23 results on '"Keratograph 5M"'
Search Results
2. Nichtinvasive Keratographen-Tränenfilmaufreißzeit im Vergleich zur Fluoreszein-Tränenfilmaufreißzeit.
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Berisha, Bujar, Nepp, Johannes, Rabensteiner, Dieter Franz, Wagner, Georg, Boldin, Ingrid, Aminfar, Haleh, and Horwath-Winter, Jutta
- Abstract
Copyright of Spektrum der Augenheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2022
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3. Preoperative dry eyes disease in cataract patients with deficient tear break up time: evaluation of OSDI questionnaire, its subcategories and Keratograph 5M device results.
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Fydanaki, Ourania, Chalkiadaki, Evangelia, Tsiogka, Anastasia, Gartaganis, Panos S., and Karmiris, Efthymios
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Purpose: To evaluate preoperatively dry eye disease (DED) in patients with pathological Tear Break Up Time (TBUT), utilising subjective Ocular Surface Disease Index (OSDI) with its subcategories and objective Keratograph 5M characteristics. Methods: Fifty-four cataract patients were included in this prospective study having a screening slit lamp TBUT of less than 10 s and more or equal to 5 s. Subjective evaluation of DED was performed with OSDI questionnaire and objective evaluation with Keratograph 5M. Tear Meniscus Height (TMH), bulbar and limbal redness and meibography grade were evaluated. Further analysis of OSDI subcategories, Visual Function Related (VFR), Ocular Symptoms related (OS) and Environmental Triggered (ET), was performed with linear and logistic multivariate regression models. Age, gender and logMAR visual acuity (VA) were also included in our models. Results: Following the initial TBUT screening we identified 27(50%) normal and 27(50%) dry eye patients, using OSDI questionnaire. There was no statistical difference in TMH (p = 0.64), bulbar redness (p = 0.54), limbal redness (p = 0.72) and meibography grade (p = 0.25), between normal and dry eye OSDI group. In our regression analysis, average logMAR VA was highly associated with a higher total OSDI score (p < 0.001) and with a higher OSDI-VFR score (p < 0.001). Female gender was associated with a higher OSDI-ET score (p = 0.03). Multivariate logistic regression models were performed by sorting patients into 2 categories of normal and dry eye group according to their total OSDI,OSDI-VRF,OSDI-OS and OSDI-ET score. An increase in logMAR VA increased the odds of having abnormal total OSDI score (p = 0.007) and OSDI-VFR score (p = 0.006). Females had increased odds of having abnormal OSDI-ET score (p = 0.044). Conclusions: Clinicians should be aware of OSDI limitations when screening cataract patients for dry eyes, as there is high correlation with VA. Female patients were more susceptible to environmental factors. Keratograph results should be interpreted with caution when they are evaluated in conjunction with OSDI during preoperative assessment of DED in cataract patients. [ABSTRACT FROM AUTHOR] more...
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- 2022
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4. The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy.
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Inferrera, Leandro, Aragona, Emanuela, Wylęgała, Adam, Valastro, Antonio, Latino, Gianluigi, Postorino, Elisa I., Gargano, Romana, Orzechowska-Wylęgała, Bogusława, Wylęgała, Edward, and Roszkowska, Anna M. more...
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CORNEA , *HEALING , *SURFACE defects , *CONFOCAL microscopy , *CORNEAL transplantation ,CORNEAL ulcer - Abstract
To prove the role of high-tech investigation in monitoring corneal morphological changes in patients with neurotrophic keratopathy (NK) using Keratograph 5M (K5M) and anterior segment OCT (AS-OCT), corneal healing was monitored with Keratograph 5M (Oculus, Wetzlar, Germany) and AS-OCT (DRI, Triton, Topcon, Tokyo, Japan) in 13 patients (8F and 5M), aged from 24 to 93 years (67.8 ± 19) with severe NK, who were treated with Cenegermin 0.002% (20 μg/mL) (Oxervate®, Dompè, Farmaceutici Spa, Milan, Italy). The surface defects were evaluated on Keratograph 5M with ImageJ software and the corneal thickness variations were measured using DRI-Triton OCT software. Instrumental procedures were performed at baseline, and after 4 and 8 weeks of the treatment, respectively. The main outcome measures were reduction of the ulcers' area and corneal thickness recovery. The mean area of the corneal ulcers was reduced between baseline and 4 weeks examination in all patients, and at 8 weeks all ulcers were completely healed. An increase of the corneal thickness was evidenced between the baseline visit and after the 4- and 8-week follow-up, respectively. Additionally, only in collaborating subjects the In Vivo Confocal Microscopy (IVCM) was performed with HRT Rostock Cornea Module (Heidelberg Eng GmbH) to study the corneal nerves fibres. High-tech diagnostics with K5M, AS-OCT and IVCM proved useful in the assessment of corneal morphology and the healing process in patients with NK and could be extended to assess other corneal pathologies. [ABSTRACT FROM AUTHOR] more...
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- 2022
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5. Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection
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Müller C, Marx S, Wittekind J, and Sickenberger W
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pre-lens tear film stability ,wettability ,nik-dut ,drying-up time ,daily disposable contact lenses ,keratograph 5m ,Ophthalmology ,RE1-994 - Abstract
Christiane Müller,1 Sebastian Marx,1,2 Julia Wittekind,2 Wolfgang Sickenberger2,3 1Jenalens Kontaktlinsenstudio GmbH, Jena, Germany; 2JenVis Research c/o Ernst-Abbe University of Applied Sciences Jena, Jena, Germany; 3Department of Optometry & Vision Science, Ernst-Abbe University of Applied Sciences Jena, Jena, GermanyCorrespondence: Sebastian MarxJenVis Research c/o Ernst-Abbe University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, Jena 07745, GermanyTel +49 3641 205870Email s.marx@jenvis-research.comPurpose: To subjectively evaluate the in vivo tear film stability of three daily disposable contact lenses (DDCLs) using placido ring reflection at lens wear times of 5 mins and 8 and 12 hrs.Patients and Methods: This prospective, randomized, observer-masked, 3-way crossover study evaluated 28 subjects with good tear film stability. In vivo tear film stability was assessed for three DDCLs (nelfilcon A, etafilcon A, omafilcon A) on three different days over 12 hrs of lens wear. Time to first distortion by non-invasive keratography drying-up time (NIK-DUTf) was assessed by reviewing the captured videos. Lens wettability was also graded subjectively by three investigators using a scale from 0 (no visible distortions) to 3 (distortions in more than one-third of the ring reflection zone). Medians were analyzed statistically.Results: Mean NIKDUTf at 8 hrs was longer for nelfilcon A and shorter for etafilcon A and omafilcon A, but the differences were not significant. NIK-DUTf did not differ significantly among nelfilcon A, etafilcon A and omafilcon A DDCLs at all visits (p=0.36). Subjective wettability grades after 5 mins, 8 hrs, and 12 hrs differed significantly for etafilcon A (P < 0.01) and omafilcon A (p < 0.01), but not for nelfilcon A (p = 0.05), DDCLs.Conclusion: Grading was sufficiently sensitive to differentiate the wettability performances of the three lens materials. Nelfilcon A maintained wettability over the wearing period, whereas etafilcon A material showed faster dewetting at 8 and 12 hrs than at 5 mins after lens insertion.Keywords: pre-lens tear film stability, wettability, NIK-DUT, drying-up time, daily disposable contact lenses, Keratograph 5M more...
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- 2020
6. Comparing meibomian gland visibility on optical coherence tomography and Keratograph 5M images using objective and subjective grading methods.
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Ravichandran, Swetha and Pucker, Andrew D.
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MEIBOMIAN glands , *OPTICAL coherence tomography , *DRY eye syndromes , *MENISCUS injuries , *EYELIDS - Abstract
To investigate if there is a visible difference in meibomian gland (MG) length between images captured with the Visante optical coherence tomography (OCT; wavelength = 1,310 nm) and the OCULUS Keratograph 5M (K5M; wavelength = 880 nm). Adults between 18 and 40 years were recruited. Baseline dry eye disease was evaluated with the Standard Patient Evaluation of Eye Dryness (SPEED) and tear meniscus height and tear breakup time with the K5M. Right upper and lower eyelid MGs were imaged with the K5M and Visante OCT. Each image was graded with the 0 to 3 meiboscore scale. The central 5 MGs were evaluated with ImageJ for percent gland length visibility. Thirty participants were analyzed with a median (interquartile range [IQR]) age of 23.0 (5.0) years (53.3 % female). Overall, participants were asymptomatic and had normal tear films. Meiboscores based on K5M and Visante OCT was significantly different for the lower eyelid (0[1] vs 1[2]; p = 0.007) but not the upper eyelid (0[1] vs 0[1]; p = 1.00). The mean percent gland visibility of the upper eyelid (82.7[9.6] vs 75.2[13.5]; p < 0.001) and the lower eyelid (81.2[12.7] vs 64.1[17.6]; p < 0.001) were significantly greater on the Visante OCT than the K5M images, respectively. OCT images had significantly greater percent visible MG lengths than the K5M images. This suggests viable segments of the MGs may be missed with typical imaging, which may explain how it is possible that studies have found less post-treatment MG atrophy. [ABSTRACT FROM AUTHOR] more...
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- 2024
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7. Changes of ocular surface before and after phacoemulsification
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Meng-Ting Yu, Wen-Jie Wu, Xin-Na Wu, Ting Yu, and Zhi-Wei Li
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phacoemulsification ,cytology ,Keratograph 5M ,conjunctival impression cytology ,ocular surface ,Ophthalmology ,RE1-994 - Abstract
AIM: To evaluate ocular parameters changes after age-related cataract phacoemulsification surgery using Keratograph 5M combined with conjunctival impression cytology.METHODS: This prospective study included 39 eyes(39 patients)from December 2016 to December 2017, who underwent cataract phacoemulsification and intraocular lens implantation in Fujian Provincial Hospital. OSDI questionnaire, tear meniscus height, tear break-up time, conjunctival hyperemia and impression cytology were performed preoperatively at 1d, 1wk, 1mo and 2mo after surgery.RESULTS: GCD and OSDI were worsen at 1d, 1wk, 1mo, 2mo, postoperatively(PPPCONCLUSION: phacoemulsification will influence ocular surface parameters. The tear instability and conjunctival cell damage began at 1d postoperatively, and aggravated at 1wk postoperatively. It still couldn't return to preoperative level even at 2mo postoperatively. more...
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- 2019
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8. Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency
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Alfaro-Juárez A, Caro-Magdaleno M, Montero-Iruzubieta J, Fernández-Palacín A, Muñoz-Morales A, Castilla-Martino MA, Spínola-Muñoz C, and Rodríguez de la Rúa E
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Keratograph 5M ,Limbal Stem Cell Deficiency ,Noninvasive Keratograph Tear Break-Up Time ,Ocular Surface Disease Index ,Tear Break-Up Time ,Ophthalmology ,RE1-994 - Abstract
Asunción Alfaro-Juárez,1,* Manuel Caro-Magdaleno,1,2,* Jesús Montero-Iruzubieta,1,2 Ana Fernández-Palacín,3 Ana Muñoz-Morales,1 Manuel Alberto Castilla-Martino,1 Consuelo Spínola-Muñoz,1 Enrique Rodríguez de la Rúa1,2 1U.G.C. Oftalmología, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain; 2Deparmento de Cirugía, Universidad de Sevilla, Sevilla, Spain; 3Deparmento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, Spain*These authors contributed equally to this workCorrespondence: Manuel Caro-MagdalenoU.G.C. Oftalmología, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, C/Bogota 7, Bloq.3, 1st-B, Sevilla 41013, SpainTel +34609030403Email mcaro79@gmail.comPurpose: In limbal stem cell deficiency, both the Ocular Surface Disease Index (OSDI) questionnaire and tear break-up time (BUT) are comparable between traditional methods and the Keratograph 5M. In this study, we aimed to correlate OSDI with Keratograph 5M interviewed OSDI, as well as slit-lamp tear BUT with Keratograph 5M noninvasive tear break-up time (NIKBUT) in limbal stem cell deficiency.Patients and methods: Thirty-eight limbal stem cell-deficiency patients (76 eyes) from Virgen Macarena-Rocio Hospital (Seville, Spain) underwent this diagnostic test study. All patients completed the traditional OSDI. We measured the BUT, performed a Keratograph 5M analysis of NIKBUT first (employed for the analysis) followed by the average NIKBUT, the level of dryness, and conducted the OSDI questionnaire through an interview. For each pair of tests, we analyzed the means and applied an intraclass correlation coefficient (r), creating a Bland-Altman plot for data dispersion.Results: Average values were 47.5 points (±25.8), and 47.3 points (±27.5) for traditional OSDI and Keratograph OSDI, respectively (P =0.87); the r value indicates good agreement (0.72). The Bland-Altman plot followed a linear pattern, and the results were similarly distributed. The NIKBUT mean was shorter than the BUT mean (P = 0.007); the r value indicates moderate agreement (0.574). The Bland-Altman plot formed an almost horizontal line, with almost all values between the mean and two standard deviations.Conclusion: Keratograph 5M is useful for the evaluation of the ocular surface in limbal stem cell deficiency. NIKBUT can substitute BUT based on its advantages of being noninvasive, objective, with intraobserver and interobserver repeatability and reliability. The Keratograph 5M OSDI is comparable to the traditional questionnaire.Keywords: keratograph, limbal stem cell deficiency, noninvasive keratograph tear break-up time, ocular surface desease index, tear break-up time more...
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- 2019
9. Study on the difference of clinical manifestations of dry eye between children and adults
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Yan-Hong Li, Jin-Xin Song, Jian-Gang Yang, and Yu Cheng
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children ,dry eye ,Keratograph 5M ,difference ,tear film break-up time ,meibomian gland ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore the difference of dry eyes between children and adults in terms of symptoms and laboratory examinations.METHODS: Patients in 2018-06/2019-02 with the subjective symptoms of dry eye, and served in Xi'an First Hospital, including 52 children clinic cases(52 eyes)and 55 adult patients cases(55 eyes), all the cases were consulted and examined by slit lamp microscope in anterior segment. Both eyes of tear meniscus height(TMH), the first tear film break-up time(BUTf), the average tear film break-up time(BUTave), lipid layer thickness(LLT)and mesangial gland loss rate were measured by a Keratograph 5M non-invasive ocular surface analyzer.RESULTS: In children, patients' TMH(0.15±0.04mm), BUTf(3.22±1.24s), BUTave(4.27±1.67s), and the rate of meibomian gland loss \〖0.00%(0.00%, 5.03%)\〗 were significantly lower than those in the adult group [0.20±0.05mm, 4.36±1.93s, 5.15±1.49s, 9.90%(5.30%, 18.40%), all Pvs 68.58±21.05nm, P>0.05). Both groups of patients had positive correlation sympathise with BUTf and BUTave, with no correlation between LLT and meibomian gland loss rate in children(rs=-0.23,P=0.10), and adult group patients with negative correlation of LLT and meibomian gland loss rate(rs=-0.28,PCONCLUSION: Children's dry eyes and adult dry eyes in the symptoms, clinical manifestations and examination are different. The main symptom is the increase in the number of blinks. The inspection is mainly characterized by a short BUT. With the decrease of TMH, the rate of meibomian gland loss is relatively insignificant. more...
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- 2019
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10. Ocular Surface Disease in Patients under Topical Treatment for Glaucoma
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Pérez Bartolomé, Francisco, Martínez De La Casa Fernández-Borrella, José María, Arriola Villalobos, Pedro, Fernández Pérez, Cristina, Polo Llorens, Vicente, García Feijoo, Julián, Pérez Bartolomé, Francisco, Martínez De La Casa Fernández-Borrella, José María, Arriola Villalobos, Pedro, Fernández Pérez, Cristina, Polo Llorens, Vicente, and García Feijoo, Julián more...
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Purpose: To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI). Results: Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R −0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK plus polyquaternium-containing drops (OR 5.09) or higher OSDI (OR 1.06) and abnormal corneal staining test results and between older age (mean ratio [MR] 1.05), longer treatment duration (MR 1.02), or corneal staining presence (MR 1.22) and a higher OSDI score. Conclusions: Ocular surface disease was more prevalent in the medication group. The main factors impacting OSD were drops with preservatives, longer treatment duration, and older age., Unidad Docente de Inmunología, Oftalmología y ORL, Fac. de Óptica y Optometría, TRUE, pub more...
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- 2023
11. Effectiveness and comfort of Oculus Keratograph on tear film function test before corneal refractive surgery
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Peng Zhang, Ju-Ling Lyu, Ju-Fen Wu, Lan Wang, Jie Zhang, Shu-Ping Huo, and Jin-Peng Chen
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Keratograph 5M ,excimer laser corneal operation ,tear film ,comfort ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore correlation, consistency and comfort between traditional tear film examination methods and Oculus Keratograph. METHODS: A retrospective study. Totally 101 cases(101 eyes)were diagnosed myopia and then accepted LASEK(laser epithelial keratomileusis). Non-invasive tear film break-up time(NIBUT), lower tear meniscus height(LTMH)were measured with Oculus Keratograph, fluorescein tear film break-up time(fl-BUT)and Schimer Ⅰ test(SⅠt)were performed on all cases. The correlations analysis between NIBUT and fl-BUT, LTMH and SⅠt were performed by Spearman rank correlation, consistency check between NIBUT and fl-BUT by Bland-Altman analysis. Visual analogue scale(VAS)was applied on evaluating the comfort of two kinds of examination methods. RESULTS: LTMH and SⅠt showed positive correlation(rs=0.346, P=0.001). NIBUT and fl-BUT showed positive correlation(rs=0.393, P=0.001), 95% consistency limits range -9.62 to 14.18 in Bland-Altman Figure. There was significant difference between VAS of NIBUT and VAS of fl-BUT(z=-2.324, P=0.020). There was significant difference between VAS of LTMH and VAS of SⅠt(z=-8.845,P=0.001).CONCLUSION: Oculus Keratograph can objectively measure NIBUT and LTMH, and was more comfortable than traditional tear film examination methods. It can effectively assess tear film function before corneal refractive surgery. more...
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- 2017
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12. Effect of forced eye opening on non-invasive tear film break-up time by Keratograph 5M in healthy individuals
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Ju-Ling Lyu, Ju-Fen Wu, Lan Wang, and Peng Zhang
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tear film ,tear film break-up time ,non-invasive ,Keratograph 5M ,Ophthalmology ,RE1-994 - Abstract
AIM:To investigate the difference of non-invasive tear film break-up time(NIBUT)by Keratograph 5M before and after forced eye opening in healthy individuals. METHODS: Prospective case self-control study. Forty normal volunteers(79 eyes)were enrolled. Tear film images were captured, non-invasive first tear film break-up time(NIBUTf), non-invasive average tear film break-up time(NIBUTav)and dry eye level were measured by Keratograph 5M automatically before and after forced eye opening in each subject. For the first time, we checked the left eye after the right eye, and the second time checked the right eye after the left eye. RESULTS: The average of NIBUTf and NIBUTav were 9.18±5.52s, 11.74±5.59s respectively and percentage of every level of dry eye were 43%, 37%, 20% respectively before forced eye opening. The average of NIBUTf and NIBUTav were 8.91±5.54s, 11.76±5.58s and percentage of dry eye at different levels were 35%, 48%, 16% respectively after forced eye opening. There was no significant difference on NIBUT and dry eye level by Oculus keratograph 5M in normal subjects(t=0.37, P=0.72; t=-0.038, P=0.97; Z=-0.42, P=0.68). CONCLUSION: There is no influence on NIBUT and dry eye level by detected Keratograph 5M before and after forced eye opening in healthy subjects. more...
- Published
- 2018
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13. Influence of Vitreoretinal Surgery on Ocular Surface Dynamics Using Keratograph 5M.
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Hwang GE, Lee ES, and Kim HD
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Purpose: To evaluate changes of ocular surface dynamics using Keratograph 5M for 3 months after vitreoretinal surgery., Methods: Eighty-three patients were divided into three groups: phacoemulsification group, vitrectomy group, and combined group. Keratograph 5M was performed for all patients at 1 week, 1 month, and 3 months after the surgery. Ocular surface dynamics parameters measured by Keratograph 5M, including noninvasive keratograph first tear film breakup time (NifBUT), noninvasive keratograph average tear film breakup time (NiaBUT), and tear meniscus height (TMH) were compared among the three groups over time., Results: The mean age of all patients (46 men and 37 women) was 62.2 ± 8.4 years. NifBUT and NiaBUT were significantly decreased at 1 week after surgery compared to those at baseline in all three groups (all p < 0.001). NifBUT and NiaBUT in the phacoemulsification group almost recovered to the preoperative level, while those in the vitrectomy group and the combined group were still significantly less than those at baseline. NifBUT and NiaBUT in the phacoemulsification group were significantly longer than those in the vitrectomy group and the combined group at 3 months. After 1 week, TMHs were significantly higher in the vitrectomy group (p = 0.001) and the combined group (p = 0.022) than in the phacoemulsification group, while TMHs were significantly less in the vitrectomy group (p = 0.010) and the combined group (p < 0.001) than in the phacoemulsification group at 3 months after surgery., Conclusions: These results suggest that vitreoretinal surgery could induce alteration of ocular surface dynamics for 3 months. The vitrectomy group and the combined group showed tear film instability compared to the cataract surgery alone group. Patients who underwent vitreoretinal surgery experienced more severe dry eye syndrome symptoms than those who underwent cataract surgery. Thus, managing dry eye syndrome after vitreoretinal surgery should be considered important for patients. more...
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- 2023
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14. Ocular Redness Measured with the Keratograph 5M in Patients Using Anti-Glaucoma Eye Drops.
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Pérez Bartolomé, Francisco, Martínez de la Casa, Jose María, Arriola Villalobos, Pedro, Fernández Pérez, Cristina, Polo, Vicente, Sánchez Jean, Ruben, and García Feijoó, Julián
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OPTICAL coherence tomography , *OPEN-angle glaucoma , *OCULAR hypertension , *HYPEREMIA , *EYE inflammation - Abstract
Purpose: To examine correlations between ocular redness measured with the new topographer Keratograph 5M and the use of topical anti-glaucoma medication.Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication and 51 eyes of 51 healthy volunteers were recruited over 10 months. Outcome variables were keratograph redness scores (RS): overall, bulbar temporal (BT), bulbar nasal (BN), limbar temporal (LT), and limbar nasal (LN). In each subject, we also recorded the intraocular pressure-lowering eye drops used, daily doses and daily and cumulative preservative concentrations, fluorescein corneal staining score (OXFORD), lower tear meniscus height (Fourier-domain OCT), non-invasive tear film breakup time (Keratograph 5M), and ocular surface disease questionnaire index (OSDI).Results: Higher RS were recorded in the medication than control group (P < 0.01 all scores). Within the medication group, older patients returned greater RS (P < 0.05 all scores). Prostaglandin was a strong predictor of higher scores, except LN RS. A higher OSDI was associated with a higher LN RS (β = 0.007; P < 0.05), while the use of β-blockers was linked to a lower LN RS (β = -0.225; P < 0.05). The use of ≥3 daily eye drops with preservative gave rise to a higher BN RS and ≥3 daily eye drops to a higher LN RS (β = 0.366, P < 0.01; β = 0.296, P < 0.05, respectively).Conclusion: Keratograph 5M can objectively detect the hyperaemia induced by glaucoma medication. The factors contributing to ocular redness were advanced age, more daily eye drops (nasal sectors), a higher OSDI, and prostaglandin as the medication used. [ABSTRACT FROM AUTHOR] more...- Published
- 2018
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15. Observation of the early tear film changes after trabeculectomy with Keratograph 5M
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Zhong-Qi Lai, Wei-Na Li, and Hui-Na Li
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Keratograph 5M ,trabeculectomy ,tear film ,Ophthalmology ,RE1-994 - Abstract
AIM: To observe the early tear film changes after trabeculectomy using Keratograph 5M.METHODS: Fourty-one patients(46 eyes)of glaucoma who underwent trabeculectomy were involved. First tear break up time(FTBUT), average tear break up time(ATBUT), non-invasive tear meniscus height(NITMH), lipid layer thickness and meibomian gland scores were measured at 1d preoperatively and at 1d, 1wk, 1mo postoperatively.RESULTS:At 1d, 1wk and 1mo postoperatively, FTBUT and ATBUT decreased greatly(PPPP>0.05).CONCLUSION:Keratograph 5M could be used to evaluate tear film function rapidly and accurately. Trabeculectomy significantly alters tear film stability and tear secretion in the short term after operation. more...
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- 2015
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16. A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction.
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YUANYUAN QI, CHEN ZHANG, SHAOZHEN ZHAO, YUE HUANG, and RUIBO YANG
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MEIBOMIAN glands , *DRY eye syndromes , *RANK correlation (Statistics) , *MANN Whitney U Test , *STATISTICAL hypothesis testing - Abstract
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland. Meibomian gland loss (MGL) on the upper lid was evaluated using noncontact meibography. The first NITBUT (NITBUTf) was significantly shorter than the average NITBUT (NITBUTav; Mann-Whitney U-test, P<0.01). There was a weak negative Spearman correlation between NITBUTf and OSDI (rs=-0.251, P=0.046) as well as between NITBUTav and OSDI (rs=-0.250, P=0.046). Furthermore, MGL showed a statistically significant Spearman correlation with OSDI (rs=0.562; P<0.01). In the MGD group, NITBUTf was significantly shorter (P<0.01), and MGL and OSDI score were significantly greater (P<0.01 and <0.01, respectively) than in the control group. In the MGD group, the first tear film break-up point was most frequently located in the inferonasal quadrant, while it was most frequently located in the supertemporal quadrant in the control group, and there was a significant difference with this regard (χ²=3.937, P=0.047). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P=0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ²=0.525, P=0.469). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P=0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ²=0.525, P=0.469). As the NITBUTs showed only a weak correlation with OSDI, they may not be a strong indicator of the OSDI. However, MGL indicated changes of meibomian gland morphology in the MGD group and the first tear film break-up point was likely located in the inferonasal quadrant in the MGD group. [ABSTRACT FROM AUTHOR] more...
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- 2017
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17. The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy
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Leandro Inferrera, Emanuela Aragona, Adam Wylęgała, Antonio Valastro, Gianluigi Latino, Elisa I. Postorino, Romana Gargano, Bogusława Orzechowska-Wylęgała, Edward Wylęgała, Anna M. Roszkowska, Inferrera, L., Aragona, E., Wylegala, A., Valastro, A., Latino, G., Postorino, E. I., Gargano, R., Orzechowska-Wylegala, B., Wylegala, E., and Roszkowska, A. M. more...
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Persistent epithelial defects ,genetic structures ,Keratograph 5M ,Neurotrophic keratopathy ,AS-OCT ,General Medicine ,high-tech diagnostics ,neurotrophic keratopathy ,rh-NGF ,persistent epithelial defects ,corneal ulcers ,corneal healing ,Corneal healing ,Rh-NGF ,eye diseases ,High-tech diagnostics ,Persistent epithelial defect ,Corneal ulcers ,sense organs ,High-tech diagnostic ,Corneal ulcer - Abstract
To prove the role of high-tech investigation in monitoring corneal morphological changes in patients with neurotrophic keratopathy (NK) using Keratograph 5M (K5M) and anterior segment OCT (AS-OCT), corneal healing was monitored with Keratograph 5M (Oculus, Wetzlar, Germany) and AS-OCT (DRI, Triton, Topcon, Tokyo, Japan) in 13 patients (8F and 5M), aged from 24 to 93 years (67.8 ± 19) with severe NK, who were treated with Cenegermin 0.002% (20 μg/mL) (Oxervate®, Dompè, Farmaceutici Spa, Milan, Italy). The surface defects were evaluated on Keratograph 5M with ImageJ software and the corneal thickness variations were measured using DRI-Triton OCT software. Instrumental procedures were performed at baseline, and after 4 and 8 weeks of the treatment, respectively. The main outcome measures were reduction of the ulcers’ area and corneal thickness recovery. The mean area of the corneal ulcers was reduced between baseline and 4 weeks examination in all patients, and at 8 weeks all ulcers were completely healed. An increase of the corneal thickness was evidenced between the baseline visit and after the 4- and 8-week follow-up, respectively. Additionally, only in collaborating subjects the In Vivo Confocal Microscopy (IVCM) was performed with HRT Rostock Cornea Module (Heidelberg Eng GmbH) to study the corneal nerves fibres. High-tech diagnostics with K5M, AS-OCT and IVCM proved useful in the assessment of corneal morphology and the healing process in patients with NK and could be extended to assess other corneal pathologies. more...
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- 2022
18. Long-term changes in the ocular surface during orthokeratology lens wear and their correlations with ocular discomfort symptoms.
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Xie, Caiyuan and Wei, Ruihua
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ORTHOKERATOLOGY , *TRANSFER functions , *VISION , *LOW vision - Abstract
To evaluate the changes in ocular surface parameters during orthokeratology lens wear and determine their correlations with ocular discomfort symptoms. Fifty individuals were enrolled in this prospective pilot study. Clinical evaluation of the ocular surface included the ocular surface disease index, slit-lamp examination, Keratograph 5M, optical quality analysis system, and corneal staining. After baseline examinations, clinical tests were performed at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after orthokeratology lens wear. Correlations between ocular discomfort symptoms and signs of ocular discomfort were evaluated. Overall ocular surface disease index score and two subscale scores (ocular symptoms and vision-related function) significantly increased at the 3-month visit (P < 0.05), and decreased to levels close to baseline at the12-month visit (P > 0.05). The basic objective scatter index and the mean tear film objective scatter index increased, peaking at 3-month visit (P < 0.05) and gradually decreased thereafter. The modulation transfer function cut-off significantly decreased at the 3-month visit (P < 0.05). During the 12-month study period, the overall ocular surface disease index score and vision-related function score were significantly and positively correlated with the basic objective scatter index and mean tear film objective scatter index (P < 0.05). After 1 week of lens wear, Grade 1 corneal staining increased to 16.4 %, mostly involving the central and inferior cornea. Orthokeratology lens wear increased ocular discomfort symptoms and decreased the function of tear film, mainly within 3 months of lens wear. Tear-related visual function parameters were correlated with ocular discomfort. A new parameter, tear film objective scatter index, measured with the optical quality analysis system, was more sensitive in detecting the quality and stability of tear film than traditional indicators. [ABSTRACT FROM AUTHOR] more...
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- 2023
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19. Repeatability of Noninvasive Keratograph 5M Measurements Associated With Contact Lens Wear
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García Montero, María, Rico del Viejo, Laura, Lorente Velázquez, Amalia, Martínez Alberquilla, Irene, Hernández Verdejo, José Luis, Madrid Costa, David, García Montero, María, Rico del Viejo, Laura, Lorente Velázquez, Amalia, Martínez Alberquilla, Irene, Hernández Verdejo, José Luis, and Madrid Costa, David more...
- Abstract
Epub ahead of print (26/04/2019), Objetive: To assess the intrarater repeatability of the measurements of tear meniscus height (TMH), noninvasive keratograph tear break-up time (NIKBUTs), and ocular redness measurements obtained with the Keratograph 5M (K5M) in a sample of soft silicone hydrogel contact lens (CL) wearers over 15 days. Methods: Prospective study over two consecutive weeks. Three measurements of TMH, NIKBUTs (NIKBUT first and NIKBUT average), and ocular redness were obtained in different sessions; the first day (baseline, at 8 hr of wear, and after lens removal) and the last day of wear-15th day (at 8 hr of wear and after lens removal). The repeatability of measurements were assessed by two intraclass correlation coefficient (ICC) forms; single measurement [ICC (2,1)] and multiple measurements (k=3) [ICC (2, k)]. Results: Sixty-four eyes were analyzed. The repeatability of baseline TMH [ICC (2,1) greater than 0.90; coefficient of repeatability (CR)=0.06 mm] and after and during CL wear [ICC (2,k) greater than 0.90; CR≤0.07 mm] were excellent. The repeatability of baseline NIKBUT average [ICC (2,k)=0.89 (0.82-0.93); CR=6.07 sec] was maintained after CL removal but was poorer during CL wear. The repeatability of baseline NIKBUT first [ICC (2,k) =0.80 (0.69-0.87); CR=8.74 sec] was maintained after CL removal and during CL wear at moderate-good level. Conclusions: Intrarater repeatability of TMH, NIKBUTs, and ocular redness performed by K5M after CL wear remains stable when three measurements are performed. However, intrarater repeatability during CL wear decreased only for NIKBUT average and was not affected by time of use (15 days)., Unión Europea. H2020, Depto. de Optometría y Visión, Fac. de Óptica y Optometría, TRUE, pub more...
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- 2019
20. Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection
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Christiane, Müller, Sebastian, Marx, Julia, Wittekind, and Wolfgang, Sickenberger
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pre-lens tear film stability ,Keratograph 5M ,daily disposable contact lenses ,wettability ,drying-up time ,NIK-DUT ,Original Research - Abstract
Purpose To subjectively evaluate the in vivo tear film stability of three daily disposable contact lenses (DDCLs) using placido ring reflection at lens wear times of 5 mins and 8 and 12 hrs. Patients and Methods This prospective, randomized, observer-masked, 3-way crossover study evaluated 28 subjects with good tear film stability. In vivo tear film stability was assessed for three DDCLs (nelfilcon A, etafilcon A, omafilcon A) on three different days over 12 hrs of lens wear. Time to first distortion by non-invasive keratography drying-up time (NIK-DUTf) was assessed by reviewing the captured videos. Lens wettability was also graded subjectively by three investigators using a scale from 0 (no visible distortions) to 3 (distortions in more than one-third of the ring reflection zone). Medians were analyzed statistically. Results Mean NIKDUTf at 8 hrs was longer for nelfilcon A and shorter for etafilcon A and omafilcon A, but the differences were not significant. NIK-DUTf did not differ significantly among nelfilcon A, etafilcon A and omafilcon A DDCLs at all visits (p=0.36). Subjective wettability grades after 5 mins, 8 hrs, and 12 hrs differed significantly for etafilcon A (P more...
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- 2019
21. Assessment of ocular redness measurements obtained with keratograph 5M and correlation with subjective grading scales.
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Pérez-Bartolomé F, Sanz-Pozo C, Martínez-de la Casa JM, Arriola-Villalobos P, Fernández-Pérez C, and García-Feijoó J
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- Aged, Color, Conjunctiva pathology, Cross-Sectional Studies, Female, Glaucoma drug therapy, Humans, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents adverse effects, Male, Middle Aged, Ophthalmic Solutions administration & dosage, Research Design, Diagnostic Techniques, Ophthalmological, Eye Diseases chemically induced, Eye Diseases diagnosis, Hyperemia chemically induced, Hyperemia diagnosis, Ophthalmic Solutions adverse effects, Photography instrumentation, Photography methods
- Abstract
Objective: To examine correlations between ocular redness scores provided by the Keratograph 5M and those determined using two image-based grading scales., Methods: Observational prospective cross-sectional study. Two hundred and twenty six eyes of two hundred and twenty six participants (175 patients using anti-glaucoma eye drops and 51 subjects untreated). All subjects were scored automatically using the keratograph 5M. These redness scores (RS) were then correlated with the gradings provided by the Efron and McMonnies/Chapman-Davies scale (MC-D) scales (two observers)., Results: Excellent reproducibility was observed for both the Efron (weighted K=0.897, 95% CI 0.823-0.904) and MC-D (weighted K=0.783, 95% CI 0.752-0.795) scales. Keratograph RS and the scores obtained with both Efron (Spearman's Rho=0.43, P<0.001) and MC-D (Spearman's Rho=0.48, P<0.001) scales were significantly correlated. RS for the bulbar and limbal - nasal and temporal quadrants also correlated moderately with the two subjective scales. Through Bland Altman analysis, poor agreement was detected between the objective and subjective methods: agreement values for the Efron scale or MC-D scale (matching scorers between observers) versus overall RS showed high biases (-15.58 and -22.05 respectively) and wide limits of agreement (LOA) (-46.169 to 15.005 and -52.534 to 8.19 respectively). Lowest bias was observed between temporal limbal RS and Observer 2 Efron score (-0.04)., Conclusions: Although it emerged as a reliable objective method, the keratograph 5M overestimated the scores compared with the subjective grading scales when used to grade the degree of ocular redness. Therefore, they should not be interchangeable methods., (Copyright © 2018 Elsevier Masson SAS. All rights reserved.) more...
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- 2018
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22. Ocular Surface Disease in Patients under Topical Treatment for Glaucoma.
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Pérez-Bartolomé F, Martínez-de-la-Casa JM, Arriola-Villalobos P, Fernández-Pérez C, Polo V, and García-Feijoó J
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- Adult, Aged, Antihypertensive Agents therapeutic use, Benzalkonium Compounds adverse effects, Case-Control Studies, Cornea metabolism, Cornea pathology, Cross-Sectional Studies, Female, Fluorescein metabolism, Humans, Intraocular Pressure, Male, Middle Aged, Multivariate Analysis, Ophthalmic Solutions therapeutic use, Preservatives, Pharmaceutical adverse effects, Prospective Studies, Tears metabolism, Tonometry, Ocular, Antihypertensive Agents adverse effects, Glaucoma, Open-Angle drug therapy, Ocular Hypertension drug therapy, Ophthalmic Solutions adverse effects
- Abstract
Purpose: To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy., Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI)., Results: Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R -0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK plus polyquaternium-containing drops (OR 5.09) or higher OSDI (OR 1.06) and abnormal corneal staining test results and between older age (mean ratio [MR] 1.05), longer treatment duration (MR 1.02), or corneal staining presence (MR 1.22) and a higher OSDI score., Conclusions: Ocular surface disease was more prevalent in the medication group. The main factors impacting OSD were drops with preservatives, longer treatment duration, and older age. more...
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- 2017
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23. A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction.
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Qi Y, Zhang C, Zhao S, Huang Y, and Yang R
- Abstract
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland. Meibomian gland loss (MGL) on the upper lid was evaluated using noncontact meibography. The first NITBUT (NITBUTf) was significantly shorter than the average NITBUT (NITBUTav; Mann-Whitney U-test, P<0.01). There was a weak negative Spearman correlation between NITBUTf and OSDI (rs=-0.251, P=0.046) as well as between NITBUTav and OSDI (rs=-0.250, P=0.046). Furthermore, MGL showed a statistically significant Spearman correlation with OSDI (rs=0.562; P<0.01). In the MGD group, NITBUTf was significantly shorter (P<0.01), and MGL and OSDI score were significantly greater (P<0.01 and <0.01, respectively) than in the control group. In the MGD group, the first tear film break-up point was most frequently located in the inferonasal quadrant, while it was most frequently located in the supertemporal quadrant in the control group, and there was a significant difference with this regard (χ
2 =3.937, P=0.047). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P=0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ2 =0.525, P=0.469). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P=0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ2 =0.525, P=0.469). As the NITBUTs showed only a weak correlation with OSDI, they may not be a strong indicator of the OSDI. However, MGL indicated changes of meibomian gland morphology in the MGD group and the first tear film break-up point was likely located in the inferonasal quadrant in the MGD group. more...- Published
- 2017
- Full Text
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