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1. Probing $WW\gamma \gamma$ and $ZZ\gamma \gamma$ quartic anomalous couplings with 10 pb$^{-1}$ at the LHC

Author

Chapon, E. and Royon, O. Kepka. C.

Subjects
High Energy Physics - Phenomenology
Abstract

We report on a possible measurement at the LHC using the first data and a luminosity of 10 pb$^{-1}$ of $W$ and $Z$ pair production via two-photon exchange. This measurement allows to increase the present sensitivity on $WW\gamma \gamma$ and $ZZ\gamma \gamma$ quartic anomalous couplings from the LEP experiments by almost three orders of magnitude., Comment: 4 pages, 3 figures

Published
2009

3. Non-invasive characterization of pancoronary inflammation by computed tomography angiography in patients with recent spontaneous coronary dissection

Author

Wolny, R, primary, Kwiecinski, J, additional, Zalewska, J, additional, Michalowska, I, additional, Kruk, M, additional, Kepka, C, additional, Prejbisz, A, additional, Pregowski, J, additional, Skowronski, J, additional, Kobierska, A, additional, Ciesielski, R, additional, Januszewicz, A, additional, Witkowski, A, additional, Adlam, D, additional, and Kadziela, J, additional

Published
2022
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8. Pilot study of the multicentre DISCHARGE trial

Author

Rubeis, G. de, Napp, A.E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H.H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J.F., Valente, F.X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J.D., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A.N., Lecumberri, I., Gonzales, I.D., Ruzsics, B., Fisher, M., Dewey, M., Francone, M., and DISCHARGE Trial Grp

Abstract

The original version of this article, published on 16 December 2019, unfortunately contained two mistakes.

Published
2020

9. Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography

Author

Rubeis, G. de, Napp, A.E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H.H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J.F., Valente, F.X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A.N., Lecumberri, I., Gonzales, I.D., Ruzsics, B., Fisher, M., Dewey, M., Francone, M., and DISCHARGE Trial Grp

Subjects
Male, medicine.medical_specialty, Computed Tomography Angiography, Image quality, Pilot Projects, Computed tomography, Coronary Angiography, Coronary artery disease, angiography, coronary, coronary artery disease, CT angiography, medical imaging, trial protocols, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Medical imaging, Humans, Radiology, Nuclear Medicine and imaging, Neuroradiology, Protocol (science), medicine.diagnostic_test, business.industry, Angiography, Reproducibility of Results, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Coronary Vessels, Invasive coronary angiography, 030220 oncology & carcinogenesis, Trial protocols, Female, Radiology, business
Abstract

To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13).We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.• Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.

Published
2020

10. Correction to: Pilot study of the multicentre DISCHARGE trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography

Author

De Rubeis, G., Napp, A. E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H. H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J. F., Valente, F. X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J. D., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A. N., Lecumberri, I., Gonzales, I. D., Ruzsics, B., Fisher, M., Dewey, M., and Francone, M.

Subjects
TAVI, CT, MR, Radiology, Nuclear Medicine and imaging, General Medicine
Published
2020

13. Coronary arteries in fibromuscular dysplasia. 3-Dimensional coronary CT, case-control study. The ARCARDIA-POL BIS study

Author

Kruk, M, primary, Szkamruk, K, additional, Adlam, D, additional, Persu, A, additional, Pappaccogli, M, additional, Van Der Niepen, P, additional, Kepka, C, additional, Januszewicz, M, additional, Pregowski, J, additional, Skowronski, J, additional, Kabat, M, additional, Warchol-Celinska, E, additional, Prejbisz, A, additional, Dobrowolski, P, additional, and Januszewicz, A, additional

Published
2020
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14. Aortic invovement in fibromuscular dysplasia. 3-dimensional CT, case-control study. THE ARCADIA-POL BIS study

Author

Szkamruk, K, primary, Kruk, M, additional, Kepka, C, additional, Adlam, D, additional, Persu, A, additional, Canning, C, additional, Pappaccogli, M, additional, Van Der Niepen, P, additional, Januszewicz, M, additional, Kabat, M, additional, Warchol-Celinska, E, additional, Prejbisz, A, additional, Jozwik-Plebanek, K, additional, Dobrowolski, P, additional, and Januszewicz, A, additional

Published
2020
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22. P5866Economic outcomes of the CAT-CAD randomised trial assessing coronary artery computed tomography as the first-choice anatomic test for individuals with suspected significant coronary artery disease

Author

Rudzinski, P.N., primary, Kruk, M., additional, Kepka, C., additional, Schoepf, U.J., additional, Duguay, T., additional, Dzielinska, Z., additional, Pregowski, J., additional, Witkowski, A., additional, Ruzyllo, W., additional, and Demkow, M., additional

Published
2017
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24. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart

Author

Bartnik M., Ryden L., Ferrari R., Malmberg K., Pyorala K., Simoons M., Standl E., Soler-Soler J., Ohrvik J., Manini M., Bramley C., Laforest V., Taylor C., Del Gaiso S., Huber K., De Backer G., Sirakova V., Cerbak R., Thayssen P., Lehto S., Delahaye F., Kobulia B., Zeymer U., Cokkinos D., Karlocai K., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Mareev V., Riecansky I., Kenda M. F., Lopez-Sendon J. L., Rosengren A., Buser P., Okay T., Sychov O., Fox K., Wood D., Alonso A., Boersma E., Crijns H., Gitt A., McGregor K., Mulder B., Nieminen M., Priori S., Tavazzi L., Vahanian A., Vardas P., Wijns W., Aydinkoc K., Spenka M., Wascher T. C., Sourij H., Dusko V., Radivojevic M., Goudev A. R., Tzekova M. L., Simeonov P., Pentchev V., Yotov Y., Torbova S. G., Stoyanovsky V., Stoynev E., Ostrovsky I., Moroz-Vadalazhskaya N., Cocco G., Antoniades L., Kyprianou D., Florian J., Yaghmaee S., Kvasnika J., Krizova A., Rosolova H., Petrlova B., Borivoj S., Poloczek M., Niebauer J., Drechsler K., Sechtem U., Vogelsberg H., Blank E., Breithardt G., Wedekind H., Ksoll B., Laks T., Ambos A., Tupits H., Kalinina L., Anton L., Planken U., Saad A., Andraos A. W., Shafy S. A., Metias B. D., Ibrahim M. A., Tantawi H., Lopez Bescos L., Huelmos A., Fernandez Aviles F., De La Fuente Galan L., Vinuela P. T., Velasco Rami J. A., Soriano F. R., Soledad Alcasena-Juango M., Berjon-Reyero J., Orcajo N. A., Garcia Calabozo R., Masia R., Sala J., Rohlfs I., De Diego J. J. G., Martin L. S., De El Escorial S. L., Latasa M. I., Miranda I. A., Garcia A. A., Andrade M. A., Conde A. C., Ortuno F. M., Climent V., Gonzalo F. E., Martinez V. B., Ortega J. A. R., De Alicante S. J., Galvez C. P., Rivero R. F., Belsue F. V., Rubio J. R. S., Escorihuela A. L., Gonzalez V. B., Iglesias F. C., Minguezy Enriquez De Salamanca I., Rejon F. R., Cobo A. L., Tarin N., Savolainen K., Nieminen M. S., Syvanne M., Pietila M., Mustonen J., Juntunen I., Marco J., Gilliume S., Bassand J. P., Espinosa D. P., Adgey J., Brien A. O., Cleland J. G. F., Reddy D. H., Pathmanathan R. K., Fairbrother K. L., Tabidze G., Tvildiani L., Chumburidze V., Kikalishvili T., Kurashvili R., Khelashvili M., Anifantakis A., Voudris V., Tsiavou N., Toutouzas P. K., Latsios G., Richter D., Karabinos I. K., Giannopoulou G., Gotsis A., Bozia P., Savvopoulou A., Kotsis V., Bozas G., Efstathios M., Koulouris S., Vardas P. E., Marketou M., Papadopoulos G., Patsourakos N., Anastassios L., Keltai M., Ostor E., Borbola J., Liptia C., Lupkovics G., Barnabas N., Matoltsy A., Hontvari L., Sido Z., Szamosi K., Forster T., Nemes A., Szakal I., Topal L., Badics A., Engelthaler G., Nagy A., Di Sciascio G., Cecilia Scimia M., Ambrosio D., Pesola A., Robiglio L., Aloisi B., Cavallaro A., Mazzola C., Ciconte V., Giancotti D., Naccarella F., Maranga S. S., Lepera G., Sergnoli E., Zanetti M., Causarano A., Zoli V., Novo S., Coppola G., Evola G., Tanzi P., Colecchia D., Macali L., Terrana R., Zanetta M., Vegis D., Bernardi D., Tramarin R., Opasich C., Slapikas R., Gustiene O., Petrulioniene Z., Kovaite M., Georgievska-Ismail L., Poposka L., Davceva-Pavlovska J., Peovska I., Bosevski M., Deckers J. W., Jansen C. G., De Boer M. J., Van Rijn N., Brons R., Bootsma A., Van Hoogenhuyze D. C. A., Leenders C. M., Veerhoek M. J., Haan D., Baur L., Van Den Dool A., Fransen H., Nieuwlaat R., Widdershofen J. W. M. G., Broers H., Werter C., Bijl M., Koppelaar C., Ruzyllo W., Przyluski J., Kepka C., Maczynska R., Krzciuk M., Kubicka B., Dluzniewski M., Krzyzak P., Supinski W., Myczka T., Schulowska A., Zinka E., Gsecki M., Budaj A., Kokowicz P., Opolski G., Roik M., Rekosz J., Biegajlo J., Kleinrok A., Czochra W., Rynkiewicz A., Grzybowski A., Bellwon J., De Oliveira E. I., Nobrega J., Ferreira R., Baptista S., Veloso Gomes M. J., Candeias R. A. C., Rufino E., Providencia L. A., Monteiro P., Carrageta M., Bento L., Albert I., Svensson A. M., Petersson A., Torelund G., Patel H., Hage C., Lidin M., Lainscak M., Dernic J., Ambrozic J., Mocnik F. S., Glavnmik A., Fras Z., Latific-Jasnic D., Bunc M., Klemenc M., Lobnik A., Kompara G., Koval O. A., Prog R. V., Tkachenko J., Knyazkova I., Tasic I., Cardiology, Bartnik M., Ryden L., Ferrari R., Malmberg K., Pyorala K., Simoons M., Standl E., Soler-Soler J., Ohrvik J., Manini M., Bramley C., Laforest V., Taylor C., Del Gaiso S., Huber K., De Backer G., Sirakova V., Cerbak R., Thayssen P., Lehto S., Delahaye F., Kobulia B., Zeymer U., Cokkinos D., Karlocai K., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Mareev V., Riecansky I., Kenda M.F., Lopez-Sendon J.L., Rosengren A., Buser P., Okay T., Sychov O., Fox K., Wood D., Alonso A., Boersma E., Crijns H., Gitt A., McGregor K., Mulder B., Nieminen M., Priori S., Tavazzi L., Vahanian A., Vardas P., Wijns W., Aydinkoc K., Spenka M., Wascher T.C., Sourij H., Dusko V., Radivojevic M., Goudev A.R., Tzekova M.L., Simeonov P., Pentchev V., Yotov Y., Torbova S.G., Stoyanovsky V., Stoynev E., Ostrovsky I., Moroz-Vadalazhskaya N., Cocco G., Antoniades L., Kyprianou D., Florian J., Yaghmaee S., Kvasnika J., Krizova A., Rosolova H., Petrlova B., Borivoj S., Poloczek M., Niebauer J., Drechsler K., Sechtem U., Vogelsberg H., Blank E., Breithardt G., Wedekind H., Ksoll B., Laks T., Ambos A., Tupits H., Kalinina L., Anton L., Planken U., Saad A., Andraos A.W., Shafy S.A., Metias B.D., Ibrahim M.A., Tantawi H., Lopez Bescos L., Huelmos A., Fernandez Aviles F., De La Fuente Galan L., Vinuela P.T., Velasco Rami J.A., Soriano F.R., Soledad Alcasena-Juango M., Berjon-Reyero J., Orcajo N.A., Garcia Calabozo R., Masia R., Sala J., Rohlfs I., De Diego J.J.G., Martin L.S., De El Escorial S.L., Latasa M.I., Miranda I.A., Garcia A.A., Andrade M.A., Conde A.C., Ortuno F.M., Climent V., Gonzalo F.E., Martinez V.B., Ortega J.A.R., De Alicante S.J., Galvez C.P., Rivero R.F., Belsue F.V., Rubio J.R.S., Escorihuela A.L., Gonzalez V.B., Iglesias F.C., Minguezy Enriquez De Salamanca I., Rejon F.R., Cobo A.L., Tarin N., Savolainen K., Nieminen M.S., Syvanne M., Pietila M., Mustonen J., Juntunen I., Marco J., Gilliume S., Bassand J.P., Espinosa D.P., Adgey J., Brien A.O., Cleland J.G.F., Reddy D.H., Pathmanathan R.K., Fairbrother K.L., Tabidze G., Tvildiani L., Chumburidze V., Kikalishvili T., Kurashvili R., Khelashvili M., Anifantakis A., Voudris V., Tsiavou N., Toutouzas P.K., Latsios G., Richter D., Karabinos I.K., Giannopoulou G., Gotsis A., Bozia P., Savvopoulou A., Kotsis V., Bozas G., Efstathios M., Koulouris S., Vardas P.E., Marketou M., Papadopoulos G., Patsourakos N., Anastassios L., Keltai M., Ostor E., Borbola J., Liptia C., Lupkovics G., Barnabas N., Matoltsy A., Hontvari L., Sido Z., Szamosi K., Forster T., Nemes A., Szakal I., Topal L., Badics A., Engelthaler G., Nagy A., Di Sciascio G., Cecilia Scimia M., Ambrosio D., Pesola A., Robiglio L., Aloisi B., Cavallaro A., Mazzola C., Ciconte V., Giancotti D., Naccarella F., Maranga S.S., Lepera G., Sergnoli E., Zanetti M., Causarano A., Zoli V., Novo S., Coppola G., Evola G., Tanzi P., Colecchia D., Macali L., Terrana R., Zanetta M., Vegis D., Bernardi D., Tramarin R., Opasich C., Slapikas R., Gustiene O., Petrulioniene Z., Kovaite M., Georgievska-Ismail L., Poposka L., Davceva-Pavlovska J., Peovska I., Bosevski M., Deckers J.W., Jansen C.G., De Boer M.J., Van Rijn N., Brons R., Bootsma A., Van Hoogenhuyze D.C.A., Leenders C.M., Veerhoek M.J., Haan D., Baur L., Van Den Dool A., Fransen H., Nieuwlaat R., Widdershofen J.W.M.G., Broers H., Werter C., Bijl M., Koppelaar C., Ruzyllo W., Przyluski J., Kepka C., Maczynska R., Krzciuk M., Kubicka B., Dluzniewski M., Krzyzak P., Supinski W., Myczka T., Schulowska A., Zinka E., Gsecki M., Budaj A., Kokowicz P., Opolski G., Roik M., Rekosz J., Biegajlo J., Kleinrok A., Czochra W., Rynkiewicz A., Grzybowski A., Bellwon J., De Oliveira E.I., Nobrega J., Ferreira R., Baptista S., Veloso Gomes M.J., Candeias R.A.C., Rufino E., Providencia L.A., Monteiro P., Carrageta M., Bento L., Albert I., Svensson A.M., Petersson A., Torelund G., Patel H., Hage C., Lidin M., Lainscak M., Dernic J., Ambrozic J., Mocnik F.S., Glavnmik A., Fras Z., Latific-Jasnic D., Bunc M., Klemenc M., Lobnik A., Kompara G., Koval O.A., Prog R.V., Tkachenko J., Knyazkova I., and Tasic I.

Subjects
Adult, Blood Glucose, Male, Diabetes mellitu, medicine.medical_specialty, Abnormal glucose, Diabetic Angiopathie, Oral glucose tolerance test, Coronary Artery Disease, Impaired glucose tolerance, Coronary artery disease, SDG 3 - Good Health and Well-being, Risk Factors, Diabetes mellitus, Internal medicine, Epidemiology, medicine, Humans, In patient, Aged, Glucose tolerance test, medicine.diagnostic_test, business.industry, Glucose Tolerance Test, Middle Aged, medicine.disease, Surgery, Europe, Diabetes Mellitus, Type 2, Blood sugar regulation, Female, Cardiology and Cardiovascular Medicine, business, Diabetic Angiopathies, Human
Abstract

Aim The objective behind the Euro Heart Survey on diabetes and the heart was to study the prevalence of abnormal glucose regulation in adult patients with coronary artery disease (CAD). Methods and results The survey engaged 110 centres in 25 countries recruiting 4196 patients referred to a cardiologist due to CAD out of whom 2107 were admitted on an acute basis and 2854 had an elective consultation. Patient data were collected via a web-based case record form. An oral glucose tolerance test (OGTT) was used for the characterisation of the glucose metabolism. Thirty-one per cent of the patients had diabetes. An OGTT was performed on the 1920 patients without known diabetes, of whom 923 had acute and 997 had a stable manifestation of CAD, respectively. In patients with acute CAD, 36% had impaired glucose regulation and 22% newly detected diabetes. In the stable group these proportions were 37% and 14%. Conclusion This survey demonstrates that normal glucose regulation is less common than abnormal glucose regulation in patients with CAD. OGTT easily discloses the glucometabolic state and should be a routine procedure. The knowledge of glucometabolic state among these patients should influence their future management because it has great potential to improve the outcome.

Published
2004

25. Probing $WW����$ and $ZZ����$ quartic anomalous couplings with 10 pb$^{-1}$ at the LHC

Author

Chapon, E. and Royon, O. Kepka. C.

Subjects
High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences
Abstract

We report on a possible measurement at the LHC using the first data and a luminosity of 10 pb$^{-1}$ of $W$ and $Z$ pair production via two-photon exchange. This measurement allows to increase the present sensitivity on $WW����$ and $ZZ����$ quartic anomalous couplings from the LEP experiments by almost three orders of magnitude., 4 pages, 3 figures

Published
2009
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28. Decreased eGFR is associated with increased all-cause and cardiovascular mortality even nine years after ST-Elevated Myocardial Infarction (STEMI). The ANIN Myocardial Infarction registry

Author

Polanska-Skrzypczyk, M., primary, Karcz, M., additional, Bekta, P., additional, Kepka, C., additional, Przyluski, J., additional, Kruk, M., additional, Ksiezycka, E., additional, Ciszewski, A., additional, Ruzyllo, W., additional, and Witkowski, A., additional

Published
2013
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31. Abstracts

Author

Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. 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S., additional, Sattar, A., additional, Swadia, T., additional, Chattahi, J., additional, Qureshi, W., additional, Khalid, F., additional, Gonzalez, A., additional, Hechavarria, S., additional, Takamura, K., additional, Fujimoto, S., additional, Nakanishi, R., additional, Yamashina, S., additional, Namiki, A., additional, Yamazaki, J., additional, Koshino, K., additional, Hashikawa, Y., additional, Teramoto, N., additional, Hikake, M., additional, Ishikane, S., additional, Ikeda, T., additional, Iida, H., additional, Takahashi, Y., additional, Oriuchi, N., additional, Higashino, H., additional, Endo, K., additional, Mochizuki, T., additional, Murase, K., additional, Baali, A., additional, Moreno, R., additional, Chau, M., additional, Rousseau, H., additional, Nicoud, F., additional, Dolliner, P., additional, Brammen, L., additional, Steurer, G., additional, Traub-Weidinger, T., additional, Ubl, P., additional, Schaffarich, P., additional, Dobrozemsky, G., additional, Staudenherz, A., additional, Ozgen Kiratli, M., additional, Temelli, B., additional, Kanat, N. B., additional, Aksoy, T., additional, Slavich, G. A., additional, Piccoli, G., additional, Puppato, M., additional, Grillone, S., additional, Gasparini, D., additional, Dunet, V., additional, Perruchoud, S., additional, Poitry-Yamate, C., additional, Lepore, M., additional, Gruetter, R., additional, Pedrazzini, T., additional, Anselm, D., additional, Anselm, A., additional, Atkins, H., additional, Renaud, J., additional, Dekemp, R., additional, Burwash, I., additional, Guo, A., additional, Beanlands, R., additional, Glover, C., additional, Vilardi, I., additional, Zangheri, B., additional, Calabrese, L., additional, Romano, P., additional, Bruno, A., additional, Fernandez Cimadevilla, O. C., additional, Uusitalo, V. A., additional, Luotolahti, M., additional, Wendelin-Saarenhovi, M., additional, Sundell, J., additional, Raitakari, O., additional, Huidu, S., additional, Gadiraju, R., additional, Ghesani, M., additional, Uddin, Q., additional, Wosnitzer, B., additional, Takahashi, N., additional, Alhaj, E., additional, Legasto, A., additional, Abiri, B., additional, Elsaban, K., additional, El Khouly, T., additional, El Kammash, T., additional, Al Ghamdi, A., additional, Kyung Deok, B., additional, Bon Seung, K., additional, Sang Geun, Y., additional, Chang Min, D., additional, and Gwan Hong, M., additional

Published
2011
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32. Pilot-scale extraction of an intracellular recombinant cutinase from E-coli cell homogenate using a thermoseparating aqueous two-phase system

Author

Kepka, C., Collet, E., Persson, J., Stahl, A., Lagerstedt, T., Tjerneld, F., Veide, Andres, Kepka, C., Collet, E., Persson, J., Stahl, A., Lagerstedt, T., Tjerneld, F., and Veide, Andres

Abstract

A thermoseparating aqueous two-phase system for extraction of a recombinant cutinase fusion protein from Escherichia coli homogenate has been scaled up to pilot scale. The target protein ZZ-cutinase-(WP)(4) was produced in a fed batch process at 500 1 to a concentration of 12% of the total protein and at a cell concentration of 19.7 g l(-1). After harvest and high-pressure homogenisation a first extraction step was performed in an EO50PO50 (50% (w/w) ethylene oxide and 50% (w/w) propylene oxide) thermopolymer/amylopectin rich Waxy barley starch system. The (WP)4 tag was used for enhanced target protein partitioning to the EO50PO50 phase while the cell debris was collected in the starch phase. A second extraction step followed where the recovered EO50PO50 phase from the first step was supplemented with a non-ionic detergent (C12-18EO5) and heated to the cloud point (CP) temperature (45 degreesC). One polymer-rich liquid phase and one almost pure aqueous phase were formed. The target protein could be obtained in a water phase after the thermal phase separation at a total recovery over the extraction steps of 71% and a purification factor of 2.5. We were able to demonstrate that a disk-stack centrifugal separator could be adapted for rapid separation of both primary and thermoseparated phase systems., QC 20100525

Published
2003
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35. Computed tomography to predict surgical revascularization of a left anterior descending artery occlusion incompletely visualized by conventional angiography.

Author

Kepka C, Opolski MP, Juraszynski Z, Kruk M, Pregowski J, Pracon R, Dyk W, Demkow M, Witkowski A, Ruzyllo W, Kepka, Cezary, Opolski, Maksymilian P, Juraszynski, Zbigniew, Kruk, Mariusz, Pregowski, Jerzy, Pracon, Radoslaw, Dyk, Wojciech, Demkow, Marcin, Witkowski, Adam, and Ruzyllo, Witold

Published
2012
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37. Comparison of different methods of ST segment resolution analysis for prediction of 1-year mortality after primary angioplasty for acute myocardial infarction.

Author

Przyluski J, Karcz M, Kalinczuk L, Kruk M, Pregowski J, Kaczmarska E, Petryka J, Bekta P, Deptuch T, Kepka C, Witkowski A, Ruzyllo W, ANIN Myocardial Infarction Registry, Przyluski, Jakub, Karcz, Maciej, Kalińczuk, Lukasz, Kruk, Mariusz, Pregowski, Jerzy, Kaczmarska, Edyta, and Petryka, Joanna

Abstract

Background: Resolution of ST segment elevation corresponds with myocardial tissue reperfusion and correlates with clinical outcome after ST elevation myocardial infarction. Simpler method evaluating the extent of maximal deviation persisting in a single ECG lead was an even stronger mortality predictor. Our aim was to evaluate and compare prognostic accuracy of different methods of ST segment elevation resolution analysis after primary percutaneous coronary intervention (PCI) in a real-life setting.Methods: Paired 12-lead ECGs were analyzed in 324 consecutive and unselected patients treated routinely with primary PCI in a single high-volume center. ST segment resolution was quantified and categorized into complete, partial, or none, upon the (1) sum of multilead ST elevations (sumSTE) and (2) sum of ST elevations plus reciprocal depressions (sumSTE+D); or into the low-, medium-, and high-risk groups by (3) the single-lead extent of maximal postprocedural ST deviation (maxSTE).Results: Complete, partial, and nonresolution groups by sumSTE constituted 39%, 40%, and 21% of patients, respective groups by sumSTE+D comprised 40%, 39%, and 21%. The low-, medium-, and high-risk groups constituted 43%, 32%, and 25%. One-year mortality rates for rising risk groups by sumSTE were 4.7%, 10.2%, and 14.5% (P = 0.049), for sumSTE+D 3.8%, 9.6%, and 17.6% (P = 0.004) and for maxSTE 5.1%, 6.7%, and 18.5% (P = 0.001), respectively. After adjustment for multiple covariates only maxSTE (high vs low-risk, odds ratio [OR] 3.10; 95% confidence interval [CI] 1.11-8.63; P = 0.030) and age (OR 1.07; 95% CI 1.02-1.11; P = 0.002) remained independent predictors of mortality.Conclusions: In unselected population risk stratifications based on the postprocedural ST resolution analysis correlate with 1-year mortality after primary PCI. However, only the single-lead ST deviation analysis allows an independent mortality prediction. [ABSTRACT FROM AUTHOR]

Published
2007

38. Polymer-glue as a life and kidney function saver: a life-threatening hemorrhage in the ruptured upper pole artery of the kidney managed by percutaneous embolization — a case report and literature review

Author

Antoniewicz Artur, Wojtkowska Izabela, Dziekiewicz Mirosław, Kępka Cezary, Kremis Elżbieta, Zapała Łukasz, Skiba Ryszard, and Stępińska Janina

Subjects
polymer-glue, percutaneous embolization, a life-threatening kidney hemorrhage, Medicine
Published
2013
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43. Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain: A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial.

Author

Bosserdt M, Serna-Higuita LM, Feuchtner G, Merkely B, Kofoed KF, Benedek T, Donnelly P, Rodriguez-Palomares J, Erglis A, Štechovský C, Šakalyte G, Adic NC, Gutberlet M, Dodd JD, Diez I, Davis G, Zimmermann E, Kepka C, Vidakovic R, Francone M, Ilnicka-Suckiel M, Plank F, Knuuti J, Faria R, Schröder S, Berry C, Saba L, Ruzsics B, Rieckmann N, Kubiak C, Hansen KS, Müller-Nordhorn J, Szilveszter B, Sigvardsen PE, Benedek I, Orr C, Valente FX, Zvaigzne L, Suchánek V, Jankauskas A, Adic F, Woinke M, Hensey M, Lecumberri I, Thwaite E, Laule M, Kruk M, Neskovic AN, Mancone M, Kusmierz D, Pietilä M, Ribeiro VG, Drosch T, Delles C, Porcu M, Fisher M, Boussoussou M, Kragelund C, Aurelian R, Kelly S, Garcia Del Blanco B, Rubio A, Maurovich-Horvat P, Hove JD, Rodean I, Regan S, Cuellar-Calabria H, Molnár L, Larsen L, Hodas R, Napp AE, Haase R, Feger S, Mohamed M, Neumann K, Dreger H, Rief M, Wieske V, Estrella M, Martus P, Sox HC, and Dewey M

Subjects
Female, Humans, Middle Aged, Chest Pain etiology, Chest Pain diagnosis, Coronary Angiography methods, Tomography, X-Ray Computed, Male, Aged, Coronary Artery Disease complications, Coronary Artery Disease diagnostic imaging
Abstract

Importance: The effectiveness and safety of computed tomography (CT) and invasive coronary angiography (ICA) in different age groups is unknown., Objective: To determine the association of age with outcomes of CT and ICA in patients with stable chest pain., Design, Setting, and Participants: The assessor-blinded Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial was conducted between October 2015 and April 2019 in 26 European centers. Patients referred for ICA with stable chest pain and an intermediate probability of obstructive coronary artery disease were analyzed in an intention-to-treat analysis. Data were analyzed from July 2022 to January 2023., Interventions: Patients were randomly assigned to a CT-first strategy or a direct-to-ICA strategy., Main Outcomes and Measures: MACE (ie, cardiovascular death, nonfatal myocardial infarction, or stroke) and major procedure-related complications. The primary prespecified outcome of this secondary analysis of age was major adverse cardiovascular events (MACE) at a median follow-up of 3.5 years., Results: Among 3561 patients (mean [SD] age, 60.1 [10.1] years; 2002 female [56.2%]), 2360 (66.3%) were younger than 65 years, 982 (27.6%) were between ages 65 to 75 years, and 219 (6.1%) were older than 75 years. The primary outcome was MACE at a median (IQR) follow-up of 3.5 (2.9-4.2) years for 3523 patients (99%). Modeling age as a continuous variable, age, and randomization group were not associated with MACE (hazard ratio, 1.02; 95% CI, 0.98-1.07; P for interaction = .31). Age and randomization group were associated with major procedure-related complications (odds ratio, 1.15; 95% CI, 1.05-1.27; P for interaction = .005), which were lower in younger patients., Conclusions and Relevance: Age did not modify the effect of randomization group on the primary outcome of MACE but did modify the effect on major procedure-related complications. Results suggest that CT was associated with a lower risk of major procedure-related complications in younger patients., Trial Registration: ClinicalTrials.gov Identifier: NCT02400229.

Published
2024
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44. Pericoronary adipose tissue density is increased in patients with recent spontaneous coronary dissection.

Author

Wolny RR, Kwieciński J, Zalewska J, Michałowska I, Kruk M, Kepka C, Prejbisz A, Pręgowski J, Chwała A, Skowroński J, Kobierska A, Ciesielski R, Januszewicz A, Witkowski A, Adlam D, Dey D, and Kądziela J

Subjects
Humans, Female, Male, Coronary Angiography methods, Heart, Computed Tomography Angiography methods, Coronary Vessels diagnostic imaging, Adipose Tissue diagnostic imaging, Coronary Artery Disease diagnostic imaging
Abstract

Objective: Inflammatory activity is one of the potential mechanisms of spontaneous coronary artery dissection (SCAD). Recently, the pericoronary adipose tissue attenuation (PCAT) derived from CT angiography (CTA) has been established as a method for measuring vascular inflammation. We aimed to characterise the pancoronary and vessel-specific PCAT in patients with and without recent SCAD., Methods: The study comprised patients with SCAD referred to a tertiary centre between 2017 and 2022 who underwent CTA and were compared with individuals with no prior SCAD. PCAT was analysed on end-diastolic CTA reconstructions along proximal 40 mm of all major coronary vessels as well as the SCAD-related vessel. We analysed 48 patients with recent SCAD (median 6.1 (IQR 3.5-14.9) months since SCAD, 95.8% female) and 48 patients in the group without SCAD., Results: Pancoronary PCAT was higher in patients with SCAD compared with those without SCAD (-80.6±7.9 vs -85.3 HU±6.1, p=0.002). Vessel-specific PCAT in patients with SCAD compared with patients without SCAD was higher for both the RCA (-80.9±9.5 vs -87.1±6.9 HU, p=0.001) and the LCA (-80.3±7.8 vs -83.4±7.2 HU, p=0.04). In patients with SCAD, PCAT of the SCAD-related vessel was not significantly different from averaged PCAT of unaffected vessels (-81.2±9.2 vs -80.6±7.6, p=0.74). There was no association between PCAT and the interval from SCAD to CTA., Conclusions: Patients with recent SCAD have higher PCAT compared with patients without SCAD, suggesting an increased perivascular inflammatory activity. This association is not restricted to the dissected vessel., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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45. Computed tomography perfusion and angiography in patients with chronic total occlusion undergoing percutaneous coronary intervention.

Author

Kwiecinski J, Oleksiak A, Kruk M, Zysk A, Debski A, Knaapen P, Schumacher SP, Barbero U, Witkowski A, Kepka C, and Opolski MP

Subjects
Humans, Male, Middle Aged, Aged, Female, Coronary Angiography methods, Predictive Value of Tests, Tomography, X-Ray Computed, Computed Tomography Angiography, Chronic Disease, Treatment Outcome, Percutaneous Coronary Intervention, Vascular Diseases, Coronary Occlusion diagnostic imaging, Coronary Occlusion surgery, Myocardial Perfusion Imaging methods
Abstract

Background and Aims: Myocardial perfusion imaging (MPI) and anatomical imaging with coronary computed tomography angiography (CCTA) can play an important role in the preprocedural planning of a chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We aimed to establish the feasibility of a novel dynamic computed tomography perfusion (CTP) analysis for the assessment of myocardial perfusion before and after a successful recanalization of CTO in patients undergoing CCTA as part of a standard preprocedural workup., Methods: In a prospective observational study symptomatic patients underwent dynamic CTP on a dual-source CT scanner both before and 3 months after successful CTO PCI., Results: Twenty-seven patients completed the study (63 ± 8 years old, 78% male). Following successful CTO PCI, there was a significant reduction in the ischemic burden (5 [5-7] versus 1 [0-2] segments, p < 0.001), and improvement in myocardial blood flow (85.3 [71.7-94.1] versus 134.6 [123.8-156.9] mL/min, p < 0.001) resulting in an increase in the relative flow reserve (0.49 [0.41-0.57] versus 0.88 [0.74-0.95], p < 0.001)., Conclusions: CTP emerges as a robust and safe method for MPI in CTO patients. The single imaging session assessment of both coronary anatomy and perfusion with CT lends itself to precise disease phenotyping in the challenging population of CTO patients., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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46. Can the Application of Fractional Flow Reserve Computed Tomography in High-risk Patients With Chronic Coronary Syndrome Obviate Downstream Diagnostic Invasive Coronary Procedures?

Author

Rudzinski PN, Kruk M, Debski M, Demkow M, and Kepka C

Subjects
Humans, Tomography, X-Ray Computed methods, Coronary Angiography methods, Computed Tomography Angiography methods, Predictive Value of Tests, Coronary Vessels, Severity of Illness Index, Fractional Flow Reserve, Myocardial, Coronary Artery Disease, Coronary Stenosis
Abstract

Competing Interests: The authors declare no conflicts of interest.

Published
2023
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47. Atherosclerosis Imaging Quantitative Computed Tomography (AI-QCT) to guide referral to invasive coronary angiography in the randomized controlled CONSERVE trial.

Author

Kim Y, Choi AD, Telluri A, Lipkin I, Bradley AJ, Sidahmed A, Jonas R, Andreini D, Bathina R, Baggiano A, Cerci R, Choi EY, Choi JH, Choi SY, Chung N, Cole J, Doh JH, Ha SJ, Her AY, Kepka C, Kim JY, Kim JW, Kim SW, Kim W, Pontone G, Villines TC, Cho I, Danad I, Heo R, Lee SE, Lee JH, Park HB, Sung JM, Crabtree T, Earls JP, Min JK, and Chang HJ

Subjects
Humans, Female, Male, Coronary Angiography methods, Constriction, Pathologic complications, Artificial Intelligence, Tomography, X-Ray Computed, Computed Tomography Angiography methods, Referral and Consultation, Predictive Value of Tests, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease complications, Coronary Stenosis complications, Atherosclerosis complications, Fractional Flow Reserve, Myocardial
Abstract

Aims: We compared diagnostic performance, costs, and association with major adverse cardiovascular events (MACE) of clinical coronary computed tomography angiography (CCTA) interpretation versus semiautomated approach that use artificial intelligence and machine learning for atherosclerosis imaging-quantitative computed tomography (AI-QCT) for patients being referred for nonemergent invasive coronary angiography (ICA)., Methods: CCTA data from individuals enrolled into the randomized controlled Computed Tomographic Angiography for Selective Cardiac Catheterization trial for an American College of Cardiology (ACC)/American Heart Association (AHA) guideline indication for ICA were analyzed. Site interpretation of CCTAs were compared to those analyzed by a cloud-based software (Cleerly, Inc.) that performs AI-QCT for stenosis determination, coronary vascular measurements and quantification and characterization of atherosclerotic plaque. CCTA interpretation and AI-QCT guided findings were related to MACE at 1-year follow-up., Results: Seven hundred forty-seven stable patients (60 ± 12.2 years, 49% women) were included. Using AI-QCT, 9% of patients had no CAD compared with 34% for clinical CCTA interpretation. Application of AI-QCT to identify obstructive coronary stenosis at the ≥50% and ≥70% threshold would have reduced ICA by 87% and 95%, respectively. Clinical outcomes for patients without AI-QCT-identified obstructive stenosis was excellent; for 78% of patients with maximum stenosis < 50%, no cardiovascular death or acute myocardial infarction occurred. When applying an AI-QCT referral management approach to avoid ICA in patients with <50% or <70% stenosis, overall costs were reduced by 26% and 34%, respectively., Conclusions: In stable patients referred for ACC/AHA guideline-indicated nonemergent ICA, application of artificial intelligence and machine learning for AI-QCT can significantly reduce ICA rates and costs with no change in 1-year MACE., (© 2023 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.)

Published
2023
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48. Computed tomographic characteristics of congenital coronary artery fistulas in an adult population.

Author

Michałowska AM, Skowroński J, Michałowska I, Tyczyński P, Kowalik I, Wolny R, Opolski MP, Demkow M, Hoffman P, Lazarczyk H, Kruk M, Kepka C, Kusmierczyk M, Witkowski A, and Pręgowski J

Subjects
Adult, Humans, Male, Coronary Angiography methods, Tomography, X-Ray Computed methods, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease epidemiology, Fistula, Coronary Vessel Anomalies diagnostic imaging, Coronary Vessel Anomalies epidemiology
Abstract

Background: Coronary artery fistulas (CAFs) are usually congenital coronary artery anomalies of termination., Aims: This study aimed to assess the prevalence, anatomic characteristics, and clinical significance of CAFs detected by computed tomography (CT) in an adult population., Methods: We performed 45 817 CT examinations in 39 066 subjects between 2008 and 2020. The electronic database was manually checked using specific keywords to identify patients with CAFs. The CT characteristics of CAFs were evaluated. CAF was defined as clinically significant if it was the most plausible cause of myocardial infarction, infective endocarditis, heart failure, death during follow-up, hospitalization, or if it required either percutaneous or surgical intervention., Results: Of 39 066 patients, 56 CAFs were detected in 42 subjects (20 men, 47.6%) with a prevalence of 0.11%. Most CAFs originated from the right coronary artery (RCA) (48.2%) and drained into the pulmonary artery (PA) (58.9%). CAFs terminating in the PA were more frequently multiple (P <0.001) and tortuous (P <0.001) as compared to CAFs without PA drainage. Clinically significant CAFs, identified in 7 of 42 patients, were more common in younger (P = 0.03) and male (P = 0.04) subjects and had larger lumen area and diameter at the site of origin (P = 0.03, P = 0.03, respectively)., Conclusions: In the unselected adult population undergoing coronary CT angiography, the RCA and the PA are the most common sites of origin and termination of CAFs, respectively. CAFs draining into the PA are more often multiple and tortuous. Clinically meaningful CAFs are larger and most frequently detected in younger and male patients.

Published
2023
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49. CT in Transcatheter-delivered Treatment of Valvular Heart Disease.

Author

Rudzinski PN, Leipsic JA, Schoepf UJ, Dudek D, Schwarz F, Andreas M, Zlahoda-Huzior A, Thilo C, Renker M, Burt JR, Emrich T, Varga-Szemes A, Amoroso NS, Steinberg DH, Pukacki P, Demkow M, Kepka C, and Bayer RR

Subjects
Aortic Valve diagnostic imaging, Cardiac Catheterization, Echocardiography, Humans, Multimodal Imaging, Tomography, X-Ray Computed methods, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation methods, Transcatheter Aortic Valve Replacement
Abstract

Minimally invasive strategies to treat valvular heart disease have emerged over the past 2 decades. The use of transcatheter aortic valve replacement in the treatment of severe aortic stenosis, for example, has recently expanded from high- to low-risk patients and became an alternative treatment for those with prohibitive surgical risk. With the increase in transcatheter strategies, multimodality imaging, including echocardiography, CT, fluoroscopy, and cardiac MRI, are used. Strategies for preprocedural imaging strategies vary depending on the targeted valve. Herein, an overview of preprocedural imaging strategies and their postprocessing approaches is provided, with a focus on CT. Transcatheter aortic valve replacement is reviewed, as well as less established minimally invasive treatments of the mitral and tricuspid valves. In addition, device-specific details and the goals of CT imaging are discussed. Future imaging developments, such as peri-procedural fusion imaging, machine learning for image processing, and mixed reality applications, are presented., (© RSNA, 2022.)

Published
2022
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50. Feasibility of computed tomography perfusion in patients with chronic total occlusion undergoing percutaneous coronary intervention.

Author

Opolski MP, Kwiecinski J, Oleksiak A, Kruk M, Debski A, Knaapen P, Schumacher SP, Zysk A, Witkowski A, and Kepka C

Subjects
Humans, Chronic Disease, Coronary Angiography, Coronary Circulation physiology, Feasibility Studies, Predictive Value of Tests, Stroke Volume, Treatment Outcome, Ventricular Function, Left, Coronary Occlusion diagnostic imaging, Coronary Occlusion therapy, Myocardial Perfusion Imaging adverse effects, Myocardial Perfusion Imaging methods, Percutaneous Coronary Intervention, Tomography, X-Ray Computed adverse effects
Abstract

We aimed to establish the feasibility and safety of dynamic computed tomography perfusion (CTP) in patients with chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI). Ten consecutive CTO patients with preserved left ventricular ejection fraction (≥50%) underwent regadenoson dynamic CTP prior to and at least 3 months after successful CTO recanalization. Quantitative absolute and indexed values of stress myocardial blood flow (MBF) were measured for each myocardial segment, and perfusion defect size was defined by the number of segments with indexed MBF ≤0.78. The control group comprised 10 subjects without ischemia on CTP. Out of 20 CTP studies with 320 segments, 311 segments (97.2%) were interpretable. The dose-length product for CTP was 589.5 ​± ​144.3 mGy cm, and no severe adverse reactions to either regadenoson or contrast were observed. Successful PCI resulted in a significant increase in stress MBF in CTO (101.8 [82.9-127.1] vs. 158.4 [132.6-172] ml/100ml/min, p ​= ​0.004). Overall, there were significant reductions in both CTO and total defect size post-PCI (5 [5-6] vs. 1 [0.3-2] and 6 [5-8.5] vs. 1.5 [1-3.8] segments, both p ​= ​0.002). In segment analysis, the indexed MBF was lowest in the pre-PCI CTO group (0.90 [0.53-1.0]), followed by post-PCI CTO group (0.96 [0.88-1.0]) and the control group (0.98 [0.94-1.0]). Dynamic CTP is feasible and safe, and shows large perfusion defects in patients with CTO. While ischemic burden can be significantly improved after successful CTO PCI, it is still larger as compared with normal myocardium. NCT04465526: The Influence of Coronary Chronic Total Occlusion on Myocardial Perfusion on Computed Tomography (COPACABANA)., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)

Published
2022
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