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41 results on '"Key, Pauline"'

4. E954: Saccharin

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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6. E320: BHA

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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13. E249–50: Nitrites

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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16. E416: Karaya gum

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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21. E110: Sunset yellow

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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23. E310–12: Gallates

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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24. E220–8: Sulphites

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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30. Introduction

Author

Wood, Roger, primary, Foster, Lucy, additional, Damant, Andrew, additional, and Key, Pauline, additional

Published
2004
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40. Precision estimates produced by specially-designed ruggedness tests compared with those derived from collaborative trials, in relation to estimation of measurement uncertainty

Author

Thompson, Michael, Guffogg, Stephen, Stangroom, Stephen, Osborne, Paula, Key, Pauline, and Wood, Roger

Abstract

We have compared the reproducibility precisions provided by collaborative trials with precisions obtained from ruggedness tests specially designed to try to simulate between-laboratory variation. We found that the ruggedness tests underestimated the reproducibility variability consistently for those analytical methods requiring empirical calibration. The ruggedness tests provided on average a precision merely comparable with repeatability precision. This finding has implications for the estimation of uncertainty.

Published
2002

41. Absolute bioavailability of [14C] genistein in the rat; plasma pharmacokinetics of parent compound, genistein glucuronide and total radioactivity

Author

Coldham, Nick, Zhang, Ai-Qin, Key, Pauline, and Sauer, Maurice

Abstract

Summary: The systemic plasma pharmacokinetics of genistein were determined in rats to evaluate the absolute oral bioavailability and make comparison with similar data in the literature derived from humans subjects. The plasma concentrations of genistein, genistein glucuronide and carbon-14 were determined by LC-MS/MS and liquid scintillation counting following oral and intravenous dosing with [14C]genistein (4 mg kg−1 body weight). The absorption of total radioactivity from the gut, (parent compound and metabolites), was 56 and 111% in male and female rats, respectively. In contrast, the absolute oral bioavailability of genistein in male and female rats was 7 and 15%. There was a significant (P<0.001) difference between Cmax of genistein after intravenous (6921 and 4392 ng/ml) and oral (21 and 22 ng/ml) dosing in male and female rats, respectively. After oral administration, the concentration profile of genistein glucuronide in plasma greatly exceeded that of parent compound during the absorption/distribution phase suggesting extensive first pass metabolism, and provided evidence of entero-hepatic circulation. Selective plasma analysis by LC-MS/MS, without prior enzymatic hydrolysis, enabled ready discrimination between parent and conjugated metabolites and prevented gross overestimation of genistein bioavailability. Pharmacokinetic parameters Cmax, Tmax and AUC were similar to those reported in humans, which supports the use of the rat model for genistein toxicity studies.

Published
2002
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