodrigo G., Huber, Anthony I., Huber, Zachary B., Hubmayr, Johannes, Keller, Ben, Lin, Lawrence T., Niemack, Michael D., Patel, Darshan, Sinclair, Adrian K., Smith, Ema, Vaskuri, Anna, Vavagiakis, Eve M., Vissers, Michael, Wang, Yuhan, and Wheeler, Jordan
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Prime-Cam, one of the primary instruments for the Fred Young Submillimeter Telescope (FYST) developed by the CCAT Collaboration, will house up to seven instrument modules, with the first operating at 280 GHz. Each module will include three arrays of superconducting microwave kinetic inductance detectors (KIDs). The first KID array fabricated for the 280 GHz module uses titanium-nitride (TiN) as the superconducting material and has 3,456 individual detectors, while the other two arrays use aluminum. This paper presents the design and laboratory characterization of the 280 GHz TiN array, which is cooled below its critical temperature to ~0.1 K and read out over six RF feedlines. LED mapping, a technique for matching the measured resonant frequency of a detector to its physical position, was performed on the array so that the results can be used to lithographically trim the KID capacitors and increase the yield of the array by reducing frequency collisions. We present the methods and results of LED mapping the 280 GHz TiN KID array before deployment on FYST., Comment: 4 pages, 4 figures, submitted to IEEE Transactions on Applied Superconductivity (IEEE TAS)
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- 2024
9. Classification of the Prime Graphs of $\operatorname{Sz}(8)$-, $\operatorname{Sz}(32)$-, and $\operatorname{PSL}(2, 2^5)$-Solvable Groups
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Keller, Thomas Michael, Martin, Zachary, Renner, Alexa, Roca, Gabriel, and Yu, Eric
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Mathematics - Group Theory ,20D60 and 05C25 - Abstract
For a finite group $G$, the vertices of the prime graph $\Gamma(G)$ are the primes that divide $|G|$, and two vertices $p$ and $q$ are connected by an edge if there is an element of order $pq$ in $G$. Prime graphs of solvable groups have been classified, and prime graphs of groups whose noncyclic composition factors are isomorphic to a single nonabelian simple group $T$ have been classified in the case where $T$ has order divisible by exactly three or four distinct primes, except for the cases $T = \operatorname{Sz}(8)$, $T = \operatorname{Sz}(32)$, and $T = \operatorname{PSL}(2,q)$, which in some sense are the hardest cases. In this paper, we complete the classification for $T = \operatorname{Sz}(32)$, $T = \operatorname{Sz}(8)$, and $T = \operatorname{PSL}(2,2^5)$, with the latter two being the first cases ever studied where $|\text{Out}(T)|$ has prime factors which do not divide $|T|$. The groups studied in this paper are also the first ones requiring knowledge of their Brauer character tables to complete the classification task., Comment: 32 pages, 4 figures
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- 2024
10. Are LLMs Better than Reported? Detecting Label Errors and Mitigating Their Effect on Model Performance
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Nahum, Omer, Calderon, Nitay, Keller, Orgad, Szpektor, Idan, and Reichart, Roi
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Computer Science - Computation and Language - Abstract
NLP benchmarks rely on standardized datasets for training and evaluating models and are crucial for advancing the field. Traditionally, expert annotations ensure high-quality labels; however, the cost of expert annotation does not scale well with the growing demand for larger datasets required by modern models. While crowd-sourcing provides a more scalable solution, it often comes at the expense of annotation precision and consistency. Recent advancements in large language models (LLMs) offer new opportunities to enhance the annotation process, particularly for detecting label errors in existing datasets. In this work, we consider the recent approach of LLM-as-a-judge, leveraging an ensemble of LLMs to flag potentially mislabeled examples. Through a case study of four datasets from the TRUE benchmark, covering different tasks and domains, we empirically analyze the labeling quality of existing datasets, and compare expert, crowd-sourced, and our LLM-based annotations in terms of agreement, label quality, and efficiency, demonstrating the strengths and limitations of each annotation method. Our findings reveal a substantial number of label errors, which, when corrected, induce a significant upward shift in reported model performance. This suggests that many of the LLMs so-called mistakes are due to label errors rather than genuine model failures. Additionally, we discuss the implications of mislabeled data and propose methods to mitigate them in training to improve model performance.
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- 2024
11. Neutrinoless Double Beta Decay Sensitivity of the XLZD Rare Event Observatory
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XLZD Collaboration, Aalbers, J., Abe, K., Adrover, M., Maouloud, S. Ahmed, Akerib, D. S., Musalhi, A. K. Al, Alder, F., Althueser, L., Amaral, D. W. P., Amarasinghe, C. S., Ames, A., Andrieu, B., Angelides, N., Angelino, E., Antunovic, B., Aprile, E., Araújo, H. M., Armstrong, J. E., Arthurs, M., Babicz, M., Bajpai, D., Baker, A., Balzer, M., Bang, J., Barberio, E., Bargemann, J. W., Barillier, E., Basharina-Freshville, A., Baudis, L., Bauer, D., Bazyk, M., Beattie, K., Beaupere, N., Bell, N. F., Bellagamba, L., Benson, T., Bhatti, A., Biesiadzinski, T. P., Biondi, R., Biondi, Y., Birch, H. J., Bishop, E., Bismark, A., Boehm, C., Boese, K., Bolotnikov, A., Brás, P., Braun, R., Breskin, A., Brew, C. A. J., Brommer, S., Brown, A., Bruni, G., Budnik, R., Burdin, S., Cai, C., Capelli, C., Carini, G., Carmona-Benitez, M. C., Carter, M., Chauvin, A., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Chavez, A. P. Cimental, Clark, K., Colijn, A. P., Colling, D. J., Conrad, J., Converse, M. V., Coronel, R., Costanzo, D., Cottle, A., Cox, G., Cuenca-García, J. J., Curran, D., Cussans, D., D'Andrea, V., Garcia, L. C. Daniel, Darlington, I., Dave, S., David, A., Davies, G. J., Decowski, M. P., Deisting, A., Delgaudio, J., Dey, S., Di Donato, C., Di Felice, L., Di Gangi, P., Diglio, S., Ding, C., Dobson, J. E. Y., Doerenkamp, M., Drexlin, G., Druszkiewicz, E., Dunbar, C. L., Eitel, K., Elykov, A., Engel, R., Eriksen, S. R., Fayer, S., Fearon, N. M., Ferella, A. D., Ferrari, C., Fieldhouse, N., Fischer, H., Flaecher, H., Flehmke, T., Flierman, M., Fraser, E. D., Fruth, T. M. A., Fujikawa, K., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gaitskell, R. J., Gallice, N., Galloway, M., Gao, F., Garroum, N., Geffre, A., Genovesi, J., Ghag, C., Ghosh, S., Giacomobono, R., Gibbons, R., Girard, F., Glade-Beucke, R., Glück, F., Gokhale, S., Grandi, L., Green, J., Grigat, J., van der Grinten, M. G. D., Größle, R., Guan, H., Guida, M., Gyorgy, P., Haiston, J. J., Hall, C. R., Hall, T., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M., Hertel, S. A., Higuera, A., Hils, C., Hiraoka, K., Hoetzsch, L., Hoferichter, M., Homenides, G. J., Hood, N. F., Horn, M., Huang, D. Q., Hughes, S., Hunt, D., Iacovacci, M., Itow, Y., Jacquet, E., Jakob, J., James, R. S., Joerg, F., Jones, S., Kaboth, A. C., Kahlert, F., Kamaha, A. C., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kemp-Russell, P., Khaitan, D., Kharbanda, P., Kilminster, B., Kim, J., Kirk, R., Kleifges, M., Klute, M., Kobayashi, M., Kodroff, D., Koke, D., Kopec, A., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., von Krosigk, B., Kudryavtsev, V. A., Kuger, F., Kurita, N., Landsman, H., Lang, R. F., Lawes, C., Lee, J., Lehnert, B., Leonard, D. S., Lesko, K. T., Levinson, L., Li, A., Li, I., Li, S., Liang, S., Liang, Z., Lin, J., Lin, Y. -T., Lindemann, S., Linden, S., Lindner, M., Lindote, A., Lippincott, W. H., Liu, K., Loizeau, J., Lombardi, F., Lopes, J. A. M., Lopes, M. I., Lorenzon, W., Loutit, M., Lu, C., Lucchetti, G. M., Luce, T., Luitz, S., Ma, Y., Macolino, C., Mahlstedt, J., Maier, B., Majewski, P. A., Manalaysay, A., Mancuso, A., Manenti, L., Mannino, R. L., Marignetti, F., Marley, T., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Maupin, C., McCabe, C., McCarthy, M. E., McKinsey, D. N., McLaughlin, J. B., Melchiorre, A., Menéndez, J., Messina, M., Miller, E. H., Milosovic, B., Milutinovic, S., Miuchi, K., Miyata, R., Mizrachi, E., Molinario, A., Monteiro, C. M. B., Monzani, M. E., Morå, K., Moriyama, S., Morrison, E., Morteau, E., Mosbacher, Y., Mount, B. J., Müller, J., Murdy, M., Murphy, A. St. J., Murra, M., Naylor, A., Nelson, H. N., Neves, F., Newstead, J. L., Nguyen, A., Ni, K., O'Hare, C., Oberlack, U., Obradovic, M., Olcina, I., Oliver-Mallory, K. C., Gann, G. D. Orebi, Orpwood, J., Ostrowskiy, I., Ouahada, S., Oyulmaz, K., Paetsch, B., Palladino, K. J., Palmer, J., Pan, Y., Pandurovic, M., Pannifer, N. J., Paramesvaran, S., Patton, S. J., Pellegrini, Q., Penning, B., Pereira, G., Peres, R., Perry, E., Pershing, T., Piastra, F., Pienaar, J., Piepke, A., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qiao, K., Qie, Y., Qin, J., Radeka, S., Radeka, V., Rajado, M., García, D. Ramírez, Ravindran, A., Razeto, A., Reichenbacher, J., Rhyne, C. A., Richards, A., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Roy, A., Rushton, T., Rynders, D., Saakyan, R., Sanchez, L., Sanchez-Lucas, P., Santone, D., Santos, J. M. F. dos, Sartorelli, G., Sazzad, A. B. M. R., Scaffidi, A., Schnee, R. W., Schreiner, J., Schulte, P., Schulze, H., Eißing, Schumann, M., Schwenck, A., Schwenk, A., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shaw, S., Shen, W., Sherman, L., Shi, S., Shi, S. Y., Shimada, T., Shutt, T., Silk, J. J., Silva, C., Simgen, H., Sinev, G., Singh, R., Siniscalco, J., Solmaz, M., Solovov, V. N., Song, Z., Sorensen, P., Soria, J., Stanley, O., Steidl, M., Stenhouse, T., Stevens, A., Stifter, K., Sumner, T. J., Takeda, A., Tan, P. -L., Taylor, D. J., Taylor, W. C., Thers, D., Thümmler, T., Tiedt, D. R., Tönnies, F., Tong, Z., Toschi, F., Tovey, D. R., Tranter, J., Trask, M., Trinchero, G., Tripathi, M., Tronstad, D. R., Trotta, R., Tunnell, C. D., Urquijo, P., Usón, A., Utoyama, M., Vaitkus, A. C., Valentino, O., Valerius, K., Vecchi, S., Velan, V., Vetter, S., de Viveiros, L., Volta, G., Vorkapic, D., Wang, A., Wang, J. J., Wang, W., Wang, Y., Waters, D., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Whitis, T. J., Wild, K., Williams, M., Wilson, M., Wilson, S. T., Wittweg, C., Wolf, J., Wolfs, F. L. H., Woodford, S., Woodward, D., Worcester, M., Wright, C. J., Wu, V. H. S., üstling, S. W, Wurm, M., Xia, Q., Xing, Y., Xu, D., Xu, J., Xu, Y., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yeh, M., Yu, B., Zavattini, G., Zha, W., Zhong, M., and Zuber, K.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
The XLZD collaboration is developing a two-phase xenon time projection chamber with an active mass of 60 to 80 t capable of probing the remaining WIMP-nucleon interaction parameter space down to the so-called neutrino fog. In this work we show that, based on the performance of currently operating detectors using the same technology and a realistic reduction of radioactivity in detector materials, such an experiment will also be able to competitively search for neutrinoless double beta decay in $^{136}$Xe using a natural-abundance xenon target. XLZD can reach a 3$\sigma$ discovery potential half-life of 5.7$\times$10$^{27}$ yr (and a 90% CL exclusion of 1.3$\times$10$^{28}$ yr) with 10 years of data taking, corresponding to a Majorana mass range of 7.3-31.3 meV (4.8-20.5 meV). XLZD will thus exclude the inverted neutrino mass ordering parameter space and will start to probe the normal ordering region for most of the nuclear matrix elements commonly considered by the community., Comment: 29 pages, 7 figures
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- 2024
12. The XLZD Design Book: Towards the Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics
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XLZD Collaboration, Aalbers, J., Abe, K., Adrover, M., Maouloud, S. Ahmed, Akerib, D. S., Musalhi, A. K. Al, Alder, F., Althueser, L., Amaral, D. W. P., Amarasinghe, C. S., Ames, A., Andrieu, B., Angelides, N., Angelino, E., Antunovic, B., Aprile, E., Araújo, H. M., Armstrong, J. E., Arthurs, M., Babicz, M., Bajpai, D., Baker, A., Balzer, M., Bang, J., Barberio, E., Bargemann, J. W., Barillier, E., Basharina-Freshville, A., Baudis, L., Bauer, D., Bazyk, M., Beattie, K., Beaupere, N., Bell, N. F., Bellagamba, L., Benson, T., Bhatti, A., Biesiadzinski, T. P., Biondi, R., Biondi, Y., Birch, H. J., Bishop, E., Bismark, A., Boehm, C., Boese, K., Bolotnikov, A., Brás, P., Braun, R., Breskin, A., Brew, C. A. J., Brommer, S., Brown, A., Bruni, G., Budnik, R., Burdin, S., Cai, C., Capelli, C., Carini, G., Carmona-Benitez, M. C., Carter, M., Chauvin, A., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Chavez, A. P. Cimental, Clark, K., Colijn, A. P., Colling, D. J., Conrad, J., Converse, M. V., Coronel, R., Costanzo, D., Cottle, A., Cox, G., Cuenca-García, J. J., Curran, D., Cussans, D., D'Andrea, V., Garcia, L. C. Daniel, Darlington, I., Dave, S., David, A., Davies, G. J., Decowski, M. P., Deisting, A., Delgaudio, J., Dey, S., Di Donato, C., Di Felice, L., Di Gangi, P., Diglio, S., Ding, C., Dobson, J. E. Y., Doerenkamp, M., Drexlin, G., Druszkiewicz, E., Dunbar, C. L., Eitel, K., Elykov, A., Engel, R., Eriksen, S. R., Fayer, S., Fearon, N. M., Ferella, A. D., Ferrari, C., Fieldhouse, N., Fischer, H., Flaecher, H., Flehmke, T., Flierman, M., Fraser, E. D., Fruth, T. M. A., Fujikawa, K., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gaitskell, R. J., Gallice, N., Galloway, M., Gao, F., Garroum, N., Geffre, A., Genovesi, J., Ghag, C., Ghosh, S., Giacomobono, R., Gibbons, R., Girard, F., Glade-Beucke, R., Glück, F., Gokhale, S., Grandi, L., Green, J., Grigat, J., van der Grinten, M. G. D., Größle, R., Guan, H., Guida, M., Gyorgy, P., Haiston, J. J., Hall, C. R., Hall, T., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M., Hertel, S. A., Higuera, A., Hils, C., Hiraoka, K., Hoetzsch, L., Hoferichter, M., Homenides, G. J., Hood, N. F., Horn, M., Huang, D. Q., Hughes, S., Hunt, D., Iacovacci, M., Itow, Y., Jacquet, E., Jakob, J., James, R. S., Joerg, F., Jones, S., Kaboth, A. C., Kahlert, F., Kamaha, A. C., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kemp-Russell, P., Khaitan, D., Kharbanda, P., Kilminster, B., Kim, J., Kirk, R., Kleifges, M., Klute, M., Kobayashi, M., Kodroff, D., Koke, D., Kopec, A., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., von Krosigk, B., Kudryavtsev, V. A., Kuger, F., Kurita, N., Landsman, H., Lang, R. F., Lawes, C., Lee, J., Lehnert, B., Leonard, D. S., Lesko, K. T., Levinson, L., Li, A., Li, I., Li, S., Liang, S., Liang, Z., Lin, J., Lin, Y. -T., Lindemann, S., Linden, S., Lindner, M., Lindote, A., Lippincott, W. H., Liu, K., Loizeau, J., Lombardi, F., Lopes, J. A. M., Lopes, M. I., Lorenzon, W., Loutit, M., Lu, C., Lucchetti, G. M., Luce, T., Luitz, S., Ma, Y., Macolino, C., Mahlstedt, J., Maier, B., Majewski, P. A., Manalaysay, A., Mancuso, A., Manenti, L., Mannino, R. L., Marignetti, F., Marley, T., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Maupin, C., McCabe, C., McCarthy, M. E., McKinsey, D. N., McLaughlin, J. B., Melchiorre, A., Menéndez, J., Messina, M., Miller, E. H., Milosovic, B., Milutinovic, S., Miuchi, K., Miyata, R., Mizrachi, E., Molinario, A., Monteiro, C. M. B., Monzani, M. E., Morå, K., Moriyama, S., Morrison, E., Morteau, E., Mosbacher, Y., Mount, B. J., Müller, J., Murdy, M., Murphy, A. St. J., Murra, M., Naylor, A., Nelson, H. N., Neves, F., Newstead, J. L., Nguyen, A., Ni, K., O'Hare, C., Oberlack, U., Obradovic, M., Olcina, I., Oliver-Mallory, K. C., Gann, G. D. Orebi, Orpwood, J., Ostrowskiy, I., Ouahada, S., Oyulmaz, K., Paetsch, B., Palladino, K. J., Palmer, J., Pan, Y., Pandurovic, M., Pannifer, N. J., Paramesvaran, S., Patton, S. J., Pellegrini, Q., Penning, B., Pereira, G., Peres, R., Perry, E., Pershing, T., Piastra, F., Pienaar, J., Piepke, A., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qiao, K., Qie, Y., Qin, J., Radeka, S., Radeka, V., Rajado, M., García, D. Ramírez, Ravindran, A., Razeto, A., Reichenbacher, J., Rhyne, C. A., Richards, A., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Roy, A., Rushton, T., Rynders, D., Saakyan, R., Sanchez, L., Sanchez-Lucas, P., Santone, D., Santos, J. M. F. dos, Sartorelli, G., Sazzad, A. B. M. R., Scaffidi, A., Schnee, R. W., Schreiner, J., Schulte, P., Schulze, H., Eißing, Schumann, M., Schwenck, A., Schwenk, A., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shaw, S., Shen, W., Sherman, L., Shi, S., Shi, S. Y., Shimada, T., Shutt, T., Silk, J. J., Silva, C., Simgen, H., Sinev, G., Singh, R., Siniscalco, J., Solmaz, M., Solovov, V. N., Song, Z., Sorensen, P., Soria, J., Stanley, O., Steidl, M., Stenhouse, T., Stevens, A., Stifter, K., Sumner, T. J., Takeda, A., Tan, P. -L., Taylor, D. J., Taylor, W. C., Thers, D., Thümmler, T., Tiedt, D. R., Tönnies, F., Tong, Z., Toschi, F., Tovey, D. R., Tranter, J., Trask, M., Trinchero, G., Tripathi, M., Tronstad, D. R., Trotta, R., Tunnell, C. D., Urquijo, P., Usón, A., Utoyama, M., Vaitkus, A. C., Valentino, O., Valerius, K., Vecchi, S., Velan, V., Vetter, S., de Viveiros, L., Volta, G., Vorkapic, D., Wang, A., Wang, J. J., Wang, W., Wang, Y., Waters, D., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Whitis, T. J., Wild, K., Williams, M., Wilson, M., Wilson, S. T., Wittweg, C., Wolf, J., Wolfs, F. L. H., Woodford, S., Woodward, D., Worcester, M., Wright, C. J., Wu, V. H. S., üstling, S. W, Wurm, M., Xia, Q., Xing, Y., Xu, D., Xu, J., Xu, Y., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yeh, M., Yu, B., Zavattini, G., Zha, W., Zhong, M., and Zuber, K.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
This report describes the experimental strategy and technologies for a next-generation xenon observatory sensitive to dark matter and neutrino physics. The detector will have an active liquid xenon target mass of 60-80 tonnes and is proposed by the XENON-LUX-ZEPLIN-DARWIN (XLZD) collaboration. The design is based on the mature liquid xenon time projection chamber technology of the current-generation experiments, LZ and XENONnT. A baseline design and opportunities for further optimization of the individual detector components are discussed. The experiment envisaged here has the capability to explore parameter space for Weakly Interacting Massive Particle (WIMP) dark matter down to the neutrino fog, with a 3$\sigma$ evidence potential for the spin-independent WIMP-nucleon cross sections as low as $3\times10^{-49}\rm cm^2$ (at 40 GeV/c$^2$ WIMP mass). The observatory is also projected to have a 3$\sigma$ observation potential of neutrinoless double-beta decay of $^{136}$Xe at a half-life of up to $5.7\times 10^{27}$ years. Additionally, it is sensitive to astrophysical neutrinos from the atmosphere, sun, and galactic supernovae., Comment: 32 pages, 14 figures
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- 2024
13. Crystallization of Binary Nanocrystal Superlattices and the Relevance of Short-Range Attraction
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Marino, Emanuele, LaCour, R. Allen, Moore, Timothy C., van Dongen, Sjoerd W., Keller, Austin W., An, Di, Yang, Shengsong, Rosen, Daniel J., Gouget, Guillaume, Tsai, Esther H. R., Kagan, Cherie R., Kodger, Thomas E., Glotzer, Sharon C., and Murray, Christopher B.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Soft Condensed Matter - Abstract
The synthesis of binary nanocrystal superlattices (BNSLs) enables the targeted integration of orthogonal physical properties, like photoluminescence and magnetism, into a single superstructure, unlocking a vast design space for multifunctional materials. Yet, the formation mechanism of BNSLs remains poorly understood, restricting the use of simulation to predict the structure and properties of the superlattices. Here, we use a combination of in situ scattering and molecular simulation to elucidate the self-assembly of two common BNSLs through emulsion templating. Our self-assembly experiments reveal that no intermediate structures precede the formation of the final binary phases, indicating that their formation proceeds through classical nucleation. Using simulations, we find that, despite the formation of AlB2 and NaZn13 typically being attributed to entropy, their self-assembly is most consistent with the nanocrystals possessing short-range interparticle attraction, which we find can dramatically accelerate nucleation kinetics in BNSLs. We also find homogenous, classical nucleation in simulation, corroborating our experiments. These results establish a robust correspondence between experiment and theory, paving the way towards a priori prediction of BNSLs.
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- 2024
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14. Structure and Magnetic Properties of a Maple Leaf antiferromagnet Ho$_3$ScO$_6$
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Aguilar-Maldonado, C., Feyerherm, R., Prokeš, K., Keller, L., and Lake, B.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Ho$_3$ScO$_6$ harbours a frustrated Maple Leaf Lattice (MLL). It crystalizes in the Mg$_3$TeO$_6$-type structure, and has a centrosymmetric trigonal space group (R$\bar{3}$). This system contains stacked layers of magnetic rings along the c-axis consisting of six magnetic Ho$^{3+}$ ions forming Ho hexagons, which are connected into a 2-dimensional network by equilateral and isosceles triangles to form a rare example of a MLL. Long range magnetic order is reached below $T_N=4.1$ K with a 120$^\circ$ spin arrangement on the equilateral triangles resulting in a positive vector chirality ground state configuration.
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- 2024
15. PEtra: A Flexible and Open-Source PE Loop Tracer for Polymer Thin-Film Transducers
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Wessner, Marc-Andre, Villani, Federico, Papa, Sofia, Keller, Kirill, Ferrari, Laura, Greco, Francesco, Benini, Luca, and Leitner, Christoph
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Electrical Engineering and Systems Science - Systems and Control ,Physics - Instrumentation and Detectors - Abstract
Accurate characterization of ferroelectric properties in polymer piezoelectrics is critical for optimizing the performance of flexible and wearable ultrasound transducers, such as screen-printed PVDF devices. Standard charge measurement techniques, like the Sawyer-Tower circuit, often fall short when applied to ferroelectric polymers due to low-frequency leakage. In this work, we present PEtra, an open-source and versatile piezoelectric loop tracer. PEtra employs a transimpedance amplifier (LMP7721, TI) to convert picoampere-level currents into measurable voltages, covering a frequency range of 0.1 Hz to 5 Hz for a gain setting of 10^7 V/A, and 0.1 Hz to 200 Hz for gain settings between 10^3 V/A to 10^6 V/A (10-fold increments). We demonstrate through simulations and experimental validations that PEtra achieves a sensitivity down to 2 pA, effectively addressing the limitations of traditional charge measurement methods. Compared to the Sawyer-Tower circuit, PEtra directly amplifies currents without the need for a reference capacitor. As a result, it is less susceptible to leakage and can operate at lower frequencies, improving measurement accuracy and reliability. PEtra's design is fully open source, offering researchers and engineers a versatile tool to drive advancements in flexible PVDF transducer technology.
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- 2024
16. Optimization of an eigenvalue arising in optimal insulation with a lower bound
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Bartels, Sören, Buttazzo, Giuseppe, and Keller, Hedwig
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Mathematics - Numerical Analysis ,Mathematics - Optimization and Control - Abstract
An eigenvalue problem arising in optimal insulation related to the minimization of the heat decay rate of an insulated body is adapted to enforce a positive lower bound imposed on the distribution of insulating material. We prove the existence of optimal domains among a class of convex shapes and propose a numerical scheme to approximate the eigenvalue. The stability of the shape optimization among convex, bounded domains in $\mathbb{R}^3$ is proven for an approximation with polyhedral domains under a non-conformal convexity constraint. We prove that on the ball, symmetry breaking of the optimal insulation can be expected in general. To observe how the lower bound affects the breaking of symmetry in the optimal insulation and the shape optimization, the eigenvalue and optimal domains are approximated for several values of mass $m$ and lower bounds $\ell_{\min}\ge0$. The numerical experiments suggest, that in general symmetry breaking still arises, unless $m$ is close to a critical value $m_0$, and $\ell_{\min}$ large enough such that almost all of the mass $m$ is fixed through the lower bound. For $\ell_{\min}=0$, the numerical results are consistent with previous numerical experiments on shape optimization restricted to rotationally symmetric, convex domains.
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- 2024
17. Enhancing AI Accessibility in Veterinary Medicine: Linking Classifiers and Electronic Health Records
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Kong, Chun Yin, Vasquez, Picasso, Farhoodimoghadam, Makan, Brandt, Chris, Brown, Titus C., Reagan, Krystle L., Zwingenberger, Allison, and Keller, Stefan M.
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Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
In the rapidly evolving landscape of veterinary healthcare, integrating machine learning (ML) clinical decision-making tools with electronic health records (EHRs) promises to improve diagnostic accuracy and patient care. However, the seamless integration of ML classifiers into existing EHRs in veterinary medicine is frequently hindered by the rigidity of EHR systems or the limited availability of IT resources. To address this shortcoming, we present Anna, a freely-available software solution that provides ML classifier results for EHR laboratory data in real-time.
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- 2024
18. Deformation Quantization via Categorical Factorization Homology
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Karlsson, Eilind, Keller, Corina, Müller, Lukas, and Pulmann, Ján
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Mathematics - Quantum Algebra ,Mathematical Physics ,Mathematics - Algebraic Topology ,Mathematics - Symplectic Geometry - Abstract
This paper develops an approach to categorical deformation quantization via factorization homology. We show that a quantization of the local coefficients for factorization homology is equivalent to consistent quantizations of its value on manifolds. To formulate our results we introduce the concepts of shifted almost Poisson and BD categories. Our main example is the character stack of flat principal bundles for a reductive algebraic group $G$, where we show that applying the general framework to the Drinfeld category reproduces deformations previously introduced by Li-Bland and \v{S}evera. As a direct consequence, we can conclude a precise relation between their quantization and those introduced by Alekseev, Grosse, and Schomerus. To arrive at our results we compute factorization homology with values in a ribbon category enriched over complete $\mathbb{C}[[\hbar]]$-modules. More generally, we define enriched skein categories which compute factorization homology for ribbon categories enriched over a general closed symmetric monoidal category $\mathcal{V}$., Comment: 84 pages. First version, comments and suggestions welcome
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- 2024
19. BookWorm: A Dataset for Character Description and Analysis
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Papoudakis, Argyrios, Lapata, Mirella, and Keller, Frank
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
Characters are at the heart of every story, driving the plot and engaging readers. In this study, we explore the understanding of characters in full-length books, which contain complex narratives and numerous interacting characters. We define two tasks: character description, which generates a brief factual profile, and character analysis, which offers an in-depth interpretation, including character development, personality, and social context. We introduce the BookWorm dataset, pairing books from the Gutenberg Project with human-written descriptions and analyses. Using this dataset, we evaluate state-of-the-art long-context models in zero-shot and fine-tuning settings, utilizing both retrieval-based and hierarchical processing for book-length inputs. Our findings show that retrieval-based approaches outperform hierarchical ones in both tasks. Additionally, fine-tuned models using coreference-based retrieval produce the most factual descriptions, as measured by fact- and entailment-based metrics. We hope our dataset, experiments, and analysis will inspire further research in character-based narrative understanding., Comment: 30 pages, 2 figures, EMNLP 2024 Findings
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- 2024
20. Term structure shapes and their consistent dynamics in the Svensson family
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Keller-Ressel, Martin and Sachse, Felix
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Quantitative Finance - Mathematical Finance ,Economics - Theoretical Economics ,Mathematics - Dynamical Systems ,91G30 - Abstract
We examine the shapes attainable by the forward- and yield-curve in the widely-used Svensson family, including the Nelson-Siegel and Bliss subfamilies. We provide a complete classification of all attainable shapes and partition the parameter space of each family according to these shapes. Building upon these results, we then examine the consistent dynamic evolution of the Svensson family under absence of arbitrage. Our analysis shows that consistent dynamics further restrict the set of attainable shapes, and we demonstrate that certain complex shapes can no longer appear after a deterministic time horizon. Moreover a single shape (either inverse of normal curves) must dominate in the long-run.
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- 2024
21. Large deviations in mean-field quantum spin systems
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Keller, Matthias and van de Ven, Christiaan J. F.
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Mathematical Physics - Abstract
Continuous fields (or bundles) of $C^*$-algebras form an important ingredient for describing emergent phenomena, such as phase transitions and spontaneous symmetry breaking. In this work, we consider the continuous $C^*$-bundle generated by increasing symmetric tensor powers of the complex $\ell\times\ell$ matrices $M_\ell(\mathbb{C})$, which can be interpreted as abstract description of mean-field theories defining the macroscopic limit of infinite quantum systems. Within this framework we discuss the principle of large deviations for the local Gibbs state in the high temperature regime and characterize the limit of the ensuing logarithmic generating function., Comment: 24 pages
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- 2024
22. Unsupervised Representation Learning from Sparse Transformation Analysis
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Song, Yue, Keller, Thomas Anderson, Yue, Yisong, Perona, Pietro, and Welling, Max
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Computer Science - Machine Learning ,Computer Science - Computer Vision and Pattern Recognition - Abstract
There is a vast literature on representation learning based on principles such as coding efficiency, statistical independence, causality, controllability, or symmetry. In this paper we propose to learn representations from sequence data by factorizing the transformations of the latent variables into sparse components. Input data are first encoded as distributions of latent activations and subsequently transformed using a probability flow model, before being decoded to predict a future input state. The flow model is decomposed into a number of rotational (divergence-free) vector fields and a number of potential flow (curl-free) fields. Our sparsity prior encourages only a small number of these fields to be active at any instant and infers the speed with which the probability flows along these fields. Training this model is completely unsupervised using a standard variational objective and results in a new form of disentangled representations where the input is not only represented by a combination of independent factors, but also by a combination of independent transformation primitives given by the learned flow fields. When viewing the transformations as symmetries one may interpret this as learning approximately equivariant representations. Empirically we demonstrate that this model achieves state of the art in terms of both data likelihood and unsupervised approximate equivariance errors on datasets composed of sequence transformations., Comment: submitted to T-PAMI
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- 2024
23. Integrated or Segregated? User Behavior Change after Cross-Party Interactions on Reddit
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Xia, Yan, Monti, Corrado, Keller, Barbara, and Kivelä, Mikko
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Computer Science - Social and Information Networks ,Computer Science - Computers and Society - Abstract
It has been a widely shared concern that social media reinforces echo chambers of like-minded users and exacerbate political polarization. While fostering interactions across party lines is recognized as an important strategy to break echo chambers, there is a lack of empirical evidence on whether users will actually become more integrated or instead more segregated following such interactions on real social media platforms. We fill this gap by inspecting how users change their community engagement after receiving a cross-party reply in the U.S. politics discussion on Reddit. More specifically, we investigate if they increase their activity in communities of the opposing party, or in communities of their own party. We find that receiving a cross-party reply to a comment in a non-partisan discussion space is not significantly associated with increased out-party subreddit activity, unless the comment itself is already a reply to another comment. Meanwhile, receiving a cross-party reply is significantly associated with increased in-party subreddit activity, but the effect is comparable to that of receiving a same-party reply. Our results reveal a highly conditional depolarization effect following cross-party interactions in spurring activity in out-party communities, which is likely part of a more general dynamic of feedback-boosted engagement., Comment: To appear in Proceedings of the International AAAI Conference on Web and Social Media (ICWSM 2025)
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- 2024
24. A Framework for Automatic Validation and Application of Lossy Data Compression in Ensemble Data Assimilation
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Keller, Kai, Yashiro, Hisashi, Wahib, Mohamed, Gerofi, Balazs, Kestelman, Adrian Cristal, and Bautista-Gomez, Leonardo
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Physics - Geophysics ,Physics - Atmospheric and Oceanic Physics - Abstract
Ensemble data assimilation techniques form an indispensable part of numerical weather prediction. As the ensemble size grows and model resolution increases, the amount of required storage becomes a major issue. Data compression schemes may come to the rescue not only for operational weather prediction, but also for weather history archives. In this paper, we present the design and implementation of an easy-to-use framework for evaluating the impact of lossy data compression in large scale ensemble data assimilation. The framework leverages robust statistical qualifiers to determine which compression parameters can be safely applied to the climate variables. Furthermore, our proposal can be used to apply the best parameters during operation, while monitoring data integrity. We perform an exemplary study on the Lorenz96 model to identify viable compression parameters and achieve a 1/3 saving in storage space and an effective speedup of 6% per assimilation cycle, while monitoring the state integrity., Comment: 12 pages, 6 figures
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- 2024
25. Analyzing Byte-Pair Encoding on Monophonic and Polyphonic Symbolic Music: A Focus on Musical Phrase Segmentation
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Le, Dinh-Viet-Toan, Bigo, Louis, and Keller, Mikaela
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Computer Science - Information Retrieval ,Computer Science - Computation and Language ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Byte-Pair Encoding (BPE) is an algorithm commonly used in Natural Language Processing to build a vocabulary of subwords, which has been recently applied to symbolic music. Given that symbolic music can differ significantly from text, particularly with polyphony, we investigate how BPE behaves with different types of musical content. This study provides a qualitative analysis of BPE's behavior across various instrumentations and evaluates its impact on a musical phrase segmentation task for both monophonic and polyphonic music. Our findings show that the BPE training process is highly dependent on the instrumentation and that BPE "supertokens" succeed in capturing abstract musical content. In a musical phrase segmentation task, BPE notably improves performance in a polyphonic setting, but enhances performance in monophonic tunes only within a specific range of BPE merges., Comment: Accepted to 3rd Workshop on NLP for Music and Audio (NLP4MusA, co-located with ISMIR 2024)
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- 2024
26. Direct Imaging of Transition-Edge Sensors with Scanning SQUID Microscopy
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Walker, Samantha, Kaczmarek, Austin, Austermann, Jason, Bennett, Douglas, Duff, Shannon M., Hubmayr, Johannes, Keller, Ben, Morgan, Kelsey, Murphy, Colin C., Swetz, Daniel, Ullom, Joel, Niemack, Michael D., and Nowack, Katja C.
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Condensed Matter - Superconductivity ,Astrophysics - Instrumentation and Methods for Astrophysics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Significant advancements have been made in understanding the physics of transition-edge sensors (TESs) over the past decade. However, key questions remain, particularly a detailed understanding of the current-dependent resistance of these detectors when biased within their superconducting transition. We use scanning superconducting quantum interference device (SQUID) microscopy (SSM) to image the local diamagnetic response of aluminum-manganese alloy (Al-Mn) transition-edge sensors (TESs) near their critical temperature of approximately 175 mK. By doing so, we gain insights into how the device dimensions influence TES transition width, which in turn affects device operation and informs optimal device design. Our images reveal that the Al-Mn thin film near the niobium (Nb) leads exhibits an excess diamagnetic response at temperatures several milli-Kelvin (mK) higher than the bulk of the film farther from the contacts. A possible origin of this behavior is a longitudinal proximity effect between the Nb and Al-Mn where the TES acts as a weak link between superconducting leads. We discuss how this effect shapes the temperature dependence of the resistance as the spacing between the leads decreases. This work demonstrates that magnetic imaging with SSM is a powerful tool for local characterization of superconducting detectors., Comment: 5 pages, 4 figures, Applied Superconductivity Conference (ASC 2024) proceedings, submitted to IEEE Transactions on Applied Superconductivity (IEEE TAS)
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- 2024
27. Model-independent searches of new physics in DARWIN with a semi-supervised deep learning pipeline
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Aalbers, J., Abe, K., Adrover, M., Maouloud, S. Ahmed, Althueser, L., Amaral, D. W. P., Andrieu, B., Angelino, E., Martin, D. Antón, Antunovic, B., Aprile, E., Babicz, M., Bajpai, D., Balzer, M., Barberio, E., Baudis, L., Bazyk, M., Bell, N. F., Bellagamba, L., Biondi, R., Biondi, Y., Bismark, A., Boehm, C., Boese, K., Braun, R., Breskin, A., Brommer, S., Brown, A., Bruni, G., Budnik, R., Cai, C., Capelli, C., Chauvin, A., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Garcia, L. C. Daniel, Decowski, M. P., Deisting, A., Di Donato, C., Di Gangi, P., Diglio, S., Doerenkamp, M., Drexlin, G., Eitel, K., Elykov, A., Engel, R., Ferella, A. D., Ferrari, C., Fischer, H., Flehmke, T., Flierman, M., Fujikawa, K., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Garroum, N., Giacomobono, R., Girard, F., Glade-Beucke, R., Glück, F., Grandi, L., Grigat, J., Größle, R., Guan, H., Guida, M., Gyorgy, P., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Higuera, A., Hils, C., Hiraoka, K., Hoetzsch, L., Hoferichter, M., Hood, N. F., Iacovacci, M., Itow, Y., Jakob, J., James, R. S., Joerg, F., Kahlert, F., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kharbanda, P., Kilminster, B., Kleifges, M., Klute, M., Kobayashi, M., Koke, D., Kopec, A., von Krosigk, B., Kuger, F., LaCascio, L., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, A., Li, S., Liang, S., Liang, Z., Lin, Y. -T., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Lucchetti, G. M., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Maier, B., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Melchiorre, A., Menéndez, J., Messina, M., Milosovic, B., Milutinovic, S., Miuchi, K., Miyata, R., Molinario, A., Monteiro, C. M. B., Morå, K., Moriyama, S., Morteau, E., Mosbacher, Y., Müller, J., Murra, M., Newstead, J. L., Ni, K., O'Hare, C., Oberlack, U., Obradovic, M., Ostrowskiy, I., Ouahada, S., Paetsch, B., Pan, Y., Pandurovic, M., Pellegrini, Q., Peres, R., Piastra, F., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qiao, K., Qin, J., Rajado, M., García, D. Ramírez, Ravindran, A., Razeto, A., Sanchez, L., Sanchez-Lucas, P., Sartorelli, G., Scaffidi, A., Schreiner, J., Schulte, P., Eißing, H. Schulze, Schumann, M., Schwenck, A., Schwenk, A., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shen, W., Shi, S. Y., Shimada, T., Simgen, H., Singh, R., Solmaz, M., Stanley, O., Steidl, M., Stevens, A., Takeda, A., Tan, P. -L., Thers, D., Thümmler, T., Tönnies, F., Toschi, F., Trinchero, G., Trotta, R., Tunnell, C. D., Urquijo, P., Utoyama, M., Valerius, K., Vecchi, S., Vetter, S., Volta, G., Vorkapic, D., Wang, W., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Wilson, M., Wittweg, C., Wolf, J., Wu, V. H. S., Wüstling, S., Wurm, M., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zuber, K.
- Subjects
Physics - Instrumentation and Detectors - Abstract
We present a novel deep learning pipeline to perform a model-independent, likelihood-free search for anomalous (i.e., non-background) events in the proposed next generation multi-ton scale liquid Xenon-based direct detection experiment, DARWIN. We train an anomaly detector comprising a variational autoencoder and a classifier on extensive, high-dimensional simulated detector response data and construct a one-dimensional anomaly score optimised to reject the background only hypothesis in the presence of an excess of non-background-like events. We benchmark the procedure with a sensitivity study that determines its power to reject the background-only hypothesis in the presence of an injected WIMP dark matter signal, outperforming the classical, likelihood-based background rejection test. We show that our neural networks learn relevant energy features of the events from low-level, high-dimensional detector outputs, without the need to compress this data into lower-dimensional observables, thus reducing computational effort and information loss. For the future, our approach lays the foundation for an efficient end-to-end pipeline that eliminates the need for many of the corrections and cuts that are traditionally part of the analysis chain, with the potential of achieving higher accuracy and significant reduction of analysis time., Comment: 10 Figures, 3 Tables, 23 Pages (incl. references)
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- 2024
28. $g$-vectors and $DT$-$F$-polynomials for Grassmannians
- Author
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Bakshi, Sarjick and Keller, Bernhard
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Mathematics - Representation Theory ,Mathematics - Algebraic Geometry ,13F60, 18G80, 14M15 - Abstract
We review $\mathrm{Hom}$-infinite Frobenius categorification of cluster algebras with coefficients and use it to give two applications of Jensen--King--Su's Frobenius categorification of the Grassmannian: 1) we determine the $g$-vectors of the Pl\"ucker coordinates with respect to the triangular initial seed and 2) we express the $F$-polynomials associated with the Donaldson--Thomas transformation in terms of $3$-dimensional Young diagrams thus providing a new proof for a theorem of Daping Weng., Comment: 34 pages
- Published
- 2024
29. Report on the Workshop on Simulations for Information Access (Sim4IA 2024) at SIGIR 2024
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Breuer, Timo, Kreutz, Christin Katharina, Fuhr, Norbert, Balog, Krisztian, Schaer, Philipp, Bernard, Nolwenn, Frommholz, Ingo, Gohsen, Marcel, Ji, Kaixin, Jones, Gareth J. F., Keller, Jüri, Liu, Jiqun, Mladenov, Martin, Pasi, Gabriella, Trippas, Johanne, Wang, Xi, Zerhoudi, Saber, and Zhai, ChengXiang
- Subjects
Computer Science - Information Retrieval - Abstract
This paper is a report of the Workshop on Simulations for Information Access (Sim4IA) workshop at SIGIR 2024. The workshop had two keynotes, a panel discussion, nine lightning talks, and two breakout sessions. Key takeaways were user simulation's importance in academia and industry, the possible bridging of online and offline evaluation, and the issues of organizing a companion shared task around user simulations for information access. We report on how we organized the workshop, provide a brief overview of what happened at the workshop, and summarize the main topics and findings of the workshop and future work., Comment: Preprint of a SIGIR Forum submission for Vol. 58 No. 2 - December 2024
- Published
- 2024
30. A Spacetime Perspective on Dynamical Computation in Neural Information Processing Systems
- Author
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Keller, T. Anderson, Muller, Lyle, Sejnowski, Terrence J., and Welling, Max
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Quantitative Biology - Neurons and Cognition ,Computer Science - Neural and Evolutionary Computing - Abstract
There is now substantial evidence for traveling waves and other structured spatiotemporal recurrent neural dynamics in cortical structures; but these observations have typically been difficult to reconcile with notions of topographically organized selectivity and feedforward receptive fields. We introduce a new 'spacetime' perspective on neural computation in which structured selectivity and dynamics are not contradictory but instead are complimentary. We show that spatiotemporal dynamics may be a mechanism by which natural neural systems encode approximate visual, temporal, and abstract symmetries of the world as conserved quantities, thereby enabling improved generalization and long-term working memory.
- Published
- 2024
31. Generating Visual Stories with Grounded and Coreferent Characters
- Author
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Liu, Danyang, Lapata, Mirella, and Keller, Frank
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Characters are important in narratives. They move the plot forward, create emotional connections, and embody the story's themes. Visual storytelling methods focus more on the plot and events relating to it, without building the narrative around specific characters. As a result, the generated stories feel generic, with character mentions being absent, vague, or incorrect. To mitigate these issues, we introduce the new task of character-centric story generation and present the first model capable of predicting visual stories with consistently grounded and coreferent character mentions. Our model is finetuned on a new dataset which we build on top of the widely used VIST benchmark. Specifically, we develop an automated pipeline to enrich VIST with visual and textual character coreference chains. We also propose new evaluation metrics to measure the richness of characters and coreference in stories. Experimental results show that our model generates stories with recurring characters which are consistent and coreferent to larger extent compared to baselines and state-of-the-art systems.
- Published
- 2024
32. Hardware-efficient quantum error correction using concatenated bosonic qubits
- Author
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Putterman, Harald, Noh, Kyungjoo, Hann, Connor T., MacCabe, Gregory S., Aghaeimeibodi, Shahriar, Patel, Rishi N., Lee, Menyoung, Jones, William M., Moradinejad, Hesam, Rodriguez, Roberto, Mahuli, Neha, Rose, Jefferson, Owens, John Clai, Levine, Harry, Rosenfeld, Emma, Reinhold, Philip, Moncelsi, Lorenzo, Alcid, Joshua Ari, Alidoust, Nasser, Arrangoiz-Arriola, Patricio, Barnett, James, Bienias, Przemyslaw, Carson, Hugh A., Chen, Cliff, Chen, Li, Chinkezian, Harutiun, Chisholm, Eric M., Chou, Ming-Han, Clerk, Aashish, Clifford, Andrew, Cosmic, R., Curiel, Ana Valdes, Davis, Erik, DeLorenzo, Laura, D'Ewart, J. Mitchell, Diky, Art, D'Souza, Nathan, Dumitrescu, Philipp T., Eisenmann, Shmuel, Elkhouly, Essam, Evenbly, Glen, Fang, Michael T., Fang, Yawen, Fling, Matthew J., Fon, Warren, Garcia, Gabriel, Gorshkov, Alexey V., Grant, Julia A., Gray, Mason J., Grimberg, Sebastian, Grimsmo, Arne L., Haim, Arbel, Hand, Justin, He, Yuan, Hernandez, Mike, Hover, David, Hung, Jimmy S. C., Hunt, Matthew, Iverson, Joe, Jarrige, Ignace, Jaskula, Jean-Christophe, Jiang, Liang, Kalaee, Mahmoud, Karabalin, Rassul, Karalekas, Peter J., Keller, Andrew J., Khalajhedayati, Amirhossein, Kubica, Aleksander, Lee, Hanho, Leroux, Catherine, Lieu, Simon, Ly, Victor, Madrigal, Keven Villegas, Marcaud, Guillaume, McCabe, Gavin, Miles, Cody, Milsted, Ashley, Minguzzi, Joaquin, Mishra, Anurag, Mukherjee, Biswaroop, Naghiloo, Mahdi, Oblepias, Eric, Ortuno, Gerson, Pagdilao, Jason, Pancotti, Nicola, Panduro, Ashley, Paquette, JP, Park, Minje, Peairs, Gregory A., Perello, David, Peterson, Eric C., Ponte, Sophia, Preskill, John, Qiao, Johnson, Refael, Gil, Resnick, Rachel, Retzker, Alex, Reyna, Omar A., Runyan, Marc, Ryan, Colm A., Sahmoud, Abdulrahman, Sanchez, Ernesto, Sanil, Rohan, Sankar, Krishanu, Sato, Yuki, Scaffidi, Thomas, Siavoshi, Salome, Sivarajah, Prasahnt, Skogland, Trenton, Su, Chun-Ju, Swenson, Loren J., Teo, Stephanie M., Tomada, Astrid, Torlai, Giacomo, Wollack, E. Alex, Ye, Yufeng, Zerrudo, Jessica A., Zhang, Kailing, Brandão, Fernando G. S. L., Matheny, Matthew H., and Painter, Oskar
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Quantum Physics - Abstract
In order to solve problems of practical importance, quantum computers will likely need to incorporate quantum error correction, where a logical qubit is redundantly encoded in many noisy physical qubits. The large physical-qubit overhead typically associated with error correction motivates the search for more hardware-efficient approaches. Here, using a microfabricated superconducting quantum circuit, we realize a logical qubit memory formed from the concatenation of encoded bosonic cat qubits with an outer repetition code of distance $d=5$. The bosonic cat qubits are passively protected against bit flips using a stabilizing circuit. Cat-qubit phase-flip errors are corrected by the repetition code which uses ancilla transmons for syndrome measurement. We realize a noise-biased CX gate which ensures bit-flip error suppression is maintained during error correction. We study the performance and scaling of the logical qubit memory, finding that the phase-flip correcting repetition code operates below threshold, with logical phase-flip error decreasing with code distance from $d=3$ to $d=5$. Concurrently, the logical bit-flip error is suppressed with increasing cat-qubit mean photon number. The minimum measured logical error per cycle is on average $1.75(2)\%$ for the distance-3 code sections, and $1.65(3)\%$ for the longer distance-5 code, demonstrating the effectiveness of bit-flip error suppression throughout the error correction cycle. These results, where the intrinsic error suppression of the bosonic encodings allows us to use a hardware-efficient outer error correcting code, indicate that concatenated bosonic codes are a compelling paradigm for reaching fault-tolerant quantum computation., Comment: Comments on the manuscript welcome!
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- 2024
33. Validating Convex Optimization of Reconfigurable Intelligent Surfaces via Measurements
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Lang, Hans-Dieter, Nyffenegger, Michel A., Keller, Sven, Stöckli, Patrik, Hoffman, Nathan A., Mathis, Heinz, and Zhang, Xingqi
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Mathematics - Optimization and Control - Abstract
Reconfigurable Intelligent Surfaces (RISs) can be designed in various ways. A previously proposed semidefinite relaxation-based optimization method for maximizing power transfer efficiency showed promise, but earlier results were only theoretical. This paper evaluates a small RIS at 3.55GHz, the center of the 5G band "n78", for practical verification of this method. The presented results not only empirically confirm the desired performance of the optimized RIS, but also affirm the optimality of the resulting reactance values. Additionally, this paper discusses several practical aspects of RIS design and measurement, such as the operation of varactor diodes and time gating to omit the direct line-of-sight (LOS) path., Comment: 5 pages, conference
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- 2024
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34. Toward Mitigating Sex Bias in Pilot Trainees' Stress and Fatigue Modeling
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Pfeifer, Rachel, Vhaduri, Sudip, Wilson, Mark, and Keller, Julius
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Computer Science - Machine Learning ,Computer Science - Computers and Society - Abstract
While researchers have been trying to understand the stress and fatigue among pilots, especially pilot trainees, and to develop stress/fatigue models to automate the process of detecting stress/fatigue, they often do not consider biases such as sex in those models. However, in a critical profession like aviation, where the demographic distribution is disproportionately skewed to one sex, it is urgent to mitigate biases for fair and safe model predictions. In this work, we investigate the perceived stress/fatigue of 69 college students, including 40 pilot trainees with around 63% male. We construct models with decision trees first without bias mitigation and then with bias mitigation using a threshold optimizer with demographic parity and equalized odds constraints 30 times with random instances. Using bias mitigation, we achieve improvements of 88.31% (demographic parity difference) and 54.26% (equalized odds difference), which are also found to be statistically significant., Comment: Accepted at 2024 IEEE-EMBS International Conference on Body Sensor Networks (IEEE BSN 2024)
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- 2024
35. SpeechTaxi: On Multilingual Semantic Speech Classification
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Keller, Lennart and Glavaš, Goran
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Computer Science - Computation and Language ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Recent advancements in multilingual speech encoding as well as transcription raise the question of the most effective approach to semantic speech classification. Concretely, can (1) end-to-end (E2E) classifiers obtained by fine-tuning state-of-the-art multilingual speech encoders (MSEs) match or surpass the performance of (2) cascading (CA), where speech is first transcribed into text and classification is delegated to a text-based classifier. To answer this, we first construct SpeechTaxi, an 80-hour multilingual dataset for semantic speech classification of Bible verses, covering 28 diverse languages. We then leverage SpeechTaxi to conduct a wide range of experiments comparing E2E and CA in monolingual semantic speech classification as well as in cross-lingual transfer. We find that E2E based on MSEs outperforms CA in monolingual setups, i.e., when trained on in-language data. However, MSEs seem to have poor cross-lingual transfer abilities, with E2E substantially lagging CA both in (1) zero-shot transfer to languages unseen in training and (2) multilingual training, i.e., joint training on multiple languages. Finally, we devise a novel CA approach based on transcription to Romanized text as a language-agnostic intermediate representation and show that it represents a robust solution for languages without native ASR support. Our SpeechTaxi dataset is publicly available at: https://huggingface.co/ datasets/LennartKeller/SpeechTaxi/.
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- 2024
36. Classification performance and reproducibility of GPT-4 omni for information extraction from veterinary electronic health records
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Wulcan, Judit M, Jacques, Kevin L, Lee, Mary Ann, Kovacs, Samantha L, Dausend, Nicole, Prince, Lauren E, Wulcan, Jonatan, Marsilio, Sina, and Keller, Stefan M
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Computer Science - Computation and Language ,Computer Science - Information Retrieval - Abstract
Large language models (LLMs) can extract information from veterinary electronic health records (EHRs), but performance differences between models, the effect of temperature settings, and the influence of text ambiguity have not been previously evaluated. This study addresses these gaps by comparing the performance of GPT-4 omni (GPT-4o) and GPT-3.5 Turbo under different conditions and investigating the relationship between human interobserver agreement and LLM errors. The LLMs and five humans were tasked with identifying six clinical signs associated with Feline chronic enteropathy in 250 EHRs from a veterinary referral hospital. At temperature 0, the performance of GPT-4o compared to the majority opinion of human respondents, achieved 96.9% sensitivity (interquartile range [IQR] 92.9-99.3%), 97.6% specificity (IQR 96.5-98.5%), 80.7% positive predictive value (IQR 70.8-84.6%), 99.5% negative predictive value (IQR 99.0-99.9%), 84.4% F1 score (IQR 77.3-90.4%), and 96.3% balanced accuracy (IQR 95.0-97.9%). The performance of GPT-4o was significantly better than that of its predecessor, GPT-3.5 Turbo, particularly with respect to sensitivity where GPT-3.5 Turbo only achieved 81.7% (IQR 78.9-84.8%). Adjusting the temperature for GPT-4o did not significantly impact classification performance. GPT-4o demonstrated greater reproducibility than human pairs regardless of temperature, with an average Cohen's kappa of 0.98 (IQR 0.98-0.99) at temperature 0 compared to 0.8 (IQR 0.78-0.81) for humans. Most GPT-4o errors occurred in instances where humans disagreed (35/43 errors, 81.4%), suggesting that these errors were more likely caused by ambiguity of the EHR than explicit model faults. Using GPT-4o to automate information extraction from veterinary EHRs is a viable alternative to manual extraction., Comment: 24 pages, 3 figures, 8 supplementary figures
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- 2024
37. Replicability Measures for Longitudinal Information Retrieval Evaluation
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Keller, Jüri, Breuer, Timo, and Schaer, Philipp
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Computer Science - Information Retrieval - Abstract
Information Retrieval (IR) systems are exposed to constant changes in most components. Documents are created, updated, or deleted, the information needs are changing, and even relevance might not be static. While it is generally expected that the IR systems retain a consistent utility for the users, test collection evaluations rely on a fixed experimental setup. Based on the LongEval shared task and test collection, this work explores how the effectiveness measured in evolving experiments can be assessed. Specifically, the persistency of effectiveness is investigated as a replicability task. It is observed how the effectiveness progressively deteriorates over time compared to the initial measurement. Employing adapted replicability measures provides further insight into the persistence of effectiveness. The ranking of systems varies across retrieval measures and time. In conclusion, it was found that the most effective systems are not necessarily the ones with the most persistent performance., Comment: Experimental IR Meets Multilinguality, Multimodality, and Interaction - 15th International Conference of the CLEF Association, CLEF 2024, Grenoble, France, September 9-12, 2024, Proceedings. arXiv admin note: text overlap with arXiv:2308.10549
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- 2024
38. Design of a Standard-Compliant Real-Time Neural Receiver for 5G NR
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Wiesmayr, Reinhard, Cammerer, Sebastian, Aoudia, Fayçal Aït, Hoydis, Jakob, Zakrzewski, Jakub, and Keller, Alexander
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
We detail the steps required to deploy a multi-user multiple-input multiple-output (MU-MIMO) neural receiver (NRX) in an actual cellular communication system. This raises several exciting research challenges, including the need for real-time inference and compatibility with the 5G NR standard. As the network configuration in a practical setup can change dynamically within milliseconds, we propose an adaptive NRX architecture capable of supporting dynamic modulation and coding scheme (MCS) configurations without the need for any re-training and without additional inference cost. We optimize the latency of the neural network (NN) architecture to achieve inference times of less than 1ms on an NVIDIA A100 GPU using the TensorRT inference library. These latency constraints effectively limit the size of the NN and we quantify the resulting signal-to-noise ratio (SNR) degradation as less than 0.7 dB when compared to a preliminary non-real-time NRX architecture. Finally, we explore the potential for site-specific adaptation of the receiver by investigating the required size of the training dataset and the number of fine-tuning iterations to optimize the NRX for specific radio environments using a ray tracing-based channel model. The resulting NRX is ready for deployment in a real-time 5G NR system and the source code including the TensorRT experiments is available online.
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- 2024
39. Generative Principal Component Regression via Variational Inference
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Talbot, Austin, Keller, Corey J, Carlson, David E, and Kotlar, Alex V
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Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
The ability to manipulate complex systems, such as the brain, to modify specific outcomes has far-reaching implications, particularly in the treatment of psychiatric disorders. One approach to designing appropriate manipulations is to target key features of predictive models. While generative latent variable models, such as probabilistic principal component analysis (PPCA), is a powerful tool for identifying targets, they struggle incorporating information relevant to low-variance outcomes into the latent space. When stimulation targets are designed on the latent space in such a scenario, the intervention can be suboptimal with minimal efficacy. To address this problem, we develop a novel objective based on supervised variational autoencoders (SVAEs) that enforces such information is represented in the latent space. The novel objective can be used with linear models, such as PPCA, which we refer to as generative principal component regression (gPCR). We show in simulations that gPCR dramatically improves target selection in manipulation as compared to standard PCR and SVAEs. As part of these simulations, we develop a metric for detecting when relevant information is not properly incorporated into the loadings. We then show in two neural datasets related to stress and social behavior in which gPCR dramatically outperforms PCR in predictive performance and that SVAEs exhibit low incorporation of relevant information into the loadings. Overall, this work suggests that our method significantly improves target selection for manipulation using latent variable models over competitor inference schemes.
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- 2024
40. CCAT: Nonlinear effects in 280 GHz aluminum kinetic inductance detectors
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Duell, Cody J., Austermann, Jason, Burgoyne, James R., Chapman, Scott C., Choi, Steve K., Crites, Abigail T., Freundt, Rodrigo G., Huber, Anthony I., Huber, Zachary B., Hubmayr, Johannes, Keller, Ben, Lin, Lawrence T., Middleton, Alicia M., Murphy, Colin C., Niemack, Michael D., Nikola, Thomas, Patel, Darshan, Sinclair, Adrian K., Smith, Ema, Stacey, Gordon J., Vaskuri, Anna, Vavagiakis, Eve M., Vissers, Michael, Walker, Samantha, and Wheeler, Jordan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Prime-Cam, a first-generation science instrument for the Atacama-based Fred Young Submillimeter Telescope, is being built by the CCAT Collaboration to observe at millimeter and submillimeter wavelengths using kinetic inductance detectors (KIDs). Prime-Cam's 280 GHz instrument module will deploy with two aluminum-based KID arrays and one titanium nitride-based KID array, totaling approximately 10,000 detectors at the focal plane, all of which have been fabricated and are currently undergoing testing. One complication of fielding large arrays of KIDs under dynamic loading conditions is tuning the detector tone powers to maximize signal-to-noise while avoiding bifurcation due to the nonlinear kinetic inductance. For aluminum-based KIDs, this is further complicated by additional nonlinear effects which couple tone power to resonator quality factors and resonant frequencies. While both nonequilibrium quasiparticle dynamics and two-level system fluctuations have been shown to give rise to qualitatively similar distortions, modeling these effects alongside nonlinear kinetic inductance is inefficient when fitting thousands of resonators on-sky with existing models. For this reason, it is necessary to have a detailed understanding of the nonlinear effects across relevant detector loading conditions, including how they impact on on-sky noise and how to diagnose the detector's relative performance. We present a study of the competing nonlinearities seen in Prime-Cam's 280 GHz aluminum KIDs, with a particular emphasis on the resulting distortions to the resonator line shape and how these impact detector parameter estimation., Comment: 10 pages, 4 figures, Conference proceedings from SPIE Astronomical Telescopes + Instrumentation (AS24)
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- 2024
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41. Container Data Item: An Abstract Datatype for Efficient Container-based Edge Computing
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Rahman, Md Rezwanur, Annapareddy, Tarun, Ebadi, Shirin, Natarajan, Varsha, Srinivasan, Adarsh, Keller, Eric, and Mishra, Shivakant
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
We present Container Data Item (CDI), an abstract datatype that allows multiple containers to efficiently operate on a common data item while preserving their strong security and isolation semantics. Application developers can use CDIs to enable multiple containers to operate on the same data, synchronize execution among themselves, and control the ownership of the shared data item during runtime. These containers may reside on the same server or different servers. CDI is designed to support microservice based applications comprised of a set of interconnected microservices, each implemented by a separate dedicated container. CDI preserves the important isolation semantics of containers by ensuring that exactly one container owns a CDI object at any instant and the ownership of a CDI object may be transferred from one container to another only by the current CDI object owner. We present three different implementations of CDI that allow different containers residing on the same server as well containers residing on different servers to use CDI for efficiently operating on a common data item. The paper provides an extensive performance evaluation of CDI along with two representative applications, an augmented reality application and a decentralized workflow orchestrator.
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- 2024
42. Defining, Identifying, and Estimating Causal Effects with the Potential Outcomes Framework: A Review for Education Research
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Bryan Keller and Zach Branson
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Causal inference involves determining whether a treatment (e.g., an education program) causes a change in outcomes (e.g., academic achievement). It is well-known that causal effects are more challenging to estimate than associations. Over the past 50 years, the potential outcomes framework has become one of the most widely used approaches for defining, identifying, and estimating causal effects. In this paper, we review the potential outcomes framework with a focus on potential outcomes notation to define individual and average causal effects. We then show how three canonical assumptions, Unconfoundedness, Positivity, and Consistency, may be used to identify average causal effects. The identification results motivate methods for estimating causal effects in practice, which include model-based estimators, such as regression, inverse probability weighting, and doubly robust estimation, and procedures that target covariate balance, such as matching and stratification. Examples and discussion are grounded in the context of a running example of a study aimed at assessing the causal effect of receipt of special education services on 5th grade mathematics achievement in school-aged children. Practical considerations for education research are discussed.
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- 2024
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43. Curriculum-Based Measurement in Languages Other than English: A Scoping Review and Call for Research
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Mariana Vazquez, Anna L. Laakman, Elias S. Loria Garro, Samantha X. L. Tan, and Milena A. Keller-Margulis
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Approximately five million students in US public schools have a home language other than English and are actively learning English (National Center for Education Statistics, 2020), indicating that a large number of students could be considered emergent bilingual (EB). Although measuring student skills in English may be informative, it does not provide a complete understanding of student skill and language development because the student's native language is not considered. Curriculum-based measurement (CBM) is often used in schools to measure student academic skills because of its utility in understanding student performance, educational decision-making, and progress monitoring. However, there is limited understanding of the extent of the empirical literature focused on CBMs in languages other than English. Results of this scoping review of the available empirical literature on CBM in other languages with linguistically diverse student populations highlight the need to further understand and expand this area of research given the rise of the emergent bilingual student population and dual-language program in US public schools.
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- 2024
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44. Exploring the Impact of COVID-19 Restrictions on Nursing Home Residents, Families, and Staffs Perceptions of Bioethical Principles: A Qualitative Study.
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Ge, Yimin, Xu, Shengjia, Capron, Alexander, Keller, Michelle, and Hlávka, Jakub
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COVID-19 ,bioethics ,long-term services and supports ,nursing homes ,policy ,qualitative methods ,Humans ,Nursing Homes ,COVID-19 ,Qualitative Research ,Male ,Female ,Family ,Aged ,SARS-CoV-2 ,Middle Aged ,Attitude of Health Personnel ,Adult ,Interviews as Topic ,Bioethical Issues ,Homes for the Aged ,Infection Control - Abstract
In this study, we employed a pre-interview survey and conducted interviews with nursing home staff members and residents/family members to understand their perceptions of whether the COVID-19 restrictions fulfilled obligations to nursing home residents under various principles, including autonomy, beneficence, nonmaleficence, justice, and privacy. We conducted 20 semi-structured interviews with staff members from 14 facilities, and 20 with residents and/or family members from 13 facilities. We used a qualitative descriptive study design and thematic analysis methodology to analyze the interviews. Findings from the pre-interview survey indicated that, compared to nursing home staff, residents and their families perceived lower adherence to bioethics principles during the pandemic. Qualitative analysis themes included specific restrictions, challenges, facility notifications, consequences, communication, and relationships between staff and residents/family members. Our study exposes the struggle to balance infection control with respecting bioethical principles in nursing homes, suggesting avenues for improving processes and policies during public health emergencies.
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- 2024
45. Factors influencing survival in sphingosine phosphate lyase insufficiency syndrome: a retrospective cross-sectional natural history study of 76 patients
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Keller, Nancy, Midgley, Julian, Khalid, Ehtesham, Lesmana, Harry, Mathew, Georgie, Mincham, Christine, Teig, Norbert, Khan, Zubair, Khosla, Indu, Mehr, Sam, Guran, Tulay, Buder, Kathrin, Xu, Hong, Alhasan, Khalid, Buyukyilmaz, Gonul, Weaver, Nicole, and Saba, Julie D
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Biological Sciences ,Biomedical and Clinical Sciences ,Clinical Sciences ,Organ Transplantation ,Transplantation ,Kidney Disease ,Genetics ,Rare Diseases ,Clinical Research ,Pediatric ,Renal and urogenital ,Humans ,Retrospective Studies ,Male ,Female ,Child ,Preschool ,Aldehyde-Lyases ,Child ,Infant ,Cross-Sectional Studies ,Adolescent ,Kidney Transplantation ,Mutation ,Nephrotic Syndrome ,SGPL1 ,Adrenal insufficiency ,Gene therapy ,Inborn error of metabolism ,Kidney transplantation ,Nephrotic syndrome ,Pyridoxal 5′-phosphate ,SPLIS ,Vitamin B6 ,Other Medical and Health Sciences ,Genetics & Heredity ,Clinical sciences - Abstract
BackgroundSphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a recently recognized inborn error of metabolism associated with steroid-resistant nephrotic syndrome as well as adrenal insufficiency and immunological, neurological, and skin manifestations. SPLIS is caused by inactivating mutations in SGPL1, encoding the pyridoxal 5'phosphate-dependent enzyme sphingosine-1-phosphate lyase, which catalyzes the final step of sphingolipid metabolism. Some SPLIS patients have undergone kidney transplantation, and others have been treated with vitamin B6 supplementation. In addition, targeted therapies including gene therapy are in preclinical development. In anticipation of clinical trials, it will be essential to characterize the full spectrum and natural history of SPLIS. We performed a retrospective analysis of 76 patients in whom the diagnosis of SPLIS was established in a proband with at least one suggestive finding and biallelic SGPL1 variants identified by molecular genetic testing. The main objective of the study was to identify factors influencing survival in SPLIS subjects.ResultsOverall survival at last report was 50%. Major influences on survival included: (1) age and organ involvement at first presentation; (2) receiving a kidney transplant, and (3) SGPL1 genotype. Among 48 SPLIS patients with nephropathy who had not received a kidney transplant, two clinical subgroups were distinguished. Of children diagnosed with SPLIS nephropathy before age one (n = 30), less than 30% were alive 2 years after diagnosis, and 17% were living at last report. Among those diagnosed at or after age one (n = 18), ~ 70% were alive 2 years after diagnosis, and 72% were living at time of last report. SPLIS patients homozygous for the SPL R222Q variant survived longer compared to patients with other genotypes. Kidney transplantation significantly extended survival outcomes.ConclusionOur results demonstrate that SPLIS is a phenotypically heterogeneous condition. We find that patients diagnosed with SPLIS nephropathy in the first year of life and patients presenting with prenatal findings represent two high-risk subgroups, whereas patients harboring the R222Q SGPL1 variant fare better than the rest. Time to progression from onset of proteinuria to end stage kidney disease varies from less than one month to five years, and kidney transplantation may be lifesaving.
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- 2024
46. Measuring entanglement along collective operators
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Descamps, Éloi, Keller, Arne, and Milman, Pérola
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Quantum Physics - Abstract
We introduce a framework for the study of multiparty entanglement by analyzing the behavior of collective variables. Throughout the manuscript, we explore a specific type of multiparty entanglement which can be detected through the fluctuation of a collective observable. We thoroughly analyze its properties and how it can be extended to mixed states while placing it within the context of the existing literature. The novelty of our approach also lies in the fact that we present a graphical point of view. This is done by introducing a spectral space on which the various properties of our entanglement quantifier have a direct pictorial interpretation. Notably, this approach proves particularly effective for assessing $k$-entanglement, as we show its ability to extend previously established inequalities. To enhance understanding, we also demonstrate how this framework applies to specific scenarios, encompassing both finite-dimensional cases and infinite-dimensional systems, the latter being exemplified by the time-frequency modal degree of freedom of co-propagating single photons., Comment: 15 pages, 5 figures
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- 2024
47. Key Science Goals for the Next Generation Very Large Array (ngVLA): Update from the ngVLA Science Advisory Council (2024)
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Wilner, David J., Matthews, Brenda C., McGuire, Brett, Bergner, Jennifer, Walter, Fabian, Somerville, Rachel, DeCesar, Megan, van der Horst, Alexander, Osten, Rachel, Corsi, Alessandra, Baker, Andrew, Bergin, Edwin, Bolatto, Alberto, Blecha, Laura, Bower, Geoff, Burke-Spolaor, Sarah, Carrasco-Gonzalez, Carlos, de Keller, Katherine, de Pater, Imke, Dickinson, Mark, Drout, Maria, Hallinan, Gregg, Hatsukade, Bunyo, Isella, Andrea, Izumi, Takuma, Johnson, Megan, Lazio, Joseph, Leroy, Adam, Maccarone, Thomas, Mills, Betsy, Momose, Munetake, Ng, Cherry, Rosolowsky, Eric, Sakai, Nami, and Zensus, Anton
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
In 2017, the next generation Very Large Array (ngVLA) Science Advisory Council, together with the international astronomy community, developed a set of five Key Science Goals (KSGs) to inform, prioritize and refine the technical capabilities of a future radio telescope array for high angular resolution operation from 1.2 - 116 GHz with 10 times the sensitivity of the Jansky VLA and ALMA. The resulting KSGs, which require observations at centimeter and millimeter wavelengths that cannot be achieved by any other facility, represent a small subset of the broad range of astrophysical problems that the ngVLA will be able address. This document presents an update to the original ngVLA KSGs, taking account of new results and progress in the 7+ years since their initial presentation, again drawing on the expertise of the ngVLA Science Advisory Council and the broader community in the ngVLA Science Working Groups. As the design of the ngVLA has also matured substantially in this period, this document also briefly addresses initial expectations for ngVLA data products and processing that will be needed to achieve the KSGs. The original ngVLA KSGs endure as outstanding problems of high priority. In brief, they are: (1) Unveiling the Formation of Solar System Analogues; (2) Probing the Initial Conditions for Planetary Systems and Life with Astrochemistry; (3) Charting the Assembly, Structure, and Evolution of Galaxies from the First Billion Years to the Present; (4) Science at the Extremes: Pulsars as Laboratories for Fundamental Physics; (5) Understanding the Formation and Evolution of Stellar and Supermassive Black Holes in the Era of Multi-Messenger Astronomy., Comment: 29 pages, 9 figures, ngVLA memo 125. arXiv admin note: text overlap with arXiv:1711.09960
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- 2024
48. AI-assisted Automated Short Answer Grading of Handwritten University Level Mathematics Exams
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Liu, Tianyi, Chatain, Julia, Kobel-Keller, Laura, Kortemeyer, Gerd, Willwacher, Thomas, and Sachan, Mrinmaya
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Mathematics - History and Overview - Abstract
Effective and timely feedback in educational assessments is essential but labor-intensive, especially for complex tasks. Recent developments in automated feedback systems, ranging from deterministic response grading to the evaluation of semi-open and open-ended essays, have been facilitated by advances in machine learning. The emergence of pre-trained Large Language Models, such as GPT-4, offers promising new opportunities for efficiently processing diverse response types with minimal customization. This study evaluates the effectiveness of a pre-trained GPT-4 model in grading semi-open handwritten responses in a university-level mathematics exam. Our findings indicate that GPT-4 provides surprisingly reliable and cost-effective initial grading, subject to subsequent human verification. Future research should focus on refining grading rules and enhancing the extraction of handwritten responses to further leverage these technologies., Comment: 17 pages, 12 figures, 4 tables
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- 2024
49. Varying water activity and momentum transfer on comet 67P/Churyumov-Gerasimenko from its non-gravitational forces and torques
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Attree, N., Gutiérrez, P., Groussin, O., Bürger, J., Keller, H. U., Kramer, T., Manghi, R. Lasagni, Läuter, M., Lemos, P., Markkanen, J., Marschall, R., and Schuckart, C.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We investigate the ability of a simultaneous fitting of comet 67P/Churyumov-Gerasimenko's non-gravitational forces, torques and total water-outgassing rate, as observed by Rosetta, to constrain complex thermophysical models of cometary material. We extend the previous work of fitting geographically defined surface outgassing models to the Rosetta observations by testing the effects of a more detailed geomorphological mapping, the resolution of the shape-model used, self-heating by neighbouring facets on the shape-model, thermal inertia in the outgassing solution, and variation in the momentum coupling between the gas and the nucleus. We also directly compare the non-gravitational acceleration curves available in the literature. We correct an error in the calculation of pole-orientation in the previous paper. We find that, under the assumptions of the model: non-gravitational forces and torques are driven by water sublimation from the nucleus, thermal inertia and self-heating have only minor effects, spatially uniform activity cannot explain 67P's non-gravitational dynamics, spatially uniform momentum transfer cannot explain 67P's non-gravitational dynamics, and different terrain types have different instantaneous responses to insolation. Consolidated terrain facing south on 67P/Churyumov-Gerasimenko has a high outgassing flux, steep response to insolation, and large gas momentum transfer coefficient. Meanwhile, that facing north behaves differently, producing low-to-no water outgassing, and with a lower momentum transfer efficiency. Dusty terrain also has a lower outgassing rate and momentum transfer efficiency, and either depletes its volatile component or is buried in fall-back as the comet approaches the Sun. Momentum transfer appears correlated with insolation, likely due to an increased enhancement in the gas temperature as the dust it flows through is heated., Comment: 11 pages, 8 figures, accepted for publication in A&A
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- 2024
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50. From total positivity to pure free resolutions
- Author
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Sam, Steven V and VandeBogert, Keller
- Subjects
Mathematics - Commutative Algebra ,Mathematics - Combinatorics ,Mathematics - Representation Theory - Abstract
Using the Jacobi-Trudi identity as a base, we establish parallels between the theory of totally positive integer sequences and Koszul algebras. We then focus on the case of quadric hypersurface rings and use this parallel to construct new analogues of Schur modules. We investigate some of their Lie-theoretic properties (and in more detail in a followup article) and use them to construct pure free resolutions for quadric hypersurface rings which are completely analogous to the construction given by Eisenbud, Fl{\o}ystad, and Weyman in the case of polynomial rings., Comment: 38 pages
- Published
- 2024
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