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39 results on '"Khairani, Candrika D."'

1. Low absolute risk of thrombotic and cardiovascular events in outpatient pregnant women with COVID-19

Author

Bikdeli, Behnood, Krishnathasan, Darsiya, Khairani, Candrika D., Bejjani, Antoine, Davies, Julia, Porio, Nicole, Tristani, Anthony, Armero, Andre, Assi, Ali A., Nauffal, Victor, Campia, Umberto, Almarzooq, Zaid, Wei, Eric, Ortiz-Rios, Marcos D., Zuluaga-Sánchez, Valeria, Achanta, Aditya, Jesudasen, Sirus J., Tiu, Bruce, Merli, Geno J., Leiva, Orly, Fanikos, John, Grandone, Elvira, Sharma, Aditya, Rizzo, Samantha, Pfeferman, Mariana B., Morrison, Ruth B., Vishnevsky, Alec, Hsia, Judith, Nehler, Mark R., Welker, James, Bonaca, Marc P., Carroll, Brett, Goldhaber, Samuel Z., Lan, Zhou, and Piazza, Gregory

Published
2024
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2. When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review

Author

Bejjani, Antoine, Khairani, Candrika D., Assi, Ali, Piazza, Gregory, Sadeghipour, Parham, Talasaz, Azita H., Fanikos, John, Connors, Jean M., Siegal, Deborah M., Barnes, Geoffrey D., Martin, Karlyn A., Angiolillo, Dominick J., Kleindorfer, Dawn, Monreal, Manuel, Jimenez, David, Middeldorp, Saskia, Elkind, Mitchell S.V., Ruff, Christian T., Goldhaber, Samuel Z., Krumholz, Harlan M., Mehran, Roxana, Cushman, Mary, Eikelboom, John W., Lip, Gregory Y.H., Weitz, Jeffrey I., Lopes, Renato D., and Bikdeli, Behnood

Published
2024
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3. Major cardiovascular events after COVID-19, event rates post-vaccination, antiviral or anti-inflammatory therapy, and temporal trends: Rationale and methodology of the CORONA-VTE-Network study

Author

Bikdeli, Behnood, Khairani, Candrika D., Krishnathasan, Darsiya, Bejjani, Antoine, Armero, Andre, Tristani, Anthony, Davies, Julia, Porio, Nicole, Assi, Ali A., Nauffal, Victor, Campia, Umberto, Almarzooq, Zaid, Wei, Eric, Achanta, Aditya, Jesudasen, Sirus J., Tiu, Bruce C., Merli, Geno J., Leiva, Orly, Fanikos, John, Sharma, Aditya, Vishnevsky, Alec, Hsia, Judith, Nehler, Mark R., Welker, James, Bonaca, Marc P., Carroll, Brett J., Lan, Zhou, Goldhaber, Samuel Z., and Piazza, Gregory

Published
2023
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4. Abstract 17709: ICD-10 Codes Have Low Sensitivity and Suboptimal Positive Predictive Value for Identifying Cases of Pulmonary Embolism With Cor Pulmonale in Electronic Healthcare Records

Author

Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, Krumholz, Harlan M, and Bikdeli, Behnood

Published
2023
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5. Abstract 17700: Double Trouble With Identification of Isolated Sub-Segmental Pulmonary Embolism Using ICD-10 Discharge Diagnosis Codes: The PE-EHR+ Study

Author

Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Krumholz, Harlan M, Piazza, Gregory, and Bikdeli, Behnood

Published
2023
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6. Abstract 17282: Ninety-Day Thrombotic Events in Patients With COVID-19, Association With Vaccination Status, and Changes Over Time: The Corona-VTE Network Study

Author

Bikdeli, Behnood, Krishnathasan, Darsiya, Bejjani, Antoine, Khairani, Candrika D, Porio, Nicole D, Davies, Julia, Armero, Andre, Tristani, Anthony, Assi, Ali, Nauffal, Victor, Cambia, Umberto, Almarzooq, Zaid, Wei, Eric, Achanta, Aditya, Jesudasen, Sirus, Tiu, Bruce, Merli, Geno J, Fanikos, John, Vishnevsky, Alec, Sharma, Aditya, Nehler, Mark, Hsia, Judith A, Welker, James, Carroll, Brett, Bonaca, Marc P, Lan, ZHou, Goldhaber, Samuel, and Piazza, Gregory

Published
2023
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7. Abstract 17286: Ninety-Day Adjudicated Cardiovascular Events in Patients With Covid-19: Association With Vaccination Status and Changes Over Time in the Corona-VTE Network Study

Author

Bikdeli, Behnood, Bejjani, Antoine, Khairani, Candrika D, Krishnathasan, Darsiya, Davies, Julia, Porio, Nicole D, Tristani, Anthony, Armero, Andre, Assi, Ali, Nauffal, Victor, Cambia, Umberto, Almarzooq, Zaid, Wei, Eric, Achanta, Aditya, Jesudasen, Sirus, Tiu, Bruce, Merli, Geno J, Leiva, Orly, Fanikos, John, Sharma, Aditya, Vishnevsky, Alec, Hsia, Judith A, Nehler, Mark, Welker, James, Bonaca, Marc P, Carroll, Brett, Lan, ZHou, Goldhaber, Samuel, and Piazza, Gregory

Published
2023
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8. Abstract 16342: Age- and Sex-Differences in Accuracy of ICD-10 Codes for Identifying Adults With Pulmonary Embolism: PE-EHR+ Study

Author

Mahajan, Shiwani, Lo, Ying-Chih, Bejjani, Antoine, Khairani, Candrika D, Jimenez, David, Barco, Stefano, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, Krumholz, Harlan M, and Bikdeli, Behnood

Published
2023
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9. Abstract 14344: Pitfalls of ICD-10 Codes for Identifying Pulmonary Embolism in Electronic Records: Results From the Multicenter PE-EHR+ Study

Author

Bikdeli, Behnood, Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, and Krumholz, Harlan M

Published
2023
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11. Developmental or Procedural Vena Cava Interruption and Venous Thromboembolism: A Review.

Author

Bikdeli, Behnood, Sadeghipour, Parham, Lou, Junyang, Bejjani, Antoine, Khairani, Candrika D., Rashedi, Sina, Lookstein, Robert, Lansky, Alexandra, Vedantham, Suresh, Sobieszczyk, Piotr, Mena-Hurtado, Carlos, Aghayev, Ayaz, Henke, Peter, Mehdipoor, Ghazaleh, Tufano, Antonella, Chatterjee, Saurav, Middeldorp, Saskia, Wasan, Suman, Bashir, Riyaz, and Lang, Irene M.

Subjects
VENAE cavae, THROMBOEMBOLISM, VENA cava superior, VENOUS thrombosis, RIGHT heart atrium
Abstract

The inferior vena cava (IVC) and superior vena cava are the main conduits of the systemic venous circulation into the right atrium. Developmental or procedural interruptions of vena cava might predispose to stasis and deep vein thrombosis (DVT) distal to the anomaly and may impact the subsequent rate of pulmonary embolism (PE). This study aimed to review the various etiologies of developmental or procedural vena cava interruption and their impact on venous thromboembolism. A systematic search was performed in PubMed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines per each clinical question. For management questions with no high-quality evidence and no mutual agreements between authors, Delphi methods were used. IVC agenesis is the most common form of congenital vena cava interruption, is associated with an increased risk of DVT, and should be suspected in young patients with unexpected extensive bilateral DVT. Surgical techniques for vena cava interruption (ligation, clipping, and plication) to prevent PE have been largely abandoned due to short-term procedural risks and long-term complications, although survivors of prior procedures are occasionally encountered. Vena cava filters are now the most commonly used method of procedural interruption, frequently placed in the infrarenal IVC. The most agreed-upon indication for vena cava filters is for patients with acute venous thromboembolism and coexisting contraindications to anticoagulation. Familiarity with different forms of vena cava interruption and their local and systemic adverse effects is important to minimize complications and thrombotic events. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Abstract 13807: Sex Differences in Patients Characteristics, Risk Factors, and Symptomatology in Older Adults With Pulmonary Embolism: Findings From the SERIOUS-PE Study

Author

Bikdeli, Behnood, Jimenez, David, Piazza, Gregory, Muriel, Alfonso, wang, yun, Khairani, Candrika D, Rosovsky, Rachel, Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Diaz Brasero, Ana María, Mehdipoor, Ghazaleh, OʼDonoghue, Michelle, Spagnolo, Primavera A, Lu, Yuan, BERTOLETTI, Laurent, Lopez-Jimenez, Luciano, Nunez-Fernandez, Manuel J, Blanco-Molina, Angeles, Bates, Shannon, Gerhard-Herman, Marie, Goldhaber, Samuel, Monreal, Manuel, and Krumholz, Harlan M

Published
2022
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15. Abstract 12596: Comparison of the Efficacy and Safety of Direct Oral Anticoagulants With Vitamin K Antagonists in Patients With Thrombotic Antiphospholipid Syndrome: Systematic Review and Meta-analysis of Randomized Clinical Trials

Author

Bejjani, Antoine, Khairani, Candrika D, Piazza, Gregory, Jimenez, David, Monreal, Manuel, Chatterjee, Saurav, Pengo, Vittorio, Woller, Scott, Cortes-Hernandez, Josefina, Connors, Jean M, Kanthi, Yogendra, Krumholz, Harlan M, Middeldorp, Saskia, Falanga, Anna, Cushman, Mary, Goldhaber, Samuel Z, Garcia, David, and Bikdeli, Behnood

Published
2022
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17. Abstract 598: Patients With High Bleeding Risk In A Randomized Controlled Trial Of Alert-based Computerized Decision Support For Stroke Prevention In Atrial Fibrillation: An AF-ALERT II Substudy

Author

Khairani, Candrika D, primary, Bejjani, Antoine, additional, Armero, Andre, additional, Porio, Nicole D, additional, Krishnathasan, Darsiya, additional, Tristani, Anthony, additional, Davies, Julia, additional, Goldhaber, Samuel, additional, and Piazza, Gregory, additional

Published
2023
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18. Electronic alerts for ambulatory patients with atrial fibrillation not prescribed anticoagulation: A randomized, controlled trial (AF-ALERT2)

Author

Piazza, Gregory, primary, Hurwitz, Shelley, additional, Campia, Umberto, additional, Bikdeli, Behnood, additional, Lou, Junyang, additional, Khairani, Candrika D., additional, Bejjani, Antoine, additional, Snyder, Julia E., additional, Pfeferman, Mariana, additional, Barns, Briana, additional, Rizzo, Samantha, additional, Glezer, Alexandra, additional, and Goldhaber, Samuel Z., additional

Published
2023
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19. Abstract 379: The Accuracy Of ICD-10 Discharge Diagnosis Codes For Identification Of Isolated Sub-Segmental Pulmonary Embolism: A PE-EHR+ Substudy

Author

Bejjani, Antoine, primary, Khairani, Candrika D, additional, Lo, Ying-Chih, additional, Jimenez, David, additional, Barco, Stefano, additional, Mahajan, Shiwani, additional, Caraballo, Cesar, additional, Klok, Erik, additional, Secemsky, Eric A, additional, Aghayev, Ayaz, additional, Hunsaker, Andetta, additional, Hussain, Mohamad A, additional, Appah-Sampong, Abena, additional, Khera, Rohan, additional, Goldhaber, Samuel, additional, Zhou, Li, additional, Monreal, Manuel, additional, Krumholz, Harlan M, additional, Piazza, Gregory, additional, and Bikdeli, Behnood, additional

Published
2023
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20. Right Ventricular Recovery: Early and Late Changes after Acute PE Diagnosis.

Author

Bejjani, Antoine, Khairani, Candrika D., and Piazza, Gregory

Subjects
*PULMONARY embolism, *RIGHT ventricular dysfunction, *DIAGNOSIS, *THERAPEUTICS, *PULMONARY hypertension, *PROGNOSIS
Abstract

Right ventricular (RV) failure is a critical cause of morbidity and mortality in patients presenting with pulmonary embolism (PE). The presentation of RV failure is based on the combination of clinical findings, laboratory abnormalities, and imaging evidence. An improved understanding of the pathophysiology of RV dysfunction following PE has given rise to more accurate risk stratification and broader therapeutic approaches. A subset of patients with PE develop chronic RV dysfunction with or without pulmonary hypertension. In this review, we focus on the impact of PE on the RV and its implications for risk stratification, prognosis, acute management, and long-term therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study.

Author

Bikdeli, Behnood, Muriel, Alfonso, Wang, Yun, Piazza, Gregory, Khairani, Candrika D., Rosovsky, Rachel P., Mehdipoor, Ghazaleh, O'Donoghue, Michelle L., Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Brasero, Ana Maria Diaz, Grandone, Elvira, Spagnolo, Primavera A., Lu, Yuan, Bertoletti, Laurent, López-Jiménez, Luciano, Núñez, Manuel Jesús, Blanco-Molina, Ángeles, and Gerhard-Herman, Marie

Subjects
OLDER people, PULMONARY embolism, OLDER women, SYMPTOMS, VARICOSE veins, AGE groups
Abstract

Sex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged ≥65 years) with PE in a large international PE registry replete with information about relevant clinical characteristics (RIETE registry, 2001–2021). To provide national data from the United States, we assessed sex differences in clinical characteristics and risk factors of Medicare beneficiaries with PE (2001–2019). The majority of older adults with PE in RIETE (19,294/33,462, 57.7%) and in the Medicare database (551,492/948,823, 58.7%) were women. Compared with men, women with PE less frequently had atherosclerotic diseases, lung disease, cancer, or unprovoked PE, but more frequently had varicose veins, depression, prolonged immobility, or history of hormonal therapy (p < 0.001 for all). Women less often presented with chest pain (37.3 vs. 40.6%) or hemoptysis (2.4 vs. 5.6%) but more often with dyspnea (84.6 vs. 80.9%) (p < 0.001 for all). Measures of clot burden, PE risk stratification, and use of imaging modalities were comparable between women and men. PE is more common in elderly women than in men. Cancer and cardiovascular disease are more common in men, whereas transient provoking factors including trauma, immobility, or hormone therapy are more common in elderly women with PE. Whether such differences correlate with disparities in treatment or differences in short- or long-term clinical outcomes warrants further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes

Author

Khairani, Candrika D., primary, Bejjani, Antoine, additional, Piazza, Gregory, additional, Jimenez, David, additional, Monreal, Manuel, additional, Chatterjee, Saurav, additional, Pengo, Vittorio, additional, Woller, Scott C., additional, Cortes-Hernandez, Josefina, additional, Connors, Jean M., additional, Kanthi, Yogendra, additional, Krumholz, Harlan M., additional, Middeldorp, Saskia, additional, Falanga, Anna, additional, Cushman, Mary, additional, Goldhaber, Samuel Z., additional, Garcia, David A., additional, and Bikdeli, Behnood, additional

Published
2023
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23. Direct oral anticoagulants in thrombotic antiphospholipid syndrome: Addressing misinterpretations in subgroup analysis.

Author

Khairani, Candrika D., Bejjani, Antoine, and Bikdeli, Behnood

Subjects
*ANTICOAGULANTS, *ORAL medication, *WOMEN'S hospitals, *ACADEMIC medical centers, *ANTIPHOSPHOLIPID syndrome
Abstract

The article discusses the misinterpretation of subgroup analysis in the British Society for Haematology Guidelines on the investigation and management of antiphospholipid syndrome (APS). The authors argue that subgroup analyses are inherently underpowered and that it is misleading to selectively report findings within specific subgroups. They clarify that their original study did not find a significant difference in the risk of subsequent arterial thrombotic events between patients with and without triple-positive antibodies. They suggest that the current best evidence indicates that traditional doses of direct oral anticoagulants (DOACs) are inferior to warfarin for protection against future thrombosis. However, they emphasize the importance of providing accurate information to readers. [Extracted from the article]

Published
2024
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25. Developing Validated Tools to Identify Pulmonary Embolism in Electronic Databases: Rationale and Design of the PE-EHR+ Study.

Author

Bikdeli, Behnood, Lo, Ying-Chih, Khairani, Candrika D., Bejjani, Antoine, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, César, Secemsky, Eric A., Klok, Frederikus A., Hunsaker, Andetta R., Aghayev, Ayaz, Muriel, Alfonso, Wang, Yun, Hussain, Mohamad A., Appah-Sampong, Abena, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, and Khera, Rohan

Published
2023
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27. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study

Author

Bikdeli, Behnood, primary, Piazza, Gregory, additional, Jimenez, David, additional, Muriel, Alfonso, additional, Wang, Yun, additional, Khairani, Candrika D., additional, Rosovsky, Rachel P., additional, Mehdipoor, Ghazaleh, additional, O'Donoghue, Michelle L., additional, Spagnolo, Primavera, additional, Dreyer, Rachel P., additional, Bertoletti, Laurent, additional, López-Jiménez, Luciano, additional, Núñez, Manuel Jesús, additional, Blanco-Molina, Ángeles, additional, Bates, Shannon M., additional, Gerhard-Herman, Marie, additional, Goldhaber, Samuel Z., additional, Monreal, Manuel, additional, and Krumholz, Harlan M., additional

Published
2022
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29. Women's representation in venous thromboembolism randomized trials and registries: The illustrative example of direct oral anticoagulants for acute treatment

Author

Bikdeli, Behnood, primary, Khairani, Candrika D., additional, Barns, Briana M., additional, Rosovsky, Rachel P., additional, Jimenez, David, additional, Monreal, Manuel, additional, Sylvester, Katelyn W., additional, Middeldorp, Saskia, additional, Bates, Shannon M., additional, Krumholz, Harlan M., additional, Goldhaber, Samuel Z., additional, Hunt, Beverley J., additional, and Piazza, Gregory, additional

Published
2022
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30. LOW ABSOLUTE RISK OF THROMBOTIC AND MAJOR CARDIOVASCULAR EVENTS IN OUTPATIENT PREGNANT WOMEN WITH COVID-19

Author

Bikdeli, Behnood, Krishnathasan, Darsiya, Lan, Zhou, Bejjani, Antoine, Khairani, Candrika D., Davies, Julia, Porio, Nicole, Campia, Umberto, Almarzooq, Zaid, Nauffal, Victor, Wei, Eric, Achanta, Aditya, Ortiz-Rios, Marcos, Jesudasen, Sirus, Merli, Geno J., Leiva, Orly, Rizzo, Samantha, Pfeferman, Mariana, Vishnevsky, Alec, Hsia, Judith A., Bonaca, Marc P., Carroll, Brett, Goldhaber, Samuel Z., and Piazza, Gregory

Published
2024
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31. ASSOCIATION BETWEEN OBESITY AND THE RISK OF THROMBOTIC AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH COVID-19

Author

Krishnathasan, Darsiya, Davies, Julia, Bejjani, Antoine, Khairani, Candrika D., Porio, Nicole, Armero, Andre, Tristani, Anthony, Campia, Umberto, Almarzooq, Zaid, Assi, Ali, Wei, Eric, Ortiz-Rios, Marcos, Merli, Geno J., Zuluaga-Sanchez, Valeria, Jesudasen, Sirus, Hsia, Judith A., Nehler, Mark, Bonaca, Marc P., Nauffal, Victor, Sharma, Aditya M., Carroll, Brett, Lan, Zhou, Goldhaber, Samuel Z., Bikdeli, Behnood, and Piazza, Gregory

Published
2024
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32. ADJUDICATED CARDIOVASCULAR EVENTS IN PATIENTS WITH COVID-19: ASSOCIATION WITH VACCINATION STATUS AND CHANGES OVER TIME IN THE CORONA-VTE NETWORK STUDY

Author

Bikdeli, Behnood, Krishnathasan, Darsiya, Bejjani, Antoine, Khairani, Candrika D., Davies, Julia, Porio, Nicole, Armero, Andre, Tristani, Anthony, Campia, Umberto, Almarzooq, Zaid, Wei, Eric, Ortiz-Rios, Marcos, Achanta, Aditya, Merli, Geno J., Rizzo, Samantha, Pfeferman, Mariana, Vishnevsky, Alec, Hsia, Judith A., Nehler, Mark, Bonaca, Marc P., Sharma, Aditya M., Carroll, Brett, Lan, Zhou, Goldhaber, Samuel Z., and Piazza, Gregory

Published
2024
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33. SEX DIFFERENCES IN TREATMENT STRATEGIES FOR PULMONARY EMBOLISM IN OLDER ADULTS: THE SERIOUS-PE STUDY

Author

Bikdeli, Behnood, Jimenez, David, Garcia, Alfonso Muriel, Lin, Zhenqiu, Piazza, Gregory, Leyva, Hannah, Khairani, Candrika D., Rosovsky, Rachel, Mehdipoor, Ghazaleh, O'Donoghue, Michelle L., LOPEZ-SAEZ, JUAN-BOSCO, Madridano, Olga, Grandone, Elvira, Lu, Yuan, López-Jiménez, Luciano, Gerhard-Herman, Marie D., Molina, Ángeles Blanco, Bertoletti, Laurent, Goldhaber, Samuel Z., Bates, Shannon, Krumholz, Harlan M., and Monreal, Manuel

Published
2024
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34. OPTIMIZING PHENOTYPING ALGORITHMS FOR IDENTIFYING PULMONARY EMBOLISM IN ELECTRONIC DATABASES: THE MULTICENTER PE-EHR+ STUDY

Author

Bikdeli, Behnood, Bejjani, Antoine, Lo, Ying-Chih, Khairani, Candrika D., Mahajan, Shiwani, Secemsky, Eric Alexander, Jimenez, Jose Victor, Aghayev, Ayaz, Hunsaker, Andetta, Wang, Liqin, Hussain, Mohamad, Appah-Sampong, Abena, Mojibian, Hamid, Lin, Zhenqiu, Aneja, Sanjay, Barco, Stefano, Klok, Frederikus, Konstantinides, Stavros V., Zhou, Li, Monreal, Manuel, Jimenez, David, Piazza, Gregory, and Krumholz, Harlan M.

Published
2024
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35. Direct Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials.

Author

Khairani, Candrika D., Bejjani, Antoine, Piazza, Gregory, Jimenez, David, Monreal, Manuel, Chatterjee, Saurav, Pengo, Vittorio, Woller, Scott C., Cortes-Hernandez, Josefina, Connors, Jean M., Kanthi, Yogendra, Krumholz, Harlan M., Middeldorp, Saskia, Falanga, Anna, Cushman, Mary, Goldhaber, Samuel Z., Garcia, David A., and Bikdeli, Behnood

Subjects
*ANTICOAGULANTS, *ANTIPHOSPHOLIPID syndrome, *ORAL medication, *RANDOM effects model, *RANDOMIZED controlled trials
Abstract

Background: The efficacy and safety of direct oral anticoagulants (DOACs) for patients with thrombotic antiphospholipid syndrome (APS) remain controversial.Objectives: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared DOACs with vitamin-K antagonists (VKAs).Methods: We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials through April 9, 2022. The two main efficacy outcomes were a composite of arterial thrombotic events, and venous thromboembolic events (VTE). The main safety outcome was major bleeding. Random effects models with inverse variance were used.Results: Our search retrieved 253 studies. Four open-label RCTs involving 472 patients were included (mean control-arm time-in-therapeutic-range: 60%). All had proper random sequence generation and adequate allocation concealment. Overall, use of DOACs compared with VKAs was associated with increased odds of subsequent arterial thrombotic events (OR 5.43, 95% confidence interval [CI] 1.87-15.75, p < 0.001, I2 = 0%), especially stroke, and composite of arterial thrombotic events or VTE (OR 4.46, 95% CI 1.12-17.84, p = 0.03, I2 = 0%). The odds of subsequent VTE (OR 1.20, 95% CI 0.31-4.55, p = 0.79, I2 = 0%), or major bleeding (OR 1.02, 95% CI 0.42-2.47, p = 0.97, I2 = 0%) were not significantly different between the two groups. Most findings were consistent within subgroups.Conclusions: Patients with thrombotic APS randomized to DOACs compared to VKAs appear to have increased risk for arterial thrombosis. No significant differences were observed between patients randomized to DOACs vs VKAs in the risk of subsequent VTE or major bleeding. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Extended-Duration Low-Intensity Apixaban to Prevent Recurrence in Patients with Provoked Venous Thromboembolism and Enduring Risk Factors: Rationale and Design of the HI-PRO Trial

Author

Bikdeli, Behnood, additional, Hogan, Heather, additional, Morrison, Ruth B., additional, Fanikos, John, additional, Campia, Umberto, additional, Barns, Briana M., additional, Pfeferman, Mariana B., additional, Snyder, Julia E., additional, Khairani, Candrika D., additional, Goldhaber, Samuel Z., additional, and Piazza, Gregory, additional

Published
2021
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