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3. Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions

Author

Khanh, Vuong Cat, primary, Fukushige, Mizuho, additional, Chang, Yun Hsuan, additional, Hoang, Ngo Nhat, additional, Yamashita, Toshiharu, additional, Obata-Yasuoka, Mana, additional, Hamada, Hiromi, additional, Osaka, Motoo, additional, Hiramatsu, Yuji, additional, and Ohneda, Osamu, additional

Published
2021
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8. Corrigendum to “SDF-1 improves wound healing ability of glucocorticoid-treated adipose tissue-derived mesenchymal stem cells” [Biochem. Biophys. Res. Commun. 493/2 (2017) 1010–1017]

Author

Kato, Toshiki, primary, Khanh, Vuong Cat, additional, Sato, Kazutoshi, additional, Takeuchi, Kosuke, additional, Carolina, Erica, additional, Yamashita, Toshiharu, additional, Sugaya, Hisashi, additional, Yoshioka, Tomokazu, additional, Mishima, Hajime, additional, and Ohneda, Osamu, additional

Published
2018
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12. Elevated Expression of Dkk-1 by Glucocorticoid Treatment Impairs Bone Regenerative Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells.

Author

Khanh, Vuong Cat, Sato, Kazutoshi, Kimura, Kenichi, Yamashita, Toshiharu, Ohneda, Osamu, Kato, Toshiki, Mishima, Hajime, Sugaya, Hisashi, and Yoshioka, Tomokazu

Subjects
*GLUCOCORTICOIDS, *BONE regeneration, *STEM cells, *ADIPOSE tissues, *INFLAMMATION
Abstract

Glucocorticoids are steroid hormones used as anti-inflammatory treatments. However, this strong immunomodulation causes undesirable side effects that impair bones, such as osteoporosis. Glucocorticoid therapy is a major risk factor for developing steroid-induced osteonecrosis of the femur head (ONFH). Since ONFH is incurable, therapy with mesenchymal stem cells (MSCs) that can differentiate into osteoblasts are a first-line choice. Bone marrow-derived MSCs (BM-MSCs) are often used as a source of stem cell therapy for ONFH, but their proliferative activity is impaired after steroid treatment. Adipose tissue-derived MSCs (AT-MSCs) may be an attractive alternative source; however, it is unknown whether AT-MSCs from steroid-induced ONFH (sAT-MSCs) have the same differentiation ability as BM-MSCs or normal AT-MSCs (nAT-MSCs). In this study, we demonstrate that nAT-MSCs chronically exposed to glucocorticoids show lower alkaline phosphatase activity leading to reduced osteogenic differentiation ability. This impaired osteogenesis is mediated by high expression of Dickkopf1 (Dkk-1) that inhibits wnt/β-catenin signaling. Increased Dkk-1 also causes impaired osteogenesis along with reductions in bone regenerative capacity in sAT-MSCs. Of note, plasma Dkk-1 levels are elevated in steroid-induced ONFH patients. Collectively, our findings suggest that glucocorticoid-induced expression of Dkk-1 could be a key factor in modulating the differentiation ability of MSCs used for ONFH and other stem cell therapies. [ABSTRACT FROM AUTHOR]

Published
2018
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