11 results on '"Kenichiro, Konishi"'
Search Results
2. The Outcome of Patients With Cystic Biliary Atresia With Intact Proximal Hepatic Ducts Following Hepatic-Cyst-Jejunostomy
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Akihiro, Asai, Jia-Feng, Wu, Kasper S, Wang, Atsuyuki, Yamataka, Masaki, Nio, Da-Jyun, Su, Celia, Short, Koichi, Tsuboi, Takanori, Ochi, Hideyuki, Sasaki, Ryuji, Okubo, Toshifumi, Yodoshi, Kenichiro, Konishi, Michael E, Rogers, and Gregory M, Tiao
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Biliary Atresia ,Cysts ,Child, Preschool ,Liver Diseases ,Pediatrics, Perinatology and Child Health ,Gastroenterology ,Jejunostomy ,Humans ,Hepatic Duct, Common ,Portoenterostomy, Hepatic ,Retrospective Studies - Abstract
To determine the outcomes of patients with cystic biliary atresia by correlating the anatomy of the hepatic ducts with the choice of biliary reconstruction surgery.The Kasai hepatoportoenterostomy (Kasai) is the initial surgical procedure offered to most patients with biliary atresia. In contrast, a hepatic-cyst-jejunostomy has been reported to be effective in patients with the cystic form of biliary atresia.We performed an international multicenter retrospective review. Two hundred eighty-seven patients were included, and 33 cases of cystic biliary atresia were identified. Outcomes were the serum total bilirubin level 3 months post-surgery and native liver survival at 2 years of age and were compared between cases who received the Kasai versus hepatic-cyst-jejunostomy in correlation to the anatomy of proximal hepatic ducts. The patients were categorized into 3 anatomical groups: patent intact hepatic ducts (n = 10), patent hypoplastic hepatic ducts (n = 13), and obliterated hepatic ducts (n = 10). All 10 patients with patent intact hepatic duct group underwent hepatic-cyst-jejunostomy, and 9 experienced bile drainage and native liver survival. Among the 13 patients with hypoplastic hepatic ducts, 11 underwent the Kasai procedure, and 9 had bile drainage, whereas 2 underwent hepatic-cyst-jejunostomy, and one survived with the native liver. All of the patients with obliterated hepatic ducts underwent the Kasai procedure; 5 established biliary drainage and survived with the native liver. Of 5 who did not drain, 3 underwent liver transplantation.In patients with cystic biliary atresia, the subset with a connection between cyst and intrahepatic bile ducts via intact proximal hepatic ducts had favorable clinical outcomes following hepatic-cyst-jejunostomy.
- Published
- 2022
3. A novel de novo SLC26A3 mutation causing congenital chloride diarrhea in a Japanese neonate
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Kenichiro Konishi, Kazuko Wada, Yuri Etani, Tatsuki Mizuochi, Ken Yamamoto, Hitoshi Honma, and Kazue Morikawa
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0301 basic medicine ,Diarrhea ,Male ,Congenital chloride diarrhea ,lcsh:QH426-470 ,SLC26A3 ,030105 genetics & heredity ,Compound heterozygosity ,medicine.disease_cause ,03 medical and health sciences ,symbols.namesake ,Exon ,Meconium ,Genetics ,Medicine ,Humans ,Chloride-Bicarbonate Antiporters ,Molecular Biology ,Genetics (clinical) ,Sanger sequencing ,Mutation ,biology ,business.industry ,urogenital system ,Infant, Newborn ,Original Articles ,medicine.disease ,Molecular biology ,lcsh:Genetics ,030104 developmental biology ,Sulfate Transporters ,symbols ,biology.protein ,Original Article ,medicine.symptom ,business ,Metabolism, Inborn Errors - Abstract
Background Congenital chloride diarrhea (CCD) is characterized by persistent chloride (Cl)‐rich diarrhea evident from birth. CCD is a rare autosomal recessive disorder caused by defects in the solute carrier family 26 member 3 (SLC26A3) gene, which encodes an intestinal Cl−/HCO3−, Na+‐independent exchanger. Various mutations of SLC26A3 have been described in CCD. However, no de novo mutations have been found to be responsible for CCD. Here we report the first such occurrence. Methods Clinical and laboratory findings during the perinatal period were obtained retrospectively from medical records. Mutations involving SLC26A3 were detected by Sanger sequencing. Results The male infant reported here was delivered at 29 weeks of gestation. Just after birth, he had watery diarrhea without meconium passage. High chloride concentrations in the diarrhea led to a diagnosis of CCD. Direct sequencing of all coding exons in SLC26A3 including exon‐intron boundaries disclosed 2 compound heterozygous mutations: c.382G>A, p.G128S and c.2063‐1g>t. The c. 2063‐1g>t mutation was confirmed in his mother's DNA, but c.382G>A, p.G128S was absent in both mother and father. Conclusion We concluded that c.382G>A, p.G128S represented a de novo mutation of SLC26A3, a very rare event in autosomal recessive disorders. To our knowledge, this is the first CCD case involving a de novo novel mutation of SLC26A3., The manuscript describes a Japanese newborn who was diagnosed with congenital chloride diarrhea caused by a novel de novo mutation of SLC26A3. De novo mutation in an autosomal recessive disorder may be extremely rare. To our knowledge, this is the first reported case of congenital chloride diarrhea with a de novo novel mutation in SLC26A3.
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- 2020
4. Congenital chloride diarrhea in a Japanese neonate with a novel SLC26A3 mutation
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Ichiro Takeuchi, Katsuhiro Arai, Tatsuki Mizuochi, Ken Yamamoto, and Kenichiro Konishi
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Diarrhea ,Polyhydramnios ,medicine.medical_specialty ,Congenital chloride diarrhea ,SLC26A3 ,Gastroenterology ,Japan ,Pregnancy ,Internal medicine ,medicine ,Humans ,Chloride-Bicarbonate Antiporters ,biology ,business.industry ,Infant, Newborn ,medicine.disease ,Sulfate Transporters ,Pediatrics, Perinatology and Child Health ,Mutation (genetic algorithm) ,Mutation ,biology.protein ,Fetal diagnosis ,Female ,business ,Metabolism, Inborn Errors - Published
- 2020
5. Tracheal cartilage growth promotion by intra-tracheal administration of basic FGF
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Hiroko Komura, Makoto Komura, Tsuyoshi Takato, Kazuto Hoshi, Tetsuya Ishimaru, Hiroaki Komuro, and Kenichiro Konishi
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Outer diameter ,medicine.medical_treatment ,Basic fibroblast growth factor ,Growth promotion ,Tracheal lumen ,03 medical and health sciences ,chemistry.chemical_compound ,Basic fgf ,Mice ,0302 clinical medicine ,030225 pediatrics ,medicine ,Animals ,business.industry ,Cartilage ,Tracheal intubation ,General Medicine ,respiratory system ,Trachea ,Tracheal ring ,medicine.anatomical_structure ,chemistry ,Anesthesia ,Pediatrics, Perinatology and Child Health ,030211 gastroenterology & hepatology ,Surgery ,Fibroblast Growth Factor 2 ,business - Abstract
This study aimed to investigate whether intra-tracheal administration of basic fibroblast growth factor (b-FGF) promotes the growth of tracheal cartilage. Trachea of 4-week old mice were intubated and 2.5 μg b-FGF administered (Group 4) for periods from 1 to 5 days. Cervical tracheal outer diameter and tracheal ring length were compared in Group 1 (no intervention), Group 2 (tracheal intubation), Group 3 (intra-tracheal administration of distilled water) and Group 4, at 8 weeks of age. Outer diameter and tracheal ring length in Group 4 were also compared with that in Group 1 at 12 and 16 weeks of age. At 8 weeks of age, tracheal ring length with b-FGF administration for more than 4 days in Group 4 was significantly increased over that following 1-day administration. At 8 weeks of age, mean outer diameter and the mean tracheal ring length in Group 4 were significantly greater than in the other groups. Mean outer diameter and mean tracheal ring length were significantly greater in Group 4 than in Group 1 at 12 and 16 weeks of age. This study has shown that intra-tracheal administration of b-FGF enlarges the tracheal lumen.
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- 2019
6. Long-term follow-up of tracheal cartilage growth promotion by intratracheal injection of basic fibroblast growth factor
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Atsuyuki Hikita, Kazuko Obana, Hiroko Komura, Kenichiro Konishi, Kazuto Hoshi, Tsuyoshi Takato, Hiroaki Komuro, Kenichi Ikebukuro, and Makoto Komura
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Long term follow up ,Basic fibroblast growth factor ,Type II collagen ,Growth promotion ,Andrology ,Glycosaminoglycan ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,030225 pediatrics ,medicine ,Animals ,Collagen Type II ,Glycosaminoglycans ,business.industry ,Cartilage ,General Medicine ,Single injection ,medicine.disease ,Trachea ,medicine.anatomical_structure ,chemistry ,Tracheomalacia ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Surgery ,Female ,Fibroblast Growth Factor 2 ,Rabbits ,business ,Follow-Up Studies - Abstract
Background Intratracheal injection of basic fibroblast growth factor (b-FGF) has been shown to enlarge the tracheal lumen 4 weeks after treatment. The objective of this study was to investigate the long-term effect of tracheal cartilage growth promotion by intratracheal injection of b-FGF. Materials and methods New Zealand white rabbits were classified into four groups to receive either distilled water alone (Group 1; n = 16; control), 40 μg (Group 2; n = 10), 100 μg (Group 3; n = 13), or 200 μg (Group 4; n = 16) of b-FGF dissolved in water. The treatment was injected into the posterior wall of the cervical trachea using a tracheoscope. The animals were sacrificed 4 or 12 weeks later. Results Four weeks after treatment, the mean luminal areas of tracheas for Groups 1, 2, 3, and 4 were 27.2, 25.6, 32.2, and 36.2 mm2, respectively. At 12 weeks, these were 29.3, 37.9, 42.5, and 56.0 mm2, respectively. The levels of glycosaminoglycan at 12 weeks were 93.9, 152.5, 123.2, and 210.6 μg/mg, respectively. At 12 weeks, the levels of type II collagen were 77.2, 133.1, 99.2, and 148.9 μg/mg, respectively. Conclusion Twelve weeks after a single injection of b-FGF, the mean luminal area of the trachea continued to increase.
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- 2018
7. Prostaglandin E-major urinary metabolite as a noninvasive surrogate marker for infantile necrotizing enterocolitis
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Atsushi Hirota, Saori Nakahara, Mariko Yoshida, Takayuki Odashima, Chisa Tsurisawa, Kinji Yokomori, Keiji Tsuchiya, Atsushi Nakao, Kenichiro Konishi, Mutsunori Fujiwara, Masaaki Matsuura, Kazuo Ishida, Satoru Ito, Shusuke Amagata, Tomohiro Takeda, Kunihiko Ichiki, and Yoshiya Hisaeda
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Urinary system ,Prostaglandin ,Disease ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Enterocolitis, Necrotizing ,030225 pediatrics ,Internal medicine ,Medicine ,Humans ,Retrospective Studies ,business.industry ,Surrogate endpoint ,Prostaglandins E ,Infant, Newborn ,Infant ,General Medicine ,medicine.disease ,digestive system diseases ,chemistry ,Blood chemistry ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Necrotizing enterocolitis ,Biomarker (medicine) ,Surgery ,Female ,business ,Biomarkers ,Prostaglandin E - Abstract
Background Early definitive diagnosis of necrotizing enterocolitis (NEC) based on Bell's staging criteria is difficult because there are few observable changes on abdominal imaging and blood chemistry tests at the onset of the disease. Purpose To investigate whether prostaglandin E-2 major urinary metabolite (PGE-MUM) can be a useful surrogate marker reflecting the disease state and severity of NEC in infants. Methods Infants were enrolled in this study between January 2014 and December 2016. NEC diagnosis was based on Bell's staging criteria > Stage II or necrotic bowel observed at surgery. After diagnosis, PGE-MUM level was measured and compared with that of the other disease and healthy infant groups. Results Median PGE-MUM value was highest in the NEC group (576 [65–3672] μg/g•Cre/BSA × 1000), followed by the other disease group (94 [57–296] μg/g•Cre/BSA × 1000) and the healthy infant group (19 [10–44] μg/g•Cre/BSA × 1000) (sensitivity: 92.3%, specificity: 81.5%, accuracy: 85.0%; p Conclusions PGE-MUM level may be a useful surrogate biomarker reflecting the disease state of NEC. The method of urine sample collection is also advantageous, being noninvasive for infants. This is the first study reporting PGE-MUM level in NEC. Type of study Study of diagnostic test. Level of evidence LEVEL II.
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- 2018
8. Optimal Amount of Basic Fibroblast Growth Factor in Gelatin Sponges Incorporating β-Tricalcium Phosphate with Chondrocytes
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Tadashi Iwanaka, Kazuto Hoshi, Yushi Otani, Tetsuya Ishimaru, Kenichiro Konishi, Hiroko Komura, Tsuyoshi Takato, Makoto Komura, Hiroaki Komuro, and Yasuhiko Tabata
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Calcium Phosphates ,Cartilage, Articular ,Auricular cartilage ,Scaffold ,food.ingredient ,Basic fibroblast growth factor ,Biomedical Engineering ,Biocompatible Materials ,Bioengineering ,Biochemistry ,Gelatin ,Biomaterials ,chemistry.chemical_compound ,Chondrocytes ,food ,Materials Testing ,medicine ,Humans ,Cells, Cultured ,β tricalcium phosphate ,Gelatin sponge ,Dose-Response Relationship, Drug ,Tissue Engineering ,Tissue Scaffolds ,Cartilage ,Original Articles ,Equipment Design ,Chondrogenesis ,Gelatin Sponge, Absorbable ,Equipment Failure Analysis ,medicine.anatomical_structure ,chemistry ,Delayed-Action Preparations ,Printing, Three-Dimensional ,Fibroblast Growth Factor 2 ,Biomedical engineering - Abstract
A gelatin sponge with slowly releasing basic fibroblast growth factor (b-FGF) enhances chondrogenesis. This study investigated the optimal amount of b-FGF in gelatin sponges to fabricate engineered cartilage.b-FGF (0, 10, 100, 500, 1000, and 2000 μg/cm(3))-impregnated gelatin sponges incorporating β-tricalcium phosphate (β-TCP) were produced. Chondrocytes were isolated from the auricular cartilage of C57B6J mice and expanded. The expanded auricular chondrocytes (10×10(6) cells/cm(3)) were seeded onto the gelatin sponges, which served as scaffolds. The construct assembly was implanted in the subcutaneous space of mice through a syngeneic fashion. Thereafter, constructs were retrieved at 2, 4, or 6 weeks.(1) Morphology: The size of implanted constructs was larger than the size of the scaffold with 500, 1000, and 2000 μg/cm(3) b-FGF-impregnated gelatin sponges incorporating β-TCP at 4 and 6 weeks after implantation. (2) The weight of the constructs increased roughly proportional to the increase in volume of the b-FGF-impregnated scaffold at 2, 4, and 6 weeks after implantation, except in the 2000 μg/cm(3) b-FGF-impregnated constructs group. (3) Histological examination: Extracellular matrix in the center of the constructs was observed in gelatin sponges impregnated with more than 100 μg/cm(3) b-FGF at 4 weeks after implantation. The areas of cells with an abundant extracellular matrix were positive for cartilage-specific marker type 2 collagen in the constructs. (4) Protein assay: Glycosaminoglycan and collagen type 2 expression were significantly increased at 4 and 6 weeks on implantation of gelatin sponges impregnated with more than 100 μg/cm(3) b-FGF. At 6 weeks after implantation, the ratio of type 2 collagen to type 1 collagen in constructs impregnated with 100 μg/cm(3) or more b-FGF was higher than that in mice auricular cartilage.Gelatin sponges impregnated with more than 100 μg/cm(3) b-FGF incorporating β-TCP with chondrocytes (10×10(6) cells/cm(3)) can fabricate engineered cartilage at 4 weeks after implantation.
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- 2015
9. Study on At-home Wrist Rehabilitation System by Remote Passive Exercise
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Kenichiro Konishi, Ato Kitagawa, Zhen Xiu, Hideyuki Tsukagoshi, and Canghai Liu
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Engineering ,business.industry ,General Medicine ,business - Published
- 2010
10. Study on At-home Wrist Rehabilitation System by Active Exercise Using Wrist Characteristics Obtained in Passive Exercise
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Ato Kitagawa, Hideyuki Tsukagoshi, Zhen Xiu, Canghai Liu, and Kenichiro Konishi
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medicine.medical_specialty ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,business.industry ,medicine ,Passive exercise ,General Medicine ,Wrist ,business ,Wrist rehabilitation ,Active exercise - Published
- 2010
11. AN INTERNERT-BASED TELE-REHABILITATION SYSTEM WITH SINGLE-MASTER AND MULTI-SLAVES
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Kenichiro Konishi, Zhen Xiu, Canghai Liu, Ato Kitagawa, and Hideyuki Tsukagoshi
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Telerobotics ,medicine.medical_specialty ,Engineering ,Rehabilitation ,Multimedia ,business.industry ,medicine.medical_treatment ,Control (management) ,Master/slave ,General Medicine ,computer.software_genre ,Physical medicine and rehabilitation ,Tele-rehabilitation ,Hardware_GENERAL ,Teleoperation ,medicine ,ComputingMilieux_COMPUTERSANDSOCIETY ,The Internet ,InformationSystems_MISCELLANEOUS ,Architecture ,business ,computer - Abstract
This paper discusses an Internet-based tele-rehabilitation system with Single-Master and Multi-Slaves, which aims to achieve the situation where multiple stay-home patients in scattered places can share rehabilitation instruction from one physical therapist. After the introduction of whole system's concept, ‘ Passive-Active Shift’ rehabilitation is proposed considering the varied symptom of different patients. Then after introduction of master slave system's designing, for passive rehabilitation which is carried through internet-based bilateral teleoperation system by therapist who is necessary, novel control architecture to ensure the stability of tele-rehabilitation system with time delay is proposed. For active rehabilitation, game-based active rehabilitation is proposed to draw the patients' mind into rehabilitation which is important to reestablish neuromuscular control.
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- 2008
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