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24 results on '"Khanna, Hari D."'

13. Evaluation of Oxidative Stress Status Following Polyherbal Formulation Therapy In Patients of Cholelithiasis with Choledocholithiasis

Author

Srivastava, Pankaj, Sahu, M., Khanna, Shruti, and Khanna, Hari D.

Subjects
MDA status, Oxidative stress, Polyherbal drug therapy, Bile, Original Article
Abstract

Free radicals produce persistent oxidative stress in biological system and are highly reactive molecules produced as a byproduct of metabolism. A reactive free redical generated in the body reacts with non-radical molecules and results in free radical chain reaction leading to formation of new free radicals. If the defense mechanism of body fails to combat them or they are not properly utilized in the body -these silent killers pose a threat by injuring tissues, their proteins and fat contents. Lipids in the cell membrane undergo degradation to form hydroperoxides((1, 2, 3).) Polyunsaturated fatty acids, PUFA, are especially liable to lipid peroxidation. Lipid hydroperoxids decompose to form a variety of products including malondialdehyde (MDA) which is used as an indicator of oxidative damage of cells and tissues((4).)The present investigations involve the study of oxidative stress in the bile juice from the patients of cholecystitis/cholelithiasis with choledocholithiasis treated by cholecystectomy with choledochotomy (CBD exploration) with T-tube drainage. Results of malondialdehyde status in the bile juice of these patients pre-operatively and following polyherbal formulation therapy from 3(rd) to 10(th) post operative day are discussed.

Published
2005

23. Protein Damage and Antioxidant Status Alterations Caused by Oxidative Injury in Chronic Myeloid Leukemia.

Author

Pande, Deepti, Negi, Reena, Khanna, Ranjana S., and Khanna, Hari D.

Subjects
*CHRONIC myeloid leukemia, *OXIDATIVE stress, *ANTIOXIDANT analysis, *MYELOPROLIFERATIVE neoplasms, *PATIENTS, *CHROMOSOME abnormalities, *ACQUISITION of data, *SERUM, *CARCINOGENESIS, *DISEASES
Abstract

The article focuses on a study related to the evaluation of oxidative stress and antioxidant defense in patients with chronic myeloid leukemia (CML). The study mentions that CML is a myeloproliferative disorder and results from chromosomal translocation. The study informs that data were collected with serum from 40 clinically diagnosed cases of CML as well as 40 healthy controls. The study further concludes that oxidative stress may play a role in the pathogenesis of CML.

Published
2011

24. A novel approach to study oxidative stress in neonatal respiratory distress syndrome.

Author

Negi R, Pande D, Karki K, Kumar A, Khanna RS, and Khanna HD

Abstract

Background: Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS., Methods: Markers of oxidative stress and antioxidant activity in umbilical cord blood were studied in infants with neonatal respiratory distress syndrome with reference to healthy newborns., Results: Status of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns., Conclusion: The study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA, which indicates the augmentation of oxidative stress., General Significance: The identification of the potential biomarker of oxidative stress consists of a promising strategy to study the pathophysiology of neonatal RDS.

Published
2014
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