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13 results on '"Kerp, Helena"'

1. Combination of nivolumab with standard induction chemotherapy in children and adults with EBV-positive nasopharyngeal carcinoma: Protocol of a prospective multicenter phase 2 trial

Author

Römer, Tristan, Vokuhl, Christian, Staatz, Gundula, Mottaghy, Felix M., Christiansen, Hans, Eble, Michael J., Timmermann, Beate, Klussmann, Jens Peter, Elbracht, Miriam, Calaminus, Gabriele, Zimmermann, Martin, Brümmendorf, Tim H., Feuchtinger, Tobias, Kerp, Helena, and Kontny, Udo

Published
2024
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7. Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure

Author

Kerp, Helena, Hönes, Georg Sebastian, Tolstik, Elen, Hönes-Wendland, Judith, Gassen, Janina, Möller, Lars, Lorenz, Kristina, and Führer, Dagmar

Subjects
thyroid hormones, mice, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Endokrinologie, Diabetologie und Stoffwechsel, maladaptive cardiac hypertrophy, Medizin, pressure-overload, heart failure, ddc:610, Cardiovascular Medicine, Cardiology and Cardiovascular Medicine, heart Failure, Original Research
Abstract

Purpose: Thyroid hormones (TH) play a central role for cardiac function. TH influence heart rate and cardiac contractility, and altered thyroid function is associated with increased cardiovascular morbidity and mortality. The precise role of TH in onset and progression of heart failure still requires clarification. Methods: Chronic left ventricular pressure overload was induced in mouse hearts by transverse aortic constriction (TAC). One week after TAC, alteration of TH status was induced and the impact on cardiac disease progression was studied longitudinally over 4 weeks in mice with hypo- or hyperthyroidism and was compared to euthyroid TAC controls. Serial assessment was performed for heart function (2D M-mode echocardiography), heart morphology (weight, fibrosis, and cardiomyocyte cross-sectional area), andmolecular changes in heart tissues (TH target gene expression, apoptosis, and mTOR activation) at 2 and 4 weeks. Results: In diseased heart, subsequent TH restriction stopped progression of maladaptive cardiac hypertrophy and improved cardiac function. In contrast and compared to euthyroid TAC controls, increased TH availability after TAC propelled maladaptive cardiac growth and development of heart failure. This was accompanied by a rise in cardiomyocyte apoptosis and mTOR pathway activation. Conclusion: This study shows, for the first time, a protective effect of TH deprivation against progression of pathological cardiac hypertrophy and development of congestive heart failure in mice with left ventricular pressure overload. Whether this also applies to the human situation needs to be determined in clinical studies and would infer a critical re-thinking of management of TH status in patients with hypertensive heart disease. OA Förderung 2021

Published
2021
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9. Supplemental files for TAC manuscript

Author

Kerp, Helena

Subjects
stomatognathic diseases, stomatognathic system, education, chemical and pharmacologic phenomena, humanities
Abstract

Supplemental tables and figures for TAC manuscript

Published
2021
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12. Thyroid Related Quality of Life in Elderly with Subclinical Hypothyroidism and Improvement on Levothyroxine is Distinct from that in Young Patients (TSAGE)

Author

Recker, Stefanie, Voigtländer, Richard, Viehmann, Anja, Dunschen, Karin, Kerp, Helena, Frank-Raue, Karin, Leidig-Bruckner, Gudrun, Graf, Dieter, Lederbogen, Sebastian, Dietrich, Johannes W., Görges, Rainer, Brabant, Georg, Völker, Uwe, Watt, Torquil, Zwanziger, Denise, Moeller, Lars Christian, Führer, Dagmar, Recker, Stefanie, Voigtländer, Richard, Viehmann, Anja, Dunschen, Karin, Kerp, Helena, Frank-Raue, Karin, Leidig-Bruckner, Gudrun, Graf, Dieter, Lederbogen, Sebastian, Dietrich, Johannes W., Görges, Rainer, Brabant, Georg, Völker, Uwe, Watt, Torquil, Zwanziger, Denise, Moeller, Lars Christian, and Führer, Dagmar

Abstract

The aim of this study was to investigate in a longitudinal approach whether levothyroxine (LT4) substitution has a different impact on quality of life (QoL) and thyroid related QoL in younger (<40 years) and older subjects (>60 years) with elevated thyroid-stimulating hormone (TSH) concentrations. The study included male and female patients with newly diagnosed, untreated subclinical hypothyroidism defined by TSH>8 mU/l. Patients were recruited throughout Germany from 2013-2016 and evaluated by clinical assessment, blood sampling and questionnaires for health related QoL and thyroid-disease thyroid-related QoL (ThyPRO) at time of diagnosis and six months after initiation of LT4 treatment. We found significantly lower QoL in both young and old patients with subclinical hypothyroidism compared to age-matched healthy individuals. Higher scores on follow-up were found in all patients irrespective of age, indicating better QoL on LT4 therapy. Analysis of the ThyPRO questionnaire showed that old patients experienced less Emotional Susceptibility, Tiredness, and Impaired Day Life on LT4, while young patients reported less Cognitive Complaints, Emotional Susceptibility, and Impaired Day Life compared to baseline assessment. Hypothyroidism with TSH concentrations>8 mU/l is associated with impairment in general and ThyPRO QoL in young and old age. Older patients benefited from LT4 therapy and remarkably show similar degree of improvement as younger patients, albeit with some thematic variation in ThyPRO QoL. Our data confirm current recommendations on initiation of LT4 substitution and suggest that this should not be withheld in elderly with TSH concentration above 8-10 mU/l.

Published
2019

13. Thyroid Related Quality of Life in Elderly with Subclinical Hypothyroidism and Improvement on Levothyroxine is Distinct from that in Young Patients (TSAGE)

Author

Recker, Stefanie, additional, Voigtländer, Richard, additional, Viehmann, Anja, additional, Dunschen, Karin, additional, Kerp, Helena, additional, Frank-Raue, Karin, additional, Leidig-Bruckner, Gudrun, additional, Graf, Dieter, additional, Lederbogen, Sebastian, additional, Dietrich, Johannes W., additional, Görges, Rainer, additional, Brabant, Georg, additional, Völker, Uwe, additional, Watt, Torquil, additional, Zwanziger, Denise, additional, Moeller, Lars Christian, additional, and Führer, Dagmar, additional

Published
2019
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