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1. Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial

Author

Kenkhuis, Marlou-Floor, Stelten, Stephanie, Hartman, Yvonne AW., Brouwer, Calvin G., ten Tusscher, Marieke R., van Lonkhuijzen, Luc RCW., Kenter, Gemma G., van Driel, Willemien J., Winkels, Renate M., Bekkers, Ruud LM., Ottevanger, Nelleke PB., Hoedjes, Meeke, and Buffart, Laurien M.

Published
2024
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3. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians.

Author

Stelten, Stephanie, ten Tusscher, Marieke R., Stuiver, Martijn M., Hartman, Yvonne A. W., van Lonkhuijzen, Luc R. C. W., Kenter, Gemma G., van der Leeden, Marike, Hoedjes, Meeke, and Buffart, Laurien M.

Subjects
MEDICAL logic, PATIENT education, PATIENT safety, RESEARCH funding, OVARIAN tumors, EXERCISE therapy, CANCER patients, DECISION making in clinical medicine, CANCER chemotherapy, COMBINED modality therapy, ADVERSE health care events, CASE studies, COMORBIDITY, DIET therapy
Abstract

Purpose: This study aims to capture the complex clinical reasoning process during tailoring of exercise and dietary interventions to adverse effects and comorbidities of patients with ovarian cancer receiving chemotherapy. Methods: Clinical vignettes were presented to expert physical therapists (n = 4) and dietitians (n = 3). Using the think aloud method, these experts were asked to verbalize their clinical reasoning on how they would tailor the intervention to adverse effects of ovarian cancer and its treatment and comorbidities. Clinical reasoning steps were categorized in questions raised to obtain additional information; anticipated answers; and actions to be taken. Questions and actions were labeled according to the evidence-based practice model. Results: Questions to obtain additional information were frequently related to the patients' capacities, safety or the etiology of health issues. Various hypothetical answers were proposed which led to different actions. Suggested actions by the experts included extensive monitoring of symptoms and parameters, specific adaptations to the exercise protocol and dietary-related patient education. Conclusions: Our study obtained insight into the complex process of clinical reasoning, in which a variety of patient-related variables are used to tailor interventions. This insight can be useful for description and fidelity assessment of interventions and training of healthcare professionals. IMPLICATIONS FOR REHABILITATION: The delivery of exercise and dietary programs is not a one-size fits all approach but involves a complex clinical reasoning process. Therefore, protocols should not only describe the intervention content, but also the strategy on how to tailor the intervention to individual adverse effects and pre-existing comorbidities. Education of healthcare professionals delivering the intervention is important as these professionals need to have good clinical reasoning skills to adequately tailor the intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians

Author

Stelten, Stephanie, primary, ten Tusscher, Marieke R., additional, Stuiver, Martijn M., additional, Hartman, Yvonne A. W., additional, van Lonkhuijzen, Luc R. C. W., additional, Kenter, Gemma G., additional, van der Leeden, Marike, additional, Hoedjes, Meeke, additional, and Buffart, Laurien M., additional

Published
2023
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8. Cost-effectiveness of laparoscopy as diagnostic tool before primary cytoreductive surgery in ovarian cancer

Author

van de Vrie, Roelien, van Meurs, Hannah S., Rutten, Marianne J., Naaktgeboren, Christiana A., Opmeer, Brent C., Gaarenstroom, Katja N., van Gorp, Toon, Ter Brugge, Henk G., Hofhuis, Ward, Schreuder, Henk W.R., Arts, Henriette J.G., Zusterzeel, Petra L.M., Pijnenborg, Johanna M.A., van Haaften, Maarten, Engelen, Mirjam J.A., Boss, Erik A., Vos, M. Caroline, Gerestein, Kees G., Schutter, Eltjo M.J., Kenter, Gemma G., Bossuyt, Patrick M.M., Mol, Ben Willem, and Buist, Marrije R.

Published
2017
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11. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians

Author

Stelten, S., Tusscher, M. ten, Stuiver, M.M., Hartman, Y.A.W., Lonkhuijzen, L.R. van, Kenter, Gemma G., Hoedjes, Meeke, Buffart, L.M., Stelten, S., Tusscher, M. ten, Stuiver, M.M., Hartman, Y.A.W., Lonkhuijzen, L.R. van, Kenter, Gemma G., Hoedjes, Meeke, and Buffart, L.M.

Abstract

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Published
2023

13. Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994.

Author

Kenter, Gemma G., Greggi, Stefano, Vergote, Ignace, Katsaros, Dionyssios, Kobierski, Juliusz, van Doorn, Heleen, Landoni, Fabio, van der Velden, Jacobus, Reed, Nicholas, Coens, Corneel, van Luijk, Iske, Colombo, Nicoletta, Steen-Banasik, Elzbietta van der, Ottevanger, Nelleke, Casado, Antonio, Schratter-Sehn, Annemarie, Vermorken, Jan Baptist, Altintas, Sevilay, Kridelka, Frederic, and Goffin, Frédéric

Published
2023
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14. Figure S2 from Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

Author

Rotman, Jossie, primary, Heeren, A. Marijne, primary, Gassama, Awa A., primary, Lougheed, Sinead M., primary, Pocorni, Noëlle, primary, Stam, Anita G.M., primary, Bleeker, Maaike C.G., primary, Zijlmans, Henry J.M.A.A, primary, Mom, Constantijne H., primary, Kenter, Gemma G., primary, Jordanova, Ekaterina S., primary, and de Gruijl, Tanja D., primary

Published
2023
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15. Figure S1 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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16. Table S2 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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17. Data from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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18. Supplementary Materials and Methods from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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19. Table S1 from Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

Author

Rotman, Jossie, primary, Heeren, A. Marijne, primary, Gassama, Awa A., primary, Lougheed, Sinead M., primary, Pocorni, Noëlle, primary, Stam, Anita G.M., primary, Bleeker, Maaike C.G., primary, Zijlmans, Henry J.M.A.A, primary, Mom, Constantijne H., primary, Kenter, Gemma G., primary, Jordanova, Ekaterina S., primary, and de Gruijl, Tanja D., primary

Published
2023
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20. Supplementary Materials from Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Author

van Poelgeest, Mariëtte I.E., primary, Welters, Marij J.P., primary, Vermeij, Renee, primary, Stynenbosch, Linda F.M., primary, Loof, Nikki M., primary, Berends-van der Meer, Dorien M.A., primary, Löwik, Margriet J.G., primary, Hamming, Ineke L.E., primary, van Esch, Edith M.G., primary, Hellebrekers, Bart W.J., primary, van Beurden, Marc, primary, Schreuder, Henk W., primary, Kagie, Marjolein J., primary, Trimbos, J. Baptist M.Z., primary, Fathers, Lorraine M., primary, Daemen, Toos, primary, Hollema, Harry, primary, Valentijn, A. Rob P.M., primary, Oostendorp, Jaap, primary, Oude Elberink, J. Hanneke N.G., primary, Fleuren, Gertjan J., primary, Bosse, Tjalling, primary, Kenter, Gemma G., primary, Stijnen, Theo, primary, Nijman, Hans W., primary, Melief, Cornelis J.M., primary, and van der Burg, Sjoerd H., primary

Published
2023
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23. Supplementary Figure Legend from An Unexpectedly Large Polyclonal Repertoire of HPV-Specific T Cells Is Poised for Action in Patients with Cervical Cancer

Author

de Vos van Steenwijk, Peggy J., primary, Heusinkveld, Moniek, primary, Ramwadhdoebe, Tamara H., primary, Löwik, Margriet J., primary, van der Hulst, Jeanette M., primary, Goedemans, Renske, primary, Piersma, Sytse J., primary, Kenter, Gemma G., primary, and van der Burg, Sjoerd H., primary

Published
2023
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25. HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia

Author

Samuels, Sanne, Marijne Heeren, A., Zijlmans, Henry J. M. A. A., Welters, Marij J. P., van den Berg, Joost H., Philips, Daisy, Kvistborg, Pia, Ehsan, Ilina, Scholl, Suzy M. E., Nuijen, Bastiaan, Schumacher, Ton N. M., van Beurden, Marc, Jordanova, Ekaterina S., Haanen, John B. A. G., van der Burg, Sjoerd H., and Kenter, Gemma G.

Published
2017
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32. Association between Energy Balance-Related Factors and Clinical Outcomes in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis

Author

Stelten, Stephanie, primary, Schofield, Christelle, additional, Hartman, Yvonne A. W., additional, Lopez, Pedro, additional, Kenter, Gemma G., additional, Newton, Robert U., additional, Galvão, Daniel A., additional, Hoedjes, Meeke, additional, Taaffe, Dennis R., additional, van Lonkhuijzen, Luc R. C. W., additional, McIntyre, Carolyn, additional, and Buffart, Laurien M., additional

Published
2022
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33. Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study)

Author

Kremer, Wieke W., primary, Dick, Stèfanie, additional, Heideman, Daniëlle A.M., additional, Steenbergen, Renske D.M., additional, Bleeker, Maaike C.G., additional, Verhoeve, Harold R., additional, van Baal, W. Marchien, additional, van Trommel, Nienke, additional, Kenter, Gemma G., additional, Meijer, Chris J.L.M., additional, and Berkhof, Johannes, additional

Published
2022
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35. Association between energy balance-related factors and clinical outcomes in patients with ovarian cancer: A systematic review and meta-analysis

Author

Stelten, Stephanie, Schofield, Christelle, Hartman, Yvonne A. W., Lopez, Pedro, Kenter, Gemma G., Newton, Robert U., Galvão, Daniel A., Hoedjes, Meeke, Taaffe, Dennis R., van Lonkhuijzen, Luc R. C. W., McIntyre, Carolyn, Buffart, Laurien M., Stelten, Stephanie, Schofield, Christelle, Hartman, Yvonne A. W., Lopez, Pedro, Kenter, Gemma G., Newton, Robert U., Galvão, Daniel A., Hoedjes, Meeke, Taaffe, Dennis R., van Lonkhuijzen, Luc R. C. W., McIntyre, Carolyn, and Buffart, Laurien M.

Abstract

Background: This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions. Methods: Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects. Results: Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses revealed that a higher BMI was associated with a higher risk of post-surgical complications (n = 5, HR: 1.63, 95 % CI: 1.06 – 2.51, p = 0.030), a higher muscle mass was associated with a better progression-free survival (n = 3, HR: 1.41, 95 % CI: 1.04 – 1.91, p = 0.030) and a higher muscle density was associated with a better overall survival (n = 3, HR: 2.12, 95 % CI: 1.62 – 2.79, p < 0.001). Muscle measures were not significantly associated with surgical or chemotherapy-related outcomes. Conclusions: The prognostic value of baseline BMI for clinical outcomes is limited, but muscle mass and density may have more prognostic potential. High-quality studies with comprehensive reporting of results are required to improve our understanding of the prognostic value of body composition measures for clinical outcomes. Systematic review registration number: PROSPERO identifier CRD42020163058.

Published
2022

40. FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years

Author

Vink, Frederique J, primary, Meijer, Chris J L M, additional, Hesselink, Albertus T, additional, Floore, Arno N, additional, Lissenberg-Witte, Birgit I, additional, Bonde, Jesper H, additional, Pedersen, Helle, additional, Cuschieri, Kate, additional, Bhatia, Ramya, additional, Poljak, Mario, additional, Oštrbenk Valenčak, Anja, additional, Hillemanns, Peter, additional, Quint, Wim G V, additional, del Pino, Marta, additional, Kenter, Gemma G, additional, Steenbergen, Renske D M, additional, Heideman, Daniëlle A M, additional, and Bleeker, Maaike C G, additional

Published
2022
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43. Immunotherapeutic Approaches for the Treatment of HPV-Associated (Pre-)Cancer of the Cervix, Vulva and Penis

Author

Rafael, Tynisha S., Rotman, Jossie, Brouwer, Oscar R., van der Poel, Henk G., Mom, Constantijne H., Kenter, Gemma G., de Gruijl, Tanja D., and Jordanova, Ekaterina S.

Subjects
General Medicine, female genital diseases and pregnancy complications
Abstract

Human papillomavirus (HPV) infection drives tumorigenesis in almost all cervical cancers and a fraction of vulvar and penile cancers. Due to increasing incidence and low vaccination rates, many will still have to face HPV-related morbidity and mortality in the upcoming years. Current treatment options (i.e., surgery and/or chemoradiation) for urogenital (pre-)malignancies can have profound psychosocial and psychosexual effects on patients. Moreover, in the setting of advanced disease, responses to current therapies remain poor and nondurable, highlighting the unmet need for novel therapies that prevent recurrent disease and improve clinical outcome. Immunotherapy can be a useful addition to the current therapeutic strategies in various settings of disease, offering relatively fewer adverse effects and potential improvement in survival. This review discusses immune evasion mechanisms accompanying HPV infection and HPV-related tumorigenesis and summarizes current immunotherapeutic approaches for the treatment of HPV-related (pre-)malignant lesions of the uterine cervix, vulva, and penis.

Published
2022
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45. Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

Author

Welters, Marij J. P., Kenter, Gemma G., de Vos van Steenwijk, Peggy J., Löwik, Margriet J. G., der Meer, Dorien M. A. Berends-van, Essahsah, Farah, Stynenbosch, Linda F. M., Vloon, Annelies P. G., Ramwadhdoebe, Tamara H., Piersma, Sytse J., van der Hulst, Jeanette M., Valentijn, A. Rob P. M., Fathers, Lorraine M., Drijfhout, Jan W., Franken, Kees L. M. C., Oostendorp, Jaap, Fleuren, Gert Jan, Melief, Cornelis J. M., van der Burg, Sjoerd H., and van Rood, Johannes J.

Published
2010

47. The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study

Author

de Vos van Steenwijk, Peggy J., van Poelgeest, Mariette I. E., Ramwadhdoebe, Tamara H., Löwik, Margriet J. G., Berends-van der Meer, Dorien M. A., van der Minne, Caroline E., Loof, Nikki M., Stynenbosch, Linda F. M., Fathers, Lorraine M., Valentijn, A. Rob P. M., Oostendorp, Jaap, Osse, Elisabeth M., Fleuren, Gert Jan, Nooij, Linda, Kagie, Marjolein J., Hellebrekers, Bart W. J., Melief, Cornelis J. M., Welters, Marij J. P., van der Burg, Sjoerd H., and Kenter, Gemma G.

Published
2014
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49. FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years.

Author

Vink, Frederique J, Meijer, Chris J L M, Hesselink, Albertus T, Floore, Arno N, Lissenberg-Witte, Birgit I, Bonde, Jesper H, Pedersen, Helle, Cuschieri, Kate, Bhatia, Ramya, Poljak, Mario, Valenčak, Anja Oštrbenk, Hillemanns, Peter, Quint, Wim G V, Pino, Marta del, Kenter, Gemma G, Steenbergen, Renske D M, Heideman, Daniëlle A M, and Bleeker, Maaike C G

Subjects
PAPILLOMAVIRUS disease diagnosis, PAPILLOMAVIRUSES, BIOMARKERS, RESEARCH, IMMUNOHISTOCHEMISTRY, CERVICAL intraepithelial neoplasia, RETROSPECTIVE studies, DNA methylation, GENOTYPES, CERVIX uteri tumors, WOMEN'S health
Abstract

Background High-grade squamous intraepithelial lesions (HSIL) or cervical intraepithelial neoplasia (CIN) grade 2/3 lesions in human papillomavirus (HPV)–positive women <30 years of age have high spontaneous regression rates. To reduce overtreatment, biomarkers are needed to delineate advanced CIN lesions that require treatment. We analyzed the FAM19A4/miR124-2 methylation test and HPV16/18 genotyping in HPV-positive women aged <30 years, aiming to identify CIN2/3 lesions in need of treatment. Methods A European multicenter retrospective study was designed evaluating the FAM19A4/miR124-2 methylation test and HPV16/18 genotyping in cervical scrapes of 1061 HPV-positive women aged 15–29 years (690 ≤CIN1, 166 CIN2, and 205 CIN3+). A subset of 62 CIN2 and 103 CIN3 were immunohistochemically characterized by HPV E4 expression, a marker for a productive HPV infection, and p16ink4a and Ki-67, markers indicative for a transforming infection. CIN2/3 lesions with low HPV E4 expression and high p16ink4a/Ki-67 expression were considered as nonproductive, transforming CIN, compatible with advanced CIN2/3 lesions in need of treatment. Results FAM19A4/miR124-2 methylation positivity increased significantly with CIN grade and age groups (<25, 25–29, and ≥30 years), while HPV16/18 positivity was comparable across age groups. FAM19A4/miR124-2 methylation positivity was HPV type independent. Methylation-positive CIN2/3 lesions had higher p16ink4a/Ki-67-immunoscores (P =.003) and expressed less HPV E4 (P =.033) compared with methylation-negative CIN2/3 lesions. These differences in HPV E4 and p16ink4a/Ki-67 expression were not found between HPV16/18–positive and non-16/18 HPV–positive lesions. Conclusions Compared with HPV16/18 genotyping, the FAM19A4/miR124-2 methylation test detects nonproductive, transforming CIN2/3 lesions with high specificity in women aged <30 years, providing clinicians supportive information about the need for treatment of CIN2/3 in young HPV-positive women. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth

Author

Heeren, Anne Marijne, primary, Rotman, Jossie, additional, Samuels, Sanne, additional, Zijlmans, Henry J M A A, additional, Fons, Guus, additional, van de Vijver, Koen K, additional, Bleeker, Maaike C G, additional, Kenter, Gemma G, additional, Jordanova, Ekaterina J, additional, and de Gruijl, Tanja D, additional

Published
2021
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