1. Impact of Age and Cardiac Disease on Regional Left and Right Ventricular Myocardial Motion in Healthy Controls and Patients with Repaired Tetralogy of Fallot
- Author
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Haben Berhane, Michael J. Rose, James C. Carr, Kenny Sidoryk, Cynthia K. Rigsby, Roberto Sarnari, Joshua D. Robinson, Ryan S. Dolan, Alexander Ruh, Michael Markl, Kai Lin, and Arleen Li
- Subjects
Cardiac function curve ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Heart disease ,Adolescent ,Ventricular Dysfunction, Right ,Diastole ,Pilot Projects ,030204 cardiovascular system & hematology ,Article ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,Biventricular function ,03 medical and health sciences ,Ventricular Dysfunction, Left ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac Surgical Procedures ,Child ,Cardiac imaging ,Tetralogy of Fallot ,Aged ,Reproducibility ,business.industry ,Age Factors ,Infant ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Biomechanical Phenomena ,Treatment Outcome ,Case-Control Studies ,Child, Preschool ,Cardiology ,Myocardial motion ,Ventricular Function, Right ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61%, p
- Published
- 2019