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2. Neurotoxicity with the use of nanomaterials

Author

Borikar, Sachin P., primary, Jain, Shirish P., additional, Tapre, Deepali N., additional, Mahapatra, Debarshi Kar, additional, Mahajan, Asavari V., additional, Sonawane, Dipak S., additional, and Kendre, Prakash N., additional

Published
2024
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4. Contributors

Author

Acharya, Sheetal, primary, Agrawal, Mohit, additional, Alexander, Amit, additional, Ani, Angela Chinasa, additional, Arora, Mandeep Kumar, additional, Autade, Kalyani, additional, Benival, Derajram, additional, Bhalke, Rasika, additional, Borikar, Sachin P., additional, Chaudhary, Sunita, additional, Chaudhary, Ankit, additional, Chaudhary, Hema, additional, Chauhan, Bindiya, additional, Chavan, Sangita R., additional, Chorawala, Mehul R., additional, Dave, Bhavarth P., additional, Emencheta, Stephen Chijioke, additional, Gawade, Ashwini, additional, Gayakvad, Bhavin, additional, Giri, Mahendra, additional, Hingalajia, Hetal, additional, Jain, Shirish P., additional, Jasoria, Yash, additional, Kamble, Sarika Maruti, additional, Kanayo Oranu, Chukwuka, additional, Kanthale, Sangameshwar B., additional, Kapoor, Devesh, additional, Kaushal, Mona Amit, additional, Kendre, Prakash N., additional, Khodakiya, Akruti, additional, Khunt, Dignesh, additional, Kothari, Nirjari R., additional, Kulkarni, Mangesh, additional, Kumar, Bhavna, additional, Lokwani, Deepak K., additional, Mahajan, Asavari V., additional, Mahapatra, Debarshi Kar, additional, Maheshwari, Shubhrat, additional, Mehta, Nakshee, additional, Modi, Chetna, additional, Onyekwe, Chukwuemezue Praises, additional, Orah, Kosarachi Jennifer, additional, Paliwal, Himanshu, additional, Pande, Vishal, additional, Pandya, Tosha, additional, Pandya, Aanshi J., additional, Pandya, Vidhi, additional, Parejiya, Punit B., additional, Parikh, Nisha H., additional, Parikh, Palak K., additional, Patel, Ami, additional, Patel, Meenakshi, additional, Patel, Ravish J., additional, Patel, Amit A., additional, Patel, Nikita A., additional, Patel, Shivani, additional, Patel, Viral, additional, Pathak, Yashwant, additional, Patil, Kalpesh Ramdas, additional, Polshettiwar, Satish, additional, Pote, Ajinkya, additional, Prajapati, Vipul, additional, Prajapati, Bhupendra Gopalbhai, additional, Rana, Dhwani, additional, Rao, Hetansh J., additional, Rawal, Shruti, additional, Raytthatha, Nensi, additional, Sahoo, Jagannath, additional, Salave, Sagar, additional, Satani, Bhavik, additional, Sawant, Krutika, additional, Shah, Aayushi C., additional, Shah, Kashish, additional, Sharma, Deepak, additional, Shetty, Srishti, additional, Shetty, Saritha, additional, Shinde, Shraddha, additional, Shrivastav, Princy, additional, Singh, Sudarshan, additional, Singh, Aditya, additional, Singhal, Manmohan, additional, Sonawane, Dipak S., additional, Sumbe, Rajashri, additional, Tapre, Deepali N., additional, Tiwari, Shradha S., additional, Trivedi, Nidhi, additional, Ugale, Vinod G., additional, Upaganlawar, Aman B., additional, Vibhute, Somnath K., additional, Vyas, Jigar, additional, Xavier, Gauravi, additional, and Yadav, M.R., additional

Published
2024
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8. Methods for nanoencapsulation

Author

Prajapati, Bhupendra G., primary, Prajapati, Vipul D., additional, Basu, Biswajit, additional, Kendre, Prakash N., additional, Mukherjee, Swarupananda, additional, Pal, Tiyas, additional, Kundu, Moumita, additional, Singh, Sudarshan, additional, Bhattacharya, Sankha, additional, Dharmameher, Jidnesh B., additional, and Parikh, Dhaivat C., additional

Published
2023
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9. List of contributors

Author

AbouSamra, Mona M., primary, Alavala, Rajasekhar Reddy, additional, Anagha, K.K., additional, Arya, Sandeep, additional, Babu, A. Kishore, additional, Basha, Mona, additional, Basu, Biswajit, additional, Bhattacharya, Sankha, additional, Biswas, Arunima, additional, Budha, Roja Rani, additional, Chintamaneni, Pavan Kumar, additional, Deshmukh, Prashant K., additional, Dharmameher, Jidnesh B., additional, Giram, Prabhanjan S., additional, Islam, S.K. Manirul, additional, Jacob, Anu, additional, Jain, Pallavi, additional, Jena, Goutam Kumar, additional, Kamel, Rabab, additional, Kamwar, Kriti, additional, Kaur, Gurpreet, additional, Kaur, Jaspreet, additional, Kaur, Palki Sahib, additional, Kaur, Snimmer, additional, Kendre, Prakash N., additional, Kole, Eknath B., additional, KTK, Ashif, additional, Kumar, Aditya, additional, Kundu, Moumita, additional, Mandpe, Shilpa R., additional, Mohanta, Bibhash Chandra, additional, More, Mahesh P., additional, Mukherjee, Swarupananda, additional, Naik, Jitendra B., additional, Nair, Anagha R., additional, Nangare, Sopan S., additional, Pagar, Roshani, additional, Pal, Tiyas, additional, Pardeshi, Chandrakantsing V., additional, Pardeshi, Sagar R., additional, Parhi, Rabinarayan, additional, Parikh, Dhaivat C., additional, Patil, Pravin O., additional, Patil, Pritam B., additional, Patil, Tulshidas S., additional, Prajapati, Bhupendra G., additional, Prajapati, Vipul D., additional, Rajeshkumar, L., additional, Raman, Anirudh Pratap Singh, additional, Ramesh, M., additional, Rao, GSN Koteswara, additional, Saha, Amrita, additional, Sahoo, Suvendu Kumar, additional, Shailaja, P., additional, Sharma, Roopali, additional, Shinomol George, K., additional, Singh, Anoop, additional, Singh, Prashant, additional, Singh, Sudarshan, additional, Sivadasu, Praveen, additional, Sondhi, Sonica, additional, Vigneshwari, N., additional, and Yadav, Khushwant S., additional

Published
2023
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12. Chapter 3 - Methods for nanoencapsulation

Author

Prajapati, Bhupendra G., Prajapati, Vipul D., Basu, Biswajit, Kendre, Prakash N., Mukherjee, Swarupananda, Pal, Tiyas, Kundu, Moumita, Singh, Sudarshan, Bhattacharya, Sankha, Dharmameher, Jidnesh B., and Parikh, Dhaivat C.

Published
2023
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18. An effort to tailor the solid dispersion loaded, surface-modified, microporous-cryogel formulation of acitretin for the treatment of psoriasis.

Author

Kendre, Prakash N., Borawake, Nikita, Jain, Shirish P, Vibhute, Somnath K., and Pote, Ajinkya K.

Subjects
*DRUG solubility, *DISPERSION (Chemistry), *PSORIASIS, *SKIN permeability, *SURFACE properties, *SOLIDS
Abstract

Acitretin is the drug of choice for the treatment of psoriasis, but due to its poor solubility, the development of oral and topical formulations of acitretin has been restricted. The aim of the present investigation was to enhance the solubility of acitretin. Solid dispersions of acitretin were prepared using a lipidic solubilizer, Gelucire® 44/14. These solid dispersions were characterized through FT-IR, DSC, XRD, drug content and solubility studies. The most solubilized dispersion was loaded on an N,N-methylenebisacrylamide microporous cryogel. Physical parameters of the solubilized drug such as the porosity, rheological behaviour, surface properties, appearance, drug content and diffusion behaviour were studied. It was concluded that the solubilized form of acitretin, loaded on a surface-modified cryogel, is the best option for the treatment of psoriasis. The hydration of the skin was excellent, and the permeability of the acitretin into the skin was better. [ABSTRACT FROM AUTHOR]

Published
2022
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19. EFFECT OF HYDROPHILIC POLYMER ON DESIGN EXPERT ASSISTED ORO-DISPERSIBLE STRIP (ODS) OF ISOSORBIDE MONONITRATE.

Author

Kendre, Prakash N., Aher, Akash R., Vibhute, Somnath K., Pote, Ajinkya K., Deshmane, Subhash V., and Jain, Shirish P.

Subjects
*FACTORIAL experiment designs, *ANGINA pectoris, *TENSILE strength, *POLYMERS, *INDEPENDENT variables
Abstract

Oral conventional formulations like tablets, capsules and liquids have many limitations. Due to this and patient incompliance, there is a need to develop new formulations with better efficiency and stability. The aim of the present study was to develop and optimize fast dissolving Oro-dispersible strips (ODS) of isosorbide mononitrate by 3²-full factorial design. HpMC E15 (X1) concentration and glycerin (X2) concentration were selected as the independent variables, whereas, in vitro disintegration time (Y1), percent drug release (Y2) and tensile strength (Y3) were selected as dependent variables. Fast dissolving Oro-dispersible strips of isosorbide mononitrate were prepared by the solvent casting method.Tensile strength, disintegration time and in vitro dissolution of ODS of the strip were found to be within accepted range for optimized formulation. Statistical validity of the polynomials was established by ANOVA using Design-Expert software. The study suggests isosorbide mononitrate fast dissolving Oro-dispersible strip as potential alternative dosage form in management of angina pectoris. [ABSTRACT FROM AUTHOR]

Published
2022
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23. ANALYTICAL STANDARDIZATION AND PROFILING OF AYUSH-64: AN AYURVEDIC TABLET FORMULATION.

Author

Deshpande, Sarang J., Kendre, Prakash N., and Patle, Abhishek R.

Subjects
*STANDARDIZATION, *QUALITY control standards, *CURRENT good manufacturing practices, *QUALITY assurance, *PRODUCT quality
Abstract

Success of any healthcare product is based on its performance, which is further dependent upon the quality of the product. Quality of the polyherbal ayurvedic formulation is assured by developing proper analytical standards with the help of the guidelines provided by CCRAS (Central Council for Research in Ayurvedic Sciences), which will also ensure its authentication. Ayush-64 is a polyherbal formulation and its analytical standards were developed for various parameters like organoleptic properties, physicalchemical and chromatographic profiling etc. These standards were developed by studying and analyzing three batches of self-manufactured Ayush-64 tablets with the help of good manufacturing practices (GMP). These parameters were found to be sufficient to standardize and authenticate the quality of the formulation, which can be used further as a reference standard for quality control and quality assurance of the final product. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Tailoring hybrid organic-inorganic film forming topical gel: A tuneable approach for Tramadol HCl delivery.

Author

Kendre, Prakash N., Dusane, Gayatri, Jain, Shirish P., Giri, Mahendra A., and Pote, Ajinkya K.

Subjects
*PHARMACEUTICAL gels, *TRANSDERMAL medication, *TRAMADOL, *PATIENT compliance, *CHEMICAL stability
Abstract

Drug release properties for transdermal route can be better modified as per requirement which is mostly dependent upon the carrier system. In case of organic film-forming systems, the physical properties may not be achieved for successful delivery of drug through transdermal route. A novel organic-inorganic hybrid film-forming gel may fulfil these expectations to many extend. The present study focuses on the development of the organic-inorganic hybrid film-forming gel. A smooth, transparent, clear film-forming gel of tramadol was prepared for application on the intact skin with better comfort and modified drug release rate properties. The key properties of the adhesive films produced from the hybrid gels were investigated and the results showed that the incorporation of appropriate PVA: TEOS: Glycerine: HCl in the ratio of 46:12.5:25.5:6 respectively. Resultant hybrid film-forming gel has modified the physical properties and improved drug release properties. Furthermore, the investigations of skin irritation suggested no irritation to skin after topical application. This study has provided an alternative to the presently available organic gel and films for transdermal delivery of drugs with better patient compliance and modified physical and chemical stability. [ABSTRACT FROM AUTHOR]

Published
2021
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27. NOVEL FORMULATION STRATEGY TO ENHANCE SOLUBILITY OF QUERCETIN.

Author

Kendre, Prakash N., Pande, Vishal V., and Chavan, Kishori M.

Subjects
*QUERCETIN, *DRUG formularies, *SOLUBILITY, *PROPYLENE glycols, *X-ray diffraction, *HYDROGEN-ion concentration, *THERAPEUTICS
Abstract

The aim of present study to enhance the solubility of quercetin, a poorly water soluble drug, quercetin containing blends (keeping total concentration 40% w/v, constant) was fabricated by mixed-solvency approach. In this technique, blends of solubilizers (sodium acetate, sodium citrate, urea as hydrotropic agent, propylene glycol, glycerin, PEG 200, PEG 400, PEG 600 as co solvents, PEG 4000, PEG 6000 as water soluble solvents etc.) have been employed to increase the solubility. The significant enhancement in solubility of drug in mixed solvents was observed in A4 blends which contain 10% sodium citrate, 5% sodium acetate and 25% S co-solvents (25% S co-solvents contains PG, glycerin, PEG 200, PEG 400, PEG 600, PEG 4000, PEG 6000). After improvement of solubility of quercetin in selected blends that incorporated into topical dosage form (prepared gel) by utilizing Carbopol ETD 2020 as gelling agent. The prepared blends and gel were evaluated for pH, surface tension, specific gravity and viscosity and in--vitro diffusion study, skin irritation studies, spreadability respectively. The characterization of pure quercetin, blend, and gel was performed by differential scanning calorimetry (DSC); X-ray diffraction (XRD) etc. From experimental work it was found that the prepared formulation is safe, effective, non-irritant, non-toxic and stable with good spreadability. The results showed that mixed solvency has valuable and unique strategy to ameliorating the solubility of lipophilic herbal anticancer component, quercetin. [ABSTRACT FROM AUTHOR]

Published
2014

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