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3. Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Author

Mathurin, P., Gournay, J., Nguyen-Khac, E., De Ledinghen, V., Larrey, D., Tran, A., Bourliere, M., Maynard-Muet, M., Asselah, T., Henrion, J., Nevens, F., Cassiman, D., Geerts, A., Moreno, C., Beuers, U.H., Galle, P.R., Spengler, U., Bugianesi, E., Craxi, A., Angelico, M., Fargion, S., Voiculescu, M., Gheorghe, L., Preotescu, L., Caballeria, J., Andrade, R.J., Crespo, J., Callera, J.L., Ala, A., Aithal, G., Abouda, G., Luketic, V., Huang, M.A., Gordon, S., Pockros, P., Poordad, F., Shores, N., Moehlen, M.W., Bambha, K., Clark, V., Satapathy, S., Parekh, S., Reddy, R.K., Sheikh, M.Y., Szabo, G., Vierling, J., Foster, T., Umpierrez, G., Chang, C., Box, T., Gallegos-Orozco, J., Ratziu, Vlad, Harrison, Stephen A., Francque, Sven, Bedossa, Pierre, Lehert, Philippe, Serfaty, Lawrence, Romero-Gomez, Manuel, Boursier, Jérôme, Abdelmalek, Manal, Caldwell, Steve, Drenth, Joost, Anstee, Quentin M., Hum, Dean, Hanf, Remy, Roudot, Alice, Megnien, Sophie, Staels, Bart, and Sanyal, Arun

Published
2016
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5. Incidence, Clinical Presentation, and Associated Factors of Microscopic Colitis in Northern France: A Population-Based Study

Author

Fumery, Mathurin, Kohut, Mathieu, Gower-Rousseau, Corinne, Duhamel, Alain, Brazier, Franck, Thelu, Francoise, Nagorniewicz, Francis, Lamarche, Francois, Nguyen-Khac, Eric, Sabbagh, Charles, Loreau, Julien, Colombel, Jean-Frederic, Savoye, Guillaume, Chatelain, Denis, Dupas, Jean-Louis, Bartoli, E., Bental, A., Brazier, F., Butel, J., Capron-Chivrac, D., Coevoet, H., Cohen, G., Dadamessi, I., Delcenserie, R., Delgrange, T., Descombes, P., Dupas, J. L., Heyman, B., Joly, J. P., Lagarde, M., Laude, D., Mancheron, H., Nguyen-Khac, E., Papazian, A., Pauwels, B., Pauwels, M., Prevost, J. C., Reix-Branche, N., Rudelli, A., Sevenet, F., Triplet, C., Wantiez, M., On behalf on the Somme MC group, and EPIMAD group

Published
2017
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6. Impact of Extra-Intestinal Manifestations at Diagnosis on Disease Outcome in Pediatric- and Elderly-Onset Crohn′s Disease: A French Population-Based Study

Author

Duricova, Dana, Sarter, Hélène, Savoye, Guillaume, Leroyer, Ariane, Pariente, Benjamin, Armengol-Debeir, Laura, Bouguen, Guillaume, Ley, Delphine, Turck, Dominique, Templier, Carole, Buche, Sebastien, Peyrin-Biroulet, Laurent, Gower-Rousseau, Corinne, Fumery, Mathurin, Andre, J M, Antonietti, M, Aouakli, A, Armand, A, Aroichane, I, Assi, F, Aubet, J P, Auxenfants, E, Ayafi-Ramelot, F, Bankovski, D, Barbry, B, Bardoux, N, Baron, P, Baudet, A, Bazin, B, Bebahani, A, Becqwort, J P, Benet, V, Benali, H, Benguigui, C, Ben Soussan, E, Bental, A, Berkelmans, I, Bernet, J, Bernou, K, Bernou-Dron, C, Bertot, P, Bertiaux-Vandaële, N, Bertrand, V, Billoud, E, Biron, N, Bismuth, B, Bleuet, M, Blondel, F, Blondin, V, Bohon, P, Boniface, E, Bonnière, P, Bonvarlet, E, Bonvarlet, P, Boruchowicz, A, Bostvironnois, R, Boualit, M, Bouche, B, Boudaillez, C, Bourgeaux, C, Bourgeois, M, Bourguet, A, Bourienne, A, Branche, J, Bray, G, Brazier, F, Breban, P, Brihier, H, Brung-Lefebvre, V, Bulois, P, Burgiere, P, Butel, J, Canva, J Y, Canva-Delcambre, V, Capron, J P, Cardot, F, Carpentier, P, Cartier, E, Cassar, J F, Cassagnou, M, Castex, J F, Catala, P, Cattan, S, Catteau, S, Caujolle, B, Cayron, G, Chandelier, C, Chantre, M, Charles, J, Charneau, T, Chavance-Thelu, M, Chirita, D, Choteau, A, Claerbout, J F, Clergue, P Y, Coevoet, H, Cohen, G, Collet, R, Colombel, J F, Coopman, S, Corvisart, J, Cortot, A, Couttenier, F, Crinquette, J F, Crombe, V, Dadamessi, I, Dapvril, V, Davion, T, Dautreme, S, Debas, J, Degrave, N, Dehont, F, Delatre, C, Delcenserie, R, Delette, O, Delgrange, T, Delhoustal, L, Delmotte, J S, Demmane, S, Deregnaucourt, G, Descombes, P, Desechalliers, J P, Desmet, P, Desreumaux, P, Desseaux, G, Desurmont, P, Devienne, A, Devouge, E, Devred, M, Devroux, A, Dewailly, A, Dharancy, S, Di Fiore, A, Djeddi, D, Djedir, R, Dreher-Duwat, M L, Dubois, R, Dubuque, C, Ducatillon, P, Duclay, J, Ducrocq, B, Ducrot, F, Ducrotté, P, Dufilho, A, Duhamel, C, Dujardin, D, Dumant-Forest, C, Dupas, J L, Dupont, F, Duranton, Y, Duriez, A, El Achkar, K, El Farisi, M, Elie, C, Elie-Legrand, M C, Elkhaki, A, Eoche, M, Evrard, D, Evrard, J P, Fatome, A, Filoche, B, Finet, L, Flahaut, M, Flamme, C, Foissey, D, Fournier, P, Foutrein- Comes, M C, Foutrein, P, Fremond, D, Frere, T, Fumery, M, Gallet, P, Gamblin, C, Ganga-Zandzou, S, Gerard, R, Geslin, G, Gheyssens, Y, Ghossini, N, Ghrib, S, Gilbert, T, Gillet, B, Godard, D, Godard, P, Godchaux, J M, Godchaux, R, Goegebeur, G, Goria, O, Gottrand, F, Gower, P, Grandmaison, B, Groux, M, Guedon, C, Guillard, J F, Guillem, L, Guillemot, F, Guimber, D, Haddouche, B, Hakim, S, Hanon, D, Hautefeuille, V, Heckestweiller, P, Hecquet, G, Hedde, J P, Hellal, H, Henneresse, P E, Heyman, B, Heraud, M, Herve, S, Hochain, P, Houssin-Bailly, L, Houcke, P, Huguenin, B, Iobagiu, S, Ivanovic, A, Iwanicki-Caron, I, Janicki, E, Jarry, M, Jeu, J, Joly, J P, Jonas, C, Katherin, F, Kerleveo, A, Khachfe, A, Kiriakos, A, Kiriakos, J, Klein, O, Kohut, M, Kornhauser, R, Koutsomanis, D, Laberenne, J E, Laffineur, G, Lagarde, M, Lannoy, P, Lapchin, J, Lapprand, M, Laude, D, Leblanc, R, Lecieux, P, Leclerc, N, Le Couteulx, C, Ledent, J, Lefebvre, J, Lefiliatre, P, Legrand, C, Le Grix, A, Lelong, P, Leluyer, B, Lenaerts, C, Lepileur, L, Leplat, A, Lepoutre-Dujardin, E, Leroi, H, Leroy, M Y, Lesage, J P, Lesage, X, Lesage, J, Lescanne-Darchis, I, Lescut, J, Lescut, D, Leurent, B, Levy, P, Lhermie, M, Lion, A, Lisambert, B, Loire, F, Louf, S, Louvet, A, Luciani, M, Lucidarme, D, Lugand, J, Macaigne, O, Maetz, D, Maillard, D, Mancheron, H, Manolache, O, Marks-Brunel, A B, Marti, R, Martin, F, Martin, G, Marzloff, E, Mathurin, P, Mauillon, J, Maunoury, V, Maupas, J L, Mesnard, B, Metayer, P, Methari, L, Meurisse, B, Meurisse, F, Michaud, L, Mirmaran, X, Modaine, P, Monthe, A, Morel, L, Mortier, P E, Moulin, E, Mouterde, O, Mudry, J, Nachury, M, N’Guyen Khac, E, Notteghem, B, Ollevier, V, Ostyn, A, Ouraghi, A, Ouvry, D, Paillot, B, Panien-Claudot, N, Paoletti, C, Papazian, A, Parent, B, Pariente, B, Paris, J C, Patrier, P, Paupart, L, Pauwels, B, Pauwels, M, Petit, R, Piat, M, Piotte, S, Plane, C, Plouvier, B, Pollet, E, Pommelet, P, Pop, D, Pordes, C, Pouchain, G, Prades, P, Prevost, A, Prevost, J C, Quesnel, B, Queuniet, A M, Quinton, J F, Rabache, A, Rabelle, P, Raclot, G, Ratajczyk, S, Rault, D, Razemon, V, Reix, N, Revillon, M, Richez, C, Robinson, P, Rodriguez, J, Roger, J, Roux, J M, Rudelli, A, Saber, A, Savoye, G, Schlosseberg, P, Segrestin, M, Seguy, D, Serin, M, Seryer, A, Sevenet, F, Shekh, N, Silvie, J, Simon, V, Spyckerelle, C, Talbodec, N, Techy, A, Thelu, J L, Thevenin, A, Thiebault, H, Thomas, J, Thorel, J M, Tielman, G, Tode, M, Toisin, J, Tonnel, J, Touchais, J Y, Touze, Y, Tranvouez, J L, Triplet, C, Turck, D, Uhlen, S, Vaillant, E, Valmage, C, Vanco, D, Vandamme, H, Vanderbecq, E, Vander Eecken, E, Vandermolen, P, Vandevenne, P, Vandeville, L, Vandewalle, A, Vandewalle, C, Vaneslander, P, Vanhoove, J P, Vanrenterghem, A, Varlet, P, Vasies, I, Verbiese, G, Vernier-Massouille, G, Vermelle, P, Verne, C, Vezilier-Cocq, P, Vigneron, B, Vincendet, M, Viot, J, Voiment, Y M, Wacrenier, A, Waeghemaecker, L, Wallez, J Y, Wantiez, M, Wartel, F, Weber, J, Willocquet, J L, Wizla, N, Wolschies, E, Zalar, A, Zaouri, B, Zellweger, A, and Ziade, C

Published
2019
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7. Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study

Author

Hochart, A, Gower-Rousseau, C, Sarter, H, Fumery, M, Ley, D, Spyckerelle, C, Peyrin-Biroulet, L, Laberenne, J-E, Vasseur, F, Savoye, G, Turck, D, Andre, JM, Antonietti, M, Aouakli, A, Armand, A, Aroichane, I, Assi, F, Aubet, JP, Auxenfants, E, Ayafi-Ramelot, F, Azzouzi, K, Bankovski, D, Barbry, B, Bardoux, N, Baron, P, Baudet, A, Bazin, B, Bebahani, A, Becqwort, JP, Benet, V, Benali, H, Benguigui, C, Ben Soussan, E, Bental, A, Berkelmans, I, Bernet, J, Bernou, K, Bernou-Dron, C, Bertot, P, Bertiaux-Vandaële, N, Bertrand, V, Billoud, E, Biron, N, Bismuth, B, Bleuet, M, Blondel, F, Blondin, V, Bohon, P, Boniface, E, Bonnière, P, Bonvarlet, E, Bonvarlet, P, Boruchowicz, A, Bostvironnois, R, Boualit, M, Bouche, B, Boudaillez, C, Bourgeaux, C, Bourgeois, M, Bourguet, A, Bourienne, A, Branche, J, Bray, G, Brazier, F, Breban, P, Bridenne, M, Brihier, H, Brung-Lefebvre, V, Bulois, P, Burgiere, P, Butel, J, Canva, JY, Canva-Delcambre, V, Capron, JP, Cardot, F, Carpentier, P, Cartier, E, Cassar, JF, Cassagnou, M, Castex, JF, Catala, P, Cattan, S, Catteau, S, Caujolle, B, Cayron, G, Chandelier, C, Chantre, M, Charles, J, Charneau, T, Chavance-Thelu, M, Chirita, D, Choteau, A, Claerbout, JF, Clergue, PY, Coevoet, H, Cohen, G, Collet, R, Colombel, JF, Coopman, S, Corvisart, J, Cortot, A, Couttenier, F, Crinquette, JF, Crombe, V, Dadamessi, I, Dapvril, V, Davion, T, Dautreme, S, Debas, J, Degrave, N, Dehont, F, Delatre, C, Delcenserie, R, Delette, O, Delgrange, T, Delhoustal, L, Delmotte, JS, Demmane, S, Deregnaucourt, G, Descombes, P, Desechalliers, JP, Desmet, P, Desreumaux, P, Desseaux, G, Desurmont, P, Devienne, A, Devouge, E, Devred, M, Devroux, A, Dewailly, A, Dharancy, S, Di Fiore, A, Djeddi, D, Djedir, R, Dreher-Duwat, ML, Dubois, R, Dubuque, C, Ducatillon, P, Duclay, J, Ducrocq, B, Ducrot, F, Ducrotte, P, Dufilho, A, Duhamel, C, Dujardin, D, Dumant-Forest, C, Dupas, JL, Dupont, F, Duranton, Y, Duriez, A, El Achkar, K, El Farisi, M, Elie, C, Elie-Legrand, MC, Elkhaki, A, Eoche, M, Evrard, D, Evrard, JP, Fatome, A, Filoche, B, Finet, L, Flahaut, M, Flamme, C, Foissey, D, Fournier, P, Foutrein-Comes, MC, Foutrein, P, Fremond, D, Frere, T, Gallet, P, Gamblin, C, Ganga, S, Gerard, R, Geslin, G, Gheyssens, Y, Ghossini, N, Ghrib, S, Gilbert, T, Gillet, B, Godard, D, Godard, P, Godchaux, JM, Godchaux, R, Goegebeur, G, Goria, O, Gottrand, F, Gower, P, Grandmaison, B, Groux, M, Guedon, C, Guillard, JF, Guillem, L, Guillemot, F, Guimberd, D, Haddouche, B, Hakim, S, Hanon, D, Hautefeuille, V, Heckestweiller, P, Hecquet, G, Hedde, JP, Hellal, H, Henneresse, PE, Heyman, B, Heraud, M, Herve, S, Hochain, P, Houssin-Bailly, L, Houcke, P, Huguenin, B, Iobagiu, S, Ivanovic, A, Iwanicki-Caron, I, Janicki, E, Jarry, M, Jeu, J, Joly, JP, Jonas, C, Katherin, F, Kerleveo, A, Khachfe, A, Kiriakos, A, Kiriakos, J, Klein, O, Kohut, M, Kornhauser, R, Koutsomanis, D, Laffineur, G, Lagarde, M, Lalanne, A, Lannoy, P, Lapchin, J, Laprand, M, Laude, D, Leblanc, R, Lecieux, P, Leclerc, N, Le Couteulx, C, Ledent, J, Lefebvre, J, Lefiliatre, P, Legrand, C, Le Grix, A, Lelong, P, Leluyer, B, Lenaerts, C, Lepileur, L, Leplat, A, Lepoutre-Dujardin, E, Leroi, H, Leroy, MY, Lesage, JP, Lesage, X, Lesage, J, Lescanne-Darchis, I, Lescut, J, Lescut, D, Leurent, B, Levy, P, Lhermie, M, Lion, A, Lisambert, B, Loire, F, Louf, S, Louvet, A, Luciani, M, Lucidarme, D, Lugand, J, Macaigne, O, Maetz, D, Maillard, D, Mancheron, H, Manolache, O, Marks-Brunel, AB, Marti, R, Martin, F, Martin, G, Marzloff, E, Mathurin, P, Mauillon, J, Maunoury, V, Maupas, JL, Mesnard, B, Metayer, P, Methari, L, Meurisse, B, Meurisse, F, Michaud, L, Mirmaran, X, Modaine, P, Monthe, A, Morel, L, Mortier, PE, Moulin, E, Mouterde, O, Mudry, J, Nachury, M, NʼGuyen Khac, E, Notteghem, B, Ollevier, V, Ostyn, A, Ouraghi, A, Ouvry, D, Paillot, B, Panien-Claudot, N, Paoletti, C, Papazian, A, Parent, B, Pariente, B, Paris, JC, Patrier, P, Paupart, L, Pauwels, B, Pauwels, M, Petit, R, Piat, M, Piotte, S, Plane, C, Plouvier, B, Pollet, E, Pommelet, P, Pop, D, Pordes, C, Pouchain, G, Prades, P, Prevost, A, Prevost, JC, Quesnel, B, Queuniet, AM, Quinton, JF, Rabache, A, Rabelle, P, Raclot, G, Ratajczyk, S, Rault, D, Razemon, V, Reix, N, Revillon, M, Richez, C, Robinson, P, Rodriguez, J, Roger, J, Roux, JM, Rudelli, A, Saber, A, Schlosseberg, P, Segrestin, M, Seguy, D, Serin, M, Seryer, A, Sevenet, F, Shekh, N, Silvie, J, Simon, V, Talbodec, N, Techy, A, Thelu, JL, Thevenin, A, Thiebault, H, Thomas, J, Thorel, JM, Tielman, G, Tode, M, Toisin, J, Tonnel, J, Touchais, JY, Touze, Y, Tranvouez, JL, Triplet, C, Uhlen, S, Vaillant, E, Valmage, C, Vanco, D, Vandamme, H, Vanderbecq, E, Vander Eecken, E, Vandermolen, P, Vandevenne, P, Vandeville, L, Vandewalle, A, Vandewalle, C, Vaneslander, P, Vanhoove, JP, Vanrenterghem, A, Varlet, P, Vasies, I, Verbiese, G, Vernier-Massouille, G, Vermelle, P, Verne, C, Vezilier-Cocq, P, Vigneron, B, Vincendet, M, Viot, J, Voiment, YM, Wacrenier, A, Waeghemaecker, L, Wallez, JY, Wantiez, M, Wartel, F, Weber, J, Willocquet, JL, Wizla, N, Wolschies, E, Zalar, A, Zaouri, B, Zellweger, A, and Ziade, C

Published
2017
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11. Complete endoscopic healing is associated with lower disability than partial mucosal healing in Crohn's disease: a prospective multicentric study

Author

Yzet, Clara, Brazier, Franck, Sebbagh, V., Vanelslander, P., Dejour, V., David, B., Nguyen-Khac, E., Diouf, M., Fumery, Mathurin, CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Compiègne-Noyon, Polyclinique Saint-Claude, Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UMI 3189 Environnement, santé, sociétés, université Cheikh Anta Diop/CNRS/ Université de Bamako/CNRST (UMI 3189), and Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Crohn’s disease (CD) has a significant impact on health status and quality of life, by affecting physical and emotional well-being and by impairment of social and functional abilities. In the era of treat to target concept, endoscopic healing has emerged to be the goal to achieve to prevent intestinal damage and disability. It is not clear what level of endoscopic healing is associated with CD disability. We, therefore, aimed to compare disability associated to complete endoscopic healing or partial endoscopic healing in patients with CD.

Published
2021
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24. Hépatite alcoolique aiguë sévère

Author

Nguyen-Khac, E., primary, Dejour, V., additional, Sarba, R., additional, Yzet, T., additional, Turpin, J., additional, Chatelain, D., additional, Marcq, I., additional, Chivot, C., additional, Maizel, J., additional, Papillon, C.A., additional, Attencourt, C., additional, and Houchi, H., additional

Published
2018
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25. Estimated risk reduction of mortality and transplantation with bezafibrate in patients with PBC and inadequate response to UDCA: application of the UK-PBC and Global PBC risk scores to the BEZURSO trial

Author

Corpechot, C., primary, Rousseau, A., additional, Chazouillères, O., additional, Antonia, L.G., additional, Habersetzer, F., additional, Mathurin, P., additional, Goria, O., additional, Pascal, P., additional, Franza, A.M., additional, Silvain, C., additional, Abergel, A., additional, Gratien, M.D., additional, Larrey, D., additional, Olivier, R., additional, Bronowicki, J.-P., additional, Boursier, J., additional, De Ledinghen, V., additional, Heurgue-Berlot, A., additional, Nguyen-Khac, E., additional, Zoulim, F., additional, Isabelle, O.-H., additional, Zarski, J.-P., additional, Gisèle, N., additional, Farid, G., additional, Admane, F.-H., additional, Simon, T., additional, and Poupon, R., additional

Published
2018
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28. Efficacy and safety of 8 weeks of elbasvir/grazoprevir in HCV GT4-infected treatment-naīve participants

Author

Asselah, T., primary, Pol, S., additional, Hezode, C., additional, Loustaud-Ratti, V., additional, Leroy, V., additional, Ahmed, S.N.S., additional, Ozenne, V., additional, Bronowicki, J.-P., additional, Larrey, D., additional, Tran, A., additional, Alric, L., additional, Nguyen-Khac, E., additional, Robertson, M., additional, Hanna, G., additional, Brown, D., additional, Asante-Appiah, E., additional, Ludmerer, S., additional, Su, M., additional, Hwang, P., additional, Klopfer, S., additional, Dutko, F., additional, Guidoum, A., additional, Hagen, K., additional, Haber, B., additional, Talwani, R., additional, and Serfaty, L., additional

Published
2018
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29. Changes in serum bile acid levels associated with bezafibrate add-on therapy in patients with primary biliary cholangitis and inadequate biochemical response to ursodeoxycholic acid: results from the BEZURSO trial (NCT01654731)

Author

Corpechot, C., Chazouilleres, O., Humbert, L., Rousseau, A., Le Gruyer, A., Habersetzer, F., Philippe Mathurin, Goria, O., Potier, P., Anne, M., Silvain, C., Abergel, A., Debette-Gratien, M., Larrey, D. G., Roux, O., Bronowicki, J. P., Boursier, J., Ledinghen, V., Heurgue-Berlot, A., Nguyen-Khac, E., Zoulim, F., Ollivier-Hourmand, I., Zarski, J. P. H., Nkontchou, G., Gaouar, F., Simon, T., Poupon, R., Rainteau, D., CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire des biomolécules (LBM UMR 7203), Université Pierre et Marie Curie - Paris 6 (UPMC)-Département de Chimie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CHU Pontchaillou [Rennes], Interactions Virus-Hôte et Maladies Hépatiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Virologie, Pôle Hépato-digestif, Les Hôpitaux Universitaires de Strasbourg (HUS), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Hospitalier Régional d'Orléans (CHRO), Unité d'Hépatologie [CHU Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Department of Digestive and Hepatobiliary Medecine, University Medical Hospital, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Pharmacologie des Immunosuppresseurs et de la Transplantation (PIST), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi], Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Méthodes Formelles pour la Bioinformatique (LS2N - équipe MéForBio), Laboratoire des Sciences du Numérique de Nantes (LS2N), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital universitaire Robert Debré [Reims], Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Service d'Hépatologie [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d’Hépato-Gastroentérologie [CHU Angers], PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Hôpital Jean Verdier [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Washington, DC, OCT 20-24, 2017; International audience

Published
2017

31. Prise en charge endoscopique des fistules gastriques après sleeve gastrectomy par prothèses double queue de cochon: Technique BARTOLI

Author

Deschepper, C, additional, Rebibo, L, additional, Le Mouel, JP, additional, Thiebault, H, additional, Wacrenier, A, additional, Brazier, F, additional, Fumery, M, additional, Delcenserie, R, additional, Cosse, C, additional, Dhahri, A, additional, Dupas, JL, additional, Regimbeau, JM, additional, Nguyen-Khac, E, additional, and Sami, H, additional

Published
2017
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32. A 2-year multicenter, double-blind, randomized, placebo-controlled study of bezafibrate for the treatment of primary biliary cholangitis in patients with inadequate biochemical response to ursodeoxycholic acid therapy (Bezurso)

Author

Corpechot, C., primary, Chazouillères, O., additional, Rousseau, A., additional, Guyader, D., additional, Habersetzer, F., additional, Mathurin, P., additional, Goria, O., additional, Potier, P., additional, Minello, A., additional, Silvain, C., additional, Abergel, A., additional, Debette-Gratien, M., additional, Larrey, D., additional, Roux, O., additional, Bronowicki, J.-P., additional, Boursier, J., additional, de Ledhingen, V., additional, Heurgue-Berlot, A., additional, Nguyen-Khac, E., additional, Zoulim, F., additional, Ollivier-Hourmand, I., additional, Zarski, J.-P., additional, Nkontchou, G., additional, Gaouar, F., additional, Simon, T., additional, and Poupon, R., additional

Published
2017
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33. Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Author

Ratziu, Vlad, primary, Harrison, Stephen A., additional, Francque, Sven, additional, Bedossa, Pierre, additional, Lehert, Philippe, additional, Serfaty, Lawrence, additional, Romero-Gomez, Manuel, additional, Boursier, Jérôme, additional, Abdelmalek, Manal, additional, Caldwell, Steve, additional, Drenth, Joost, additional, Anstee, Quentin M., additional, Hum, Dean, additional, Hanf, Remy, additional, Roudot, Alice, additional, Megnien, Sophie, additional, Staels, Bart, additional, Sanyal, Arun, additional, Mathurin, P., additional, Gournay, J., additional, Nguyen-Khac, E., additional, De Ledinghen, V., additional, Larrey, D., additional, Tran, A., additional, Bourliere, M., additional, Maynard-Muet, M., additional, Asselah, T., additional, Henrion, J., additional, Nevens, F., additional, Cassiman, D., additional, Geerts, A., additional, Moreno, C., additional, Beuers, U.H., additional, Galle, P.R., additional, Spengler, U., additional, Bugianesi, E., additional, Craxi, A., additional, Angelico, M., additional, Fargion, S., additional, Voiculescu, M., additional, Gheorghe, L., additional, Preotescu, L., additional, Caballeria, J., additional, Andrade, R.J., additional, Crespo, J., additional, Callera, J.L., additional, Ala, A., additional, Aithal, G., additional, Abouda, G., additional, Luketic, V., additional, Huang, M.A., additional, Gordon, S., additional, Pockros, P., additional, Poordad, F., additional, Shores, N., additional, Moehlen, M.W., additional, Bambha, K., additional, Clark, V., additional, Satapathy, S., additional, Parekh, S., additional, Reddy, R.K., additional, Sheikh, M.Y., additional, Szabo, G., additional, Vierling, J., additional, Foster, T., additional, Umpierrez, G., additional, Chang, C., additional, Box, T., additional, and Gallegos-Orozco, J., additional

Published
2016
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36. PS-001 - Estimated risk reduction of mortality and transplantation with bezafibrate in patients with PBC and inadequate response to UDCA: application of the UK-PBC and Global PBC risk scores to the BEZURSO trial

Author

Corpechot, C., Rousseau, A., Chazouillères, O., Antonia, L.G., Habersetzer, F., Mathurin, P., Goria, O., Pascal, P., Franza, A.M., Silvain, C., Abergel, A., Gratien, M.D., Larrey, D., Olivier, R., Bronowicki, J.-P., Boursier, J., De Ledinghen, V., Heurgue-Berlot, A., Nguyen-Khac, E., Zoulim, F., Isabelle, O.-H., Zarski, J.-P., Gisèle, N., Farid, G., Admane, F.-H., Simon, T., and Poupon, R.

Published
2018
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37. GS-006 - Efficacy and safety of 8 weeks of elbasvir/grazoprevir in HCV GT4-infected treatment-naīve participants

Author

Asselah, T., Pol, S., Hezode, C., Loustaud-Ratti, V., Leroy, V., Ahmed, S.N.S., Ozenne, V., Bronowicki, J.-P., Larrey, D., Tran, A., Alric, L., Nguyen-Khac, E., Robertson, M., Hanna, G., Brown, D., Asante-Appiah, E., Ludmerer, S., Su, M., Hwang, P., Klopfer, S., Dutko, F., Guidoum, A., Hagen, K., Haber, B., Talwani, R., and Serfaty, L.

Published
2018
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38. LP05 : Daclatasvir plus sofosbuvir with or without ribavirin in patients with HCV genotype 3 infection: Interim analysis of a french multicenter compassionate use program

Author

Hezode, C., primary, De Ledinghen, V., additional, Fontaine, H., additional, Zoulim, F., additional, Lebray, P., additional, Boyer, N., additional, Larrey, D., additional, Silvain, C., additional, Botta-Fridlund, D., additional, Leroy, V., additional, Bourliere, M., additional, D’Alteroche, L., additional, Hubert-Fouchard, I., additional, Guyader, D., additional, Rosa, I., additional, Nguyen-Khac, E., additional, Di Martino, V., additional, Carrat, F., additional, Fedchuk, L., additional, Akremi, R., additional, Bennai, Y., additional, and Bronowicki, J.-P., additional

Published
2015
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39. G08 : Incidence of hepatocellular carcinoma (HCC) and complications in alcoholic compensated cirrhosis. Preliminary results of a multicenter prospective French and belgian cohort (INCA Cirral)

Author

Ganne, N., primary, Bourcier, V., additional, Chaffaut, C., additional, Archambaud, I., additional, Oberti, F., additional, Perarnau, J.-M., additional, Roulot, D., additional, Louvet, A., additional, Moreno, C., additional, Dao, T., additional, Moirand, R., additional, Goria, O., additional, Nguyen-Khac, E., additional, Henrion, J., additional, Pol, S., additional, Tran, A., additional, de Ledinghen, V., additional, Duclos-Vallée, J.-C., additional, Carbonell, N., additional, Ozenne, V., additional, Amiot, X., additional, Zarski, J.-P., additional, and Chevret, S., additional

Published
2015
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40. P1288 : Budd chiari syndrome (BCS) in France from a large national cohort

Author

Allaire, M., primary, Ollivier-Hourmand, I., additional, Morello, R., additional, Chagneau-Derrode, C., additional, Dumortier, J., additional, Goria, O., additional, Ganne-Carrié, N., additional, Carbonell, N., additional, Cervoni, J.-P., additional, De Ledinghen, V., additional, Dharancy, S., additional, Bureau, C., additional, Abergel, A., additional, Oberti, F., additional, Minello, A., additional, Ripault, M.-P., additional, Anty, R., additional, Nousbaum, J.-B., additional, Ecochard, M., additional, Becquart, J.-P., additional, Barraud, H., additional, Archambeaud, I., additional, Guillygomarc’h, A., additional, Ozenne, V., additional, Hilleret, M.-N., additional, Radenne, S., additional, Nguyen-Khac, E., additional, Perarnau, J.-M., additional, Le Filliatre, P., additional, Dauvois, B., additional, Doffoel, M., additional, Raabe, J.-J., additional, Saillard, E., additional, Delaval, G., additional, Valla, D., additional, Dao, T., additional, and Plessier, A., additional

Published
2015
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41. Le syndrome hépato-pulmonaire

Author

Thevenot, T., Pastor, Cm., Cervoni, Jp, Jacquelinet, C., Nguyen Khac, E., Richou, C., Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis

Subjects
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2009

42. Le syndrome hepatopulmonaire

Author

Thevenot, T., Pastor, Catherine, Cervoni, J-P, Jacquelinet, C., Nguyen-Khac, E., Richou, C., Heyd, B., Vanlemmens, C., Mantion, G., Di Martino, V., and Cadranel, J.

Subjects
Anoxia/physiopathology, Enzyme Inhibitors/therapeutic use, Nitric Oxide/therapeutic use, Hypertension, Pulmonary/physiopathology, NG-Nitroarginine Methyl Ester/therapeutic use, Humans, Mass Screening, Portasystemic Shunt, Surgical, Bronchodilator Agents/therapeutic use, Hepatopulmonary Syndrome/*diagnosis/physiopathology/*therapy, Methylene Blue/therapeutic use, ddc:616.0757, Liver Transplantation
Abstract

Hepatopulmonary syndrome is characterized by the presence of portal hypertension with or without cirrhosis, an increased alveolar-arterial oxygen partial pressure difference greater than or equal to 15 mm Hg, and dilated pulmonary capillaries. Hepatopulmonary syndrome is found in up to 20% of patients with cirrhosis and should be considered in any patient who develops dyspnea or hypoxemia. Contrast echocardiography is enough to make the diagnosis of hepatopulmonary syndrome. The exact pathophysiology of hepatopulmonary syndrome remains unknown but nitric oxide is an important factor underlying hepatopulmonary syndrome. Hypoxemia progressively deteriorates and worsens the prognosis of cirrhotic patients. Hypoxemic patients must be controlled regularly to optimise the timing of liver transplantation. Indeed, a preoperative PaO(2) of less than or equal to 50 mm Hg alone or in combination with an isotopic shunt fraction greater than or equal to 20% are the strongest predictors of postoperative mortality. There are currently no effective medical therapies for hepatopulmonary syndrome but garlic powder and iloprost inhalation demonstrate clinical improvements in the pre- and in the post-transplant period.

Published
2009

43. [Hepatopulmonary syndrome]

Author

Thevenot, T., Pastor, C.-M., Cervoni, J.-P., Jacquelinet, C., Nguyen-Khac, E., Richou, C., Heyd, B., Vanlemmens, C., Mantion, G., Di Martino, V., Cadranel, J., Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Agents pathogènes et inflammation - UFC (EA 4266) (API)

Subjects
MESH: Liver Transplantation, MESH: Humans, MESH: Hypertension, Pulmonary, Hypertension, Pulmonary, MESH: Anoxia, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Nitric Oxide, Bronchodilator Agents, Liver Transplantation, Methylene Blue, MESH: NG-Nitroarginine Methyl Ester, NG-Nitroarginine Methyl Ester, MESH: Enzyme Inhibitors, MESH: Nitric Oxide, Humans, Mass Screening, Portasystemic Shunt, Surgical, MESH: Portasystemic Shunt, Surgical, MESH: Bronchodilator Agents, MESH: Mass Screening, Enzyme Inhibitors, Hypoxia, MESH: Hepatopulmonary Syndrome, MESH: Methylene Blue, Hepatopulmonary Syndrome
Abstract

International audience; Hepatopulmonary syndrome is characterized by the presence of portal hypertension with or without cirrhosis, an increased alveolar-arterial oxygen partial pressure difference greater than or equal to 15 mm Hg, and dilated pulmonary capillaries. Hepatopulmonary syndrome is found in up to 20% of patients with cirrhosis and should be considered in any patient who develops dyspnea or hypoxemia. Contrast echocardiography is enough to make the diagnosis of hepatopulmonary syndrome. The exact pathophysiology of hepatopulmonary syndrome remains unknown but nitric oxide is an important factor underlying hepatopulmonary syndrome. Hypoxemia progressively deteriorates and worsens the prognosis of cirrhotic patients. Hypoxemic patients must be controlled regularly to optimise the timing of liver transplantation. Indeed, a preoperative PaO(2) of less than or equal to 50 mm Hg alone or in combination with an isotopic shunt fraction greater than or equal to 20% are the strongest predictors of postoperative mortality. There are currently no effective medical therapies for hepatopulmonary syndrome but garlic powder and iloprost inhalation demonstrate clinical improvements in the pre- and in the post-transplant period.

Published
2008
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44. LBO-01 - A 2-year multicenter, double-blind, randomized, placebo-controlled study of bezafibrate for the treatment of primary biliary cholangitis in patients with inadequate biochemical response to ursodeoxycholic acid therapy (Bezurso)

Author

Corpechot, C., Chazouillères, O., Rousseau, A., Guyader, D., Habersetzer, F., Mathurin, P., Goria, O., Potier, P., Minello, A., Silvain, C., Abergel, A., Debette-Gratien, M., Larrey, D., Roux, O., Bronowicki, J.-P., Boursier, J., de Ledhingen, V., Heurgue-Berlot, A., Nguyen-Khac, E., Zoulim, F., Ollivier-Hourmand, I., Zarski, J.-P., Nkontchou, G., Gaouar, F., Simon, T., and Poupon, R.

Published
2017
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45. O83 NON-INVASIVE DIAGNOSIS OF LIVER FIBROSIS BY FIBROSCAN IN PATIENTS WITH ALCOHOLIC LIVER DISEASE: A META-ANALYSIS WITH INDIVIDUAL DATA

Author

Nguyen-Khac, E., primary, Nahon, P., additional, Boursier, J., additional, Moreno, C., additional, Starkel, P., additional, Mueller, S., additional, de Ledinghen, V., additional, Giune Kim, S., additional, Fernandez, M., additional, Trepo, E., additional, Ziol, M., additional, Chatelain, D., additional, and Diouf, M., additional

Published
2014
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46. O69 ALBUMIN INFUSION FOR BACTERIAL INFECTIONS OTHER THAN SPONTANEOUS BACTERIAL PERITONITIS IN CIRRHOTIC PATIENTS: A MULTICENTER RANDOMIZED CONTROLLED STUDY (ALB-CIRINF STUDY)

Author

Thévenot, T., primary, Bureau, C., additional, Oberti, F., additional, Anty, R., additional, Louvet, A., additional, Plessier, A., additional, Rudler, M., additional, Heurgué-Berlot, A., additional, Rosa, I., additional, Talbodec, N., additional, Dao, T., additional, Ozenne, V., additional, Carbonell, N., additional, Causse, X., additional, Goria, O., additional, Minello, A., additional, De Ledinghen, V., additional, Amathieu, R., additional, Barraud, H., additional, Nguyen-Khac, E., additional, Becker, C., additional, Paupard, T., additional, Botta-Fridlung, D., additional, Abdelli, N., additional, Guillemot, F., additional, Monnet, E., additional, and Di Martino, V., additional

Published
2014
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49. SAT-282 - Daclatasvir plus Sofosbuvir with or without Ribavirin in Patients with HCV Infection and Decompensated Cirrhosis: Interim Analysis of a French Multicentre Compassionate use Programme

Author

Leroy, V., Hézode, C., Métivier, S., Tateo, M., Conti, F., Nguyen-Khac, E., Lacoste, D., Vergniol, J., Truchi, R., Guyader, D., Riachi, G., Michau, C., Blaison, D., Oberti, F., Fontaine, H., Di Martino, V., Bronowicki, J.-P., Akremi, R., Bennai, Y., Filipovics, A., and Pageaux, G.-P.

Published
2016
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50. ALCOHOL LIVER DISEASE

Author

Wawrzynowicz-Syczewska, M., primary, Laurans, L., additional, Jurczyk, K., additional, Lachtara, M., additional, Kornak, D., additional, Dooley, S., additional, Hofmann, S., additional, Rakoczy, P., additional, Breitkopf-Heinlein, K., additional, Meyer, C., additional, Stickel, F., additional, Patsenker, E., additional, Buch, S., additional, Hampe, J., additional, Datz, C., additional, Seitz, H., additional, Trabut, J. B., additional, Gagni, C., additional, Patel, V., additional, Mueller, S., additional, Rausch, V., additional, Peccerella, T., additional, Yagmur, E., additional, Herzig, S., additional, Longerich, T., additional, Bantel, H., additional, Houchi, H., additional, Nguyen-Khac, E., additional, Dreher, M. L., additional, Naassila, M., additional, Borodinsky, A., additional, and Razvodovsky, Y., additional

Published
2013
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