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12. Electrospun statin-loaded nanofibers for treating diabetic wounds

Author

Pamu, Divya, Garikapati, Kusuma Kumari, Kuppusamy, Gowthamarajan, Krishnamurthy, Praveen Thaggikuppe, Ganesan, Srividhya, Naik, Mudavath Ravi, Karri, Veera Venkata Satyanarayana Reddy, Ponpandian, Nagamony, Alexiou, Athanasios, Antoniou, Sofia, Khan, Azmat Ali, Alanazi, Amer M., and Papadakis, Marios

Subjects
Streptozocin, Statins, Biological products, Collagen, Vascular endothelial growth factor, Antibacterial agents, Escherichia coli, Engineering and manufacturing industries, Science and technology
Abstract

This study aims to develop, characterize, and evaluate the best statin-loaded Collagen Silver nanoparticle-coated polycaprolactone nanofibers by electrospinning technique. The characterization and evaluation results reveal that nanofibers had shown an aligned Collagen Silver nanoparticle-coated polycaprolactone nanofibers distribution of fibers and aliment of collagen and silver nanoparticle coating material on the surface of the nanofibers. Furthermore, the electrospun nanofibers have shown no interaction between the drug and collagen and PCL polymeric material and have demonstrated controlled drug release for 360 h and significant degradation for 60 days of the study. In vitro, among the nanofiber treatment groups and the control groups, Pravastatin Collagen Silver nanoparticle-coated polycaprolactone nanofibers have shown cell proliferation and migration of NHDF cells and blood vessel development in the CAM assay and potential anti-bacterial activity against S. aureus and E. coli. In vivo, the Pravastatin Collagen Silver nanoparticle-coated polycaprolactone nanofibers have demonstrated improved wound recovery, reepithelization, fibroblast cell proliferation, angiogenesis, and ECM remodeling and enhanced VEGF-sprouting in the excised tissues of streptozotocin-induced diabetic rats for 7, 14, and 21 days of the study. Therefore, the developed Pravastatin Collagen Silver nanoparticle-coated polycaprolactone nanofibers could be a promising wound-dressing platform for effectively treating and managing diabetic wounds. Highlights * Nanofiber wound dressings provide numerous structural features in biomaterials. * Polycaprolactone can release the repurposed statin molecules into the wound site in a controlled manner. * In diabetic wounds, ECM tissue remodeling stimulates repair and vessel growth. * Pravastatin has been demonstrated to improve angiogenesis and ECM secretion for wound healing in diabetic conditions. KEYWORDS diabetic wounds, electrospinning, hypoxic microenvironment, nanofibers, pro-angiogenesis, re-epithelization, wound dressing, 1 | INTRODUCTION The most prevalent cause of death in diabetic individuals is diabetic wounds. Unfortunately, the bulk of the treatment options in the market do not entirely address how [...]

Published
2024
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20. Comparative study between the Full Factorial, Box–Behnken, and Central Composite Designs in the optimization of metronidazole immediate release tablet

Author

Narukulla, Sriram, Bogadi, Subhasri, Tallapaneni, Vyshnavi, Sanapalli, Bharat Kumar Reddy, Sanju, Sanju, Khan, Azmat Ali, Malik, Abdul, Barai, Hasi Rani, Mondal, Tonmoy Kumar, Karri, Veera Venkata Satyanarayana Reddy, Alexiou, Athanasios, Pindiprolu, Sai Kiran S.S., Kuppusamy, Gowthamarajan, Subramaniyan, Vetriselvan, Rabiul Islam, Md., and Papadakis, Marios

Published
2024
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49. Chitosan-based Mupirocin and Alkanna tinctoria extract nanoparticles for the management of burn wound: In vitro and in vivo characterization

Author

Alam Shah Muhammad Khurshid, Nawaz Asif, Latif Muhammad Shahid, Ullah Wasi, Ullah Aziz, Khan Azmat Ali, Malik Abdul, Kumarasamy Vinoth, Subramaniyan Vetriselvan, and Azad Abul Kalam

Subjects
mupirocin, alkanna tinctoria, chitosan, nanoparticles, burn wound, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Abstract

Serious consequences including septicemia and amputations can result from complex wounds, which is a serious healthcare concern. In addition, there are currently only a few choices for management, which justifies the search for novel, highly effective wound-healing medications. This research work was aimed at fabricating chitosan-based Alkanna tinctoria and Mupirocin nanoparticles by ionic gelation technique for burn wound management. Preliminary studies were conducted, and the prepared nanoparticles were characterized by various techniques that involve, high-performance liquid chromatography for the detection of components in A. tinctoria root extract, ATR-FTIR, particle size, zeta potential, percent drug content (DC%), percent entrapment efficiency (EE%), scanning electron microscopy, and transmission electron microscopy (TEM) for surface morphology. The optimized formulation CS-AT-MU-NPs3 shows a particle size of 340.8 ± 34.46 nm and positive zeta potential 27.3 ± 3.10 mV. In vitro drug release study was also performed, which demonstrated improved and controlled release of the drug from the nanoparticles. The CS-AT-MU-NPs3 exhibited a maximum release up to 92.61% (AT) and 88.35% (MU). Antibacterial and antifungal activities of the formulation were also accessed by utilizing the agar well diffusion technique. The combination of AT and MU in chitosan-based nanoparticles was significantly effective against bacterial and fungal strains like Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans as compared to other formulations. The skin irritation study was also conducted, which shows that the prepared formulation did not cause any observable changes to the skin in terms of inflammation, erythema, edema, or any other symptoms associated with skin irritation. All the chitosan-based nanoparticles showed almost 75% reduction in wound contraction, while the optimized formulation CS-AT-MU-NPs3 showed complete wound healing on the 15th day. Based on the results, it can be assumed that chitosan-based nanoparticles containing A. tinctoria and Mupirocin demonstrated good wound healing and could be used to effectively manage burn wounds of any description.

Published
2024
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