1. Cross-sectional comparison of age- and gender-related comorbidities in people living with HIV in Canada
- Author
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Jason M, Brunetta, Jean-Guy, Baril, Joseph J, de Wet, Chris, Fraser, Gary, Rubin, Réjean, Thomas, Hugues, Loemba, Ken, Logue, Michael, Silverman, Jean, Palmart, Haiyan, Jiang, René-Pierre, Lorgeoux, Harout, Tossonian, Connie J, Kim, and Alexander, Wong more...
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Adult ,Male ,Canada ,Cross-Sectional Studies ,Cardiovascular Diseases ,Prevalence ,Humans ,Female ,HIV Infections ,General Medicine ,Middle Aged ,Renal Insufficiency, Chronic ,Retrospective Studies - Abstract
Because antiretroviral therapy (ART) is allowing people living with human immunodeficiency virus (PLWH) to survive longer, they are developing more age-related comorbidities. We evaluated the effects of age and gender on the burden of age-related comorbidities among PLWH. In this retrospective real-world study, de-identified data were extracted from the medical charts of 2000 HIV-positive adults on ART across 10 sites in Canada. The prevalence of age-related comorbidities was determined in 6 age subgroups (30, 30-39, 40-49, 50-59, 60-69, and ≥70 years). The effects of gender on these comorbidities were also examined. Risks of cardiovascular disease and chronic kidney disease (CKD) were calculated using the Framingham and D:A:D equations. Most persons were White (68%), male (87%), and virologically suppressed (94%). The mean age was 50.3 years (57% aged ≥50 years), and mean CD4+ T-cell count was 616 cells/mm3. The most common comorbidities were neuropsychiatric symptoms (61%), overweight/obesity (43%), liver disease (37%), and dyslipidemia (37%). The mean number of comorbidities increased across age subgroups (P.001). Across all age subgroups, the prevalence of hypertension (P = .04), dyslipidemia (P = .04), CKD (P = .03), bone fragility (P = .03), and depression (P = .02) differed between males and females. Both age (P.001) and gender (P.001) impacted cardiovascular disease and CKD risk. Age and gender influenced the burden, types, and risks of age-related comorbidities in PLWH in this Canadian cohort. These comorbidities should be diagnosed and treated in routine clinical practice. more...
- Published
- 2022
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