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Pumps are irreplaceable products in various systems and processes. Pumps can be manufactured in various size in industry. The mini pumps are commonly used in some household electrical appliances, automobile etc. Some pumping applications is required two outlet ports. The use of two pumps in such a case brings high costs. Instead, pumping on two different lines with a single pump provides both a more compact design and lower cost, if the system is available. In this study, it is aimed to design a single-suction and double-outlet pump by using a single electric motor. For this purpose, a conceptual design for the pump has been proposed and design parameters which have an effect on the pump performance have been determined. Pump performance have been calculated by using the ANSYS Fluent, Computational Fluid Dynamics (CFD) code considering to multiphase flow, and optimization studies have been performed with the determined parameters. The pumps have been obtained by the optimization works have been manufactured and tested to investigate whether the pumps provide the expected operating conditions and performances. Finally, the CFD results have been verified by the tests and the pump provided the expected operating conditions and performances.

Neurogenesis during embryonic and adult life is tightly regulated by a network of transcriptional, growth and hormonal factors. Emerging evidence indicates that activation of the stress response, via the associated glucocorticoid increase, reduces neurogenesis and contributes to the development of adult diseases.As corticotrophin-releasing hormone (CRH) or factor is the major mediator of adaptive response to stressors, we sought to investigate its involvement in this process. Accordingly, we found that CRH could reverse the damaging effects of glucocorticoid on neural stem/progenitor cells (NS/PCs), while its genetic deficiency results in compromised proliferation and enhanced apoptosis during neurogenesis. Analyses in fetal and adult mouse brain revealed significant expression of CRH receptors in proliferating neuronal progenitors. Furthermore, by using primary cultures of NS/PCs, we characterized the molecular mechanisms and identified CRH receptor-1 as the receptor mediating the neuroprotective effects of CRH. Finally, we demonstrate the expression of CRH receptors in human fetal brain from early gestational age, in areas of active neuronal proliferation. These observations raise the intriguing possibility for CRH-mediated pharmacological applications in diseases characterized by altered neuronal homeostasis, including depression, dementia, neurodegenerative diseases, brain traumas and obesity. © 2013 Macmillan Publishers Limited.