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A 42-year-old female hailing from Brahmanbaria, Bangladesh was admitted with the complaints of abdominal pain which was more marked in the left upper abdomen. Fifteen days before admission in this department, she had a history of physical assault, since then she was experiencing pain over different parts of her body including abdomen. She took analgesic for this pain. Other regional pain subsided but the abdominal pain was persisting.

Background: The "international system for reporting serous fluid cytopathology"(TIS) consists of five diagnostic categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL). The study was conducted to reclassify effusion cytology samples according to the newly proposed TIS to calculate the risk of malignancy (ROM) for each category and to conduct performance analysis. Materials and Methods: The study was a retrospective observational study conducted at a tertiary care institution in North India. Clinical data of the cases from June 2013 to July 2021 were retrieved and the cases were reviewed by two cytopathologists. All cases were reclassified according to the proposed TIS system into five categories. Results: A total of 2318 patients were included in the study over a time span of 8 years, and 1614 (69.6%) cases of pleural effusion cytology, 612 (26.4%) cases of peritoneal effusion cytology, and 92 (3.9%) cases of pericardial effusion cytology were included. All effusion cytology smears were recategorized as per TIS guidelines into ND, NFM, AUS, SFM, and MAL with 4 (0.17%), 1756 (75.75%), 12 (0.51%), 57 (2.46%), and 489 (21.11%) cases, respectively, and ROM was 25%, 17.9%, 66.7%, 75.4%, and 96.5%, respectively, for the categories. Conclusion: Besides being a simple, easy, and user-friendly system, TIS has the benefit of risk stratification and ROM for each category. The TIS system proposed a tiered scheme, which places the effusion cytology into well-defined categories, and therefore has lesser chances of false-positive and false-negative cases. [ABSTRACT FROM AUTHOR]

Background: Immunohistochemistry is the definitive diagnosis in cases where a definite diagnosis cannot be made morphologically and histologically. IHC helps classify tumors. It also helps to solve the diagnosis problem of benign and malignant tumors. Material And Methods: We studied 100 different ovarian epithelial tumors over a 2 year period. Three immune markers were included in the study. Result: Out of 100 case 70% are benign and 30% aremalignant. Serous cystadenoma was most common benign lesion(60%)& among malignant lesions Serous cystadenocarcinoma was most common(60%).83.33% cases of serous carcinoma showed positivity for CK7 & 100% negativity for CK20 & CEA Conclusion: IHC helps to classify and confirm the histological diagnosis. IHC is particularly useful in solving the diagnostic problem of ovarian cancer and is poorly differentiated. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To determine the Clinico-demographic profile and outcome of neonates born to mothers with COVID-19 infection at a Tertiary Care Hospital. METHODOLOGY: This cross-sectional study was conducted at Pediatrics Department, Ziauddin Hospital Karachi, from March 2020 to August 2021. The sample size was 31, non-probability purposive sampling technique was used. Neonates of COVID positive mothers who consented to Covid-19 testing were included. Neonates of Covid positive mothers who refused to participate were excluded. Diagnosis of coronavirus infection was based on Novel Corona Virus-2019 (nCoV-19) qualitative PCR test through nasopharyngeal swab. Clinico-demographic profile and outcome of neonates data were recorded on self -developed proforma. Standard protocols were followed per National Command and Operation Center guidelines. Data were analyzed by SPSS version 20. Frequencies and percentages were calculated, and the chi-square test was applied as a significance test with a P-value of <0.05. RESULTS: First virology test was positive for 6 (19.4%) neonates, and the second was positive for only 1 (3.2%) neonate; 17 (54.8%) neonates who were negative in the first virology test and stayed less than three days in the hospital refused to undergo a second test by their parents. After 14 days of follow-up, 29 (93.5%) neonates became asymptomatic, while 2 (6.5%) had symptoms of neonatal respiratory distress and required admission to the neonatal intensive care unit. CONCLUSION: Vertical transmission of covid-19 can occur if the mother acquires infection in the last trimester. However, these infected neonates' morbidity and mortality rate is negligible; therefore, breastfeeding and rooming should be encouraged. [ABSTRACT FROM AUTHOR]

Retrospective chart reviews of seven adolescents and young adults (ages 9-20) with autistic disorder treated with fluoxetine alone or in combination with other medications were performed. Side effects included initial appetite suppression, vivid dreams, and hyperactivity. Improvement was seen in irritability, lethargy, sterotypy, and inappropriate speech. (Author/CR)

Over the past two decades, non‐covalent chemistry has introduced various promising artificial receptors and revolutionized the host‐guest chemistry. These versatile receptors have particularly been entertained in sensing and recognizing of diverse neutral molecules and/or ionic entities (e. g. anions, cations and ion‐pair) of particular interest. Notably, supramolecular chemistry had given birth to a plethora of important molecules, explored in the chemical, biological, environmental, and pharmacological world to resolve the critical issues related to the human health while keeping environmental concerns in mind. Amongst the various types of supramolecular monotopic receptors (anions, cations, and neutral molecules), heteroditopic receptors (ion‐pair receptors) consisting of distinct binding sites in one system for both cation and anion, have gained much interest from the scientific community in recent past because of their unique binding abilities. Interestingly, these promising artificial receptors have shown potential applications in sensing, recognition, transport and extraction processes besides their uses in salt/waste purification. Bearing the importance of these systems in mind, we intended to report the recent developments in ion‐pair chemistry. Herein, we divided the whole document into three main sections; first one describes the introduction and history of the ion‐pairs receptors. The second portion highlights the synthesis and applications of ion‐pair receptors in sensing, recognition, molecular machines, photoswitching behaviour, extraction and transport properties, whereas the last part of this manuscript provides concluding remarks as well as future prospects of ion‐pair receptors. We hope that this manuscript will be helpful to stimulating researchers around the globe to find out the hidden opportunities in this and related areas. [ABSTRACT FROM AUTHOR]