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231 results on '"Kevin Gray"'

1. Rapid measurement of soluble xylo-oligomers using near-infrared spectroscopy (NIRS) and multivariate statistics: calibration model development and practical approaches to model optimization

Author

Zofia Tillman, Kevin Gray, and Edward Wolfrum

Subjects
Near-infrared spectroscopy, Xylo-oligomers, Process monitoring, At-line monitoring, Bioenergy, Bioproducts, Biotechnology, TP248.13-248.65, Fuel, TP315-360
Abstract

Abstract Background Rapid monitoring of biomass conversion processes using techniques such as near-infrared (NIR) spectroscopy can be substantially quicker and less labor-, resource-, and energy-intensive than conventional measurement techniques such as gas or liquid chromatography (GC or LC) due to the lack of solvents and preparation methods, as well as removing the need to transfer samples to an external lab for analytical evaluation. The purpose of this study was to determine the feasibility of rapid monitoring of a biomass conversion process using NIR spectroscopy combined with multivariate statistical modeling, and to examine the impact of (1) subsetting the samples in the original dataset by process location and (2) reducing the spectral range used in the calibration model on model performance. Results We develop multivariate calibration models for the concentrations of soluble xylo-oligosaccharides (XOS), monomeric xylose, and total solids at multiple points in a biomass conversion process which produces and then purifies XOS compounds from sugar cane bagasse. A single model using samples from multiple locations in the process stream showed acceptable performance as measured by standard statistical measures. However, compared to the single model, we show that separate models built by segregating the calibration samples according to process location show improved performance. We also show that combining an understanding of the sample spectra with simple multivariate analysis tools can result in a calibration model with a substantially smaller spectral range that provides essentially equal performance to the full-range model. Conclusions We demonstrate that real-time monitoring of soluble xylo-oligosaccharides (XOS), monomeric xylose, and total solids concentration at multiple points in a process stream using NIR spectroscopy coupled with multivariate statistics is feasible. Segregation of sample populations by process location improves model performance. Models using a reduced spectral range containing the most relevant spectral signatures show very similar performance to the full-range model, reinforcing the importance of performing robust exploratory data analysis before beginning multivariate modeling.

Published
2024
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2. Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER InitiativeResearch in context

Author

Suchitra Rao, Rodrigo Azuero-Dajud, Vitaly Lorman, Jeremy Landeo-Gutierrez, Kyung E. Rhee, Julie Ryu, C. Kim, Megan Carmilani, Rachel S. Gross, Sindhu Mohandas, Srinivasan Suresh, L. Charles Bailey, Victor Castro, Yalini Senathirajah, Shari Esquenazi-Karonika, Shawn Murphy, Steve Caddle, Lawrence C. Kleinman, Leah Castro-Baucom, Carlos R. Oliveira, Jonathan D. Klein, Alicia Chung, Lindsay G. Cowell, Charisse Madlock-Brown, Carol Reynolds Geary, Marion R. Sills, Lorna E. Thorpe, Jacqueline Szmuszkovicz, Kelan G. Tantisira, Ivan Diaz, Rachel Kenny, Parsa Mirhaji, Ravi Jhaveri, Marc Rosenman, Christopher Forrest, Beth Tarini, Hiroki Morizono, Nathan Pajor, W. Schuyler Jones, Kieler Curtis, Rishi Kamaleswaran, Nita Deshpande, Saul Blecker, Claudia Pulgarin, Marion Sills, Erin Hinkman, Dan Fort, Timothy Guthrie, Cynthia Chuang, Wenke Hwang, Dimitri Christakis, Daksha Ranade, Shannon Herring, Aaron Mishkin, Soledad Fernandez, Neena Thomas, Yuriy Bisyuk, Jyotsna Fuloria, Elizabeth Chrischilles, Boyd Knosp, Asa Oxner, Athanasios Tsalatsanis, Lindsay Cowell, Phillip Reeder, Stephen M. Downs, Brian Ostasiewski, Rainu Kaushal, Thomas Campion, Jessica Snowden, Katherine Irby, Paul Darden, Lexie Dixon, Danielle Evans, Connor Garbe, Laura Hobart-Porter, Lee Howard, Kathy Hummel, Hannah Krehbiel, Haley Spradlin, Phaedra Yount, Amy Elliott, Grace Adam, Jyoti Angal, Maria Barber, Katelynne Clark, Clayton Dos Reis, Mandy Freesemann, Christa Friedrich, Christine Hockett, Rachel Johannsen, Emily Johnson-Vonk, Cassidy Kaiser, Alexa Kruse, Jennifer Lang, Peter Lim, Meggie McCoy, Lorie Miller, Shelby Petereit (Cerkovnik), Jaime RiChard (Werpy), Jessica Seiler, Bret Sundleaf, Joshua Svendsen, Billy Trosper, Olivia Vermeulen, Scott Young, Aul Palumbo, Sean Dabney, Marie-Christine Fahrner, Torrey Gallagher, Karilyn Martini, Mary McNally, Sarah Vivensi Stiverson, Jessica Kosut, Venkataraman Balaraman, JoAnn Cheung, Travis K.F. Hong, Shanelle Kalua, Evan Minami, Andrea Siu, Micah Tong, Ronald J. Teufel, II, Andy Atz, Marina Dantas, Tyler Kasmarcak, Kreighton Milks, Judith Ross, Chijoke Ikomi, Marisa Meyer, Connie Nguyen, Gwen Pellicciotti, Thao-Ly Phan, Karen Ravin, Victoria Reynolds, Abigail Strang, Deepika Thacker, Dan Eckrich, Annabelle Goetter, Cheyenne Katz, Karen Kowal, Carol McDevitt, Emily Zimmerman, Genesis Agosto Roman, Akram Alshawabkeh, Ishwara Ayala Ortiz, Virginia Casey, Jose Cordero, Jocelyn De Jesus, Crystal Galan, Gredia Huerta-Montanez, Nilda Otero, Mayra Rivera Robles, Priscilla Roman, Genesis Roman, Zaira Rosario-Pabon, Xiodenis Santiago, Carmen Velez-Vega, Carlos Vergara, Daniel S. Hsia, Baylea Albarado, Tracey Allen, Allison Attuso, Taylor Ayers, Emily Bebler, Grace Bella, Alexa Bennett, John Brown, Alison Carville, Sydnie Darby, Kara Devall, Amber Dragg, Angela Elderedge, Elisabeth Fontenot, Greta Fry, Bethany Gildersleeve, Sara Goff, Lauren Harrington, Lisa Jones, Victoria Kaiser, Yejee Lee, Stephen Lee, Erin LeJeune, Robert Leonhard, Jennifer Levatino, Donald Lewis, Angrielle Lloyd, Ron Monce, Susannah Munro, Meghan Phillips, Blair Pucheu, Emily Rachal, Jennifer Rood, Stacey Roussel, Renee Rumsey, Connor Sanford, Monica Santos, Aryelle Stafford, Amy Thomassie, Celeste Waguespack, Katherine Walgamotte, Meredith Welch, Aubrey Windham, Michelle Stevenson, Tiffany Bell, Jackie Boyd, Soham Dasgupta, Sarah Deans, Katie Harris, Molly Hemmerle, Sarah King, Cameo McGuire, Brie Merten, Sarah Morris, Madison Ray, Brooklyn Reinhardt, Shellese Shemwell, Theresa Simeon, Katherine Walker, Sara Watson, Kathryn Weakley, Russell McCulloh, Johnathon Figliomeni, Laura Fischer, Denise Hoover, Megan Morse, Aleisha Nabower, Evan Roberts, Alice Sato, Joann Von Bon, Hengameh Raissy, David Archuleta, Rebecca Brito, Richard Campbell, Jude Chavez, Walter Dehority, Noella Garcia-Soberanez, Eve Gronert, Matthew Kadish, Jerry Larrabee, Debbie Lovato, Karen Luo, Noah Martinez, Analyse Merlino, Emily Reese, Sarah Ward, Kevin Wilson, Amanda Bogie, Ryan Brown, Ryan Butchee, Gina Fergeson, Ryan McKee, Brandon Mohler, Tiffany Moore, Valorie Owens, Sarah Stubbs, Timothy Van Wagoner, Kelly Cowan, Meghan Bethel, Laurie Chassereau, Thomas Lahiri, Lesley Cottrell, Lauren Lake, Kathy Moffett, Emily Polak, Sarah Stutler, Charlotte Workman, David Warburton, John C. Wood, Emma Carpenter, Isabelle Dhindsa, Samantha Mejia, Nelly Moghadam, Candice Mulder, Sharon O'Neil, Alisha Osornio, Adrian Rios, Sydney Rosen, Andrea Smith, Deeba Tabibi, Sharon Tang, Ariana Teame, Melissa Stockwell, Joshua Milner, Erika B. Rosenzweig, Brett Anderson, Tawanda Aquino, Elizabeth Berg, Marina Catallozzi, Wendy Chung, Tom Connors, Aliva De, Anny Diaz Perez, Michael DiLorenzo, Dani Dumitriu, Kanwal Farooqi, Michael Fremed, Sylvie Goldman, Kayla Kaplan, Usha Krishnan, Aimee Layton, Angela Lignelli-Dipple, Son McClaren, Jonathan Overdevest, Michelle Rodriguez, Jay Selman, Wendy Silver, Raul Silverio, Ana Valdez de Romero, Celibell Vargas, Alan Werzberger, Daniella Caputo, Camille Leggieri, Pamela Pretsch, Lawrence Kleinman, Sunanda Gaur, Lisa Cerracchio, Amber Folnagy, Maria Gennaro, Sherri Gzemski, Yue Hao, Simon Li, Sandee Moroso, Manette Ness-Cochinwala, Akhil Patel, Benjamin Richlin, Harsh Sharma, Damaris Soto, Christian Suarez, Bibiana Vargas Forero, Lynn Olson, Kristin Davis, Alexander Fiks, Miranda Griffith, Donna Harris, Everly Macario, Jennifer Steffes, Alessandra Torres, Rangaraj Selvarangan, Dithi Banerjee, Chris Day, Kelsye Howell, Megan Mains, Juan C. Salazar, William T. Zempsky, Emily Bean, Carlie DeFelice, Hassan El Chebib, Katherine W. Herbst, Stephanie Lesmes, Ian C. Michelow, Melissa Santos, Noah Schulman, Wilson D. Pace, Alicia Brooks-Greien, Karinne Colin, Christina M. Hester, Ariadna Juarez-Colunga, Brian Manning, Joel Shields, Jack Westfall, Daphne York, Judy Aschner, Katharine Clouser, Justine Griswold, Donna Lee, Amanda Nowakowski, Maryellen Riordan, Hulya Bukulmez, David Kaelber, Rozina Aamir, Mohammed Abuzahrieh, Nandini Bangalore, Alexis Brown, Wendy Dalton, Suzanne Fortuna, Judi Minium, Bonnie Rosolowski, Sheila M. Nolan, Amal Ahmed, Suzanne Braniecki, Montserrat Contreras, Allen Dozor, Supriya Jain, Suzanne Kaseta, Sankaran Krishnan, Zachary Messer, Armando Ramirez, Aalok Singh, Randy Williams, Kyung Rhee, Kelan Tantisira, Almary Akerlundh, Natacha Akshoomoff, Maria Arroyo, Wendy Barrientos, Rakesh Bhattacharjee, Bryant Y. Chao, Maricela Diaz, Sergio Garcia, Sonia Garcia, Guadalupe Gomez, Trinidad Herrera, Margarita Holguin, Manaswitha Khare, Elizabeth Kiernan, Jeremy Landeo Gutierrez, Ileana Matta, Sofia Reyes, Cinthia Sanchez, Andrea Schreck, Megan R. Warner, Uzma Hasan, Elizabeth Ricciardi, Vanessa Trespalacios, Vince Faustino, Matthew Kluko, Bryant Chao, Maria Glenn-Arroyo, Elizabeth A. Kiernan, Anika Madan, Lisa Ramos Vallejo, Cinthia E. Sanchez, Maira Suarez, Patricia Kinser, Amy Salisbury, Jocelyn Espinoza, Sara Moyer, Amy Rider, Sally Russell, Michael Schecter, Lindsey Stevenson, Cheryl R. Stein, Stephanie V. Caldas, Thomas Dylan Castro Ovalle, Anthony Chung, Jonathan S. Farkas, Maria Isidoro-Chino, Deniz Kesebir, Eugenia Kim, Ashley Quarless, Alan Schlechter, Ranjini Srinivasan, Viren D'Sa, Fatoumata Barry, Phoebe Burton, Rosa Cano Lorente, Caroline Cummins, Stephanie Wehbe, Sandra Brown, Anders Dale, Terry Jernigan, Susan Tapert, Jose Aguilar, David Benjamin, Natalie C. Buchbinder, Norma Castro, Brandy Emerson, Hugh Garavan, Jennifer Graves, Amanda Guerrero, Janosch Linkersdoerfer, Robert Schooley, Wes Thompson, Thanh Trinh, Ron Yang, Megan Herting, Elizabeth Sowell, Cynthia Cisneros, Lauren Goedde, Cedric Manlhiot, Raul Gonzalez, Angela Laird, Jorge Limia, Robin Aupperle, Martin Paulus, Melanie Curry, Nour S. El-Sabbagh, Kevin Gray, Lindsay Squeglia, Samuel Agbeh, Cori Herring, Brittany Mckenzie, Bonnie Nagel, Abby Espinoza, Anthony Hill, Angie Morales, Fiona Baker, Eva Muller-Oehring, Ian Colrain, Ingrid Durley, Mirella Dapretto, Lucina Uddin, Susan Bookheimer, Christina Caldera, Jennifer Dzul, Cinthia Zarate, Marie Banich, Paola Badilla, Jennifer Keith, G. Kumar, David Messinger, Katie Prazak, Sara Jo Nixon, Melanie Cardoso, Meagan Sullivan, Stephen Villard, Linda Chang, Thomas Ernst, Christine Cloak, Huajun Liang, Meghann C. Ryan, Mary Heitzerg, Jennifer Conley, Leonard Puttler, Monica Luciana, William Iacono, Aaron Schroeder, Duncan Clark, Doyeon (Dan) Kim, Megan Retucci, Edward Freedman, John Foxe, Sile Ni Mhurchu, Samantha Spallina, Erin McGlade, Deborah Yurgelun-Todd, Liz Bell, Kirsten Cline, Lauren Heinrich, Perry Renshaw, Alexandra Potter, Cass Barrett, Sofia Lozon, Samantha Spear, Christine Larson, Krista Lisdahl, Tory Clearwater, Christine Kaiver, Caitlin Nelson, Zach Paltzer, Bridgette Peteet, James Bjork, Mike Neale, Olive Calonge, Noah Slattery, Lisa Straub, Deanna Barch, Andrew Heath, Pamela Madden, Taylor Powell, Denise Schmitz, Dylan Gee, Boris Epie, Rebekah Hobbs, Alex Williams, Zhouran (Rick) Xiang, Julie Miller, Jane Newburger, Felicia Trachtenberg, Ayesha Amarnath, James Ambrosoli, Denise Artis, Sachin Bandari, Emily Birmingham, Lozan Eyob, Kerri Hayes, Chenwei Hu, Melissa Joyce, Valentina Kazlova, Iris Liu, Amanda Marshall, Devine Mbizdenyuy, P.J. Mu, Robin Rowe, Brooke Sayles, Mo Zhang, Pei-Ni Jone, Michael Carr, Lauren Goodell, Wantanabe Kar, Kathleen Van't Hof, Kristin Sexson, Elias Moussi, David Olukayode, Sandra Pena, Ricardo Pignatelli, Faridis Serrano, Sara Sexson Tejtel, Lara Shekerdemian, Audrey Dionne, Annette Baker, Sarah DeFerrantini, Thomas Giorgio, Numaira Khan, Simran Mahanta, MaryBeth Son, Matt Oster, Melissa Burnett, Kolby Sanders-Lewis, Sonia Chavez, Georgia Reis, Jackie Szmuszkovicz, Fariborz Behzadian, Carla Canas, Andrew Cheng, Mike Gawad, Paige Johnson, Alicia Kazarians, Anastasia Sarkissian, Brandi Scott, Consuelo Secules, Jennifer Su, Crystal Vargas, Jodie Votava-Smith, Sharon Wagner-Lees, Shuo Wang, Pierre Wong, Yamuna Sanil, Sanjeev Aggarwal, Aiman Almasnaah, Nirupama Kannikeswaran, Kathleen Meert, Gautam Singh, Priya Spencer, Nancy Sullivan, Sureja Sundaralingam, Vishnu Undyala, Emily Ward, Amanda Weber, Charmaine Williams Farr, Tamara Bradford, Marla Johnston, Matthew Elias, Alex Fiks, Chris Forrest, Dana Albizem, Susan Coffin, Therese Giglia, Katherine Lupton, Grace Marks, Tonia Morrison, Shawn O'Connor, Daniel Forsha, Jennifer Nelson, Rachel Sachdeva, Dara Watkins, Ashraf S. Harahsheh, Jordyn Britton, Alix Fetch, Anita Krishnan, Onais Tariq, Sean Lang, Marisa Almaguer, Jim Cnota, Lauryn Dugan, Elise Pickering, Kathleen Rathge, Elizabeth Mitchell, Christine Capone, Nilanjana Misra, Olga Shamailova, Mark Russell, Tammy Doman, Lori Harris, Keren Hasbani, Sagar Jani, Brian McCrindle, Jessica Bainton, Maryanne Chrisant, Doris Alaby, Norma Barton, Danielle Katz, Paulette Smith, Stephanie Handler, Joe Block, Regina Cole, Jennifer Maldonado, Kim McHugh, Andrew Atz, Megan Bickford, Jason Buckley, John Costello, Delany Dennis, Elizabeth Emrath-Zwick, Mary Freeman, Lanier Jackson, Madison Johnson, Elizabeth Mack, Scott Pletzer, Natasha Ruth, Carolyn Taylor, Sinai Zyblewski, Katrina Golub, Chanel Rojas, Korsin Rosalind, Chantal Sanchez, Shubhika Srivastava, Carol Prospero, Ed Williams, Varsha Zadokar, Arash Sabati, Kylie Domian, Ashley Herzberg, Sanjana Khanna, Todd Nowlen, Susan Park, Jade Porche, Samantha Stack, Dongngan Truong, Andrea Dunn, Lilly Fagatele, Emma Joyce, Linda Lambert, Kirsten Dummer, Sherrie Bandy, Jane Burns, Katheryn Crane, Sanjeet Hedge, Joan Pancheri, Adriana Tremoulet, Ronald Mark Payne, Mary Stumpf, Michael Portman, Hidemi Kajimoto, Camden Hebson, Krissie Hock, Onyekachukwu Osakwe, Jemylle Morato, Divya Shakti, Matt Kadish, Kavita Sharma, William Anguiano, Catherine Ikemba, Alejandra Lozano, Maria Martinez, Wendy Rojas, Lerraughn Morgan, Isaura Macias, Carl Owada, Mayra Rangel, and Michelle Sykes

Subjects
PEDSnet, PCORnet, Long COVID, Chronic COVID-19 syndrome, Late sequelae of COVID-19, Long-haul COVID, Medicine (General), R5-920
Abstract

Summary: Background: Children from racial and ethnic minority groups are at greater risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is unclear whether they have increased risk for post-acute sequelae of SARS-CoV-2 (PASC). Our objectives were to assess whether the risk of respiratory and neurologic PASC differs by race/ethnicity and social drivers of health. Methods: We conducted a retrospective cohort study of individuals

Published
2025
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3. Branding Positioning, Marketing Kit, and Marketing Plan : Praktik Pengabdian di Kafe Bangsal Kopi Bantul Yogyakarta

Author

Gulam Hazmin, Adi Prasetyo, Aditya Wahana, Nashruddin Achmad, Kevin Gray Dasmasela, and Ventiratna Nur’aini

Subjects
brand awareness, marketing kit, branding identity, digital marketing., Social Sciences, Science
Abstract

This service is to increase the brand awareness of cafe Bangsal Kopi through the creation of a video profile, marketing kit and marketing plan. The implementation method of this service involves educating and assisting. The evaluation instruments used in this activity include observation and interviews, which are analyzed descriptively. The results of this service show that Bangsal Kopi can consistently and effectively manage content on Instagram by utilizing the prepared marketing plan. The visually appealing social media theme templates help strengthen the visual appeal and brand identity of Bangsal Kopi. The created video profile provides a comprehensive overview of the cafe, menu, and customer experience, maintaining the emotional connection with potential visitors. The analysis of social media performance before and after the implementation of the strategy indicates an increase in followers, engagement, and visitors. This suggests that the marketing efforts have successfully enhanced brand awareness, interaction, and interest in Bangsal Kopi. It is also expected that there will be an increase in revenue associated with the rise in the number of visitors and higher engagement levels.

Published
2023
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4. High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing

Author

Alec ST Smith, Shawn M Luttrell, Jean-Baptiste Dupont, Kevin Gray, Daniel Lih, Jacob W Fleming, Nathan J Cunningham, Sofia Jepson, Jennifer Hesson, Julie Mathieu, Lisa Maves, Bonnie J Berry, Elliot C Fisher, Nathan J Sniadecki, Nicholas A Geisse, and David L Mack

Subjects
Biochemistry, QD415-436
Abstract

Engineered muscle tissues represent powerful tools for examining tissue level contractile properties of skeletal muscle. However, limitations in the throughput associated with standard analysis methods limit their utility for longitudinal study, high throughput drug screens, and disease modeling. Here we present a method for integrating 3D engineered skeletal muscles with a magnetic sensing system to facilitate non-invasive, longitudinal analysis of developing contraction kinetics. Using this platform, we show that engineered skeletal muscle tissues derived from both induced pluripotent stem cell and primary sources undergo improvements in contractile output over time in culture. We demonstrate how magnetic sensing of contractility can be employed for simultaneous assessment of multiple tissues subjected to different doses of known skeletal muscle inotropes as well as the stratification of healthy versus diseased functional profiles in normal and dystrophic muscle cells. Based on these data, this combined culture system and magnet-based contractility platform greatly broadens the potential for 3D engineered skeletal muscle tissues to impact the translation of novel therapies from the lab to the clinic.

Published
2022
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5. A Case Study Examining Perceptions of Postsecondary Career and Technical High-Risk Education Instructors within the North Carolina Community College System

Author

Jarvis Kevin Gray

Abstract

The purpose of this research answers two research questions: How do community college welding instructors view the importance of teaching safety in the North Carolina community college welding classrooms and labs in certificate, diploma, and associate degree programs? How does it impact what they teach? What are the safety skills taught, and how do community college welding instructors interact with students in relation to teaching safety in the welding classroom and lab? A mixed methods approach was utilized to generate multiple case studies. Each case study answered the individual questions. Two phases were utilized to collect and analyze data to generate case studies. In phase one welding instructors were sent an anonymous survey link to answer questions regarding their experience, comfort level, and understanding of safety within the welding laboratory. At the conclusion of phase one instructors were given the opportunity to participate in a virtual recorded Zoom interview. In Phase two of the research 10 instructors were interviewed and transcripts were coded, categorized, and themed to answer each of the research questions. In addition, multiple artifacts were evaluated. These artifacts also included welding instructor job postings from July 1, 2021 - June 30, 2022, the safety portion of welding textbooks, and curriculum guides. Key themes that emerged from the research included: Instructors desire to teach students as much as they could about safety before they entered the workplace, recognition that workplaces differed significantly in their ability to provide adequate safety training, resources to ensure student safety are needed more than ever, the level of safety education has increased dramatically since instructors were students. Instructors often focused on technique and proper equipment setup to prevent injuries. Implications for research and practitioners in the classroom included a need for more professional development for instructors to teach supporting subjects in material handling, and fire prevention techniques. Textbooks are still lagging for up-to-date exposures that welders face in the current work environment. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2023

8. Flow: A Musical Composition Tool Using Gesture Interactions and Musical Metacreation

Author

Deja, Jordan Aiko, Chan, Kevin Gray, Dancel, Migo Andres, Gonzales, Allen Vincent, Tobias, John Patrick, Barbosa, Simone Diniz Junqueira, Series Editor, Chen, Phoebe, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, and Stephanidis, Constantine, editor

Published
2018
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12. Introduction: post-COVID transformations

Author

Kevin Gray and Barry Gills

Subjects
Public Administration, Sociology and Political Science, Geography, Planning and Development, Management, Monitoring, Policy and Law, General Economics, Econometrics and Finance
Published
2022
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13. Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues

Author

Bonnie J. Berry, Shawn M. Luttrell, Charles T. Moerk, Jesse Macadangdang, Jessica Perez, Kevin Gray, Hamed Ghazizadeh, Samir Kharoufeh, Brandon Nelsen, and Nicholas A. Geisse

Subjects
General Immunology and Microbiology, General Chemical Engineering, General Neuroscience, General Biochemistry, Genetics and Molecular Biology
Published
2023
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15. Cannabis Use Disorder in Adolescents

Author

Daniel Hashemi and Kevin Gray

Subjects
Psychiatry and Mental health, Marijuana Abuse, Adolescent, Substance-Related Disorders, Pediatrics, Perinatology and Child Health, Humans, Cannabis
Abstract

With increasing cannabis potency, increasing variety of methods of cannabis use, and lower perceived risk of cannabis use, it is increasingly important clinicians who work with adolescents remain up-to-date on the latest literature regarding cannabis use and its associated outcomes. Adolescent cannabis use is associated with chronic cognitive, psychosocial, psychiatric, and physical outcomes. Clinicians working in this field should be able to recognize cannabis use disorder, understand how adolescent cannabis use can impact the developing mind, and have informed discussions with patients and families regarding risks of use.

Published
2022

20. Abstract P1131: Modeling Contractile Diseases Using Scalable 3D Engineered Heart Tissues For Drug Discovery

Author

Nicholas Geisse, Bonnie Berry, Kevin Gray, Samir Kharoufeh, Shawn M Luttrell, Jesse Macadangdang, and Christal Worthen

Subjects
Physiology, Cardiology and Cardiovascular Medicine
Abstract

Model systems that accurately recapitulate healthy and diseased function in a dish are critical for the development of novel therapeutics. For cardiac diseases, direct assessment of contractile output constitutes the most reliable metric with which to assess overall tissue function, as other ‘proxy’ measurements are poor predictors of muscle strength. 3D engineered muscle tissues (EMTs) derived from iPSCs hold great potential for modeling contractile function. Here, we have developed a platform and device that utilizes 3D EMTs in conjunction with a label-free magnetic sensing array. The platform enables facile and reproducible fabrication of 3D EMTs using virtually any cell source and is coupled with a highly parallel direct measurement of contractile strength. This approach enables the stratification of healthy and diseased phenotypes and facilitates compound safety and efficacy screening for evaluation of a drug’s effect on contractile output. We will present data from a drug (BMS-986094) that failed clinical trials due to unanticipated cardiotoxicity. We go on to show both the acute and chronic effects of doxorubicin in cardiac EMTs. Contractile force decreased in a dose dependent-like manner when the drug was applied continuously. Interestingly, a single 1uM bolus induced a transient effect that could be washed out over time. A repeat bolus, however, irreversibly abolished contraction, suggesting that repeat dosing may have a cardiotoxic effect on the muscle. These data demonstrate a first-and-only commercial platform for high-throughput assessment of 3D cardiac muscle contraction with potential for widespread adoption within the drug development field.

Published
2022
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24. Contents

Author

Carr, Kevin Gray

Published
2012

39. Index

Author

Carr, Kevin Gray

Published
2012

40. Notes

Author

Carr, Kevin Gray

Published
2012

42. Rural, urban, and teaching hospital differences in hip fracture mortality

Author

John M. Clements, Brian M. Shear, Brendan J. Farley, Kyla Walworth, Vivian F. Lu, Matt Kirsch, and Kevin Gray

Subjects
030222 orthopedics, Hip fracture, medicine.medical_specialty, business.industry, Mortality rate, Retrospective cohort study, 030229 sport sciences, medicine.disease, Article, Odds, Teaching hospital, 03 medical and health sciences, 0302 clinical medicine, Family medicine, Health care, medicine, Orthopedics and Sports Medicine, Social determinants of health, business, Healthcare Cost and Utilization Project
Abstract

Introduction Hip fractures remain one of the most prevalent and deadly conditions afflicting those 65 years and older. For other health conditions (e.g. myocardial infarction), hospital location is associated with poorer health outcomes. To our knowledge, no study has investigated the relationship between hip fracture morality rate in the United States between urban and rural hospital settings. Methods A retrospective cohort study was conducted to examine differences in in-hospital mortality between groups treated in rural, urban-teaching, and urban-non-teaching hospitals, as well as public and private hospitals. Mortality rates were also compared for variances between surgical treatment, sex, insurance, patient location, race, and income. Discharge data was collected for 256,240 inpatient stays from the 2012 National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality. Results Odds of mortality were 14.6% greater in rural hospital hip fracture patients compared to Urban/Non-Teaching centers (p Conclusions Results from this study lend support to necessitate further research investigating prospective barriers to care of those in rural settings. This may point to limitations in resources and trained medical and surgical specialists in rural hospitals and need for continued research to mitigate such findings.

Published
2020
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43. Debating Uneven and Combined Development/Debating International Relations:A Forum

Author

Justin Rosenberg, Ayşe Zarakol, David Blagden, Olivia Rutazibwa, Kevin Gray, Olaf Corry, Kamran Matin, Felipe Antunes de Oliveira, Luke Cooper, Rosenberg, Justin [0000-0002-2950-1541], Blagden, David [0000-0001-6923-4946], Rutazibwa, Olivia [0000-0002-1123-2355], Corry, Olaf [0000-0002-7249-0913], and Apollo - University of Cambridge Repository

Subjects
Sociology and Political Science, Political Science and International Relations, JZ International relations, 4408 Political Science, international theory, disciplinarity, 44 Human Society, uneven and combined development
Abstract

This forum arises from an online event on the theory of uneven and combined development (UCD). Following an introduction which proposes a ‘special affinity’ between UCD and International Relations (IR), four presenters at that event discuss their ‘view from outside’ UCD, including perspectives from Global Historical Sociology, Realism, Decolonial theory and Gramscian Marxism. Meanwhile four members of the audience add their views on UCD and disciplinarity, the need for pluralism in UCD methodology, UCD and ‘whiteness’, and its potential contribution to ecological theory and practice. Débattre du développement inégal et combiné/Débattre des relations internationales

Published
2022
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46. Revolution and restoration in post-war East Asia: A Gramscian approach to the ‘history problem’

Author

Kevin Gray

Subjects
Economics and Econometrics, History, Sociology and Political Science
Abstract

While tensions over historical issues between Japan and South Korea have long served to impede US strategic goals in East Asia, mainstream International Relations theory has largely been unable to explain the stubborn persistence of such issues. Instead, I interpret East Asia’s post-war history through the lens of Gramsci’s concept of passive revolution, thereby situating the ‘history problem’ in the context of the dialectical relations between state (re)formation, geopolitical contestation and transnational capital accumulation in the post-war era. I argue that US intervention in 1945 was a process in which a set of state–society relations was established whereby democratising tendencies from below were repressed through the establishment of US-aligned capitalist regimes. This implied the partial restoration of certain aspects of the pre-1945 regimes in a manner that served to forestall any genuine coming to terms with past colonial history. Gramsci’s concept of passive revolution thus provides a framework for rethinking how bilateral relations between countries can be explained with reference to the broader dynamics of geopolitical contestation, transnational capital accumulation and the dynamics of state–society contestation within national social formations. While existing empirical applications of passive revolution have typically focused on particular national instances of state formation and transformation, I argue that the concept can be utilised to analyse the region-wide processes whereby the US empire was established in the aftermath of the Second World War, and by extension, how supranational processes of passive revolution subsequently generated their own tensions and contradictions as manifested in contested bilateral relations between states.

Published
2022
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47. Long-term suppression maintained after cessation of AB-729 treatment and comparable on-treatment response observed in HBeAg+ subjects

Author

Man-Fung Yuen, Elina Berliba, Wattana Sukeepaisarnjaroen, Jacinta Holmes, Apinya Leerapun, Pisit Tangkijvanich, Simone Strasser, Alina Jucov, Edward J Gane, Emily P. Thi, Heather Sevinsky, Elina Medvedeva, Varun Sharma, Kevin Gray, Deana Antoniello, Gaston Picchio, Karen Sims, and Timothy Eley

Subjects
Hepatology
Published
2022
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48. NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells

Author

Michael A. Laflamme, Joseph C. Wu, Charles E. Murry, Kevin Gray, Eunpyo Choi, Alec S.T. Smith, Elisa C. Clark, Deok Ho Kim, Leslie Tung, Jesse Macadangdang, and Eun Hyun Ahn

Subjects
Neurite, Induced Pluripotent Stem Cells, Bioengineering, 02 engineering and technology, Article, Postsynaptic potential, medicine, Humans, Myocytes, Cardiac, General Materials Science, Nanotopography, Induced pluripotent stem cell, Electrodes, Neurons, Chemistry, Mechanical Engineering, Colocalization, Cell Differentiation, General Chemistry, Multielectrode array, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electrophysiological Phenomena, Electrophysiology, medicine.anatomical_structure, Biophysics, Neuron, 0210 nano-technology
Abstract

Matrix nanotopographical cues are known to regulate the structure and function of somatic cells derived from human pluripotent stem cell (hPSC) sources. High-throughput electrophysiological analysis of excitable cells derived from hPSCs is possible via multielectrode arrays (MEAs), but conventional MEA platforms use flat substrates and do not reproduce physiologically-relevant tissue-specific architecture. To address this issue, we developed a high-throughput nanotopographically-patterned multielectrode array (nanoMEA) by integrating conductive, ion-permeable, nanotopographic patterns with 48-well MEA plates, and investigated the effect of substrate-mediated cytoskeletal organization on hPSC-derived cardiomyocyte and neuronal function at scale. Using our nanoMEA platform, we found patterned hPSC-derived cardiac monolayers exhibit both enhanced structural organization and greater sensitivity to treatment with calcium blocking or conduction inhibiting compounds when subjected to high-throughput dose-response studies. Similarly, hPSC-derived neurons grown on nanoMEA substrates exhibit faster migration and neurite outgrowth speeds, greater co-localization of pre- and post-synaptic markers, and enhanced cell-cell communication, only revealed through examination of data sets derived from multiple technical replicates. The presented data highlight the nanoMEA as a new tool to facilitate high-throughput, electrophysiological analysis of ordered cardiac and neuronal monolayers, which can have important implications for preclinical analysis of excitable cell function.

Published
2019
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