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2 results on '"Khasanova NV"'

1. [The noninvasive technique of analysis of aggregation activity of thrombocytes, leukocytes and erythrocytes].

Author

Kuznik BI, Faĭn IA, Kaminskiĭ AV, Maksimova OG, Kustovskaia EM, Bogdanova IuV, Zhdanovich NG, Rodnina OS, and Khasanova NV

Subjects
Adenosine Diphosphate pharmacology, Collagen pharmacology, Epinephrine pharmacology, Hemostasis physiology, Humans, Blood Platelets cytology, Blood Platelets drug effects, Cell Aggregation drug effects, Erythrocytes cytology, Erythrocytes drug effects, Leukocytes cytology, Leukocytes drug effects
Abstract

The article considers the noninvasive technique of analysis of aggregation activity of thrombocytes and formation of leukocytic-erythrocytic-thrombocytic aggregates and some particular indicators of hemostasis system. The speckle-analysis of characteristics of coherent light dispersion from surface of erythrocytes moving in artificially isolated vessel section. The study established high correlation ratio between light dispersion index and spontaneous ADP-, adrenalin- and collagen-induced aggregation of thrombocytes, formation of leukocytic-erythrocytic and thrombocytic-erythrocytic aggregations. The established facts permits to consider that analysis noninvasive technique makes it possible to estimate approximately the aggregation activity of blood corpuscles.

Published
2013

2. [Non-invasive methods for the assessment of platelet, leukocyte, erythrocyte aggregation and coagulation hemostasis].

Author

Kuznik BI, Faĭn IA, Kaminskiĭ AV, Maksimova OG, Kustovskaia EM, Martynova EN, Rodnina OS, and Khasanova NV

Subjects
Adolescent, Adult, Aged, Blood Chemical Analysis methods, Blood Coagulation, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Thrombosis blood, Young Adult, Blood Platelets metabolism, Erythrocyte Aggregation physiology, Erythrocytes metabolism, Hemostasis physiology, Leukocytes metabolism, Platelet Aggregation physiology, Thrombosis diagnosis
Abstract

A non-invasive method for the study of platelet aggregation and formation of leukocyte-erythrocyte-platelet aggregates as well as certain hemostatic parameters is proposed. The method is based on the speckle-analysis of coherent light scattering from the surface of erythrocytes moving in an artificially isolated vessel segment. It was shown that light scattering index significantly correlated with ADP-, adrenalin-, or collagen-induced platelet aggregation, with the formation of leukocyte-erythrocyte or platelet-erythrocyte aggregates, and with the levels of fibrinogen, soluble fibrin-monomer complexes and related parameters. It is concluded that the proposed method for the study of hemostatic system can be used to roughly evaluate intensity of intravascular blood coagulation and probability of thrombosis.

Published
2013

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