924 results on '"Keratosis, Seborrheic"'
Search Results
2. A Trial to Evaluate the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratosis
- Published
- 2024
3. Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Optimization Study
- Published
- 2023
4. Adaptive Design Study for Safety and Efficacy of Treatment Regimens With SM-020 in Subjects With Seborrheic Keratosis
- Author
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Zepeda Dermatologia
- Published
- 2023
5. Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors (Micro3)
- Published
- 2023
6. Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Study
- Published
- 2023
7. Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage (DermaSense)
- Author
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Emmanouil Papanastasiou, Assistant Professor
- Published
- 2023
8. Optical Biopsy of Human Skin in Conjunction With Laser Treatment
- Author
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Beckman Laser Institute University of California Irvine and Beckman Laser Institute and Medical Center, J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering
- Published
- 2022
9. Effectiveness of Sodium Fusidate Ointment Compared to Petrolatum for Wound Healing Following Cauterization
- Author
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Firman Parrol, Dermatology Resident
- Published
- 2022
10. Electrocautery vs Q-switch for Seborrheic Keratosis
- Author
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Murad Alam, Professor in Dermatology, Otolaryngology-Head and Neck Surgery, and Surgery
- Published
- 2021
11. Study of A-101 for the Treatment of Seborrheic Keratosis
- Published
- 2020
12. Fast Track Diagnosis of Skin Cancer by Advanced Imaging
- Author
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Mette Mogensen, MD, PhD, Ass. Prof., Chief Consultant
- Published
- 2020
13. An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses (SK-FAN)
- Published
- 2019
14. A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis
- Published
- 2019
15. Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis
- Published
- 2019
16. Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis
- Published
- 2018
17. Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?
- Published
- 2018
18. An Open-Label Safety Study of A-101 Solution
- Published
- 2018
19. A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.
- Published
- 2018
20. A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis (SK)
- Published
- 2018
21. Dermatosis Papulosa Nigra (DPN)
- Published
- 2015
22. Clonal-pattern Seborrheic Keratosis
- Author
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Joshua F, Goldsmith, Laleh, Montaser Kouhsari, and Steven R, Tahan
- Subjects
Skin Neoplasms ,Carcinoma, Squamous Cell ,Humans ,Surgery ,Epidermis ,Anatomy ,Keratosis, Seborrheic ,Pathology and Forensic Medicine - Abstract
Seborrheic keratosis is a benign epidermal tumor. Seborrheic keratosis with clonal pattern (CPSK) displays histologic features distinct from other subtypes of SK (non-CPSK). We sought to quantitatively assess the risk of recurrence and progression to squamous cell carcinoma (SCC), either in situ or invasive, of incompletely excised CPSKs. We studied all 244 cases from 238 patients of "seborrheic keratosis, clonal pattern" diagnosed in our institution over a 10-year period (2008-2018). Demographic, clinical, pathologic, and follow-up data were gleaned from electronic health records. Following glass slide review, CPSK lesions were divided into 2 groups: CPSK with cytologic atypia and CPSK without cytologic atypia. For comparison, 107 non-CPSKs were studied as controls. The minimum follow-up period was 2 years (median=4 y). All lesions were incompletely excised. Eighteen of 244 CPSKs (7.4%) recurred at or adjacent to the site of initial partial removal compared with 1.9% of non-CPSKs. Five of the 18 (28%) recurrent CPSKs recurred as CPSK, 11 (61%) as SCC in situ, and 3 (17%) as invasive SCC. The mean time to recurrence was 3.1 years. Two non-CPSKs recurred as non-CPSKs. Overall CPSKs were more likely to recur than non-CPSKs ( P =0.04). CPSKs with atypia were more likely to recur than CPSKs without atypia ( P =0.03). The upgrade rate to SCC at least in situ of all recurrent CPSK lesions with atypia was 78%. Our results suggest that pathologists should report the presence of clonal pattern when observed in seborrheic keratoses, indicate the presence of atypia, and provide lesional margin assessment.
- Published
- 2022
23. Collision tumor: pigmented Bowen's disease and seborrheic keratosis
- Author
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Karen de Almeida Pinto Fernandes, Diana Carolina Salamanca Martinez, Aretha Brito Nobre, and Gabriella Campos-do-Carmo
- Subjects
Bowen's disease ,Melanoma ,Keratosis, seborrheic ,Dermatology ,RL1-803 - Abstract
Abstract: Bowen's disease is a type of squamous cell carcinoma in situ of the skin. The pigmented form is rare and represents less than 2% of cases. We report a case of a 74-year-old black man with a blackened and asymptomatic leg injury for about 6 months. Clinically, and under dermatoscopy, the injury was suggestive of melanoma or melanoacanthoma, and a definitive diagnosis was made by histopathological examination.
- Published
- 2018
- Full Text
- View/download PDF
24. Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis
- Author
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Connor R, Zuraski, Cameron, Wales, Cuong V, Nguyen, Edward F, Chan, Carrie, Kovarik, John T, Seykora, Rosalie, Elenitsas, and Ata S, Moshiri
- Subjects
Adult ,Hyperplasia ,Skin Neoplasms ,Humans ,Ganglioneuroma ,Dermatology ,General Medicine ,Keratosis, Seborrheic ,Skin Diseases ,Pathology and Forensic Medicine - Abstract
Cutaneous ganglioneuromas (GNs) are exceptionally uncommon tumors, and many reported cases describe association with overlying epidermal hyperplasia that may be interpreted as seborrheic keratosis (SK) or SK-like proliferation. We report 5 cases of cutaneous GN in adult patients; all of which were discovered incidentally in the immediate vicinity of epidermal hyperplasia. A review of the literature demonstrates the current-although likely imperfect-understanding of the etiopathogenesis of both SK and GN in the skin. We explore the putative pathophysiologies of other common, well-characterized skin lesions and, taking them into account, provide rationale for the coexistence of cutaneous GN with overlying SK and SK-like epidermal changes. However, we ultimately acknowledge a dilemma of causality and, given the rarity of their co-occurrence, objectively question whether occasional cameo appearances by GN lying subjacent to SK and SK-like hyperplasia may be due merely to chance.
- Published
- 2022
25. Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis
- Author
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Jacqueline Morley, Clinical Research Team Leader
- Published
- 2011
26. Accuracy of dermoscopic criteria for the differential diagnosis between irritated seborrheic keratosis and squamous cell carcinoma
- Author
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Zoe Apalla, N. Sideris, Iuliana Busila, Ruben Gonzalez-Cuevas, Angeliki Panagopoulou, Theodosia Gentsidi, Ioannis Spyridis, Aimilios Lallas, Andjelka Ilieva, Irina Elena Nasturica, Konstantinos Lallas, Sofia Magdalini Manoli, Ilias Papadimitriou, Dimitrios Ioannides, and Chryssoula Papageorgiou
- Subjects
Seborrheic keratosis ,medicine.medical_specialty ,Skin Neoplasms ,Dermoscopy ,Dermatology ,Irritated seborrheic keratosis ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Basal cell ,Keratosis, Seborrheic ,Retrospective Studies ,Dermatoscopy ,medicine.diagnostic_test ,business.industry ,Odds ratio ,medicine.disease ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Differential diagnosis ,Skin cancer ,business ,Retrospective design - Abstract
Background Even with the addition of dermoscopy, a significant morphologic overlap exists between irritated seborrheic keratosis (ISK) and squamous cell carcinoma (SCC). Objective The aim of this study was to investigate the dermoscopic criteria that could serve as potent predictors for the differential diagnosis between ISK and SCC. Methods Dermoscopic images of histopathologically diagnosed ISKs and SCCs were evaluated by 3 independent investigators for the presence of predefined criteria. Results A total of 104 SCCs and 61 ISKs were included. The main dermoscopic predictors of SCC were dotted vessels (odds ratio [OR], 10.4), branched linear vessels (OR, 5.30), white structureless areas (OR, 6.78), white circles surrounding follicles (OR, 23.45), a diffuse irregular (OR, 2.55) or peripheral (OR, 2.8) vessel arrangement, and a central scale arrangement (OR, 3.35). Dermoscopic predictors of ISK were hairpin vessels (OR, 0.38), a diffuse regular vessel arrangement (OR, 0.39 and OR, 0.36), and white halos surrounding vessels covering more than 10% of the lesion (OR, 0.29 and OR, 0.12). Limitations First, the retrospective design of the study; second, the differential diagnosis included in the study was restricted to ISK and SCC. Conclusions We confirmed the significant morphologic overlap between ISK and SCC, but we also identified potent predictors for the differential diagnosis between these 2 entities.
- Published
- 2021
27. Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases
- Author
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Keisuke Goto, Kohei Ogawa, Tsunekazu Hishima, Naoki Oishi, Ozumi Tomita, Takuji Tsuyuki, Takao Oda, Yoshifumi Iwahashi, Yutaka Inaba, and Keiichiro Honma
- Subjects
Male ,Skin Neoplasms ,Dermatology ,General Medicine ,Eccrine Porocarcinoma ,Pathology and Forensic Medicine ,Sweat Gland Neoplasms ,Cell Transformation, Neoplastic ,Carcinoma, Squamous Cell ,Humans ,Female ,Keratosis, Seborrheic ,Carcinoma in Situ ,Aged - Abstract
Seborrheic keratosis is a common benign neoplasm composed of basaloid keratinocytes. However, little is known about the malignant transformation of the tumor. Eleven cases of seborrheic keratosis with malignant transformation were analyzed. The 11 patients included 5 male patients and 6 female patients with a median age of 75 years at diagnosis (68-90 years). The tumors arose at various sites from the scalp (n = 3) to the lower leg (n = 2). The median tumor size was 12 (10-32) and 40 (20-75) mm in 7 noninvasive and 4 invasive cases, respectively. One patient exhibited in-transit skin metastasis. Histopathology of the malignant components resembled porocarcinoma or inverted follicular keratosis. Bowenoid and pagetoid spreading was frequently observed. The malignant components expressed cytokeratin 5/6 (100%) and GATA3 (73%), but not cytokeratin 7 (0%), cytokeratin 19 (9%), BerEP4 (0%), c-kit (0%), and NUT (0%). No significant immunoreactivity of YAP1 was observed in any of the cases. Mutant-type immunostaining of p53 and PTEN was observed in 91% and 82% of the cases, respectively. An increase in p16 expression was seen in 6 (86%) of the 7 cases with noninvasive carcinoma, although a loss of p16 immunoexpression was seen in the invasive carcinoma component in 3 (75%) of the 4 cases. This study demonstrated that seborrheic keratosis can undergo malignant transformation, particularly in large-sized lesions in elderly patients. Malignant components mimic porocarcinoma or inverted follicular keratosis. Malignant transformation induced by TP53 and PTEN mutations and tumor invasion by CDKN2A inactivating mutations are suggested in this study.
- Published
- 2022
28. 'String of pearls pattern': report of three cases of non clear-cell acanthoma
- Author
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Ana Elena Domínguez Espinosa, Bengu Nisa Akay, and Roger Adrian González-Ramírez
- Subjects
Acanthoma ,Dermoscopy ,Keratosis, seborrheic ,Dermatology ,RL1-803 - Abstract
Abstract The coiled and dotted vessels in a serpiginous arrangement or “string of pearls” is considered a classical vascular pattern associated with clear cell acanthoma. We present three cases of epidermal tumors different from clear cell acanthoma that have the same “string of pearls” vascular pattern. Even though most authors keep considering the “string of pearls” vascular pattern an almost pathognomonic sign of clear-cell acanthoma, the cases presented here suggest that some other epidermal tumors can also show this pattern.
- Published
- 2017
- Full Text
- View/download PDF
29. Unna Nevus and Seborrheic Keratosis: Dermatoscopic Imitations
- Author
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Khatuna, Kudava
- Subjects
Skin Neoplasms ,Port-Wine Stain ,Humans ,Dermoscopy ,Keratosis, Seborrheic ,Imitative Behavior - Published
- 2022
30. Study on the correlation of high expression level of HuD with seborrheic keratosis and skin aging
- Author
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Juping Chen, Jun Liu, Zheng Wang, Jiandan Xu, Jia Tao, and Hualing Li
- Subjects
Humans ,Dermatology ,RNA, Messenger ,Keratosis, Seborrheic ,Immunohistochemistry ,Skin Aging ,Skin - Abstract
Currently, most studies of ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-like protein 4 (Hu antigen D, HuD) focus on nervous system-related diseases; the role of HuD in the occurrence of skin aging and seborrheic keratosis (SK) has not been reported.To explore the role of HuD in the occurrence of SK and skin aging and its related clinical significance.The expression levels of HuD in the skin and blood of healthy people at different ages, SK lesions, and perilesional skin of SK patients were detected by both immunohistochemistry and Western blotting. The mRNA expression levels of HuD in the skin and blood of healthy peoples at different ages were detected by quantitative real-time reverse transcription-polymerase chain reaction. The expression level of HuD was compared with the skin of healthy people, SK lesion, and perilesional skin of SK patients of the same age.The immunohistochemistry and Western blotting showed that the expression levels of HuD in SK lesions were higher than those in healthy skin and perilesional skin. The immunohistochemical staining intensity, protein and mRNA expression levels of HuD in the skin and blood of healthy people were correlated with age, which gradually increased with increasing age.HuD is highly expressed in SK lesion and aged skin, indicating that a higher HuD expression level is correlated with occurrence of SK and aging skin; however, its mechanism needs to be further studied.
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- 2022
31. Seborrheic keratosis-like melanoma: a diagnostic challenge
- Author
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Marco Romanelli, Teresa Oranges, Michela Iannone, Agata Janowska, and Valentina Dini
- Subjects
Seborrheic keratosis ,Reflectance confocal microscopy ,Cancer Research ,medicine.medical_specialty ,Skin Neoplasms ,Surgical approach ,medicine.diagnostic_test ,business.industry ,Melanoma ,Dermoscopy ,Papule ,Nodule (medicine) ,Dermatology ,medicine.disease ,Diagnosis, Differential ,Oncology ,Biopsy ,Humans ,Medicine ,medicine.symptom ,Keratosis, Seborrheic ,business ,Melanoma diagnosis - Abstract
This article summarizes the main epidemiologic and diagnostic features of seborrheic keratosis-like (SK-like) melanoma. We performed a review of the current literature. The real and current incidence and prevalence of SK-like melanoma are unknown. Many lesions are misdiagnosed and not excised with histopathologic confirmation, or excised without an appropriate surgical approach due to a benign clinical and dermoscopic appearance. SK-like melanoma presents both melanoma and SK features. SK-like melanoma and SK are often clinically indistinguishable even for experienced dermatologists. Clinically, it develops as a black-dark brown or light slightly elevated, papule, nodule or plaque with rapid growth and a regular or irregular shape. SK-like melanoma presents melanocytic and nonmelanocytic dermoscopic features. Irregular dark-brown dots/globules, a blue-grayish veil, streaks, irregular pigmentation or network and brown lines point to a melanoma diagnosis. Among the nonmelanocytic features, milia-like cysts and comedo-like openings have been highlighted. The association of polarized and nonpolarized dermoscopic techniques is more accurate for studying the dermoscopic features of SK-like melanoma. If the dermoscopic features are unclear, further investigations with reflectance confocal microscopy (RCM) or biopsy with histologic examination are essential. SK-like melanoma is a dermatologic challenge. Careful clinical and dermoscopic evaluation favor a correct diagnosis. In unclear cases, it is important to perform a biopsy with histologic examination to confirm the correct diagnosis.
- Published
- 2021
32. Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus
- Author
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Tong Wu, Shan Wang, Guan Jiang, and Quansheng Lu
- Subjects
Adult ,Male ,Seborrheic keratosis ,medicine.medical_specialty ,Skin Neoplasms ,Junctional nevus ,Verruca plana ,Dermoscopy ,Dermis ,medicine ,Intradermal Nevus ,Humans ,Nevus ,Keratosis, Seborrheic ,Dermatoscopy ,Microscopy, Confocal ,medicine.diagnostic_test ,business.industry ,General Medicine ,Compound nevus ,medicine.disease ,Dermatology ,Cross-Sectional Studies ,medicine.anatomical_structure ,Female ,Warts ,business - Abstract
Objective To describe the features of facial seborrheic keratosis, verruca plana, and nevus pigmentosus by dermatoscopy and reflective confocal microscope (RCM). Study design Cross-sectional observational study. Place and duration of study Dermatology Department of The Affiliated Hospital of Xuzhou Medical University from January 2017 to January 2019. Methodology Patients of either gender and age, clinically diagnosed as seborrheic keratosis, verruca plana, and nevus pigmentosus without any prior treatment, were enrolled. Patients with extremities and trunk involvement were excluded. One typical skin lesion was chosen from each patient and subjected to dermatoscopy and RCM separately; imaging features were recorded and analysed. Results A total of 402 patients (183 men and 219 women) between 6 and 88 years of age (mean age 41.8 years) were inducted. The duration of disease was between one week and 10 years. Seborrheic keratosis on dermatoscopy presented as acne-like openings (122/172; 70.93%, milia-like cysts (113/172; 65.70%), hairpin-like vessels (108/172; 62.79%, brain-like structures (103/172; 59.88%, worm-like pharyngeal margins (17/172; 9.88%), and fingerprint-like structures (8/172; 4.65%). On RCM, it showed epidermal cerebral gyrus structure (165/172; 95.93%), superficial vasodilatation and hyperemia (81/172; 47.09%), and keratinous cysts (73/172; 42.44%). Verruca plana on dermatoscopy showed a number of punctate hemorrhages scattered against a light-red background (108/114; 94.74%); on RCM it showed rose-like concentric structures (89/114; 78.07%). The features of nevus pigmentosus observed by dermatoscopy were homogeneous mode (23/52; 44.23%), light brown color (30/52; 57.69%) for intradermal nevus; mesh mode (18/41; 43.90%, dark brown color, little black dots and spherical structure (both 18/41; 43.90%) were visible for junctional nevus; globular mode, reticular and cobblestone structures (both 11/23; 47.83%) for compound nevus. On RCM, there were a few nevus cells visible within the dermal papilla (52/52; 100%) for intradermal nevus; bright pebble-like structures accumulated in the basal layer, nested round and elliptical nevus cells (40/41; 97.56%) for junctional nevus; nevus cells in the epidermis and dermis (21/23; 91.30%) for compound nevus. Conclusion Used in combination with clinical manifestations, the application of dermatoscopy and RCM may help distinguish seborrheic keratosis, verruca plana, and nevus pigmentosus on the basis of their respective dermatoscopic and RCM features. Key Words: Dermatoscopy, Reflective confocal microscope, Seborrheic keratosis, Verruca plana, Nevus pigmentosus, Brain-like structures, Rose-like structure.
- Published
- 2021
33. Dermatofibroma simulating seborrheic keratosis dermoscopically
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Daniel Holanda Barroso, Camila Pinon Zoby Leite, Gabriela Diniz de Souza Araujo, Márcia Almeida Galvão Teixeira, Eliane Ruth Barbosa Alencar, and Silvana Maria de Morais Cavalcanti
- Subjects
Dermoscopy ,Histiocytoma, benign fibrous ,Keratosis, seborrheic ,Dermatology ,RL1-803 - Abstract
Abstract: Dermatofibroma is a frequent benign tumor of easy clinical diagnosis in most cases, but that can mimic other dermatoses. Dermoscopy may help to define the diagnosis and its classical pattern is a central white area, similar to a scar, surrounded by a discrete pigment network. However, dermoscopic findings are not always typical. We describe here a case of dermatofibroma exhibiting ridges, furrows and pseudocomedos, a pattern which is typical of seborrheic keratosis, in dermoscopy.
- Published
- 2016
- Full Text
- View/download PDF
34. 2940-nm erbium:YAG laser versus 980-nm diode laser in the treatment of multiple seborrheic keratoses: A prospective comparative randomized study
- Author
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Mai Abdelraouf Osman
- Subjects
Treatment Outcome ,Humans ,Dermatology ,Lasers, Solid-State ,Prospective Studies ,Laser Therapy ,Lasers, Semiconductor ,Keratosis, Seborrheic ,Erbium - Abstract
Seborrheic keratoses (SKs) are the most common benign epithelial tumors encountered in clinical practice. Complications associated with traditional treatments of SKs urge the scientists to seek alternative treatment modalities. Objective To compare the efficacy and safety of 2940-nm erbium-doped yttrium aluminum garnet (Er:YAG) laser versus 980-nm diode laser both clinically and dermoscopically for the treatment of seborrheic keratosis.Thirty subjects with multiple SKs were randomized to receive two sessions of either Er:YAG laser (n = 15) or diode laser (n = 15) and were followed up for 2 weeks after each session, and at 3 and 6 months after the second session.Both lasers exhibited significant clearance of SKs with no significant difference in clinical and dermoscopic improvement between the two systems. However, Er:YAG laser showed shorter total downtime but more serious erythema, while scarring and hyperpigmentation were observed in diode laser group. No recurrence was detected in both groups at 6 months follow-up.Er:YAG and diode lasers both are effective, non-invasive and well-tolerated techniques in treatment of SKs.
- Published
- 2022
35. Baricitinib-related Eruptive Seborrheic Keratoses
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Tejal Magan, Caroline Thaung, and Kaveh Vahdani
- Subjects
Ophthalmology ,Sulfonamides ,Purines ,Azetidines ,Humans ,Pyrazoles ,Surgery ,General Medicine ,Keratosis, Seborrheic - Published
- 2022
36. Human papillomavirus genotype distribution of genital keratotic lesions
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Seol Hwa Seong, Sun Mun Jeong, Jang Hwan Jung, Do Ik Kwon, Ji Yun Jang, Joon Hee Kim, Jong Bin Park, Jae Woo Baek, Kee Suck Suh, and Min Soo Jang
- Subjects
Genotype ,Condylomata Acuminata ,Papillomavirus Infections ,Carcinoma, Squamous Cell ,Humans ,Dermatology ,Genitalia ,Alphapapillomavirus ,Keratosis, Seborrheic ,Papillomaviridae ,Precancerous Conditions - Abstract
Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high-risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low-risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tumour lacking a clear etiologic relationship with HPV. This study compared HPV genotype distributions among BP, CA and GSK and revealed that BP and GSK were related to high-risk HPV whereas CA was related to low-risk HPV. It is plausible that GSK is a distinct epidermal tumour often related to high-risk HPV rather than merely a senescent form of CA considering the overall discrepancy in the frequency distribution of HPV genotypes along with histopathological differences, and the detection of high-risk HPV in GSK alerts physicians to consider more active treatment and continued follow-ups.
- Published
- 2022
37. Combining Reflective Confocal Microscopy and Dynamic Optical Coherence Tomography to Diagnose Melanoacanthoma: Case Report
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Nadeem Marghoob, Orit Markowitz, Moshe Y. Bressler, Nyousha Yousefi, Melissa Gill, Usha Alapati, and Skye Felice
- Subjects
Adult ,Male ,Seborrheic keratosis ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Population ,Dermatology ,Biology ,Pathology and Forensic Medicine ,Diagnosis, Differential ,Optical coherence tomography ,medicine ,Humans ,Keratosis, Seborrheic ,education ,Melanoma ,education.field_of_study ,Microscopy, Confocal ,medicine.diagnostic_test ,Papule ,General Medicine ,medicine.disease ,Melanoacanthoma ,Dermal papillae ,medicine.anatomical_structure ,Pagetoid ,Melanocytes ,Epidermis ,medicine.symptom ,Tomography, Optical Coherence - Abstract
Few reported cases discuss distinguishing between melanoma and melanoacanthoma, a seborrheic keratosis (SK) variant, using noninvasive imaging devices. We present a case of a 38-year-old man with Fitzpatrick skin type IV with an asymmetric black papule showing clinical and dermoscopic features of both melanoma and SK. Reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (d-OCT) were used for further evaluation. RCM revealed acanthotic epidermis with a mixed honeycomb and cobblestone pattern, polycyclic bulbous rete ridges, and bright plump cells within entrapped, edged, dermal papillae, compatible with pigmented SK. Also noted were a population of fairly uniform bright dendritic cells scattered quite evenly at all levels of the epidermis and the notable absence of concomitant features of a melanocytic neoplasm (roundish Pagetoid cells, sheets of roundish or dendritic cells at the dermal-epidermal junction, junctional thickenings, and melanocytic nests), suggesting melanoacanthoma. d-OCT showed well-circumscribed, regular, epidermal acanthosis, superficial rounded hypodense structures, normal vascular flow, and notable absence of wiry or contoured vessels, features typically seen in SKs and benign lesions, respectively. Similarly, histologic examination revealed characteristics of pigmented SK containing a population of evenly dispersed dendritic melanocytes (decorated using Melan-A stain) confirming a diagnosis of melanoacanthoma. This case highlights the advantages of incorporating both RCM and d-OCT into clinical practice to noninvasively differentiate melanoma from its clinical mimickers.
- Published
- 2021
38. The dermoscopic inverse approach significantly improves the accuracy of human readers for lentigo maligna diagnosis
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Caterina Longo, Konstantinos Lallas, Philipp Tschandl, Giuseppe Argenziano, Aimilios Lallas, Harald Kittler, Zoe Apalla, Lallas, A., Lallas, K., Tschandl, P., Kittler, H., Apalla, Z., Longo, C., and Argenziano, G.
- Subjects
Male ,Skin Neoplasms ,maligna ,diagnosis ,Pigmented actinic keratosis ,Datasets as Topic ,Diagnostic accuracy ,Hutchinson's Melanotic Freckle ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Image Processing, Computer-Assisted ,Early Detection of Cancer ,Skin ,medicine.diagnostic_test ,pigmented actinic keratosi ,artificiai intelligence ,Middle Aged ,artificial intelligence ,Keratosis, Actinic ,diagnosi ,030220 oncology & carcinogenesis ,Female ,lentigo maligna ,Adult ,Seborrheic keratosis ,Solar Lentigo ,medicine.medical_specialty ,inverse approach ,Pattern analysis ,dermatoscopy ,Dermatology ,Lentigo maligna ,Sensitivity and Specificity ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,melanoma ,medicine ,Humans ,pigmented actinic keratosis ,Keratosis, Seborrheic ,Aged ,Dermatoscopy ,dermoscopy ,solar lentigo ,business.industry ,Actinic keratoses ,medicine.disease ,Neural Networks, Computer ,business ,Dermatologists - Abstract
Background A recently introduced dermoscopic method for the diagnosis of early lentigo maligna (LM) is based on the absence of prevalent patterns of pigmented actinic keratosis and solar lentigo/flat seborrheic keratosis. We term this the inverse approach. Objective To determine whether training on the inverse approach increases the diagnostic accuracy of readers compared to classic pattern analysis. Methods We used clinical and dermoscopic images of histopathologically diagnosed LMs, pigmented actinic keratoses, and solar lentigo/flat seborrheic keratoses. Participants in a dermoscopy masterclass classified the lesions at baseline and after training on pattern analysis and the inverse approach. We compared their diagnostic performance among the 3 timepoints and to that of a trained convolutional neural network. Results The mean sensitivity for LM without training was 51.5%; after training on pattern analysis, it increased to 56.7%; and after learning the inverse approach, it increased to 83.6%. The mean proportions of correct answers at the 3 timepoints were 62.1%, 65.5, and 78.5%. The percentages of readers outperforming the convolutional neural network were 6.4%, 15.4%, and 53.9%, respectively. Limitations The experimental setting and the inclusion of histopathologically diagnosed lesions only. Conclusions The inverse approach, added to the classic pattern analysis, significantly improves the sensitivity of human readers for early LM diagnosis.
- Published
- 2021
39. Artificial intelligence in dermatopathology: Diagnosis, education, and research
- Author
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Shaan Patel, Kiran Motaparthi, Amy Wells, and Jason B. Lee
- Subjects
Skin Neoplasms ,Histology ,Computer science ,education ,Population ,Dermatology ,Convolutional neural network ,Pathology and Forensic Medicine ,Diagnosis, Differential ,Machine Learning ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Deep Learning ,0302 clinical medicine ,Artificial Intelligence ,Pathology ,Humans ,Medical diagnosis ,Keratosis, Seborrheic ,Melanoma ,Nevus ,Observer Variation ,education.field_of_study ,Diagnostic Tests, Routine ,business.industry ,Research ,Deep learning ,food and beverages ,Cognition ,Workflow ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Neural Networks, Computer ,Artificial intelligence ,Dermatopathology ,business ,Algorithms ,Natural language - Abstract
Artificial intelligence (AI) utilizes computer algorithms to carry out tasks with human-like intelligence. Convolutional neural networks, a type of deep learning AI, can classify basal cell carcinoma, seborrheic keratosis, and conventional nevi, highlighting the potential for deep learning algorithms to improve diagnostic workflow in dermatopathology of highly routine diagnoses. Additionally, convolutional neural networks can support the diagnosis of melanoma and may help predict disease outcomes. Capabilities of machine learning in dermatopathology can extend beyond clinical diagnosis to education and research. Intelligent tutoring systems can teach visual diagnoses in inflammatory dermatoses, with measurable cognitive effects on learners. Natural language interfaces can instruct dermatopathology trainees to produce diagnostic reports that capture relevant detail for diagnosis in compliance with guidelines. Furthermore, deep learning can power computation- and population-based research. However, there are many limitations of deep learning that need to be addressed before broad incorporation into clinical practice. The current potential of AI in dermatopathology is to supplement diagnosis, and dermatopathologist guidance is essential for the development of useful deep learning algorithms. Herein, the recent progress of AI in dermatopathology is reviewed with emphasis on how deep learning can influence diagnosis, education, and research.
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- 2021
40. Dynamic thermal imaging for pigmented basal cell carcinoma and seborrheic keratosis
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Anna Kim, Yoo Sang Baek, Jiehyun Jeon, Ji Yun Seo, Jaeyoung Kim, and Chil Hwan Oh
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Seborrheic keratosis ,Diagnostic Imaging ,Cancer Research ,Pigmented basal cell carcinoma ,Materials science ,Skin Neoplasms ,Physiology ,dynamic thermal imaging ,Thermal stimulation ,basal cell carcinoma ,Region of interest ,Physiology (medical) ,medicine ,thermal imaging ,Medical technology ,Humans ,Basal cell carcinoma ,R855-855.5 ,Keratosis, Seborrheic ,skin and connective tissue diseases ,Thermal recovery ,integumentary system ,business.industry ,Significant difference ,fungi ,medicine.disease ,thermography ,Carcinoma, Basal Cell ,seborrheic keratosis ,sense organs ,Nuclear medicine ,business ,Normal skin - Abstract
BACKGROUND Clinical differentiation between pigmented basal cell carcinoma (BCC) and seborrheic keratosis (SK) can sometimes be difficult. Noninvasive diagnostic technologies, such as thermal imaging, can be helpful in these situations. This study explored the use of dynamic thermal imaging (DTI), which records thermal images after the application of external thermal stimuli (heat or cold) for the differential diagnosis of pigmented BCC and SK. MATERIALS AND METHODS Twenty-two patients with pigmented BCC and 15 patients with SK participated in this study. Dynamic thermal images of lesions (pigmented BCC or SK) and control sites (contralateral normal skin) were recorded after the heat and cold stimuli. Temperature changes in the region of interest (ROI) are plotted as a thermal response graph. After fitting an exponential equation to each thermal response graph, the rate constants were compared between groups (pigmented BCC versus control, SK versus control). RESULTS The thermal response graphs revealed that the average temperature of pigmented BCC showed faster thermal recovery to baseline than the control site. There was a significant difference in the rate constants of the fitted exponential equations between the pigmented BCCs and the control sites (p
- Published
- 2021
41. In vivo reflectance confocal microscopy for evaluating seborrheic keratosis, verruca plana, syringoma and lichen nitidus
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Hui Dai, Hong-Yan Jiang, and Ai-E Xu
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Seborrheic keratosis ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Verruca plana ,Dermatology ,01 natural sciences ,010309 optics ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Dermis ,Syringoma ,0103 physical sciences ,Humans ,Medicine ,Keratosis, Seborrheic ,Dermoepidermal junction ,Microscopy, Confocal ,integumentary system ,business.industry ,Papule ,medicine.disease ,Sweat Gland Neoplasms ,Lichen nitidus ,Dermal papillae ,medicine.anatomical_structure ,Lichen Nitidus ,Warts ,medicine.symptom ,business - Abstract
Background In clinical, common facial papule dermatosis such as seborrheic keratosis (SK), verruca plana (VP), syringoma and lichen nitidus (LN) is often misdiagnosed. Summarizing in vivo reflectance confocal microscopy (RCM) features of the facial papule dermatosis is helpful in the diagnosis of ambiguous lesions. The purpose of this study was to evaluate the features of SK, VP, syringoma, and LN in RCM. Methods We recruited 144 patients referred for unequivocal facial papule dermatosis including 60 patients with SK, 60 patients with VP, 10 patients with syringoma, and 14 patients with LN. The RCM images were evaluated at the epidermis, the dermoepidermal junction, and the dermis from both papule lesions and normal skin. Results In the epidermis, the cerebriform shape was the main RCM characteristic of SK and the "petal-like" structure was the main RCM characteristic of VP. In the dermoepidermal junction, the RCM features we found were as follows: For SK, the bright dermal papillary rings, the abnormal dermal papilla and the looped vessels were also observed at the abnormal dermal papilla. For VP, the bright dermal papillary rings and the point-like blood vessels were also observed at the round dermal papills. For LN, the round, enlarged, well-circumscribed dermal papillae and the enlarged dermal papillaes were heavily laden with individual highly refractive cells. In the dermis, RCM examination revealed brightly refractile teratogenous sweat tube, designing variably visible bright "moon" structures in all syringoma patients. Conclusion Considering our results, RCM may be useful to non-invasively discriminate SK, VP, syringoma and LN in vivo.
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- 2020
42. Ungual seborrheic keratosis with longitudinal melanonychia: A case report
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Eisuke Kameda, Yaei Togawa, Yugo Maru, and Hiroyuki Matsue
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Diagnosis, Differential ,Male ,Nail Diseases ,Skin Neoplasms ,Epidermal Cyst ,Carcinoma, Squamous Cell ,Humans ,Nails, Malformed ,Dermoscopy ,Dermatology ,General Medicine ,Keratosis, Seborrheic ,Aged - Abstract
In this paper, we report the case of a 71-year-old man with an 8-year history of melanonychia on the right little finger, who referred to our hospital because the color of pigmented area had gradually darkened and the width had expanded. Physical examination revealed longitudinal melanonychia with brown color (4 mm in width). Dermoscopic examination revealed multiple white round clods and splinter hemorrhages. No micro-Hutchinson sign was observed. We performed a punch biopsy (diameter 3 mm) of the nail matrix for diagnosis. Histopathological examination revealed irregular acanthosis of epithelium of the nail bed and distal matrix, which consisted of basaloid cells without nuclear atypia. Several zones exhibited cell whorls reminiscent of squamous eddies. The whorls were composed of large pink cells arranged in an onion peel-like fashion. The basaloid cells tested negative for human papillomavirus in situ hybridization and p16 staining. The morphology of white round clods (milia-like cysts in metaphoric term) observed in dermoscopic analysis corresponded to squamous eddies in histopathology. Considering these features, ungual seborrheic keratosis (SK) with longitudinal melanonychia was diagnosed, which is an atypical site for SK. We suggest that the dermoscopic finding of milia-like cysts may be useful for the diagnosis of ungual SK.
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- 2022
43. Real-time high-resolution millimeter-wave imaging for in-vivo skin cancer diagnosis
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Amir, Mirbeik, Robin, Ashinoff, Tannya, Jong, Allison, Aued, and Negar, Tavassolian
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Diagnosis, Differential ,Keratosis, Actinic ,Nevus, Pigmented ,Skin Neoplasms ,Multidisciplinary ,Humans ,Keratosis, Seborrheic ,Melanoma ,Skin Diseases - Abstract
High-resolution millimeter-wave imaging (HR-MMWI), with its high discrimination contrast and sufficient penetration depth, can potentially provide affordable tissue diagnostic information noninvasively. In this study, we evaluate the application of a real-time system of HR-MMWI for in-vivo skin cancer diagnosis. 136 benign and malignant skin lesions from 71 patients, including melanoma, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, melanocytic nevi, angiokeratoma, dermatofibroma, solar lentigo, and seborrheic keratosis were measured. Lesions were classified using a 3-D principal component analysis followed by five classifiers including linear discriminant analysis (LDA), K-nearest neighbor (KNN) with different K-values, linear and Gaussian support vector machine (LSVM and GSVM) with different margin factors, and multilayer perception (MLP). Our results suggested that the best classification was achieved by using five PCA components followed by MLP with 97% sensitivity and 98% specificity. Our findings establish that real-time millimeter-wave imaging can be used to distinguish malignant tissues from benign skin lesions with high diagnostic accuracy comparable with clinical examination and other methods.
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- 2022
44. SEBORRHEIC KERATOSIS: CURRENT STATE OF THE PROBLEM
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Mykhailo S, Myroshnychenko, Tetiana M, Moiseienko, Inna I, Torianyk, Victoria Yu, Ivannik, Natalia G, Popova, Ivan V, Mozhaiev, Tetiana V, Chastii, Valerii V, Minukhin, Pavlo A, Leontiev, Tetiana P, Osolodchenko, and Kyrylo Yu, Parkhomenko
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Adult ,Male ,Skin Neoplasms ,Biopsy ,Carcinoma, Squamous Cell ,Humans ,Middle Aged ,Keratosis, Seborrheic ,Skin - Abstract
The aim is to identify age, gender, clinical and morphological features of seborrheic keratosis.Material and methods: The study used biopsy material from 196 patients with a clinical diagnosis of "Seborrheic keratosis". In all cases, when studying directions for pathohistological examination, the authors analyzed gender and age characteristics, as well as localization of seborrheic keratosis. The resulting material was fixed in a 10% solution of neutral formalin (ph 7.4) for 24-48 hours. The procedure was carried out according to the generally accepted technique and the material was embedded in paraffin. Sections of 4-5×10-6m thick were made from paraffin blocks for staining with hematoxylin and eosin. The microspecimens were examined using an Olympus BX-41 microscope (Japan).Results: The study revealed a modern feature of seborrheic keratosis -"rejuvenation" of this tumor, as evidenced by its predominant development in patients aged 31 to 50 years. Seborrheic keratosis is more common in men, and is localized mainly on the skin of the face, scalp, neck and back. When diagnosing seborrheic keratosis, the author notes a significant discrepancy between clinical and morphological diagnoses, which actualizes the problem of improving the available clinical research methods and emphasizes the importance of morphological research. Hyperkeratotic and acanthotic histological variants of seborrheic keratosis are the most common. The case of seborrheic keratosis with malignancy and transformation into squamous cell carcinoma, identified by the author, should develop oncological alertness in doctors and patients.Conclusions: The study revealed age, gender, clinical and morphological features of seborrheic keratosis, which will contribute to a better understanding of this pathology by the doctors of various specialties, and improve the treatment and diagnostic process.
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- 2022
45. A case of adnexal tumor combining inverted follicular keratosis and trichoblastoma: molecular genetics evidence against a pathogenetic role of human Papillomaviruses
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Martina Lambertini, Daniela Serban, Dario de Biase, Margherita Serra, Costantino Ricci, Emi Dika, Francesca Ambrosi, Barbara Corti, Serban, Daniela, Ricci, Costantino, Ambrosi, Francesca, DE Biase, Dario, Serra, Margherita, Dika, Emi, Lambertini, Martina, and Corti, Barbara
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medicine.medical_specialty ,Pathology ,Dermatology ,Alphapapillomavirus ,Biology ,medicine.disease ,Infectious Diseases ,Trichoblastoma ,Molecular genetics ,medicine ,Humans ,Neoplasms, Adnexal and Skin Appendage ,Inverted follicular keratosis ,Hair Diseases ,Keratosis, Seborrheic ,Molecular Biology - Published
- 2022
46. HPV42-associated Seborrhoeic Keratosis-like Lesion of the Cervix: First Reported Case With High-grade Morphology
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Karen L. Talia, W. Glenn McCluggage, David Hawkes, and Siavash Rahimi
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Pathology ,medicine.medical_specialty ,Morphology (linguistics) ,Vulvar Neoplasms ,Seborrhoeic keratosis ,business.industry ,Papillomavirus Infections ,Obstetrics and Gynecology ,Cervix Uteri ,Pathology and Forensic Medicine ,Lesion ,medicine.anatomical_structure ,medicine ,Humans ,Female ,medicine.symptom ,business ,Keratosis, Seborrheic ,Cervix ,Papillomaviridae - Abstract
Seborrheic keratosis-like lesion (SKLL) is an extremely rare, morphologically distinct lesion occurring in the cervix and vagina that differs histologically from usual squamous intraepithelial lesions in these sites, by bearing close resemblance to cutaneous seborrheic keratosis and lacking koilocytosis. Like many vulvar seborrheic keratoses, which are associated with low-risk human papillomavirus (HPV), an association between SKLL and low-risk HPV is suggested based on the identification of HPV42, regarded as a low-risk genotype, in 4 of 8 reported cases. We report a further HPV42-associated SKLL of the cervix which differs from the previously reported cases by the presence of high-grade morphology and block-type p16 immunoreactivity. This novel finding challenges the classification of HPV42 as a low-risk genotype and expands the reported morphologic spectrum of SKLL, suggesting that they may not always be clinically indolent.
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- 2022
47. Facial skin characteristics and concerns in Indonesia: A cross-sectional observational study
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Yaping Du, Chandraprabha Doraiswamy, Jie Mao, Qian Zhang, Yan Liang, Zheng Du, Renuka Vasantharaghavan, and Manoj Kumar Joshi
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Adult ,Lentigo ,Water ,Dermatology ,Middle Aged ,Melanosis ,Skin Aging ,Young Adult ,Cross-Sectional Studies ,Hyperpigmentation ,Indonesia ,Acne Vulgaris ,Humans ,Female ,Keratosis, Seborrheic - Abstract
Facial skin characteristics and appearance vary according to ethnicity. While much of this knowledge is derived from the Caucasian population, lately there have been efforts to gain such understanding in various regions in Asia. In this paper, we have built an understanding of such features in Indonesia. In Indonesia, a section of females wears a traditional veil (hijab) to cover the scalp and part of face. The influence of the hijab on facial skin attributes was also investigated.In a cross-sectional observational study design involving 419 female volunteers in Jakarta, Indonesia, facial skin attributes (colour, radiance, hydration, trans-epidermal water loss [TEWL], wrinkles, fine lines, pores, and sebum levels) and conditions (melasma, post-inflammatory hyperpigmentation (PIH), solar lentigines/ senile lentigines, seborrheic keratoses and acne) were assessed by trained operators and dermatologists using standard validated instruments and scales.With age, facial skin colour showed darkening in cheek; forehead on the other hand showed slight lightening. The skin evenness and radiance decreased, substantially. Aging attributes measured in terms of lines, wrinkles, and under-eye dark circles showed deterioration with age; the decline was progressively faster than colour change. Facial image data analysis corroborated these findings. Skin hydration remained similar across the age groups even though the skin barrier function measured in terms of TEWL improved with age. Sebum levels in the skin were similar up to the age of 50 but declined in the next group of 50-60 year. Pore severity increased with age. Melasma, seborrheic keratosis and PIH showed a high prevalence (∼50%) at the young age group (20-30 years), itself. Melasma prevalence attained 100% in the age group of 41-50 year and onwards, and its severity similarly showed a steady rise with age. PIH on the other hand showed a steady decline with age. Solar lentigines prevalence (∼30%) did not change much across age groups, and the severity scores were similar in age groups up to 50 year but increased substantially in 51-60-year age groups. Seborrheic keratosis was similar (∼47%) in age groups up 20-40 year but steadily increased in upper age groups. Its severity was similar in the age groups of 20-30 year and 31-40 year but showed a two-fold increase in subsequent age groups. Acne was 10% in the age group of 20-30 year and declined gradually to 0.7% in the 51-60-year age group. Hijab wearers showed slight protection in skin colour darkening and improvement of evenness and radiance but were similar on aging (fine lines and wrinkles on crow's feet, under eye and peri-oral areas) markers to non-wearers. In general, in majority of age-groups, hijab wearers showed a higher prevalence of melasma, solar/senile lentigines, seborrheic keratosis and PIH.
- Published
- 2022
48. Dermoscopy of inflamed seborrheic keratosis: A great mimic of malignancy
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Marcial Álvarez‐Salafranca, Ignacio Gómez‐Martín, José Bañuls, Patricia Serrano, Carolina Medina, Alex Llambrich, Ángel Pizarro, Mariano Ara, and Pedro Zaballos
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squamous cell carcinoma ,Skin Neoplasms ,malignant melanoma ,Internship and Residency ,Dermoscopy ,Dermatology ,dermatoscopy ,Diagnosis, Differential ,basal cell carcinoma ,seborrheic keratosis ,Humans ,Clinical Competence ,dermoscopy ,Keratosis, Seborrheic ,Dermatologists ,Retrospective Studies - Abstract
Background Clinical and dermoscopic recognition of seborrheic keratoses (SKs) is often straightforward, and biopsy might not be required. However, inflamed SKs (iSKs) can pose a diagnostic challenge. Dermoscopic features of iSKs have not yet been evaluated to date. Objectives To assess the diagnostic ability of a group of dermatologists to diagnose iSKs by dermoscopy. To evaluate the dermoscopic findings of a long series of inflamed seborrheic keratoses. Methods Clinical and dermoscopic images of 100 difficult-to-diagnose skin tumours, including 29 iSKs, were presented to 33 clinicians (24 dermatologists and 9 dermatology residents), who were blinded to the diagnosis. The dermoscopic features of a series of 219 iSKs were retrospectively analysed. Results iSKs were correctly identified in a 37.6% of cases. Classic dermoscopic criteria were present in only 47% of iSKs. The most frequent dermoscopic feature in iSKs was the presence of vascularization (91.3%), but only a 44.5% showed predominance of hairpin vessels. A bluish hue was observed in 18.3% of lesions. Seven dermoscopic patterns were identified, based on the dermoscopic similarity to other tumours: seborrheic keratosis-like (28.8%); squamous cell carcinoma-like (25.6%); melanoma-like (17.8%); keratoacanthoma-like (6.8%); basal cell carcinoma-like (5.9%); verruca vulgaris-like (5.9%); nevus-like (2.3%). Conclusions The diagnosis of iSKs can be challenging even with dermoscopy. They may behave as authentic mimics of other cutaneous tumours, including squamous cell carcinoma or melanoma. For this reason, histopathological examination should be mandatory in these cases.
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- 2022
49. Update of pathophysiology and treatment options of seborrheic keratosis
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Surajit Gorai, Shahzaib Ahmad, Syeda Sadia Masood Raza, Hadin Darain Khan, Muhammad Asad Raza, Farshid Etaee, Clay J. Cockerell, Zoe Apalla, and Mohamad Goldust
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Male ,Young Adult ,Adolescent ,Face ,610 Medical sciences ,Electrocoagulation ,610 Medizin ,Humans ,Dermatology ,General Medicine ,Keratosis, Seborrheic ,Cryosurgery ,Aged - Abstract
Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause post-procedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.
- Published
- 2022
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50. Significance of SOX18 expression in nonmelanoma skin cancers for prediction of high‐risk patients: a preliminary study
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Enas Elsaid Ahmed Arakeeb, Yomna Mazid El-Hamd Neinaa, Hanan AlSaeid Alshenawy, and Amal A El-Ashmawy
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Seborrheic keratosis ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Keratosis ,Angiogenesis ,Dermatology ,Metastasis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,SOXF Transcription Factors ,medicine ,Carcinoma ,Humans ,Keratosis, Seborrheic ,integumentary system ,business.industry ,Endothelial Cells ,medicine.disease ,Lymphangiogenesis ,Carcinoma, Basal Cell ,Tumor progression ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Immunohistochemistry ,business - Abstract
Background SOX18 is an integral transcription factor that is involved in endothelial cells differentiation during both angiogenesis and lymphangiogenesis. Therefore, it has been implicated in tumor progression and metastasis. Objective To study SOX18 expression in nonmelanoma skin cancers (NMSCs) in comparison to seborrheic keratosis (SK) and normal control skin, and to assess its probable role in tumor evolution and progression. Patients and methods This study was conducted on 60 specimens of NMSCs: 30 basal cell carcinomas (BCC) and 30 squamous cell carcinomas (SCC), 30 specimens of SK, and 30 normal skin specimens. All were examined for immunohistochemical expression of SOX18 antibody. Additionally, morphometric assessment of vessel density (blood & lymphatic) in each specimen was estimated. Results Significant SOX18 overexpression was observed in all studied cutaneous tumors in comparison to control skin. The highest score of SOX18 expression was detected in SCC, then BCC, and the least expression was reported in SK with significant difference between them. Furthermore, significant upregulation of SOX18 expression was observed in high-risk types of both BCC and SCC compared to low-risk types. Stromal vessel density showed significant differences between the studied tumors with the highest mean value in SCC, followed by BCC and then SK. Positive correlation between SOX18 expression in the studied tumors and their vessel density was detected. Conclusions SOX18 may have a potential role in the evolution as well as progression of NMSCs, possibly through induction of both angiogenesis and lymphangiogenesis. Furthermore, it could be beneficial for prediction of NMSC patients with poor prognosis.
- Published
- 2020
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