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4. Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice

Author

Kim, Na Ri, primary, Khalil, Rougin, additional, David, Karel, additional, Antonio, Leen, additional, Schollaert, Dieter, additional, Deboel, Ludo, additional, Van Herck, Erik, additional, Wardenier, Nele, additional, Cools, Martine, additional, Decallonne, Brigitte, additional, Claessens, Frank, additional, Dubois, Vanessa, additional, and Vanderschueren, Dirk, additional

Published
2021
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5. Testosterone Reduces Body Fat in Male Mice by Stimulation of Physical Activity Via Extrahypothalamic ERα Signaling

Author

Kim, Na Ri, primary, David, Karel, additional, Corbeels, Katrien, additional, Khalil, Rougin, additional, Antonio, Leen, additional, Schollaert, Dieter, additional, Deboel, Ludo, additional, Ohlsson, Claes, additional, Gustafsson, Jan-Åke, additional, Vangoitsenhoven, Roman, additional, Van der Schueren, Bart, additional, Decallonne, Brigitte, additional, Claessens, Frank, additional, Vanderschueren, Dirk, additional, and Dubois, Vanessa, additional

Published
2021
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7. Early effects of androgen deprivation on bone and mineral homeostasis: A prospective cohort study

Author

Khalil, Rougin, primary, Antonio, Leen, additional, Laurent, Michaël R., additional, David, Karel, additional, Kim, Na Ri, additional, Evenepoel, Pieter, additional, Eisenhauer, Anton, additional, Heuser, Alexander, additional, Cavalier, Etienne, additional, Khosla, Sundeep, additional, Claessens, Frank, additional, Vanderschueren, Dirk, additional, and Decallonne, Brigitte, additional

Published
2020
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8. Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study

Author

Khalil, Rougin, primary, Antonio, Leen, additional, Laurent, Michaël R, additional, David, Karel, additional, Kim, Na Ri, additional, Evenepoel, Pieter, additional, Eisenhauer, Anton, additional, Heuser, Alexander, additional, Cavalier, Etienne, additional, Khosla, Sundeep, additional, Claessens, Frank, additional, Vanderschueren, Dirk, additional, and Decallonne, Brigitte, additional

Published
2020
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9. Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet

Author

Khalil, Rougin, primary, Simitsidellis, Ioannis, additional, Kim, Na Ri, additional, Jardi, Ferran, additional, Schollaert, Dieter, additional, Deboel, Ludo, additional, Saunders, Philippa, additional, Carmeliet, Geert, additional, Claessens, Frank, additional, Vanderschueren, Dirk, additional, and Decallonne, Brigitte, additional

Published
2020
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10. Estrogen receptor alpha signaling in extrahypothalamic neurons during late puberty decreases bone size and strength in female but not in male mice

Author

Kim, Na Ri, primary, Jardí, Ferran, additional, Khalil, Rougin, additional, Antonio, Leen, additional, Schollaert, Dieter, additional, Deboel, Ludo, additional, Lenthe, G. Harry, additional, Decallonne, Brigitte, additional, Carmeliet, Geert, additional, Gustafsson, Jan‐Åke, additional, Claessens, Frank, additional, Ohlsson, Claes, additional, Lagerquist, Marie K., additional, Dubois, Vanessa, additional, and Vanderschueren, Dirk, additional

Published
2020
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16. Testosterone boosts physical activity in male mice via dopaminergic pathways

Author

Jardí, Ferran, primary, Laurent, Michaël R., additional, Kim, Nari, additional, Khalil, Rougin, additional, De Bundel, Dimitri, additional, Van Eeckhaut, Ann, additional, Van Helleputte, Lawrence, additional, Deboel, Ludo, additional, Dubois, Vanessa, additional, Schollaert, Dieter, additional, Decallonne, Brigitte, additional, Carmeliet, Geert, additional, Van den Bosch, Ludo, additional, D’Hooge, Rudi, additional, Claessens, Frank, additional, and Vanderschueren, Dirk, additional

Published
2018
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17. A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton

Author

Jardí, Ferran, primary, Laurent, Michaël R., additional, Dubois, Vanessa, additional, Khalil, Rougin, additional, Deboel, Ludo, additional, Schollaert, Dieter, additional, Van Den Bosch, Ludo, additional, Decallonne, Brigitte, additional, Carmeliet, Geert, additional, Claessens, Frank, additional, and Vanderschueren, Dirk, additional

Published
2017
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18. Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

Author

Laurent, Michaël R., primary, Hammond, Geoffrey L., additional, Blokland, Marco, additional, Jardí, Ferran, additional, Antonio, Leen, additional, Dubois, Vanessa, additional, Khalil, Rougin, additional, Sterk, Saskia S., additional, Gielen, Evelien, additional, Decallonne, Brigitte, additional, Carmeliet, Geert, additional, Kaufman, Jean-Marc, additional, Fiers, Tom, additional, Huhtaniemi, Ilpo T., additional, Vanderschueren, Dirk, additional, and Claessens, Frank, additional

Published
2016
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21. Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice.

Author

Kim NR, Khalil R, David K, Antonio L, Schollaert D, Deboel L, Van Herck E, Wardenier N, Cools M, Decallonne B, Claessens F, Dubois V, and Vanderschueren D

Subjects
Animals, Body Composition drug effects, Bone and Bones drug effects, Bone and Bones metabolism, Gonadal Steroid Hormones pharmacology, Gonadotropin-Releasing Hormone antagonists & inhibitors, Gonadotropin-Releasing Hormone pharmacology, Hormone Antagonists pharmacology, Hypogonadism complications, Hypogonadism metabolism, Male, Mice, Mice, Inbred C57BL, Orchiectomy, Sexual Maturation physiology, Time Factors, Bone Development drug effects, Bone and Bones physiology, Gonadal Steroid Hormones deficiency, Hypogonadism pathology
Abstract

Sex steroids are critical for skeletal development and maturation during puberty as well as for skeletal maintenance during adult life. However, the exact time during puberty when sex steroids have the highest impact as well as the ability of bone to recover from transient sex steroid deficiency is unclear. Surgical castration is a common technique to study sex steroid effects in rodents, but it is irreversible, invasive, and associated with metabolic and behavioral alterations. Here, we used a low dose (LD) or a high dose (HD) of gonadotropin-releasing hormone antagonist to either temporarily or persistently suppress sex steroid action in male mice, respectively. The LD group, a model for delayed puberty, did not show changes in linear growth or body composition, but displayed reduced trabecular bone volume during puberty, which fully caught up at adult age. In contrast, the HD group, representing complete pubertal suppression, showed a phenotype reminiscent of that observed in surgically castrated rodents. Indeed, HD animals exhibited severely impaired cortical and trabecular bone acquisition, decreased body weight and lean mass, and increased fat mass. In conclusion, we developed a rodent model of chemical castration that can be used as an alternative to surgical castration. Moreover, the transient nature of the intervention enables to study the effects of delayed puberty and reversibility of sex steroid deficiency. NEW & NOTEWORTHY We developed a rodent model of chemical castration, which can be used as an alternative to surgical castration. Moreover, the transient nature of the intervention enables to study the effects of delayed puberty and reversibility of sex steroid deficiency.

Published
2021
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