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Purpose: To evaluate the surgical outcomes of Dacryocystorhinostomy with Mitomycin C versus Dacryocystorhinostomy (DCR) without Mitomycin C in patients of chronic dacryocystitis visiting tertiary oculoplastic service. Study Design: Quasi experimental study. Place and Duration of Study: Lady Reading Hospital, Medical Teaching Institute (MTI), Peshawar, from January 2015 to December 2017. Methods: A total of 80 patients with chronic Dacryocystitis were divided into two groups of 40 each. Group-1 included patients who underwent Dacryocystorhinostomy (DCR) with intraoperative Mitomycin-C and group-2 included patients with DCR without Mitomycin-C. Data was entered in SPSS version 22.00. Descriptive statistics were used to calculate Means and Standard deviation of age. For categorical factors such as gender and efficacy, frequency and percentage were determined. The Chi Square test was performed to compare the effectiveness of the two groups, with a P value of less than 0.05 considered significant. Tables were used to represent the findings. Results: There were 68 female patients (85%) and 12 male patients (15%) among the 80 patients. Male to female ratio was 1:6.27. The average age was 45.34. Six months after surgery, DCR was successful in thirty seven (92.5%) patients of group-I, and thirty six (90%) cases of group II. Overall success rate of DCR in our study was 91.25%. The Paired t test was applied and the P value was 0.697. Conclusion: There was no statistically significant difference in surgical results of DCR with Mitomycin C versus DCR without Mitomycin C. Both the procedures were equally effective in relieving symptoms. [ABSTRACT FROM AUTHOR]