1. Utility of routine pulmonary function test after autologous hematopoietic cell transplantation in lymphoma.
- Author
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Dahi, Parastoo B., Kenny, Sheila, Flynn, Jessica, Devlin, Sean M., Ruiz, Josel D., Chinapen, Stephanie A., Lahoud, Oscar B., Matasar, Matthew J., Moskowitz, Craig H., Perales, Miguel-Angel, Shah, Gunjan, Sauter, Craig S., Giralt, Sergio A., Geyer, Alexander I., and Jakubowski, Ann A.
- Subjects
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HEMATOPOIETIC stem cell transplantation , *PULMONARY function tests , *LYMPHOMAS , *INTERSTITIAL lung diseases , *LUNG diseases - Abstract
This study aims to evaluate the predictive value of routine pulmonary function testing (PFT) at the 12-month mark post-autologous hematopoietic cell transplant (AHCT) in identifying clinically significant lung disease in lymphoma survivors. In 247 patients, 173 (70%) received BEAM (carmustine, etoposide, cytarabine, melphalan), and 49 (20%) received TBC (thiotepa, busulfan, cyclophosphamide) conditioning regimens. Abnormal baseline PFT was noted in 149 patients (60%). Thirty-four patients had a significant decline (reduction of >/= 20% in DLCO or FEV1 or FVC) in post-AHCT PFT, with the highest incidence in the CNS lymphoma group (39%). The incidence of clinically significant lung disease post-transplant was low at 2% and there was no association between abnormal pre- and 1-year post-transplant PFTs with the development of clinical lung disease. While this study illustrates the impact of treatment regimens on PFT changes, it did not demonstrate a predictive value of scheduled PFTs in identifying clinically significant post-AHCT lung disease. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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