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8. The spectrum of cardiovascular complications related to immune-checkpoint inhibitor treatment: Including myocarditis and the new entity of non inflammatory left ventricular dysfunction

Author

Andres, Maria Sol, Ramalingam, Sivatharshini, Rosen, Stuart D., Baksi, John, Khattar, Rajdeep, Kirichenko, Yulia, Young, Kate, Yousaf, Nadia, Okines, Alicia, Huddart, Robert, Harrington, Kevin, Furness, Andrew J.S., Turajlic, Samra, Pickering, Lisa, Popat, Sanjay, Larkin, James, and Lyon, Alexander R.

Published
2022
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9. Sex disparities in cardiac sarcoidosis patients undergoing implantable cardioverter‐defibrillator implantation.

Author

Ahmed, Raheel, Jamil, Yumna, Ramphul, Kamleshun, Mactaggart, Sebastian, Bilal, Maham, Singh Dulay, Mansimran, Shi, Rui, Azzu, Alessia, Okafor, Joseph, Memon, Rahat A, Sakthivel, Hemamalini, Khattar, Rajdeep, Wells, Athol Umfrey, Baksi, John Arun, Wechalekar, Kshama, Kouranos, Vasilis, Chahal, Anwar, and Sharma, Rakesh

Subjects
SARCOIDOSIS treatment, TREATMENT of cardiomyopathies, HOSPITAL charges, SEX distribution, HOSPITAL care, MAJOR adverse cardiovascular events, QUESTIONNAIRES, SARCOIDOSIS, RETROSPECTIVE studies, TREATMENT effectiveness, DESCRIPTIVE statistics, HOSPITAL mortality, DISEASE prevalence, ACUTE kidney failure, ODDS ratio, IMPLANTABLE cardioverter-defibrillators, MEDICAL records, ACQUISITION of data, ATRIAL fibrillation, CARDIAC arrest, COMPARATIVE studies, CONFIDENCE intervals, LENGTH of stay in hospitals, DISEASE incidence, COMORBIDITY, DISEASE risk factors
Abstract

Introduction: In patients with cardiac sarcoidosis (CS), implantable cardioverter‐defibrillators (ICDs) are important for preventing sudden cardiac death. This study aimed to investigate sex disparities in CS patients undergoing ICD implantation. Methods: The 2016–2020 National Inpatient Sample (NIS) database compared the characteristics and outcomes of males and females with CS receiving ICDs. Results: Among 760 CS patients who underwent inpatient ICD implantation, 66.4% were male. Males were younger (55.0 vs. 56.9 years, p <.01), had higher rates of diabetes (31.7% vs. 21.6%, p <.01) and chronic kidney disease (CKD) (16.8% vs. 7.8%, p <.01) but lower prevalence of atrial fibrillation (AF) (11.9% vs. 23.5%, p <.01), sick sinus syndrome (4.0% vs. 7.8%, p =.024), ventricular fibrillation (VF) (9.9% vs. 15.7%, p =.02), and black ancestry (31.9% vs. 58.0%, p <.01). Unadjusted major adverse cardiovascular events (MACE), defined as a composite of in‐hospital death, myocardial infarction (MI), and ischemic stroke, was higher in females (11.8% vs. 6.9%, p =.024), but when adjusted for age and tCharlson Comorbidity Index (CCI), females demonstrated significantly lower odds of experiencing MACE (aOR: 0.048, 95% CI: 0.006–0.395, p =.005). Incidence of acute kidney injury (AKI) post‐ICD was significantly lower in females (15.7% vs. 23.8%, p =.01) as was the adjusted odds (aOR: 0.282, 95% CI: 0.146–0.546, p <.01). There was comparable mean length of stay and hospital charges. Conclusion: ICD utilization in CS patients is more common among males, who have a higher prevalence of diabetes and CKD but a lower prevalence of AF, sick sinus syndrome, and VF. Adjusted MACE and AKI were significantly lower in females. [ABSTRACT FROM AUTHOR]

Published
2024
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11. 94 Comparing the outcomes of an ‘early’ versus ‘late’ diagnosis of cardiac sarcoidosis following a baseline presentation of high-grade atrioventricular block

Author

Ahmed, Raheel, primary, Singh Dulay, Mansimran, additional, Liu, Alexander, additional, Okafor, Joseph, additional, Azzu, Alessia, additional, Ramphul, Kamleshun, additional, Baksi, Jonh, additional, Wechalekar, Kshama, additional, Khattar, Rajdeep, additional, Dar, Owais, additional, Collins, Peter, additional, Wells, Athol, additional, Kouranos, Vasileios, additional, and Sharma, Rakesh, additional

Published
2024
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12. 149 Clinical outcomes with cardiac resynchronization therapy in patients with cardiac sarcoidosis: a systematic review and proportional meta-analysis

Author

Ahmed, Raheel, primary, Ahmed, Mushood, additional, Ahsan, Areeba, additional, Sivasankaran, Karthikeyan, additional, Singh Dulay, Mansimran, additional, Ramphul, Kamleshun, additional, Liu, Alexander, additional, Shi, Rui, additional, Azzu, Alessia, additional, Okafor, Joseph, additional, Wechalekar, Kshama, additional, Baksi, Jonh, additional, Khattar, Rajdeep, additional, Collins, Peter, additional, Wells, Athol, additional, Kouranos, Vasileios, additional, and Sharma, Rakesh, additional

Published
2024
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13. Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Author

Ahmed, Raheel, primary, Najam, Noem, additional, Ramphul, Kamleshun, additional, Mactaggart, Sebastian, additional, Dullay, Mansimran Singh, additional, Okafor, Joseph, additional, Azzu, Alessia, additional, Bilal, Maham, additional, Memon, Rahat A, additional, Sakthivel, Hemamalini, additional, Khattar, Rajdeep, additional, Wells, Athol Umfrey, additional, Baksi, John Arun, additional, Wechalekar, Kshama, additional, Kouranos, Vasilis, additional, Chahal, Anwar, additional, and Sharma, Rakesh, additional

Published
2024
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16. Erratum for: Echocardiography versus Cardiac MRI for Measurement of Left Ventricular Ejection Fraction in Individuals with Cancer and Suspected Cardiotoxicity

Author

Nazir, Muhummad Sohaib, primary, Okafor, Joseph, additional, Murphy, Theodore, additional, Andres, Maria Sol, additional, Ramalingham, Sivatharshini, additional, Rosen, Stuart D., additional, Chiribiri, Amedeo, additional, Plein, Sven, additional, Prasad, Sanjay, additional, Mohiaddin, Raad, additional, Pennell, Dudley J., additional, Baksi, A. John, additional, Khattar, Rajdeep, additional, and Lyon, Alexander R., additional

Published
2024
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17. The United Kingdom’s First Cardio-Oncology Service

Author

Andres, Maria Sol, primary, Murphy, Theodore, additional, Poku, Nana, additional, Nazir, Muhummad Sohaib, additional, Ramalingam, Sivatharshini, additional, Baksi, John, additional, Jarman, Julian W.E., additional, Khattar, Rajdeep, additional, Sharma, Rakesh, additional, Rosen, Stuart D., additional, and Lyon, Alexander R., additional

Published
2024
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25. Predictors of outcome in a contemporary cardiac sarcoidosis population: Role of brain natriuretic peptide, left ventricular function and myocardial inflammation.

Author

Kouranos, Vasileios, Khattar, Rajdeep S., Okafor, Joseph, Ahmed, Raheel, Azzu, Alessia, Baksi, John Arun, Wechalekar, Kshama, Cowie, Martin R., Wells, Athol Umfrey, Lüscher, Thomas F., and Sharma, Rakesh

Subjects
*BRAIN natriuretic factor, *SARCOIDOSIS, *CARDIAC magnetic resonance imaging, *POSITRON emission tomography, *CARDIAC arrest, *HEART assist devices, *VENTRICULAR ejection fraction
Abstract

Aims: Cardiac sarcoidosis (CS) is a potentially fatal condition that varies in its clinical presentation. Here, we describe baseline characteristics at presentation along with prognosis and predictors of outcome in a sizable and deeply phenotyped contemporary cohort of CS patients. Methods and results: Consecutive CS patients seen at one institution were retrospectively enrolled after undergoing laboratory testing, electrocardiogram, echocardiography, cardiac magnetic resonance (CMR) imaging and 18F‐flourodeoxyglucose positron emission tomography (FDG‐PET) at baseline. The composite endpoint consisted of all‐cause mortality, aborted sudden cardiac death, major ventricular arrhythmic events, heart failure hospitalization and heart transplantation. A total of 319 CS patients were studied (67% male, 55.4 ± 12 years). During a median follow‐up of 2.2 years (range: 1 month–11 years), 8% of patients died, while 33% reached the composite endpoint. The annualized mortality rate was 2.7% and the 5‐ and 10‐year mortality rates were 6.2% and 7.5%, respectively. Multivariate analysis showed serum brain natriuretic peptide (BNP) levels (hazard ratio [HR] 2.41, 95% confidence interval [CI] 1.34–4.31, p = 0.003), CMR left ventricular ejection fraction (LVEF) (HR 0.96, 95% CI 0.94–0.98, p < 0.0001) and maximum standardized uptake value of FDG‐PET (HR 1.11, 95% CI 1.04–1.19, p = 0.001) to be independent predictors of outcome. These findings remained robust for different patient subgroups. Conclusion: Cardiac sarcoidosis is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Higher BNP levels, lower LVEF and more active myocardial inflammation were independent predictors of outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction: A Prespecified Secondary Analysis of the REVIVED-BCIS2 Trial.

Author

Perera, Divaka, Ryan, Matthew, Morgan, Holly P., Greenwood, John P., Petrie, Mark C., Dodd, Matthew, Weerackody, Roshan, O'Kane, Peter D., Masci, Pier Giorgio, Nazir, Muhummad Sohaib, Papachristidis, Alexandros, Chahal, Navtej, Khattar, Rajdeep, Ezad, Saad M., Kapetanakis, Stam, Dixon, Lana J., De Silva, Kalpa, McDiarmid, Adam K., Marber, Michael S., and McDonagh, Theresa

Published
2023
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28. Prognostic value of direct continuous ambulatory blood pressure monitoring in essential hypertension

Author

Khattar, Rajdeep Singh

Subjects
610, Medicine
Abstract

This study assessed the value of ambulatory versus clinic blood pressure measurement for the prediction of morbid events, and evaluated the long-term prediction of left ventricular mass and carotid artery structure in a sub-group of uncomplicated hypertensive patients. The study population consisted of 688 patients, 440 males and 248 females, with a baseline age of 51 ± 11 years who had undergone pretreatment 24 hour intra-arterial ambulatory blood pressure monitoring based on elevated clinic blood pressures. These patients were followed-up over a period of 9.2 ± 4.4 years and a total of 157 first events were recorded. Cox's proportional hazards analysis showed that the predictive value of a regression model containing age, gender, race, body mass index, smoking, diabetes mellitus, fasting cholesterol level and previous history of cardiovascular disease, was significantly improved by the addition of any one of the ambulatory systolic or diastolic blood pressure parameters (whether 24 hour mean, daytime mean or night-time mean) or ambulatory pulse pressure. The most predictive models contained the ambulatory systolic blood pressure parameters. In the model containing 24 hour mean ambulatory systolic blood pressure (p=0.001), age (p<0.001), male gender (p<0.001), South Asian origin (p=0.008), diabetes mellitus (p=0.05) and previous cardiovascular disease (p<0.001) were additional independent predictors of events. Whereas, 24 hour ambulatory systolic blood pressure was linearly related to the incidence of both coronary and cerebrovascular events, 24 hour ambulatory diastolic blood pressure exhibited a positive linear relationship with cerebrovascular events, but a curvilinear relationship with coronary events.

Published
1999

32. Predictors of outcome in a contemporary cardiac sarcoidosis population: Role of brain natriuretic peptide, left ventricular function and myocardial inflammation

Author

Kouranos, Vasileios; https://orcid.org/0000-0002-2723-0928, Khattar, Rajdeep S, Okafor, Joseph, Ahmed, Raheel, Azzu, Alessia, Baksi, John Arun, Wechalekar, Kshama, Cowie, Martin R, Wells, Athol Umfrey, Lüscher, Thomas F; https://orcid.org/0000-0002-5259-538X, Sharma, Rakesh, Kouranos, Vasileios; https://orcid.org/0000-0002-2723-0928, Khattar, Rajdeep S, Okafor, Joseph, Ahmed, Raheel, Azzu, Alessia, Baksi, John Arun, Wechalekar, Kshama, Cowie, Martin R, Wells, Athol Umfrey, Lüscher, Thomas F; https://orcid.org/0000-0002-5259-538X, and Sharma, Rakesh

Abstract

Aims Cardiac sarcoidosis (CS) is a potentially fatal condition that varies in its clinical presentation. Here, we describe baseline characteristics at presentation along with prognosis and predictors of outcome in a sizable and deeply phenotyped contemporary cohort of CS patients. Methods and results Consecutive CS patients seen at one institution were retrospectively enrolled after undergoing laboratory testing, electrocardiogram, echocardiography, cardiac magnetic resonance (CMR) imaging and $^{18}$F‐flourodeoxyglucose positron emission tomography (FDG‐PET) at baseline. The composite endpoint consisted of all‐cause mortality, aborted sudden cardiac death, major ventricular arrhythmic events, heart failure hospitalization and heart transplantation. A total of 319 CS patients were studied (67% male, 55.4 ± 12 years). During a median follow‐up of 2.2 years (range: 1 month–11 years), 8% of patients died, while 33% reached the composite endpoint. The annualized mortality rate was 2.7% and the 5‐ and 10‐year mortality rates were 6.2% and 7.5%, respectively. Multivariate analysis showed serum brain natriuretic peptide (BNP) levels (hazard ratio [HR] 2.41, 95% confidence interval [CI] 1.34–4.31, p = 0.003), CMR left ventricular ejection fraction (LVEF) (HR 0.96, 95% CI 0.94–0.98, p < 0.0001) and maximum standardized uptake value of FDG‐PET (HR 1.11, 95% CI 1.04–1.19, p = 0.001) to be independent predictors of outcome. These findings remained robust for different patient subgroups. Conclusion Cardiac sarcoidosis is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Higher BNP levels, lower LVEF and more active myocardial inflammation were independent predictors of outcomes.

Published
2023

34. Contributors

Author

Achenbach, Stephan, primary, Aragam, Krishna G., additional, Arnold, Suzanne V., additional, Bäck, Magnus, additional, Blaha, Michael J., additional, Blankenberg, Stefan, additional, Blumenthal, Roger S., additional, Camici, Paolo G., additional, Chung, Mina K., additional, Cigarroa, Joaquin E., additional, Crea, Filippo, additional, Davidson, Karina W., additional, De Schutter, Alban, additional, Di Carli, Marcelo F., additional, Douglas, Pamela S., additional, Ducrocq, Gregory, additional, Emdin, Connor A., additional, Emeruwa, Obi, additional, Enriquez, Jonathan R., additional, Fearon, William F., additional, Fordyce, Christopher B., additional, Gaziano, Thomas A., additional, Gersh, Bernard, additional, Gitsioudis, Gitsios, additional, Guo, Yuanlin, additional, Hachamovitch, Rory, additional, Hansson, Göran K., additional, Heinzman, Kristopher, additional, Henry, Timothy D., additional, Hussein, Ayman A., additional, Jensen, Jesper K., additional, Jolicoeur, E. Marc, additional, Kathiresan, Sekar, additional, Khattar, Rajdeep S., additional, Khera, Amit V., additional, Kosiborod, Mikhail, additional, Kwon, Lawrence, additional, Lavie, Carl J., additional, Lawlor, Matthew, additional, Marso, Steven P., additional, Martin, Seth S., additional, Marx, Nikolaus, additional, Mehta, Puja K., additional, Bairey Merz, C. Noel, additional, Michos, Erin D., additional, Milani, Richard V., additional, O’Donnell, Christopher J., additional, Opie, Lionel, additional, Parikh, Shailja V., additional, Prescott, Eva, additional, Reith, Sebastian, additional, Rimoldi, Ornella E., additional, Robinson, Jennifer G., additional, Rodgers, George, additional, Rohatgi, Anand, additional, Rosendorff, Clive, additional, Sahni, Sheila, additional, Sedehi, Daniel, additional, Senior, Roxy, additional, Steg, Philippe Gabriel, additional, Wasson, Lauren, additional, Watson, Karol E., additional, Wei, Janet, additional, Wilson, Peter W.F., additional, and Zeller, Tanja, additional

Published
2018
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37. P24 LVEF measured with same day echocardiography and CMR in patients with suspected cardiotoxicity

Author

Nazir, Muhummad Sohaib, primary, Okafor, Joseph, additional, Murphy, Theodore, additional, Andres, Maria Sol, additional, Ramalingham, Sivatharshini, additional, Rosen, Stuart D, additional, Chiribiri, Amedeo, additional, Plein, Sven, additional, Prasad, Sanjay, additional, Mohiaddin, Raad, additional, Pennell, Dudley J, additional, Khattar, Rajdeep, additional, John Baksi, A, additional, and Lyon, Alexander R, additional

Published
2022
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38. The spectrum of cardiovascular complications related to immune-checkpoint inhibitor treatment

Author

Andres, Maria Sol, primary, Ramalingam, Sivatharshini, additional, Rosen, Stuart D., additional, Baksi, John, additional, Khattar, Rajdeep, additional, Kirichenko, Yulia, additional, Young, Kate, additional, Yousaf, Nadia, additional, Okines, Alicia, additional, Huddart, Robert, additional, Harrington, Kevin, additional, Furness, Andrew, additional, Turajlic, Samra, additional, Pickering, Lisa, additional, Popat, Sanjay, additional, Larkin, James, additional, and Lyon, Alexander R., additional

Published
2022
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39. LB-469804-02 LONG-TERM OUTCOMES IN LONG STANDING PERSISTENT ATRIAL FIBRILLATION FOLLOWING CATHETER OR THORACOSCOPIC SURGICAL ABLATION USING CONTINUOUS MONITORING: 3-YEAR FOLLOW-UP OF THE CASA-AF RANDOMISED CONTROLLED TRIAL

Author

Boyalla, Vennela, Haldar, Shouvik, Khan, Habib, Kralj-Hans, Ines, Banya, Winston, Lord, Joanne, Gnanasekar, Anitha, Bahrami, Toufan, Desouza, Anthony, Clague, Jonathan, Francis, Darrel P., Hussain, Wajid, Jarman, Julian W., Jones, David G., Chen, Zhong, Mediratta, Neeraj, Hyde, Jonathan, Lewis, Michael, Mohiaddin, Raad, Salukhe, Tushar, Khattar, Rajdeep, Markides, Vias, McCready, James, Gupta, Dhiraj, and Wong, Tom

Published
2024
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42. MODE OF PRESENTATION, PROGNOSIS AND PREDICTORS OF OUTCOME IN A CONTEMPORARY CARDIAC SARCOIDOSIS POPULATION

Author

Kouranos, Vasileios, primary, Khattar, Rajdeep Singh, additional, Ahmed, Raheel, additional, Azzu, Alessia, additional, Okafor, Joseph, additional, Shi, Rui, additional, Baksi, Arun John, additional, Wechalekar, Kshama, additional, Cowie, Martin R., additional, Pennell, Dudley J., additional, Wells, Athol Umfrey, additional, and Sharma, Rakesh, additional

Published
2022
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43. LEFT VENTRICULAR EJECTION FRACTION MEASURED WITH SAME DAY 2D ECHOCARDIOGRAPHY AND CMR IN PATIENTS WITH SUSPECTED CARDIOTOXICITY

Author

Nazir, Muhummad Sohaib, primary, Andres, Maria Sol, additional, Sivatharshini Ramalingham, Theodore Murphy, additional, Baurah, Resham, additional, Rosen, Stuart D., additional, Chiribiri, Amedeo, additional, Plein, Sven, additional, Prasad, Sanjay, additional, Mohiaddin, Raad, additional, Khattar, Rajdeep, additional, Baksi, A John, additional, and Lyon, Alexander, additional

Published
2022
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46. Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCT

Author

Haldar, Shouvik, primary, Khan, Habib R, additional, Boyalla, Vennela, additional, Kralj-Hans, Ines, additional, Jones, Simon, additional, Lord, Joanne, additional, Onyimadu, Oluchukwu, additional, Sathishkumar, Anitha, additional, Bahrami, Toufan, additional, Clague, Jonathan, additional, De Souza, Anthony, additional, Francis, Darrel, additional, Hussain, Wajid, additional, Jarman, Julian, additional, Jones, David G, additional, Chen, Zhong, additional, Mediratta, Neeraj, additional, Hyde, Jonathan, additional, Lewis, Michael, additional, Mohiaddin, Raad, additional, Salukhe, Tushar, additional, Murphy, Caroline, additional, Kelly, Joanna, additional, Khattar, Rajdeep, additional, Toff, William D, additional, Markides, Vias, additional, McCready, James, additional, Gupta, Dhiraj, additional, and Wong, Tom, additional

Published
2021
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