1. Investigation of the Anticancer Activity of Coordination-Driven Self-AssembledTwo-Dimensional Ruthenium Metalla-Rectangle.
- Author
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Vardhan, Harsh, Nafady, Ayman, Al-Enizi, Abdullah M., Khandker, Khalid, El-Sagher, Hussein M., Verma, Gaurav, Acevedo-Duncan, Mildred, Alotaibi, Tawfiq M., and Ma, Shengqian
- Subjects
NUCLEAR magnetic resonance spectroscopy ,ELECTROSPRAY ionization mass spectrometry ,RUTHENIUM ,PROTON magnetic resonance spectroscopy ,OVERHAUSER effect (Nuclear physics) ,INFRARED spectroscopy - Abstract
Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η
6 -p-cymene)4 Ru4 (C6 H2 O4 )2 (2)2 ](CF3 SO3 )4 (3) by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru2 (η6 -p-cymene)2 (C6 H2 O4 )Cl2 ] (1) and bis-pyridyl amide linker (2) in the presence of AgO3 SCF3 . This cationic ruthenium metalla-rectangle (3) has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1 H-NMR), carbon nuclear magnetic resonance spectroscopy (13 C-NMR),1 H-1 H correlation spectroscopy (COSY),1 H-1 H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex (1) and the commercially used drug, cisplatin. [ABSTRACT FROM AUTHOR]- Published
- 2019
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