3,032 results on '"Kelly, D. P"'
Search Results
2. Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy
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Sultan, Hussein, Takeuchi, Yoshiko, Ward, Jeffrey P., Sharma, Naveen, Liu, Tian-Tian, Sukhov, Vladimir, Firulyova, Maria, Song, Yuang, Ameh, Samuel, Brioschi, Simone, Khantakova, Darya, Arthur, Cora D., White, J. Michael, Kohlmiller, Heather, Salazar, Andres M., Burns, Robert, Costa, Helio A., Moynihan, Kelly D., Yeung, Yik Andy, Djuretic, Ivana, Schumacher, Ton N., Sheehan, Kathleen C. F., Colonna, Marco, Allison, James P., Murphy, Kenneth M., Artyomov, Maxim N., and Schreiber, Robert D.
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- 2024
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3. Evaluating caregiver-clinician communication for tracheostomy placement in the neonatal intensive care unit: a qualitative inquiry
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Bushroe, Kylie M., Crisp, Kelly D., Politi, Mary C., Brennan, Steven K., and Housten, Ashley J.
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- 2024
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4. Lifetime Health and Economic Burden of Invasive Pneumococcal Diseases Attributable to V116 Serotypes Among Adults in the United States
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Yi, Zinan, Johnson, Kelly D., and Owusu-Edusei, Kwame
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- 2024
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5. Disparities in HIV Testing and PrEP Awareness for Black Women who Inject Drugs in San Francisco, California
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Brookins, Taqwa, Reagan, Danyion, Tate, Moranda, Suprasert, Bow, Taylor, Kelly D., Ruiz, Raul, Miller, Kassandra, Wilson, Erin C., and McFarland, Willi
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- 2024
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6. Tracking cycles of Phanerozoic opening and closing of ocean basins using detrital rutile and zircon geochronology and geochemistry
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Odlum, Margaret L, Capaldi, Tomas N, Thomson, Kelly D, and Stockli, Daniel F
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Earth Sciences ,Geochemistry ,Geology ,Geophysics ,Geochemistry & Geophysics ,Earth sciences - Abstract
Sedimentary basins provide a deep time archive of tectonic and Earth-surface processes that can be leveraged by detrital mineral U-Pb dating and geochemistry to track paleogeography, magmatism, and crustal evolution. Zircon preserves the long-term (billions of years) record of supercontinent cycles; however, it is biased toward preserving felsic crustal records. Detrital rutile complements the detrital zircon record by providing constraints on the time and temperature of rifting and mafic magmatism, metamorphism, exhumation of the middle and lower crust, subduction, and amagmatic orogenesis. We use detrital zircon U-Pb and detrital rutile U-Pb geochronology and trace element analysis of Permian to Eocene siliciclastic rocks in the southern Pyrenees to capture supercontinent cycles of ocean basins opening and closing. Detrital rutile age spectra show peaks at ca. 100 Ma associated with rifting and hyperextension in the Pyrenean realm, 200 Ma associated with the Central Atlantic Magmatic Province, and 330 Ma, 375 Ma, and 400 Ma associated with subduction and Rheic Ocean crust formation. Zr-in-rutile thermometry and rutile Cr-Nb systematics provide further insight into metamorphic facies (peak metamorphic temperatures) and source rock lithology (mafic versus felsic affinity). Detrital zircon age spectra have peaks at ca. 300 Ma, 450 Ma, and 600 Ma associated with major orogenic events and felsic magmatism, and Th/U ratios provide information on relative zircon formation temperatures. Comparison of these independent records shows that detrital rutile reflects rifting, magma-poor orogenesis, and oceanic lithospheric processes, while detrital zircon detects continental lithospheric processes. Integrated detrital zircon and rutile data sets archive past geological events across multiple Wilson cycles.
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- 2024
7. Challenges and Strengths Experienced by Fetal Alcohol Spectrum Disorder Diagnostic Clinics in Canada
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Kelly D. Harding, Colleen Burns, Christine Lafontaine, Andrew Wrath, Alicia Groom, Katherine Flannigan, Kathy Unsworth, and Audrey McFarlane
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Background: The Canadian fetal alcohol spectrum disorder (FASD) diagnostic guideline provides clinicians with the process and procedure to reach an accurate diagnosis. However, organisational structure, culture, and resource utilisation vary. The objectives of this study were to identify the key challenges and strengths of successful FASD diagnostic clinics. Method: Qualitative interviews were conducted with 12 key informants from 10 clinics representing different regions, populations served, and clinic structures. Data analysis was performed using iterative thematic inquiry. Results: Three themes related to challenges and four themes related to strengths were identified. Human resources were identified as both a challenge and strength. Additional challenges were diagnostic capacity and system level support. Additional strengths were clinic adaptability, relational connections, and culturally responsive approaches. Conclusions: FASD clinics are more alike than not in their approach to assessment and diagnosis. Some clinics are facing similar challenges that others have overcome, supporting the need for mentorship and consistent operating standards.
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- 2024
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8. Exploring Construct Measures Using Rasch Models and Discretization Methods to Analyze Existing Continuous Data
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Chen Qiu, Michael R. Peabody, and Kelly D. Bradley
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It is meaningful to create a comprehensive score to extract information from mass continuous data when they measure the same latent concept. Therefore, this study adopts the logic of psychometrics to conduct scales on continuous data under the Rasch models. This study also explores the effect of different data discretization methods on scale development by using financial profitability ratios as a demonstration. Results show that retaining more categories can benefit Rasch modeling because it can better inform the models. The dynamic clustering algorithm, k-median is a better method for extracting characteristic patterns of the continuous data and preparing the data for the Rasch model. This study illustrates that there is no one-way good discretization method for continuous data under the Rasch models. It is more reasonable to use the traditional algorithms if each continuous data variable has target benchmark(s), whereas the k-median clustering algorithm achieves good modeling results when benchmark information is lacking.
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- 2024
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9. Victim Sexual Arousal During Nonconsensual Sex: A Scoping Review
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Vandervoort, Mariève, Liosatos, Andrea, Aladhami, Haybet, Suschinsky, Kelly D., and Lalumière, Martin L.
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- 2024
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10. Continuing Low Awareness and Use of Pre-exposure Prophylaxis (PrEP) for HIV among People Who Inject Drugs (PWID), San Francisco, 2022
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Suprasert, Bow, Tate, Moranda, Reagan, Danyion, Ruiz, Raul, Gao, Katherine, McNaughton, Katherine, Miller, Kassandra, Marr, Alexander, Taylor, Kelly D., Wilson, Erin C., and McFarland, Willi
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- 2024
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11. Low Human Papillomavirus Vaccination in a Low-Income Urban Population
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Rojo, Elizabeth M, Taylor, Kelly D, and McFarland, Willi
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Public Health ,Health Sciences ,Infectious Diseases ,Women's Health ,Immunization ,HIV/AIDS ,Cancer ,HPV and/or Cervical Cancer Vaccines ,Prevention ,Vaccine Related ,Sexually Transmitted Infections ,Prevention of disease and conditions ,and promotion of well-being ,3.4 Vaccines ,Infection ,Good Health and Well Being ,Male ,Humans ,Female ,Papillomavirus Infections ,Human Papillomavirus Viruses ,Urban Population ,Papillomavirus Vaccines ,Vaccination ,Health Knowledge ,Attitudes ,Practice ,human papillomavirus ,HPV vaccine ,low-income ,health disparities ,Medical and Health Sciences ,Education ,Psychology and Cognitive Sciences ,Public health ,Applied and developmental psychology - Abstract
Despite widespread availability of human papillomavirus (HPV) vaccines and recommendations for routine use, awareness and uptake of HPV vaccination are not universal. We assessed self-reported history of HPV vaccination in a sample of low-income men and women recruited from the community using respondent-driven sampling as part of the National HIV Behavioral Surveillance (NHBS) survey in San Francisco. Of the 384 respondents, a minority (12.5%) reported they had received the HPV vaccine. In multivariate analysis, independent associations with HPV vaccination history were female sex (adjusted odds ratio [AOR] = 3.76, 95% confidence interval [CI] = [1.73, 8.17]), younger age (AOR = 0.89 per year, 95% CI = [0.86, 0.92]), and education above high school (AOR = 2.84, 95% CI = [1.37, 5.90]). Missed opportunities for HPV vaccination were evident in 84.4% of respondents having visited a health care provider in the last year, including 40.1% tested for a sexually transmitted infection, and entry into higher education programs (33.4%).
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- 2023
12. Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome
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Donovan, Micah G., Eduthan, Neetha P., Smith, Keith P., Britton, Eleanor C., Lyford, Hannah R., Araya, Paula, Granrath, Ross E., Waugh, Katherine A., Enriquez Estrada, Belinda, Rachubinski, Angela L., Sullivan, Kelly D., Galbraith, Matthew D., and Espinosa, Joaquin M.
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- 2024
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13. Mechanistic insights into SARS-CoV-2 spike protein induction of the chemokine CXCL10
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Ghazanfari, Davoud, Courreges, Maria Cecilia, Belinski, Lydia E., Hogrell, Michael J., Lloyd, Jacob, C. Bergmeier, Stephen, McCall, Kelly D., and Goetz, Douglas J.
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- 2024
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14. Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk
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Piening, Alexander, Ebert, Emily, Gottlieb, Carter, Khojandi, Niloufar, Kuehm, Lindsey M., Hoft, Stella G., Pyles, Kelly D., McCommis, Kyle S., DiPaolo, Richard J., Ferris, Stephen T., Alspach, Elise, and Teague, Ryan M.
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- 2024
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15. Responsive deep brain stimulation for the treatment of Tourette syndrome
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Okun, Michael S., Cagle, Jackson, Gomez, Julieth, Bowers, Dawn, Wong, Joshua, Foote, Kelly D., and Gunduz, Aysegul
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- 2024
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16. Towards the intentional multifunctionality of urban green infrastructure: a paradox of choice?
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Cook, Lauren M., Good, Kelly D., Moretti, Marco, Kremer, Peleg, Wadzuk, Bridget, Traver, Robert, and Smith, Virginia
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- 2024
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17. Estimating uninsured and underinsured women eligible for Minnesota’s Breast Cancer Screening Program
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Haynes, David, Hughes, Kelly D., Borrero, Maria, Haas, McKenna, Roach, Lauren, and Blaes, Anne
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- 2024
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18. Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome
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Micah G. Donovan, Neetha P. Eduthan, Keith P. Smith, Eleanor C. Britton, Hannah R. Lyford, Paula Araya, Ross E. Granrath, Katherine A. Waugh, Belinda Enriquez Estrada, Angela L. Rachubinski, Kelly D. Sullivan, Matthew D. Galbraith, and Joaquin M. Espinosa
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Science - Abstract
Abstract Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis of co-occurring conditions. The mechanisms underlying this variable developmental and clinical presentation await elucidation. We report an investigation of human chromosome 21 gene overexpression in hundreds of research participants with Down syndrome, which led to the identification of two major subsets of co-expressed genes. Using clustering analyses, we identified three main molecular subtypes of trisomy 21, based on differential overexpression patterns of chromosome 21 genes. We subsequently performed multiomics comparative analyses among subtypes using whole blood transcriptomes, plasma proteomes and metabolomes, and immune cell profiles. These efforts revealed strong heterogeneity in dysregulation of key pathophysiological processes across the three subtypes, underscored by differential multiomics signatures related to inflammation, immunity, cell growth and proliferation, and metabolism. We also observed distinct patterns of immune cell changes across subtypes. These findings provide insights into the molecular heterogeneity of trisomy 21 and lay the foundation for the development of personalized medicine approaches for the clinical management of Down syndrome.
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- 2024
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19. Lifetime Health and Economic Burden of Invasive Pneumococcal Diseases Attributable to V116 Serotypes Among Adults in the United States
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Zinan Yi, Kelly D. Johnson, and Kwame Owusu-Edusei
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Invasive pneumococcal disease ,Pneumococcal conjugate vaccine ,Markov model ,Health and economic burden ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Introduction This study aimed to estimate and compare the lifetime clinical and economic burden of invasive pneumococcal diseases (IPD) attributable to the serotypes contained in a new 21-valent pneumococcal conjugate vaccine (V116) vs. the 20-valent pneumococcal conjugate vaccine (PCV20) among adults aged 18 years and above in the USA. Methods A state-transition Markov model was used to track IPD cases and deaths as well as the associated direct medical costs (in 2023 US dollars) from a US healthcare payer perspective at 3% annual discount rate. The results were summarized for V116, PCV20, and eight unique serotypes contained in V116. A sensitivity analysis was conducted to determine the most influential inputs on the overall total direct lifetime cost. Results For the total population of US adults aged 18 years and above in 2021 (approx. 258 million residents), the estimated lifetime numbers of cases of IPD, post-meningitis sequelae (PMS), and IPD-related deaths attributable to the serotypes contained in V116 were approximately 1.4 million, 17,608, and 186,200, respectively, with a total discounted lifetime direct cost of $32.6 billion. A substantial proportion (approx. 31%) of those were attributable to the unique eight serotypes. The corresponding estimates for PCV20 were approximately 35% lower—934,000, 11,500, and 120,000, respectively—with a total discounted direct lifetime cost of $21.9 billion. Conclusion These results show that V116 serotypes (compared to PCV20) are associated with substantially higher clinical and economic burden of IPD. The addition of V116 to vaccination recommendations can help to reduce the residual burden of IPD in US adults.
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- 2024
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20. Mechanistic insights into SARS-CoV-2 spike protein induction of the chemokine CXCL10
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Davoud Ghazanfari, Maria Cecilia Courreges, Lydia E. Belinski, Michael J. Hogrell, Jacob Lloyd, Stephen C. Bergmeier, Kelly D. McCall, and Douglas J. Goetz
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SARS-CoV-2-Spike Protein ,CXCL10 (IP-10) ,Glycogen Synthase Kinase-3 ,TLR2 ,IRF ,NF-κB ,Medicine ,Science - Abstract
Abstract During a SARS-CoV-2 infection, macrophages recognize viral components resulting in cytokine production. While this response fuels virus elimination, overexpression of cytokines can lead to severe COVID-19. Previous studies suggest that the spike protein (S) of SARS-CoV-2 can elicit cytokine production via the transcription factor NF-κB and the toll-like receptors (TLRs). In this study, we found that: (i) S and the S2 subunit induce CXCL10, a chemokine implicated in severe COVID-19, gene expression by human macrophage cells (THP-1); (ii) a glycogen synthase kinase-3 inhibitor attenuates this induction; (iii) S and S2 do not activate NF-κB but do activate the transcription factor IRF; (iv) S and S2 do not require TLR2 to elicit CXCL10 production or activate IRF; and (v) S and S2 elicit CXCL10 production by peripheral blood mononuclear cells (PBMCs). We also discovered that the cellular response, or lack thereof, to S and S2 is a function of the recombinant S and S2 used. While such a finding raises the possibility of confounding LPS contamination, we offer evidence that potential contaminating LPS does not underly induced increases in CXCL10. Combined, these results provide insights into the complex immune response to SARS-CoV-2 and suggest possible therapeutic targets for severe COVID-19.
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- 2024
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21. Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk
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Alexander Piening, Emily Ebert, Carter Gottlieb, Niloufar Khojandi, Lindsey M. Kuehm, Stella G. Hoft, Kelly D. Pyles, Kyle S. McCommis, Richard J. DiPaolo, Stephen T. Ferris, Elise Alspach, and Ryan M. Teague
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Science - Abstract
Abstract Obesity is a well-established risk factor for human cancer, yet the underlying mechanisms remain elusive. Immune dysfunction is commonly associated with obesity but whether compromised immune surveillance contributes to cancer susceptibility in individuals with obesity is unclear. Here we use a mouse model of diet-induced obesity to investigate tumor-infiltrating CD8 + T cell responses in lean, obese, and previously obese hosts that lost weight through either dietary restriction or treatment with semaglutide. While both strategies reduce body mass, only dietary intervention restores T cell function and improves responses to immunotherapy. In mice exposed to a chemical carcinogen, obesity-related immune dysfunction leads to higher incidence of sarcoma development. However, impaired immunoediting in the obese environment enhances tumor immunogenicity, making the malignancies highly sensitive to immunotherapy. These findings offer insight into the complex interplay between obesity, immunity and cancer, and provide explanation for the obesity paradox observed in clinical immunotherapy settings.
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- 2024
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22. Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders
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Hitti, Frederick L, Widge, Alik S, Riva-Posse, Patricio, Malone, Donald A, Okun, Michael S, Shanechi, Maryam M, Foote, Kelly D, Lisanby, Sarah H, Ankudowich, Elizabeth, Chivukula, Srinivas, Chang, Edward F, Gunduz, Aysegul, Hamani, Clement, Feinsinger, Ashley, Kubu, Cynthia S, Chiong, Winston, Chandler, Jennifer A, Carbunaru, Rafael, Cheeran, Binith, Raike, Robert S, Davis, Rachel A, Halpern, Casey H, Vanegas-Arroyave, Nora, Markovic, Dejan, Bick, Sarah K, McIntyre, Cameron C, Richardson, R Mark, Dougherty, Darin D, Kopell, Brian H, Sweet, Jennifer A, Goodman, Wayne K, Sheth, Sameer A, and Pouratian, Nader
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Biomedical and Clinical Sciences ,Rehabilitation ,Neurosciences ,Brain Disorders ,Good Health and Well Being ,Humans ,United States ,Neurosurgery ,Deep Brain Stimulation ,Neurosurgical Procedures ,Mental Disorders ,Psychosurgery ,Deep brain stimulation ,Treatment resistant depression ,Obsessive compulsive disorder ,Tourette syndrome ,Neuromodulation ,Medical and Health Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveDespite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress.DesignThe ASSFN convened a meeting on June 3, 2022 in Atlanta, Georgia and included leaders from the fields of neurology, neurosurgery, and psychiatry along with colleagues from industry, government, ethics, and law. The goal was to review the current state of the field, assess for advances or setbacks in the interim six years, and suggest a future path forward. The participants focused on five areas of interest: interdisciplinary engagement, regulatory pathways and trial design, disease biomarkers, ethics of psychiatric surgery, and resource allocation/prioritization. The proceedings are summarized here.ConclusionThe field of surgical psychiatry has made significant progress since our last expert meeting. Although weakness and threats to the development of novel surgical therapies exist, the identified strengths and opportunities promise to move the field through methodically rigorous and biologically-based approaches. The experts agree that ethics, law, patient engagement, and multidisciplinary teams will be critical to any potential growth in this area.
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- 2023
23. Bayesian Semiparametric Model for Sequential Treatment Decisions with Informative Timing
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Oganisian, Arman, Getz, Kelly D., Alonzo, Todd A., Aplenc, Richard, and Roy, Jason A.
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Statistics - Methodology ,Computer Science - Machine Learning ,Statistics - Applications ,Statistics - Machine Learning - Abstract
We develop a Bayesian semi-parametric model for the estimating the impact of dynamic treatment rules on survival among patients diagnosed with pediatric acute myeloid leukemia (AML). The data consist of a subset of patients enrolled in the phase III AAML1031 clinical trial in which patients move through a sequence of four treatment courses. At each course, they undergo treatment that may or may not include anthracyclines (ACT). While ACT is known to be effective at treating AML, it is also cardiotoxic and can lead to early death for some patients. Our task is to estimate the potential survival probability under hypothetical dynamic ACT treatment strategies, but there are several impediments. First, since ACT was not randomized in the trial, its effect on survival is confounded over time. Second, subjects initiate the next course depending on when they recover from the previous course, making timing potentially informative of subsequent treatment and survival. Third, patients may die or drop out before ever completing the full treatment sequence. We develop a generative Bayesian semi-parametric model based on Gamma Process priors to address these complexities. At each treatment course, the model captures subjects' transition to subsequent treatment or death in continuous time under a given rule. A g-computation procedure is used to compute a posterior over potential survival probability that is adjusted for time-varying confounding. Using this approach, we conduct posterior inference for the efficacy of hypothetical treatment rules that dynamically modify ACT based on evolving cardiac function.
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- 2022
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24. Editorial: Toll-like receptor expression in transformed cells: role in tumor development and cancer therapies
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Fabian Benencia, Laura D. Alaniz, and Kelly D. McCall
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toll-like receptors ,tumor microenvironment (TME) ,cancer immune cell therapy ,B lymphocytes ,PAMP (pathogen-associated molecular pattern) ,DAMP (damage-associated molecular pattern) ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
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25. Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome
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Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, and Joaquin M. Espinosa
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CP: Developmental biology ,CP: Metabolism ,Biology (General) ,QH301-705.5 - Abstract
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia and dysregulated hematopoiesis have been documented in DS, but the underlying mechanisms and clinical consequences remain ill defined. We report an integrative multi-omic analysis of ∼400 research participants showing that people with DS display transcriptomic signatures indicative of elevated heme metabolism and increased hypoxic signaling across the lifespan, along with chronic overproduction of erythropoietin, elevated biomarkers of tissue-specific hypoxia, and hallmarks of stress erythropoiesis. Elevated heme metabolism, transcriptional signatures of hypoxia, and stress erythropoiesis are conserved in a mouse model of DS and associated with overexpression of select triplicated genes. These alterations are independent of the hyperactive interferon signaling characteristic of DS. These results reveal lifelong dysregulation of key oxygen-related processes that could contribute to the developmental and clinical hallmarks of DS.
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- 2024
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26. Antibrush Border Antibody Disease: A Case Series
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Michelle Pengshung, Vivek Charu, Megan L. Troxell, Shreeram Akilesh, Kelly D. Smith, and J. Ashley Jefferson
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Glomerular disease ,interstitial nephritis ,membranous nephropathy ,proximal tubule ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Antibrush border antibody (ABBA) disease is a rare cause of kidney disease characterized by progressive renal tubular injury associated with immune complex deposition along the basement membranes of the proximal tubule and circulating autoantibodies to brush border antigens. Several antigens have been identified as targets of autoantibodies in this disease, including low-density lipoprotein receptor related protein 2 (LRP2), cubilin, and amnionless proteins. We present 9 patients from 2 academic medical centers and describe the clinicopathologic characteristics and outcome data. All patients presented with acute kidney injury and proteinuria. Pathology confirmed immune complex deposition along proximal tubular basement membranes in all patients, but the majority (6/8) also showed segmental glomerular subepithelial immune complexes. Two of 3 patients treated with rituximab demonstrated stabilization of kidney function; 1 of these patients had mantle cell lymphoma. One patient with lung cancer showed stabilization of disease after treatment of the malignancy. The remaining patients progressed to end-stage kidney disease with either conservative therapy (3 patients) or immunosuppression with glucocorticoids (2 patients). This series highlights the poor prognosis of ABBA disease, but a potential benefit of anti-B cell therapy or treatment of an underlying malignancy in some cases.
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- 2024
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27. Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data
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Weissgerber, Tracey L., Gazda, Małgorzata Anna, Nilsonne, Gustav, ter Riet, Gerben, Cobey, Kelly D., Prieß-Buchheit, Julia, Noro, Jorge, Schulz, Robert, Tijdink, Joeri K., Bobrov, Evgeny, Bannach-Brown, Alexandra, Franzen, Delwen L., Moschini, Ugo, Naudet, Florian, Mansmann, Ulrich, Salholz-Hillel, Maia, Bandrowski, Anita, and Macleod, Malcolm R.
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- 2024
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28. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells
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Linder, Samantha J., Bernasocchi, Tiziano, Martínez-Pastor, Bárbara, Sullivan, Kelly D., Galbraith, Matthew D., Lewis, Caroline A., Ferrer, Christina M., Boon, Ruben, Silveira, Giorgia G., Cho, Hyo Min, Vidoudez, Charles, Shroff, Stuti, Oliveira-Costa, Joao P., Ross, Kenneth N., Massri, Rami, Matoba, Yusuke, Kim, Eugene, Rueda, Bo R., Stott, Shannon L., Gottlieb, Eyal, Espinosa, Joaquin M., and Mostoslavsky, Raul
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- 2023
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29. DNA barcoding and new records of Ornithodoros yumatensis from Central Mexico
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Grostieta, Estefania, Miranda-Caballero, Carlos I., Sánchez-Montes, Sokani, Colunga-Salas, Pablo, González, Carlos A. López, Valderas-Muñoz, Kelly D., Arciniega-Luna, Gustavo, and Aguilar-Tipacamú, Gabriela
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- 2023
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30. Responsive deep brain stimulation for the treatment of Tourette syndrome
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Michael S. Okun, Jackson Cagle, Julieth Gomez, Dawn Bowers, Joshua Wong, Kelly D. Foote, and Aysegul Gunduz
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Neuromodulation ,Tic ,DBS ,Closed loop ,Programming ,Selection ,Medicine ,Science - Abstract
Abstract To report the results of ‘responsive’ deep brain stimulation (DBS) for Tourette syndrome (TS) in a National Institutes of Health funded experimental cohort. The use of ‘brain derived physiology’ as a method to trigger DBS devices to deliver trains of electrical stimulation is a proposed approach to address the paroxysmal motor and vocal tic symptoms which appear as part of TS. Ten subjects underwent bilateral staged DBS surgery and each was implanted with bilateral centromedian thalamic (CM) region DBS leads and bilateral M1 region cortical strips. A series of identical experiments and data collections were conducted on three groups of consecutively recruited subjects. Group 1 (n = 2) underwent acute responsive DBS using deep and superficial leads. Group 2 (n = 4) underwent chronic responsive DBS using deep and superficial leads. Group 3 (n = 4) underwent responsive DBS using only the deep leads. The primary outcome measure for each of the 8 subjects with chronic responsive DBS was calculated as the pre-operative baseline Yale Global Tic Severity Scale (YGTSS) motor subscore compared to the 6 month embedded responsive DBS setting. A responder for the study was defined as any subject manifesting a ≥ 30 points improvement on the YGTSS motor subscale. The videotaped Modified Rush Tic Rating Scale (MRVTRS) was a secondary outcome. Outcomes were collected at 6 months across three different device states: no stimulation, conventional open-loop stimulation, and embedded responsive stimulation. The experience programming each of the groups and the methods applied for programming were captured. There were 10 medication refractory TS subjects enrolled in the study (5 male and 5 female) and 4/8 (50%) in the chronic responsive eligible cohort met the primary outcome manifesting a reduction of the YGTSS motor scale of ≥ 30% when on responsive DBS settings. Proof of concept for the use of responsive stimulation was observed in all three groups (acute responsive, cortically triggered and deep DBS leads only). The responsive approach was safe and well tolerated. TS power spectral changes associated with tics occurred consistently in the low frequency 2–10 Hz delta-theta-low alpha oscillation range. The study highlighted the variety of programming strategies which were employed to achieve responsive DBS and those used to overcome stimulation induced artifacts. Proof of concept was also established for a single DBS lead triggering bi-hemispheric delivery of therapeutic stimulation. Responsive DBS was applied to treat TS related motor and vocal tics through the application of three different experimental paradigms. The approach was safe and effective in a subset of individuals. The use of different devices in this study was not aimed at making between device comparisons, but rather, the study was adapted to the current state of the art in technology. Overall, four of the chronic responsive eligible subjects met the primary outcome variable for clinical effectiveness. Cortical physiology was used to trigger responsive DBS when therapy was limited by stimulation induced artifacts.
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- 2024
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31. Towards the intentional multifunctionality of urban green infrastructure: a paradox of choice?
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Lauren M. Cook, Kelly D. Good, Marco Moretti, Peleg Kremer, Bridget Wadzuk, Robert Traver, and Virginia Smith
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Urbanization. City and country ,HT361-384 ,City planning ,HT165.5-169.9 - Abstract
Abstract Decades of research on multifunctional Green Infrastructure (GI) has yet to translate into holistic implementation in the built environment. This oversight stems from assumptions that many ecosystem services occur passively and thus potential synergies are overlooked during planning and design. This study offers specific guidance for coordinating GI planning, design, and construction by examining the current state of academic literature on these aspects. It identifies 15 GI elements (e.g., green roofs) and 15 objectives (e.g., biodiversity) to collectively consider before implementation. The literature tends to isolate discussions of “engineered” GI elements with water-related objectives, while more “natural” GI are linked to biodiversity and human well-being. Coordinating across GI objectives and elements remains imperative, but evaluating too many options risks a paradox of choice. This study recommends short-term adherence to principles of adaptive design and, in the long-term, reemphasizes multifunctionality assessments, inter and transdisciplinary collaboration, and political will.
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- 2024
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32. Challenges and Opportunities for the Clinical Translation of Spatial Transcriptomics Technologies
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Kelly D. Smith, David K. Prince, James W. MacDonald, Theo K. Bammler, and Shreeram Akilesh
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kidney biopsy ,kidney pathology ,spatial transcriptomics ,gene expression ,clinical translation ,glomerular diseases ,precision medicine ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background: The first spatially resolved transcriptomics platforms, GeoMx (Nanostring) and Visium (10x Genomics) were launched in 2019 and were recognized as the method of the year by Nature Methods in 2020. The subsequent refinement and expansion of these and other technologies to increase -plex, work with formalin-fixed paraffin-embedded tissue, and analyze protein in addition to gene expression have only added to their significance and impact on the biomedical sciences. In this perspective, we focus on two platforms for spatial transcriptomics, GeoMx and Visium, and how these platforms have been used to provide novel insight into kidney disease. The choice of platform will depend largely on experimental questions and design. The application of these technologies to clinically sourced biopsies presents the opportunity to identify specific tissue biomarkers that help define disease etiology and more precisely target therapeutic interventions in the future. Summary: In this review, we provide a description of the existing and emerging technologies that can be used to capture spatially resolved gene and protein expression data from tissue. These technologies have provided new insight into the spatial heterogeneity of diseases, how reactions to disease are distributed within a tissue, which cells are affected, and molecular pathways that predict disease and response to therapy. Key Message: The upcoming years will see intense use of spatial transcriptomics technologies to better define the pathophysiology of kidney diseases and develop novel diagnostic tests to guide personalized treatments for patients.
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- 2024
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33. Toddler Teacher Job Strain, Resources, and Classroom Quality
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Henry, Adrienne J. L., Hatfield, Bridget E., and Chandler, Kelly D.
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Early care and education (ECE) settings are influential in shaping children's early experiences. Informed by the Job Demands-Resources model, this study had two aims. First, we examined how ECE teachers' physical (i.e. muscular skeletal strain and infectious disease experience) and psychological (i.e. depression and job dissatisfaction) job strain was associated with the quality of their interactions with children. Second, we tested whether job resources, including supervisor and co-worker support, buffered these associations. We examined survey responses from 44 toddler teachers working in centre-based classrooms with children aged 15-36 months and assessed the quality of the classroom using the Classroom Assessment Scoring System -- Toddler (CLASS-T; La Paro et al. 2012. "Classroom Assessment Scoring System (CLASS) Manual, Toddler." Baltimore, MD: Paul H. Brookes). Results indicated that teachers experienced a range of physical and psychological job strain. Co-worker and supervisor support were not significant moderators of the ECE teachers' job strain-classroom quality association. However, contrary to the mechanisms theorised within the Job Demands-Resources model, a main effect of co-worker and supervisor support on classroom quality, such that higher levels of perceived social support was related to higher classroom quality. Due to the significance of classroom quality for young children, understanding ways to create a work environment of rich social support stands to benefit teachers and the toddlers in their care.
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- 2023
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34. Physical Therapy Students' Attitudes toward Older Adults
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Kelly D. Hawthorne
- Abstract
The purpose of this study was to investigate physical therapy students' attitudes toward working with older adults. A basic qualitative design geared toward discovering physical therapy students' attitudes, where themes emerge from the findings, was used. The setting was a CAPTE Accredited Doctor of Physical Therapy (DPT) program in a 4-year, private not-for-profit university in a large city in the Midwest with a Carnegie Classification of Doctoral Universities: High Research Activity. The major themes that emerged from semi-structured participant interviews were 1) Congruence of emotion and thought due to early exposure, 2) A potpourri of emotions and thoughts, 3) Peer influence, 4) Relevancy of clinical experiences, 5) Clinical mentorship, and 6) University mission. Overall, built on the long-standing relationship with grandparents, physical therapy students interviewed in this study had emotional and positive attitudes toward older adults. In addition, the mentoring provided by clinical instructors in the clinical education portion of the curriculum was perceived to be the most beneficial when it came to preparing physical therapy students for practice with older adults. Of course, more research on physical therapy students' attitudes toward older adults is needed. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2023
35. Low Human Papillomavirus Vaccination in a Low-Income Urban Population
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Rojo, Elizabeth M., Taylor, Kelly D., and McFarland, Willi
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Despite widespread availability of human papillomavirus (HPV) vaccines and recommendations for routine use, awareness and uptake of HPV vaccination are not universal. We assessed self-reported history of HPV vaccination in a sample of low-income men and women recruited from the community using respondent-driven sampling as part of the National HIV Behavioral Surveillance (NHBS) survey in San Francisco. Of the 384 respondents, a minority (12.5%) reported they had received the HPV vaccine. In multivariate analysis, independent associations with HPV vaccination history were female sex (adjusted odds ratio [AOR] = 3.76, 95% confidence interval [CI] = [1.73, 8.17]), younger age (AOR = 0.89 per year, 95% CI = [0.86, 0.92]), and education above high school (AOR = 2.84, 95% CI = [1.37, 5.90]). Missed opportunities for HPV vaccination were evident in 84.4% of respondents having visited a health care provider in the last year, including 40.1% tested for a sexually transmitted infection, and entry into higher education programs (33.4%).
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- 2023
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36. Cardiotoxicity of CPX-351 in children and adolescents with relapsed AML: a Children's Oncology Group report
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Kasey J. Leger, Michael J. Absalon, Biniyam G. Demissei, Amanda M. Smith, Robert B. Gerbing, Todd A. Alonzo, Hari K. Narayan, Betsy A. Hirsch, Jessica A. Pollard, Bassem I. Razzouk, Kelly D. Getz, Richard Aplenc, E. Anders Kolb, Bonnie Ky, and Todd M. Cooper
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CPX-351 ,pediatric acute myeloid leukemia (AML) ,relapse ,cardiotoxicity ,liposomal anthracycline ,cardiac biomarkers ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
IntroductionAnthracyclines are effective in treating acute myeloid leukemia (AML) but limited by cardiotoxicity. CPX-351, a liposomal daunorubicin and cytarabine, may provide therapeutic benefit with less cardiotoxicity. Acute changes in left ventricular systolic function and cardiac biomarkers were evaluated after a cycle of CPX-351 in children with relapsed AML treated on the phase 1/2 Children's Oncology Group study, AAML1421.MethodsSubjects received 135 units/m2/dose of CPX-351 on days 1, 3, and 5 as cycle 1. Echocardiograms were performed and centrally quantitated at baseline and at the end of cycle 1 (day 29 +/− 1 week). High sensitivity troponin (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured at baseline and serially through the end of cycle 1 (days 5, 8, 15, 22 and 29). Differences between baseline and post-CPX-351 echo/biomarker measures were analyzed using Wilcoxon signed rank tests. Linear regression was used to model post-CPX-351 left ventricular ejection fraction (LVEF) with cTnT/NT-proBNP at each time point, controlling for baseline LVEF. Cancer therapy related cardiac dysfunction (CTRCD) was defined as a decline in LVEF of ≥10%–
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- 2024
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37. The application of Trichoderma spp., an old but new useful fungus, in sustainable soil health intensification: A comprehensive strategy for addressing challenges
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Waleed Asghar, Kelly D. Craven, Ryota Kataoka, Ahmad Mahmood, Naveed Asghar, Taqi Raza, and Farhan Iftikhar
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Trichoderma spp. ,Soil microbiome ,Plant growth promoter ,Biofertilizer ,Sustainable agriculture ,Plant ecology ,QK900-989 - Abstract
Trichoderma spp. represents a group of advantageous soil-borne microorganisms known for their capacity to enhance soil quality, facilitate plant growth, and serve as biocontrol agents against various plant diseases. Employing direct antagonism and competition, particularly within the rhizosphere, Trichoderma orchestrates microbial interactions, shaping the soil microbiome. This review comprehensively explores the potential applications and role of Trichoderma in soil for fostering sustainable agriculture. The initial focus is on how Trichoderma spp. contribute to plant growth and development, especially under biotic and abiotic stress conditions, and provide protection against plant pathogens. The article delves into diverse applications of Trichoderma species in agriculture, encompassing their use as biocontrol agents, biofertilizers, and seed treatments, collectively contributing to the sustainability of agricultural practices. A thorough examination of the advantages and challenges associated with Trichoderma utilization in agriculture is presented, including its impact on fungal and bacterial communities within the soil, crucial for safeguarding and preserving soil health. Notably, agricultural chemicals, including fungicides, pose a potential threat to Trichoderma species. Despite these challenges, the review highlights the numerous benefits of integrating Trichoderma spp. into agriculture, emphasizing its role in improving soil quality, enhancing agricultural productivity, and reducing reliance on chemical pesticides. The communication capabilities of Trichoderma with plants, whether through root colonization or acting as an endophyte, further solidify its potential as a biocontrol agent and plant growth promoter for diverse crop species. The safety, affordability, efficacy, and eco-friendly nature of Trichoderma spp. position them as a promising choice for sustainable agriculture expansion.
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- 2024
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38. Household income and health‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research
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Haley Newman, Yimei Li, Yuan‐Shung V. Huang, Caitlin W. Elgarten, Regina M. Myers, Jenny Ruiz, Daniel J. Zheng, Alison Barz Leahy, Catherine Aftandilian, Staci D. Arnold, Kira Bona, M. Monica Gramatges, Mallorie B. Heneghan, Kelly W. Maloney, Arunkumar J. Modi, Rajen J. Mody, Elaine Morgan, Jeffrey Rubnitz, Naomi Winick, Jennifer J. Wilkes, Alix E. Seif, Brian T. Fisher, Richard Aplenc, and Kelly D. Getz
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acute myeloid leukemia ,epidemiology ,pediatric cancer ,quality of Life ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective Examine the influence of household income on health‐related quality of life (HRQOL) among children with newly diagnosed acute myeloid leukemia (AML). Design Secondary analysis of data prospectively collected from pediatric patients receiving treatment for AML at 14 hospitals across the United States. Exposure Household income was self‐reported on a demographic survey. The examined mediators included the acuity of presentation and treatment toxicity. Outcome Caregiver proxy reported assessment of patient HRQOL from the Peds QL 4.0 survey. Result Children with AML (n = 131) and caregivers were prospectively enrolled to complete PedsQL assessments. HRQOL scores were better for patients in the lowest versus highest income category (mean ± SD: 76.0 ± 14 household income
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- 2024
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39. ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer
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Mota, Ines, Patrucco, Enrico, Mastini, Cristina, Mahadevan, Navin R., Thai, Tran C., Bergaggio, Elisa, Cheong, Taek-Chin, Leonardi, Giulia, Karaca-Atabay, Elif, Campisi, Marco, Poggio, Teresa, Menotti, Matteo, Ambrogio, Chiara, Longo, Dario L., Klaeger, Susan, Keshishian, Hasmik, Sztupinszki, Zsófia M., Szallasi, Zoltan, Keskin, Derin B., Duke-Cohan, Jonathan S., Reinhold, Bruce, Carr, Steven A., Wu, Catherine J., Moynihan, Kelly D., Irvine, Darrell J., Barbie, David A., Reinherz, Ellis L., Voena, Claudia, Awad, Mark M., Blasco, Rafael B., and Chiarle, Roberto
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- 2023
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40. Pneumococcal vaccination coverage among US adults enrolled in Medicaid and newly diagnosed with underlying medical conditions
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Junqing Liu, Kelly D. Johnson, and Linda Shoener Dunham
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pneumococcal vaccination coverage ,adults ,medicaid ,chronic conditions ,immunocompromising conditions ,Internal medicine ,RC31-1245 - Abstract
Background Adults with chronic or immunocompromising conditions have an elevated risk of invasive pneumococcal disease, yet their pneumococcal vaccination rates remain low. Methods This retrospective cohort study used the IBM MarketScan® Multi-State Medicaid database to examine pneumococcal vaccination uptake among adults 19–64 years of age with underlying conditions. Gompertz accelerated failure time model was used to examine factors associated with vaccination. Results In the study population of 108,159 adults, the vaccination rate was 4.1% after 1 year of follow-up and 19.4% after 10 years. The mean time from initial diagnosis to vaccination was 3.9 years. Adults aged 35–49 and 50–64 years (relative to 19–34) or those receiving an influenza vaccination were more likely to receive a pneumococcal vaccination. Adults with HIV/AIDS were more likely, while adults with chronic heart or lung disease, alcohol or tobacco dependence, or cancer were less likely to be vaccinated than adults with diabetes mellitus. Adults diagnosed by specialists were less likely to be vaccinated than those diagnosed by primary care providers. Conclusions The rates of pneumococcal vaccination among adults with Medicaid plans and underlying conditions were well under Healthy People Initiative targets. Insights into factors associated with vaccination can inform efforts to improve vaccination rates among this population.
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- 2023
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41. Health Coaching Across the Stages of Vaccine Readiness and Action: A Practical Guide for Public Health Nurses
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Harris, Orlando O, Taylor, Kelly D, Maher, Andrew, and Willard-Grace, Rachel
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Health Services and Systems ,Nursing ,Public Health ,Health Sciences ,Vaccine Related ,Biotechnology ,Immunization ,Prevention ,Good Health and Well Being ,Health Personnel ,Humans ,Mentoring ,Nurses ,Nurses ,Public Health ,Vaccines ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Published
- 2022
42. Applying the Rasch Model to Evaluate the Self-Directed Online Learning Scale (SDOLS) for Graduate Students
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Yang, Hongwei, Su, Jian, and Bradley, Kelly D.
- Abstract
With the rapid growth of online learning and the increased attention paid to student attrition in online programs, much research has been aimed at studying the effectiveness of online education to improve students' online learning experience and student retention. Utilizing the online learning literature as a multi-faceted theoretical framework, the study developed and employed a new survey instrument. The Self-Directed Online Learning Scale (SDOLS) was used to examine graduate student perceptions of effectiveness of online learning environments as demonstrated by their ability to take charge of their own learning, and to identify key factors in instructional design for effective improvements. The study applied the Rasch rating scale model to evaluate and validate SDOLS through a psychometric lens to establish the reliability and validity of SDOLS. Results from Rasch analysis addressed two research questions. First, evidence was found to generally support the new instrument as being psychometrically sound but three problematic items were also identified as grounds for future improvement of SDOLS. Second, the study assessed the importance of various factors as measured by the SDOLS items in contributing to students' ability to self-manage their own online learning. Finally, the new instrument is expected to contribute to the work of various stakeholders in online education and can serve to improve students' online learning experience and effectiveness, increase online retention rates, and reduce online dropouts.
- Published
- 2020
43. Moderated Mediation Analysis: A Review and Application to School Climate Research
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Edwards, Kelly D. and Konold, Timothy R.
- Abstract
Moderated mediation analysis is a valuable technique for assessing whether an indirect effect is conditional on values of a moderating variable. We review the basis of moderation and mediation and their integration into a combined model of moderated mediation within a regression framework. Thereafter, an analytic and interpretive illustration of the technique is provided in the context of a substantive school climate research question. The illustration is based on a sample of 318 high schools that examines whether school-wide student engagement mediates the association between the prevalence of teasing and bullying (PTB) and academic achievement on a state-mandated reading exam; and whether this indirect effect was moderated by student perceptions of teacher support.
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- 2020
44. Testing for All: An Exploration of Disproportionality in the Georgia Alternate Assessments
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Childers, Kelly D., Arrastia-Chisholm, Meagan, Adams, Katharine S., and Kelley, Heather M.
- Abstract
Public schools use standardized testing to measure students' academic achievement at the conclusion of each school year. Students with severe cognitive disabilities are evaluated through the Georgia Alternate Assessment (GAA). The purpose of this descriptive study was to describe the demographic characteristics of students who took the Georgia Alternate Assessment (GAA) and students who took the Georgia Milestones End of Grade Assessment (EOG) in English/Language Arts using publicly available data from the 2014-2015 academic year. Additionally, the study investigated disproportionality of certain student groups who took the GAA and EOG in English/Language Arts. A series of chi-square analyses resulted in significant overrepresentation of male, Black or African American, and economically disadvantaged students on the GAA. Our results indicated underrepresentation of migrant, limited English proficient, and Hispanic students on the GAA. Results of the present study have important implications for the student referral process and inclusion criteria for alternate assessment.
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- 2020
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45. Comparative study of a broad qPCR panel and centrifugal flotation for detection of gastrointestinal parasites in fecal samples from dogs and cats in the United States
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Leutenegger, Christian M., Lozoya, Cecilia E., Tereski, Jeffrey, Andrews, Jan, Mitchell, Kelly D., Meeks, Cathy, Willcox, Jennifer L., Freeman, Gregory, Richmond, Holly L., Savard, Christian, and Evason, Michelle D.
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- 2023
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46. Effective inclusion practices for neurodiverse children and adolescents in informal STEM learning: a systematic review protocol
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Jenson, Ronda J., Lee, Michele S, Day, Arden D., Hughes, Amy E., Maroushek, Emma E., and Roberts, Kelly D.
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- 2023
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47. A harmonized analysis of five Canadian pregnancy cohort studies: exploring the characteristics and pregnancy outcomes associated with prenatal alcohol exposure
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Schmidt, Rose A., Wey, Tina W., Harding, Kelly D., Fortier, Isabel, Atkinson, Stephanie, Tough, Suzanne, Letourneau, Nicole, Knight, Julia A., Fraser, William D., and Bocking, Alan
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- 2023
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48. Encyclia naranjapatensis Dodson (Orchidaceae), a new record for the Peruvian flora
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Luis Ocupa-Horna, Kelly D. Agurto-Palomino, Ayrtón Chorres-Arica, and Iván Tamayo-Cen
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Ayabaca ,Laeliinae ,floristic novelty ,Piura ,Sicchez ,Botany ,QK1-989 - Abstract
Background: Encyclia, is a genus with more than 200 species in the Neotropics, eight of which have been previously reported from Peru. During the evaluation of the orchid flora in the forests of the Sicchez district, a small population of an Encyclia species was found that could not be unequivocally matched to any previously known species in the country. Questions: Will the recent explorations of Northern Peru result in the reporting of new taxa for the country? Studied species: Orchidaceae, Laeliinae, Encyclia Hook, Encyclia naranjapatensis Dodson Study site and dates: Sicchez District, Ayabaca Province, Piura Department, Peru, 2022-2023. Methods: Specimens were collected and determined by consulting botanical collections available online, taxonomic treatments, checklists, and specialized literature. The conservation status was assessed according to IUCN methodology. Results: We report a novelty for Peru, Encyclia naranjapatensis, and an updated description including morphological information on relevant structures that will be used to diagnose this entity. In addition, E. naranjapatensis is part of a basal clade referred to as the E. diurna species group. The conservation status assessment results in Endangered and the species is linked to the Seasonally Dry Tropical Forest, an endangered ecosystem throughout the Neotropics. Conclusions: The recent entity located in Peru correspond to Encyclia naranjapatensis. This discovery allows us to investigate the geographical limits, discuss the phylogenetic and ecological affinities, update the original description, and evaluate its conservation status.
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- 2024
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49. Cardiology researchers’ practices and perceived barriers to open science: an international survey
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David Moher, Kelly D Cobey, Benjamin Hibbert, Sanam Ebrahimzadeh, Mohsen Alayche, Sara Saba, Nana Yaa Barnes, and Emilio Alarcón
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective Open science is a movement and set of practices to conduct research more transparently. Implementing open science will significantly improve public access and supports equity. It also has the potential to foster innovation and reduce duplication through data and materials sharing. Here, we survey an international group of researchers publishing in cardiovascular journals regarding their perceptions and practices related to open science.Methods We identified the top 100 ‘Cardiology and Cardiovascular Medicine’ subject category journals from the SCImago journal ranking platform. This is a publicly available portal that draws from Scopus. We then extracted the corresponding author’s name and email from all articles published in these journals between 1 March 2021 and 1 March 2022. Participants were sent a purpose-built survey about open science. The survey contained primarily multiple choice and scale-based questions for which we report count data and percentages. For the few text-based responses we conducted thematic content analysis.Results 198 participants responded to our survey. Participants had a mean response of 6.8 (N=197, SD=1.8) on a 9-point scale with endpoints, not at all familiar (1) and extremely familiar (9), when indicating how familiar they were with open science. When asked about where they obtained open science training, most participants indicated this was done on the job self-initiated while conducting research (n=103, 52%), or that they had no formal training with respect to open science (n=72, 36%). More than half of the participants indicated they would benefit from practical support from their institution on how to perform open science practices (N=106, 54%). A diversity of barriers to each of the open science practices presented to participants were acknowledged. Participants indicated that funding was the most essential incentive to adopt open science.Conclusions It is clear that policy alone will not lead to the effective implementation of open science. This survey serves as a baseline for the cardiovascular research community’s open science performance and perception and can be used to inform future interventions and monitoring.
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- 2024
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50. Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements
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Kara A. Johnson, Nico U. F. Dosenbach, Evan M. Gordon, Cristin G. Welle, Kevin B. Wilkins, Helen M. Bronte-Stewart, Valerie Voon, Takashi Morishita, Yuki Sakai, Amanda R. Merner, Gabriel Lázaro-Muñoz, Theresa Williamson, Andreas Horn, Ro'ee Gilron, Jonathan O'Keeffe, Aryn H. Gittis, Wolf-Julian Neumann, Simon Little, Nicole R. Provenza, Sameer A. Sheth, Alfonso Fasano, Abbey B. Holt-Becker, Robert S. Raike, Lisa Moore, Yagna J. Pathak, David Greene, Sara Marceglia, Lothar Krinke, Huiling Tan, Hagai Bergman, Monika Pötter-Nerger, Bomin Sun, Laura Y. Cabrera, Cameron C. McIntyre, Noam Harel, Helen S. Mayberg, Andrew D. Krystal, Nader Pouratian, Philip A. Starr, Kelly D. Foote, Michael S. Okun, and Joshua K. Wong
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deep brain stimulation (DBS) ,artificial intelligence ,neuroethics ,interventional psychiatry ,adaptive DBS ,Parkinson's disease ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9–11, 2023 in Gainesville, Florida with the theme of “Pushing the Forefront of Neuromodulation”. The keynote speaker was Dr. Nico Dosenbach from Washington University in St. Louis, Missouri. He presented his research recently published in Nature inn a collaboration with Dr. Evan Gordon to identify and characterize the somato-cognitive action network (SCAN), which has redefined the motor homunculus and has led to new hypotheses about the integrative networks underpinning therapeutic DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers, and researchers (from industry and academia) can freely discuss current and emerging DBS technologies, as well as logistical and ethical issues facing the field. The group estimated that globally more than 263,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. This year's meeting was focused on advances in the following areas: cutting-edge translational neuromodulation, cutting-edge physiology, advances in neuromodulation from Europe and Asia, neuroethical dilemmas, artificial intelligence and computational modeling, time scales in DBS for mood disorders, and advances in future neuromodulation devices.
- Published
- 2024
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