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156 results on '"Khan, Safiullah"'

19. Design and evaluation of sustained-release lipid-PLGA hybrid nanoparticles for enhanced anticancer efficacy of 5-fluorouracil.

Author

Khan, Safiullah, Madni, Asadullah, Aamir, Muhammad Naeem, Khan, Shahzeb, Ahmad, Fiaz-ud-Din, Basit, Abdul, Jan, Nasrullah, Shah, Hassan, Shafiq, Afifa, and Anwar, Maryam

Subjects
*ANTINEOPLASTIC agents, *FLUOROURACIL, *NANOPARTICLES, *COLON tumors, *ZETA potential, *CETUXIMAB, *REGORAFENIB
Abstract

The current study focuses on the preparation and optimization of lipid PLGA hybrid nanoparticles of 5-fluorouracil (5-FU-LPHNs) using a three-factor, three-level Box-Behnken design for sustained release and enhanced in-vitro anticancer efficacy. The morphology of the developed 5-FU-LPHNs was spherical and found in the range of 155.7–316.4 nm, entrapment efficiency (80%–92%), polydispersity index (0.11–0.19) and zeta potential (−19.7 mV to −29.4 mV) depicting nano-sized and stable nanoparticles. The XRD and DSC investigations showed the absence of characteristic peaks of 5-fluorouracil in the developed formulations indicating amorphization and successful encapsulation of 5-fluorouracil in the developed LPHNs. The in-vitro release showed a biphasic release pattern with an initial burst release pursued by sustained release up to 72 h. The in-vitro cytotoxicity studies of the developed 5-FU-LPHNs were found more cytotoxic than the free drug solution in HT-29 and HCT116 cancer cell lines. In both cell lines, the half maximal inhibitory concentration (IC50) values of 5-FU-LPHNs were approximately 2.06-fold and 1.83-fold, less than that of the 5-FU solution (p <.05). These results suggest that the developed LPHNs can be used as a potential drug delivery approach for the effective delivery of 5-fluorouracil with enhanced anticancer efficacy to colorectal tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Evaluation of the anti-inflammatory, antioxidant, and cytotoxic potential of Cardamine amara L. (Brassicaceae): A comprehensive biochemical, toxicological, and in silico computational study

Author

Basit, Abdul, primary, Ahmad, Saeed, additional, Khan, Kashif ur Rehman, additional, Aati, Hanan Y., additional, Sherif, Asmaa E., additional, Ovatlarnporn, Chitchamai, additional, Khan, Safiullah, additional, Rao, Huma, additional, Arshad, Muhammad Adeel, additional, Shahzad, Muhammad Nadeem, additional, and Perveen, Shagufta, additional

Published
2023
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34. Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications.

Author

Jan, Nasrullah, Madni, Asadullah, Khan, Safiullah, Shah, Hassan, Akram, Faizan, Khan, Arshad, Ertas, Derya, Bostanudin, Mohammad F., Contag, Christopher H., Ashammakhi, Nureddin, and Ertas, Yavuz Nuri

Subjects
CELL membranes, CONTROLLED release drugs, NANOMEDICINE, NANOPARTICLES, INFECTION control
Abstract

Poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability for sustained and controlled drug release. To prolong NP circulation time, enable target‐specific drug delivery and overcome physiological barriers, NPs camouflaged in cell membranes have been developed and evaluated to improve drug delivery. Here, we discuss recent advances in cell membrane‐coated PLGA NPs, their preparation methods, and their application to cancer therapy, management of inflammation, treatment of cardiovascular disease and control of infection. We address the current challenges and highlight future research directions needed for effective use of cell membrane‐camouflaged NPs. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Area-Optimized Constant-Time Hardware Implementation for Polynomial Multiplication.

Author

Khan, Safiullah, Lee, Wai-Kong, Khalid, Ayesha, Majeed, Abdul, and Hwang, Seong Oun

Abstract

This work presents a lightweight, FPGA-based hardware implementation for polynomial multiplication, which is the major bottleneck in the NTRU public-key cryptographic scheme. NTRU is a quantum-resilient, lattice-based key exchange cryptosystem, and is currently a finalist in the ongoing National Institute of Standards and Technology post-quantum cryptography standardization. It is challenging to fit these quantum-resilient schemes into Internet of Things (IoT) sensor nodes due to the strict resource constraints (smaller area, less memory, and lower energy budgets) and the limited computational capabilities in embedded devices. We undertake this compact implementation for polynomial multiplication with two motivations: 1) constant-time implementation ensuring inherent security against timing side-channel attacks and 2) optimized hardware consumption to make it suitable for IoT applications. A single-step multiplexer-based iterative architecture is proposed to achieve both goals simultaneously. Compared to the architectures presented in the literature, our proposed work eliminates the utilization of a modular arithmetic unit and replaces it with the correct selection of input followed by an accumulator, which can help to save substantial device resources. Experimental results with an FPGA show that our proposed architecture achieves an area reduction of up to $2.86 \times $ and the throughput increase up to $1.23 \times $ compared to the state-of-the-art implementation strategies, providing comparable latency along with an inherent-timing attack resilience that is absent in several NTRU hardware implementation schemes. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Author

Rahim, Muhammad Abdur, primary, Jan, Nasrullah, additional, Khan, Safiullah, additional, Shah, Hassan, additional, Madni, Asadullah, additional, Khan, Arshad, additional, Jabar, Abdul, additional, Khan, Shahzeb, additional, Elhissi, Abdelbary, additional, Hussain, Zahid, additional, Aziz, Heather C, additional, Sohail, Muhammad, additional, Khan, Mirazam, additional, and Thu, Hnin Ei, additional

Published
2021
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50. Frequenzselektive Schirme mit stark gekoppelten miniaturisierten Metamaterialresonatoren

Author

Khan, Safiullah, Eibert, Thomas F. (Prof. Dr.), and Gagliardi, Alessio (Prof. Dr.)

Subjects
Ingenieurwissenschaften, ddc:620
Abstract

Two distinct types of metamaterial resonators are tightly coupled in a single unit cell to investigate electromagnetic wave manipulation and to achieve miniaturization. The structure gives a multi-band response, it is tunable by a few parameters only, and the filtering functionality is independent from the incident angle and the polarization of the incident wave. The insertion loss of realized frequency and polarization selective surfaces is less than 0.5 dB. Zwei verschiedene, in einer miniaturisierten Einheitszelle eng gekoppelte, Metamaterialresonatoren werden genutzt, um die Manipulation von elektromagnetischen Wellen zu untersuchen. Die Filterfunktionalität der Struktur ist mehrfrequenzfähig, durch nur wenige Parameter abstimmbar, sowie unabhängig von Einfallswinkel und Polarisation der einfallenden Welle. Die Einfügungsverluste von realisierten frequenz- und polarisationsselektiven Schirmen liegen unter 0,5 dB

Published
2020

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