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7 results on '"Kelly Credille"'

1. Supplementary Figure 3 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

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Published
2023
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2. Supplementary Materials and Methods, Tables 1-2 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

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Published
2023
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3. Supplementary Figure Legends 1-4 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

Abstract

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Published
2023
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4. Supplementary Figure 4 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

Abstract

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Published
2023
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5. Supplementary Figure 1 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

Abstract

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Published
2023
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6. Data from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

Abstract

LY573636-sodium (tasisulam) is a small molecule antitumor agent with a novel mechanism of action currently being investigated in a variety of human cancers. In vitro, tasisulam induced apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Using high content cellular imaging and subpopulation analysis of a wide range of in vitro and in vivo cancer models, tasisulam increased the proportion of cells with 4N DNA content and phospho-histone H3 expression, leading to G2–M accumulation and subsequent apoptosis. Tasisulam also blocked VEGF, epidermal growth factor, and fibroblast growth factor–induced endothelial cell cord formation but did not block acute growth factor receptor signaling (unlike sunitinib, which blocks VEGF-driven angiogenesis at the receptor kinase level) or induce apoptosis in primary endothelial cells. Importantly, in vivo phenocopying of in vitro effects were observed in multiple human tumor xenografts. Tasisulam was as effective as sunitinib at inhibiting neovascularization in a Matrigel plug angiogenesis assay in vivo and also caused reversible, non G2–M–dependent growth arrest in primary endothelial cells. Tasisulam also induced vascular normalization in vivo. Interestingly, the combination of tasisulam and sunitinib significantly delayed growth of the Caki-1 renal cell carcinoma model, whereas neither agent was active alone. These data show that tasisulam has a unique, dual-faceted mechanism of action involving mitotic catastrophe and antiangiogenesis, a phenotype distinct from conventional chemotherapies and published anticancer agents. Mol Cancer Ther; 10(11); 2168–78. ©2011 AACR.

Published
2023
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7. Supplementary Figure 2 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

Author

Louis Stancato, Michele C. Smith, Robert Ilaria, Marcio Chedid, Andrew Capen, Lysiane Huber, Darryl Ballard, Kelly Credille, Glenn Evans, Xiang Ye, Debra Young, James Cook, Wayne Blosser, Julie Stewart, Robert Van Horn, Michele Dowless, Sudhakar Chintharlapalli, Mark Uhlik, and Timothy Meier

Abstract

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Published
2023
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