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Objectives To explore how advanced practice nurses implement practice change in academic medical centers to support optimal patient and staff outcomes. Data Sources Published peer reviewed literature, web-based resources, and professional society materials. Conclusion Cancer care is rapidly evolving and advanced practice nurses can shape the future of how care is delivered as well as the setting it is delivered in. Implications for Nursing Practice Advanced practice oncology nurses (Nurse Practitioners and Clinical Nurse Specialists) have an opportunity to significantly shape the patient experience by implementing programmatic changes across the continuum of care by engaging stakeholders in project design. Knowledge of change management and implementation science is critical to success.