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287 results on '"Khan, Raja B."'

3. Cerebellar Mutism Syndrome and Dentato-Thalamo-Cortical Tract Disruption in Diffusion Tractography Following Surgery for Medulloblastoma

Author

Ji, Qing, primary, McAfee, Samuel S., additional, Scoggins, Matthew, additional, Holtrop, Joseph, additional, Glass, John O., additional, Yuan, Xiaomeng, additional, Liang, Jia, additional, Li, Yimei, additional, Chiang, Jason, additional, Orr, Brent A., additional, Edwards, Angela, additional, Storment, Diana, additional, Brinkman, Tara, additional, Robinson, Giles W., additional, Gajjar, Amar, additional, Reddick, Wilburn E., additional, Patay, Zoltán, additional, Khan, Raja B., additional, and Bag, Asim K., additional

Published
2024
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5. Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE).

Author

Rodwin, Rozalyn L., Wang, Fang, Lu, Lu, Li, Zhenghong, Srivastava, Deo Kumar, Phillips, Nicholas S., Khan, Raja B., Brinkman, Tara M., Krull, Kevin R., Boop, Frederick A., Armstrong, Gregory T., Merchant, Thomas E., Gajjar, Amar, Robison, Leslie L., Hudson, Melissa M., Kadan‐Lottick, Nina S., and Ness, Kirsten K.

Subjects
CENTRAL nervous system, PERIPHERAL neuropathy, PRICE indexes, CHILDHOOD cancer, QUALITY of life, CENTRAL nervous system tumors
Abstract

Background: Survivors of childhood central nervous system (CNS) tumors can develop motor and sensory impairment from their cancer and treatment history. We estimated the prevalence of motor and sensory impairment in survivors compared with controls through clinical assessment and identified associated treatment exposures and functional, quality of life (QOL), and social outcomes. Methods: Survivors of childhood CNS tumors from the St. Jude Lifetime Cohort (n = 378, median [range] age 24.0 [18.0–53.0] years, 43.4% female) ≥5 years from diagnosis and controls (n = 445, median [range] age 34.0 [18.0–70.0] years, 55.7% female) completed in‐person evaluation for motor and sensory impairment using the modified Total Neuropathy Score. Impairment was graded by modified Common Terminology Criteria for Adverse Events. Multivariable models estimated associations between grade ≥2 motor/sensory impairment, individual/treatment characteristics, and secondary outcomes (function by Physical Performance Test, fitness by physiologic cost index, QOL by Medical Outcomes Survey Short Form‐36 physical/mental summary scores, social attainment). Results: Grade ≥2 motor or sensory impairment was more prevalent in survivors (24.1%, 95% Confidence Interval [CI] 19.8%–29.4%) than controls (2.9%, CI 1.4–4.5%). Among survivors, in multivariable models, motor impairment was associated with vinca exposure <15 mg/m2 versus none (OR 4.38, CI 1.06–18.08) and etoposide exposure >2036 mg/m2 versus none (OR 12.61, CI 2.19–72.72). Sensory impairment was associated with older age at diagnosis (OR 1.09, CI 1.01–1.16) and craniospinal irradiation versus none (OR 4.39, CI 1.68–11.50). There were lower odds of motor/sensory impairment in survivors treated in the year 2000 or later versus before 1990 (Motor: OR 0.29, CI 0.10–0.84, Sensory: OR 0.35, CI 0.13–0.96). Motor impairment was associated with impaired physical QOL (OR 2.64, CI 1.22–5.72). Conclusions: In survivors of childhood CNS tumors, motor and sensory impairment is prevalent by clinical assessment, especially after exposure to etoposide, vinca, or craniospinal radiation. Treating motor impairment may improve survivors' QOL. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Bowers, Daniel C, Verbruggen, Lisanne C, Kremer, Leontien C M, Hudson, Melissa M, Skinner, Roderick, Constine, Louis S, Sabin, Noah D, Bhangoo, Ranjeev, Haupt, Riccardo, Hawkins, Mike M, Jenkinson, Helen, Khan, Raja B, Klimo, Paul, Jr, Pretorius, Pieter, Ng, Antony, Reulen, Raoul C, Ronckers, Cécile M, Sadighi, Zsila, Scheinemann, Katrin, Schouten-van Meeteren, Netteke, Sugden, Elaine, Teepen, Jop C, Ullrich, Nicole J, Walter, Andrew, Wallace, W Hamish, Oeffinger, Kevin C, Armstrong, Gregory T, van der Pal, Helena J H, and Mulder, Renée L

Published
2021
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13. The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE)

Author

Bhakta, Nickhill, Liu, Qi, Ness, Kirsten K, Baassiri, Malek, Eissa, Hesham, Yeo, Frederick, Chemaitilly, Wassim, Ehrhardt, Matthew J, Bass, Johnnie, Bishop, Michael W, Shelton, Kyla, Lu, Lu, Huang, Sujuan, Li, Zhenghong, Caron, Eric, Lanctot, Jennifer, Howell, Carrie, Folse, Timothy, Joshi, Vijaya, Green, Daniel M, Mulrooney, Daniel A, Armstrong, Gregory T, Krull, Kevin R, Brinkman, Tara M, Khan, Raja B, Srivastava, Deo K, Hudson, Melissa M, Yasui, Yutaka, and Robison, Leslie L

Published
2017
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15. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients

Author

Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin, Kennedy, David, Khan, Raja B., Khan, Muhammad A.S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer U.l., Zafar, Sara, Shiwani, Muhammad H., Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emeshi, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, McNair, Angus G.K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V.G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Ho, Wei-Min, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., McCallum, Iain J.D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Downing, Justine, Mockford, Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R.L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T.V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel U., Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E.J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Shah, Reena, Hornby, Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee S., Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Lammy, Simon, Mohamed, Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria I., Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Giwa, Lola, Iqbal, Nusrat, Watson, Nicholas F., Aggarwal, Smeer K., Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam W.J., Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, Alistair R., Malde, Deep, Lloyd, David, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O'shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Johnstone, Marianne, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O'Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E.J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, Jonathan G., Finch, J.Guy, Parmar, Jitesh, Stirland, Euan, Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Santosh Bhandari, Christopher Taylor, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K.C., Carter, Nicholas C., Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish K., Basu, Sanjoy, Chhabra, Alok, Harilingam, Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P.J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Mohammed, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Y., Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan L., Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A.W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R.G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, McGlone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Al Amari, Khalid, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle A., Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani S., Zafrani, Zakhi, Brett, Daniel, Francombe, James, Spreadborough, Philip, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z., Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A., Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C., Hebbar, Madhusoodhana, Farag, Sameh F., Hebbar, Madhu, Spearman, John, Hamdan, Mohammed F., D'Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B., Hirst, Natalie A., Hossain, Tanvir, Pannu, Arslan, El-Dhuwaib, Yesar, Morrison, Tamsin E.M., Taylor, Greg W., Thompson, Ronald L.E., McCune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K., Simpson, Duncan J., Mawhinney, Abi, Warren, Conor, McKay, Damian, McIlmunn, Colin, Martin, Serena, MacArtney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M., Digney, Ruairi, Chan, Wei M., McCain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, McAree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, McKenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold D.K., Cassidy, John T., Boland, Michael, Burke, Paul, Nally, Deirdre M., Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, McEntee, Gerry P., O'Neill, Maeve A., Peirce, Colin, Lyons, Emma M., O'Sullivan, Adrian W., Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C., Kelly, Michael E., Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G., Martin, Sean T., Cross, Keith S., Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O., Mealy, Ken, Mohan, Helen M., Nedujchelyn, Yuwaraja, Ullah, Muhammad F., Ahmed, Irfan, Giovinazzo, Francesco, Milburn, James, Prince, Sarah, Brooke, Eleanor, Buchan, Joanna, Khalil, Ahmed M., Vaughan, Elizabeth M., Ramage, Michael I., Aldridge, Roland C., Gibson, Simon, Nicholson, Gary A., Vass, David G., Grant, Alan J., Holroyd, David J., Jones, Angharad, Sutton, Cherith M.L.R., O'Dwyer, Patrick, Nilsson, Frida, Weber, Beatrix, Williamson, Tracey K., Lalla, Kushik, Bryant, Alice, Carter, Ross, Forrest, Craig R., Hunter, David I., Nassar, Ahmad H., Orizu, Mavis N., Knight, Katrina, Qandeel, Haitham, Suttie, Stuart, Belding, Rowena, McClarey, Andrew, Boyd, Alan T., Guthrie, Graeme J.K., Lim, Pei J., Luhmann, Andreas, Watson, Angus J.M., Richards, Colin H., Nicol, Laura, Madurska, Marta, Harrison, Ewen, Boyce, Kathryn M., Roebuck, Amanda, Ferguson, Graeme, Pati, Pradeep, Wilson, Michael S.J., Dalgaty, Faith, Fothergill, Laura, Driscoll, Peter J., Mozolowski, Kirsty L., Banwell, Victoria, Bennett, Stephen P., Rogers, Paul N., Skelly, Brendan L., Rutherford, Claire L., Mirza, Ahmed K., Lazim, Taha, Lim, Henry C.C., Duke, Diana, Ahmed, Talat, Beasley, William D., Wilkinson, Marc D., Maharaj, Geta, Malcolm, Cathy, Brown, Timothy H., Shingler, Guy M., Mowbray, Nicholas, Radwan, Rami, Morcous, Paul, Wood, Simon, Kadhim, Abbas, Stewart, Duncan J., Baker, Andrew L., Tanner, Nicola, Shenoy, Hrishikesh, Sutcliffe, Robert P., Hollyman, Marianne, Hodson, James, Bonney, Glenn, Vohra, Ravi S., and Griffiths, Ewen A.

Published
2016
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16. Data from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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17. Supplemental Table 2 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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18. Supplemental Table 1 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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20. Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature

Author

Bami, Sakshi, primary, Hidinger, Jennifer, additional, Madni, Arshia, additional, Hargest, Virginia, additional, Schultz-Cherry, Stacey, additional, Cortez, Valerie, additional, Cross, Shane J, additional, Ward, Deborah A, additional, Hayden, Randall T, additional, Rubnitz, Jeffrey, additional, Pui, Ching-Hon, additional, Khan, Raja B, additional, and Hijano, Diego R, additional

Published
2022
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21. Neuropathy and neurocognitive impairment in long-term survivors of pediatric cancer treated without central nervous system (CNS) directed therapy.

Author

Williams, AnnaLynn, primary, Phillips, Nicholas Steve, additional, Goodenough, Chelsea Goodliffe, additional, Brinkman, Tara M., additional, Papini, Chiara, additional, Jacola, Lisa M, additional, Delaney, Angela M., additional, Armstrong, Gregory T., additional, Jefferies, John L., additional, Khan, Raja B., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Ness, Kirsten K., additional, and Krull, Kevin R., additional

Published
2022
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26. Concordance between Self-reported Symptoms and Clinically Ascertained Peripheral Neuropathy among Childhood Cancer Survivors: the St. Jude Lifetime Cohort Study

Author

Hayek, Samah, primary, Dhaduk, Rikeenkumar, additional, Sapkota, Yadav, additional, Evans, William E., additional, Diouf, Barthelemy, additional, Bjornard, Kari, additional, Wilson, Carmen L., additional, Hudson, Melissa M., additional, Robison, Leslie L., additional, Khan, Raja B., additional, Srivastava, Deo Kumar, additional, Krull, Kevin R., additional, and Ness, Kirsten K., additional

Published
2021
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30. Stroke-Like Migraine after Radiation Treatment Syndrome in Children with Cancer.

Author

Ahmed, Qurratulain S., Sadighi, Zsila S., Lucas, John T., and Khan, Raja B.

Subjects
METHYLPREDNISOLONE, DRUG efficacy, INTRAVENOUS therapy, CANCER cells, MIGRAINE, GLIOMAS, MAGNETIC resonance imaging, RADIOTHERAPY, CHILDREN, ADOLESCENCE
Abstract

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a symptom complex of transient neurological deficits, headache, and abnormal cortical contrast enhancement on brain MRI. Pathophysiology is unclear, but exposure to cranial radiation (RT) is a sine qua non. We report five children with SMART syndrome treated with RT therapy for medulloblastoma ( n  = 3), atypical teratoid rhabdoid tumor ( n  = 1), and pleomorphic xanthoastrocytoma ( n  = 1). Median age at tumor diagnosis was 9.4 years (range 5.1–14.7). Median follow-up from cancer diagnosis was 3.1 years (range 1.4–12.9). All patients had 54 Gy focal RT treatment and medulloblastoma children had additional 36 Gy craniospinal irradiation. Median time from the end of RT to first transient neurological deficit was 1 year (range 0.7–12.1). The median follow-up since first SMART episode was 0.6 years (range 0.3–2.6). Presenting symptoms included the gradual development of unilateral weakness ( n  = 4), non-fluent dysphasia ( n  = 1), somnolence ( n  = 1), and headaches ( n  = 3). Neurological deficits resolved within 30 minutes to 10 days. Transient cortical enhancement on magnetic resonance imaging (MRI) was confirmed in two children and was absent in the other three. Two children had a single and three had multiple episodes over the next few months. Two children with protracted symptoms responded to 3 days treatment with high dose intravenous methylprednisolone. Symptoms ultimately resolved in all patients. SMART syndrome is a rare disorder characterized by slow evolution of neurological deficits with variable abnormal cortical contrast enhancement. The use of steroids may improve symptoms and speed resolution. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Clinical features, neurologic recovery, and risk factors of postoperative posterior fossa syndrome and delayed recovery: a prospective study

Author

Khan, Raja B, primary, Patay, Zoltan, additional, Klimo, Paul, additional, Huang, Jie, additional, Kumar, Rahul, additional, Boop, Frederick A, additional, Raches, Darcy, additional, Conklin, Heather M, additional, Sharma, Richa, additional, Simmons, Andrea, additional, Sadighi, Zsila S, additional, Onar-Thomas, Arzu, additional, Gajjar, Amar, additional, and Robinson, Giles W, additional

Published
2021
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36. Side effects of methylphenidate in childhood cancer survivors: a randomized placebo-controlled trial

Author

Conklin, Heather M., Lawford, Joanne, Jasper, Bruce W., Morris, E. Brannon, Howard, Scott C., Ogg, Susan W., Wu, Shengjie, Xiong, Xiaoping, and Khan, Raja B.

Subjects
Cancer in children -- Drug therapy, Cancer in children -- Patient outcomes, Drug therapy -- Complications and side effects, Drug therapy -- Patient outcomes, Methylphenidate hydrochloride -- Complications and side effects, Methylphenidate -- Complications and side effects
Published
2009

38. NCMP-25. CLINICAL FEATURES, NEUROLOGIC RECOVERY, AND RISK PREDICTION OF POST-OPERATIVE POSTERIOR FOSSA SYNDROME: A PROSPECTIVE STUDY

Author

Khan, Raja B, primary, Patay, Zoltan, additional, Kilmo, Paul, additional, Huang, Jie, additional, Onar-Thomas, Arzu, additional, Kumar, Rahul, additional, Boop, Frederick A, additional, Raches, Darcy, additional, Conklin, Heather, additional, Sharma, Richa, additional, Simmons, Andrea, additional, Sadighi, Zsila, additional, and Gajjar, Amar, additional

Published
2020
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42. Seizures' impact on cognition and quality of life in childhood cancer survivors.

Author

Phillips, Nicholas S., Khan, Raja B., Li, Chenghong, Mirzaei Salehabadi, Sedigheh, Brinkman, Tara M., Srivastava, Deokumar, Robison, Leslie L., Hudson, Melissa M., Krull, Kevin R., and Sadighi, Zsila S.

Subjects
*CHILDHOOD cancer, *CANCER survivors, *EPILEPSY, *BRAIN tumors, *COGNITIVE testing, *QUALITY of life, *SEIZURES (Medicine), *EXECUTIVE function
Abstract

Background: The objective of this study was to determine the impact of seizure‐related factors on neurocognitive, health‐related quality of life (HRQOL), and social outcomes in survivors of childhood cancer. Methods: Survivors of childhood cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; median time since diagnosis, 23.6 years) completed neurocognitive testing and questionnaires. The presence, severity, resolution, and treatment history of seizures were abstracted from medical records. Adjusting for the age at diagnosis, sex, and prior cancer therapy, multivariable models examined the impact of seizures on neurocognitive and HRQOL outcomes. Mediation analyses were conducted for social outcomes. Results: Seizures were identified in 232 survivors (11.5%; 29.9% of survivors with central nervous system [CNS] tumors and 9.0% of those without CNS tumors). In CNS tumor survivors, seizures were associated with poorer executive function and processing speed (P <.02); in non‐CNS tumor survivors, seizures were associated with worse function in every domain (P <.05). Among non‐CNS survivors, seizure severity was associated with worse processing speed (P =.023), and resolution was associated with better executive function (P =.028) and attention (P =.044). In CNS survivors, seizure resolution was associated with improved attention (P =.047) and memory (P <.02). Mediation analysis revealed that the impact of seizures on social outcomes was mediated by neurocognitive function. Conclusions: Seizures in cancer survivors adversely affect long‐term functional and psychosocial outcomes independently of cancer therapy. The resolution of seizure occurrence is associated with better outcomes. Seizure severity is associated with poorer outcomes and should be a focus of clinical management and patient education. Adult survivors of childhood cancer are at risk for poorer cognitive, health‐related quality of life, and social outcomes. Seizure frequency, independently of the underlying etiology, is associated with poorer outcomes in non–brain tumor survivors, and this implies that they may be a more vulnerable population with a lower threshold for impact from seizures of any severity. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Balance impairment in survivors of pediatric brain cancers: risk factors and associated physical limitations

Author

Varedi, Mitra, primary, Lu, Lu, additional, Phillips, Nicholas S., additional, Partin, Robyn E., additional, Brinkman, Tara M., additional, Armstrong, Gregory T., additional, Chase, Emma, additional, Khan, Raja B., additional, Powell, Douglas, additional, McKenna, Raymond F., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Ness, Kirsten K., additional

Published
2020
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46. Peripheral motor and sensory neuropathy in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime (SJLIFE) cohort.

Author

Rodwin, Rozalyn L, primary, Lu, Lu, additional, Srivastava, Deo Kumar, additional, Brinkman, Tara M., additional, Krull, Kevin R., additional, Armstrong, Gregory T., additional, Khan, Raja B., additional, Phillips, Nicholas S., additional, Merchant, Thomas E., additional, Gajjar, Amar J., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Kadan-Lottick, Nina S., additional, and Ness, Kirsten K., additional

Published
2020
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48. Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16

Author

Jeha, Sima, primary, Pei, Deqing, additional, Choi, John, additional, Cheng, Cheng, additional, Sandlund, John T., additional, Coustan-Smith, Elaine, additional, Campana, Dario, additional, Inaba, Hiroto, additional, Rubnitz, Jeffrey E., additional, Ribeiro, Raul C., additional, Gruber, Tanja A., additional, Raimondi, Susana C., additional, Khan, Raja B., additional, Yang, Jun J., additional, Mullighan, Charles G., additional, Downing, James R., additional, Evans, William E., additional, Relling, Mary V., additional, and Pui, Ching-Hon, additional

Published
2019
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