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2. Safety, efficacy, and reliability evaluation ofa novel small-diameter defibrillation lead: Global LEADR pivotal trial results

Author

Sanders, Prashanthan, Pathak, Rajeev, Denman, Russell Allen, Mihalcz, Attila, Philippon, Francois, Tsang, Bernice, Sumner, Glenn, Chen, Minglong, Han, Xiuebin, Liu, Xingbin, Philbert, Berit Thornvig, Defaye, Pascal, Anselme, Frederic, Stellbrink, Christoph, Chan, Ngai-Yin, Tse, Hung-Fat, De Filippo, Paolo, Ando, Kenji, Kusano, Kengo, Shoda, Morio, Khelae, Surinder Kaur, Lopes do Carmo, Pedro Miguel, Milasinovic, Goran, Boey, Elaine, Anguera Camos, Ignasi, Cano Pérez, Oscar, Whinnett, Zachary, Baranowski, Bryan, Friedman, Meir, Dinerman, Jay, Schaller, Robert, Bozorgnia, Babak, Zakaib, John, Chinitz, Jason, West, Michael, Ramza, Brian, Canby, Robert, Takata, Theodore, Shah, Maully, Winner, Marshall, Wilson, David, Mason, Pamela, Richardson, Travis, Kalahasty, Gautham, Sholevar, Darius, Smith, Timothy, Crossley, George H., III, Hansky, Bert, Shah, Maully J., Richardson, Travis D., Philippon, François, Zakaib, John S., Sholevar, Darius P., Pathak, Rajeev K., Milašinović, Goran, Chinitz, Jason S., West, Michael B., Ramza, Brian M., Han, Xuebin, Carta, Roberto, Geelen, Tessa, Himes, Adam K., Platner, Megan L., Thompson, Amy E., and Mason, Pamela K.

Published
2024
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4. Predictors of atrial mechanical sensing and atrioventricular synchrony with a leadless ventricular pacemaker: Results from the MARVEL 2 Study

Author

Garweg, Christophe, Khelae, Surinder Kaur, Steinwender, Clemens, Chan, Joseph Yat Sun, Ritter, Philippe, Johansen, Jens Brock, Sagi, Venkata, Epstein, Laurence M., Piccini, Jonathan P., Pascual, Mario, Mont, Lluis, Willems, Rik, Sheldon, Todd, Splett, Vincent, Stromberg, Kurt, Wood, Nicole, and Chinitz, Larry

Published
2020
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5. The World-wide Randomized Antibiotic Envelope Infection Prevention (WRAP-IT) trial: Long-term follow-up

Author

Mittal, Suneet, Wilkoff, Bruce L., Kennergren, Charles, Poole, Jeanne E., Corey, Ralph, Bracke, Frank A., Curnis, Antonio, Addo, Kamel, Martinez-Arraras, Joaquin, Issa, Ziad F., Redpath, Calum, Moubarak, Jean, Khelae, Surinder Kaur, Boersma, Lucas V.A., Korantzopoulos, Panagiotis, Krueger, Jo, Lande, Jeff D., Morss, Gina M., Seshadri, Swathi, and Tarakji, Khaldoun G.

Published
2020
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6. Accelerometer-based atrioventricular synchronous pacing with a ventricular leadless pacemaker: Results from the Micra atrioventricular feasibility studies

Author

Chinitz, Larry, Ritter, Philippe, Khelae, Surinder Kaur, Iacopino, Saverio, Garweg, Christophe, Grazia-Bongiorni, Maria, Neuzil, Petr, Johansen, Jens Brock, Mont, Lluis, Gonzalez, Efrain, Sagi, Venkata, Duray, Gabor Z., Clementy, Nicolas, Sheldon, Todd, Splett, Vincent, Stromberg, Kurt, Wood, Nicole, and Steinwender, Clemens

Published
2018
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7. Practical considerations, indications, and future perspectives for leadless and extravascular cardiac implantable electronic devices: a position paper by EHRA/HRS/LAHRS/APHRS

Author

Boersma, Lucas V, primary, El-Chami, Mikhael, additional, Steinwender, Clemens, additional, Lambiase, Pier, additional, Murgatroyd, Francis, additional, Mela, Theofania, additional, Theuns, Dominic A M J, additional, Khelae, Surinder Kaur, additional, Kalil, Carlos, additional, Zabala, Federico, additional, Stuehlinger, Markus, additional, Lenarczyk, Radoslaw, additional, Clementy, Nicolas, additional, Tamirisa, Kamala P, additional, Rinaldi, Christopher A, additional, Knops, Reinoud, additional, Lau, Chu Pak, additional, Crozier, Ian, additional, Boveda, Serge, additional, Defaye, Pascal, additional, Deharo, Jean Claude, additional, Botto, Giovanni Luca, additional, Vassilikos, Vassilios, additional, Oliveira, Mario Martins, additional, Tse, Hung Fat, additional, Figueroa, Jorge, additional, Stambler, Bruce S, additional, Guerra, Jose M, additional, Stiles, Martin, additional, and Marques, Manlio, additional

Published
2022
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11. B-PO02-040 CORRELATION BETWEEN AV SYNCHRONY AND DEVICE COLLECTED AM-VP SEQUENCE COUNTER IN A LEADLESS VENTRICULAR PACING USING ACCELEROMETER BASED ATRIAL SENSING

Author

Garweg, Christophe, primary, Chinitz, Larry A., additional, Khelae, Surinder Kaur, additional, Sun Chan, Joseph Yat, additional, Ritter, Philippe, additional, Johansen, Jens Brock, additional, Sagi, Venkata, additional, Epstein, Laurence M., additional, Piccini, Jonathan P., additional, Pascual, Mario I., additional, Mont, Lluis, additional, Sheldon, Todd J., additional, Stromberg, Kurt, additional, Fagan, Dedra H., additional, and Steinwender, Clemens, additional

Published
2021
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13. Behavior of AV synchrony pacing mode in a leadless pacemaker during variable AV conduction and arrhythmias

Author

Garweg, Christophe, primary, Khelae, Surinder Kaur, additional, Chan, Joseph Yat Sun, additional, Chinitz, Larry, additional, Ritter, Philippe, additional, Johansen, Jens Brock, additional, Sagi, Venkata, additional, Epstein, Laurence M., additional, Piccini, Jonathan P., additional, Pascual, Mario, additional, Mont, Lluis, additional, Willems, Rik, additional, Splett, Vincent, additional, Stromberg, Kurt, additional, Sheldon, Todd, additional, Kristiansen, Nina, additional, and Steinwender, Clemens, additional

Published
2021
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14. Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia

Author

Teng, Tiew-Hwa K., primary, Tay, Wan Ting, additional, Richards, Arthur Mark, additional, Chew, Timothy Shi Ming, additional, Anand, Inder, additional, Ouwerkerk, Wouter, additional, Chandramouli, Chanchal, additional, Huang, Weiting, additional, Lawson, Claire A., additional, Kadam, Umesh T., additional, Yap, Jonathan, additional, Lim, Shirlynn, additional, Hung, Chung-Lieh, additional, MacDonald, Michael Ross, additional, Loh, Seet Yoong, additional, Shimizu, Wataru, additional, Tromp, Jasper, additional, Lam, Carolyn Su Ping, additional, Ling, Lieng Hsi, additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Ngarmukos, Tachapong, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Siswanto, Bambang B., additional, Zhang, Shu, additional, Fan, Xiaohan, additional, Chen, Keping, additional, Wu, Liqun, additional, Xie, Yucai, additional, Jin, Qi, additional, Ling, Tianyou, additional, Li, Xinli, additional, Zhou, Fang, additional, Zhou, Yanli, additional, Xu, Dongjie, additional, Zhang, Haifeng, additional, Su, Yangang, additional, Chen, Xueying, additional, Qin, Shengmei, additional, Wang, Jingfeng, additional, Gong, Xue, additional, Wu, Zhaodi, additional, Yu, Cheuk Man, additional, Sastry, B K S, additional, Gopi, Arun, additional, Raghu, K, additional, Sridevi, C, additional, Kaur, Daljeet, additional, Naik, Ajay, additional, Parikh, Keyur, additional, Chandarana, Anish, additional, Shah, Urmil, additional, Chag, Milan, additional, Baxi, Hemang, additional, Gupta, Satya, additional, Bhatia, Jyoti, additional, Khakhkhar, Vaishali, additional, Sankhla, Vineet, additional, Patel, Tejas, additional, Kapoor, Vipul, additional, Wander, Gurpreet Singh, additional, Tandon, Rohit, additional, Chopra, Vijay, additional, Kumar, Manoj, additional, Singh Sethi, Hatinder Jeet, additional, Verma, Rashmi, additional, Mittal, Sanjay, additional, Sawhney, Jitendra, additional, Sharma, Manish Kr., additional, Purayil, Mohanan Padinhare, additional, Siswanto, Bambang Budi, additional, Sadikin, RS Dr Hasan, additional, Tedjokusumo, Pintoko, additional, Martanto, Erwan, additional, Munawar, Muhammad, additional, Pambudi, Jimmy Agung, additional, Karawaci, RS Siloam, additional, Lukito, Antonia, additional, Pardede, Ingrid, additional, Thengker, Alvin, additional, Damay, Vito, additional, Danny, Siska Suridanda, additional, Surarso, Rarsari, additional, Noda, Takashi, additional, Nakajima, Ikutaro, additional, Wada, Mitsuru, additional, Ishibashi, Kohei, additional, Kurita, Takashi, additional, Yasuoka, Ryoubun, additional, Asai, Kuniya, additional, Murai, Kohji, additional, Kubota, Yoshiaki, additional, Izumi, Yuki, additional, Ikeda, Takanori, additional, Hisatake, Shinji, additional, Kabuki, Takayuki, additional, Kiuchi, Shunsuke, additional, Hagiwara, Nobuhisa, additional, Suzuki, Atsushi, additional, Suzuki, Dr Tsuyoshi, additional, Park, Sang-Weon, additional, Hong, Suk Keun, additional, Lee, SookJin, additional, Soo, Lim Dal, additional, Kim, Dong-Hyeok, additional, Shim, Jaemin, additional, Park, Seong-Mi, additional, Roh, Seung-Young, additional, Kim, Young Hoon, additional, Kim, Mina, additional, Choi, Jong-Il, additional, Na, Jin Oh, additional, Rha, Seung Woon, additional, Seo, Hong Seog, additional, Oh, Dong Joo, additional, Park, Chang Gyu, additional, Kim, Eung Ju, additional, Lee, Sunki, additional, Joung, Boyoung, additional, Uhm, Jae-Sun, additional, Lee, Moon Hyoung, additional, Cho, In-Jeong, additional, Park, Hui-Nam, additional, Park, Hyung-Wook, additional, Cho, Jeong-Gwan, additional, Yoon, Namsik, additional, Lee, KiHong, additional, Kim, Kye Hun, additional, Kim, Seong Hwan, additional, Saharudin, Sahrin, additional, Beh, Boon Cong, additional, Lee, Yu Wei, additional, Yen, Chia How, additional, Othman, Mohd Khairi, additional, Augustine, Amie-Anne, additional, Mohd Asnawi, Mohd Hariz, additional, Mojolou, Roberto Angelo, additional, Tan, You Zhuan, additional, Arbain, Aida Nurbaini, additional, Wong, Chii Koh, additional, Omar, Razali, additional, Ghazi, Azmee Mohd, additional, Khelae, Surinder Kaur, additional, Chew, David S.P., additional, Yap, Lok Bin, additional, Hussin, Azlan, additional, Muhammad, Zulkeflee, additional, Azmee, Mohd. Ghazi, additional, Abidin, Imran Zainal, additional, Mahmood Zhudi, Ahmad Syadi Bin, additional, Md Sari, Nor Ashikin, additional, Sridhar, Ganiga Srinivasaiah, additional, Mahmood Zuhdi, Ahmad Syadi, additional, Ismail, Muhammad Dzafir, additional, Ong, Tiong Kiam, additional, Cham, Yee Ling, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Yip Fong, Alan Yean, additional, Mohd Amin, Nor Hanim, additional, Seng, Keong Chua, additional, Tan, Sian Kong, additional, Yew, Kuan Leong, additional, Santos, Jones, additional, Lim, Allan, additional, Lapitan, Raul, additional, Andal, Ryan, additional, Lopez, Eleanor, additional, David Sim, Kheng Leng, additional, Tan, Boon Yew, additional, Lim, Choon Pin, additional, Teo, Louis L.Y., additional, Chan, Laura L.H., additional, Chai, Ping, additional, Raymond Wong, Ching Chiew, additional, Poh, Kian Keong, additional, Daniel Yeo, Poh Shuan, additional, Lee, Evelyn M., additional, Ching, Min Er, additional, Khoo, Deanna Z.L., additional, Yew, Min Sen, additional, Huang, Wenjie, additional, Gerard Leong, Kui Toh, additional, Jason See, Jia Hao, additional, Lim, Yaozong Benji, additional, Tan, Svenszeat, additional, Yeo, Colin, additional, Chai, Siang Chew, additional, Jaufeerally, Fazlur Rehman, additional, Tulsidas, Haresh, additional, Aung, Than, additional, Ong, Hean Yee, additional, Ling, Lee Fong, additional, Soon, Dinna Kar Nee, additional, Yeh, Hung-I, additional, Kuo, Jen-Yuan, additional, Yen, Chih-Hsuan, additional, Hwang, Juey-Jen, additional, Chien, Kuo-Liong, additional, Su, Ta-Chen, additional, Lin, Lian-Yu, additional, Juang, Jyh-Ming, additional, Lin, Yen-Hung, additional, Chiang, Fu-Tien, additional, Lin, Jiunn-Lee, additional, Ho, Yi-Lwun, additional, Lee, Chii-Ming, additional, Lin, Po-Chih, additional, Hung, Chi-Sheng, additional, Chang, Sheng-Nan, additional, Lin, Jou-Wei, additional, Hsu, Chih-Neng, additional, Yu, Wen-Chung, additional, Chao, Tze-Fan, additional, Sung, Shih-Hsien, additional, Wang, Kang-Ling, additional, Leu, Hsin-Bang, additional, Lin, Yenn-Jiang, additional, Chang, Shih-Lin, additional, Huang, Po-Hsun, additional, Lo, Li-Wei, additional, Wu, Cheng-Hsueh, additional, Liang, Hsin-Yueh, additional, Chang, Shih-Sheng, additional, Hsiao, Lien-Cheng, additional, Wang, Yu-Chen, additional, Lu, Chiung-Ray, additional, Wu, Hung-Pin, additional, Lin, Yen-Nien, additional, Chen, Ke-Wei, additional, Lo, Ping-Han, additional, Hsu, Chung-Ho, additional, Hsieh, Li-Chuan, additional, Chandavimol, Mann, additional, Yingchoncharoen, Teerapat, additional, Laothavorn, Prasart, additional, Tiyanon, Waraporn, additional, Wongcharoen, Wanwarang, additional, and Phrommintikul, Arintaya, additional

Published
2021
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17. Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker:Results From the MARVEL 2 Study

Author

Steinwender, Clemens, Khelae, Surinder Kaur, Garweg, Christophe, Chan, Joseph Yat Sun, Ritter, Philippe, Johansen, Jens Brock, Sagi, Venkata, Epstein, Laurence M, Piccini, Jonathan P, Pascual, Mario, Mont, Lluis, Sheldon, Todd, Splett, Vincent, Stromberg, Kurt, Wood, Nicole, and Chinitz, Larry

Subjects
Science & Technology, Cardiac & Cardiovascular Systems, AV block, ATRIAL, Cardiovascular System & Cardiology, cardiovascular diseases, atrioventricular synchrony, Life Sciences & Biomedicine, leadless pacemaker, TERM-FOLLOW-UP
Abstract

OBJECTIVES: This study reports on the performance of a leadless ventricular pacemaker with automated, enhanced accelerometer-based algorithms that provide atrioventricular (AV) synchronous pacing. BACKGROUND: Despite many advantages, leadless pacemakers are currently only capable of single-chamber ventricular pacing. METHODS: The prospective MARVEL 2 (Micra Atrial tRacking using a Ventricular accELerometer 2) study assessed the performance of an automated, enhanced accelerometer-based algorithm downloaded to the Micra leadless pacemaker for up to 5 h in patients with AV block. The primary efficacy objective was to demonstrate the superiority of the algorithm to provide AV synchronous (VDD) pacing versus VVI-50 pacing in patients with sinus rhythm and complete AV block. The primary safety objective was to demonstrate that the algorithm did not result in pauses or heart rates of >100 beats/min. RESULTS: Overall, 75 patients from 12 centers were enrolled; an accelerometer-based algorithm was downloaded to their leadless pacemakers. Among the 40 patients with sinus rhythm and complete AV block included in the primary efficacy objective analysis, the proportion of patients with ≥70% AV synchrony at rest was significantly greater with VDD pacing than with VVI pacing (95% vs. 0%; p

Published
2020
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19. Cryoballoon Ablation for the Treatment of Atrial Fibrillation in Patients With Concomitant Heart Failure and Either Reduced or Preserved Left Ventricular Ejection Fraction: Results From the Cryo AF Global Registry.

Author

Rordorf, Roberto, Scazzuso, Fernando, Chun, Kyoung Ryul Julian, Khelae, Surinder Kaur, Kueffer, Fred J., Braegelmann, Kendra M., Ken Okumura, Al-Kandari, Fawzia, Young Keun On, Földesi, Csaba, Okumura, Ken, On, Young Keun, and Cryo AF Global Registry Investigators

Published
2021
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20. Regional Variation of Mortality in Heart Failure With Reduced and Preserved Ejection Fraction Across Asia: Outcomes in the ASIAN‐HF Registry

Author

MacDonald, Michael R., primary, Tay, Wan Ting, additional, Teng, Tiew‐Hwa Katherine, additional, Anand, Inder, additional, Ling, Lieng Hsi, additional, Yap, Jonathan, additional, Tromp, Jasper, additional, Wander, Gurpreet S., additional, Naik, Ajay, additional, Ngarmukos, Tachapong, additional, Siswanto, Bambang B., additional, Hung, Chung‐Lieh, additional, Richards, A. Mark, additional, Lam, Carolyn S. P., additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Shimizu, Wataru, additional, Zhang, Shu, additional, Wu, Liqun, additional, Ling, Tianyou, additional, Li, Xinli, additional, Zhang, Haifeng, additional, Su, Yangang, additional, Yu, Cheuk Man, additional, Sastry, B K S, additional, Gopi, Arun, additional, Raghu, K, additional, Sridevi, C, additional, Kaur, Daljeet, additional, Parikh, Keyur, additional, Chandarana, Anish, additional, Shah, Urmil, additional, Chag, Milan, additional, Baxi, Hemang, additional, Gupta, Satya, additional, Bhatia, Jyoti, additional, Khakhkhar, Vaishali, additional, Sankhla, Vineet, additional, Patel, Tejas, additional, Kapoor, Vipul, additional, Tandon, Rohit, additional, Chopra, Vijay, additional, Kumar, Manoj, additional, Sethi, Hatinder Jeet Singh, additional, Verma, Rashmi, additional, Sawhney, Jitendra, additional, Sharma, Manish Kr., additional, Purayil, Mohanan Padinhare, additional, Munawar, Muhammad, additional, Pambudi, Jimmy Agung, additional, Lukito, Antonia, additional, Pardede, Ingrid, additional, Thengker, Alvin, additional, Damay, Vito, additional, Danny, Siska Suridanda, additional, Surarso, Rarsari, additional, Yasuoka, Ryoubun, additional, Asai, Kuniya, additional, Ikeda, Takanori, additional, Park, Sang‐Weon, additional, Hong, Suk Keun, additional, Lee, SookJin, additional, Soo, Lim Dal, additional, Kim, Dong‐Hyeok, additional, Shim, Jaemin, additional, Park, Seong‐Mi, additional, Roh, Seung‐Young, additional, Kim, Young Hoon, additional, Kim, Mina, additional, Choi, Jong‐Il, additional, Na, Jin Oh, additional, Rha, Seung Woon, additional, Seo, Hong Seog, additional, Oh, Dong Joo, additional, Park, Chang Gyu, additional, Kim, Eung Ju, additional, Lee, Sunki, additional, Joung, Boyoung, additional, Uhm, Jae‐Sun, additional, Lee, Moon Hyoung, additional, Cho, In‐Jeong, additional, Park, Hui‐Nam, additional, Park, Hyung‐Wook, additional, Cho, Jeong‐Gwan, additional, Yoon, Namsik, additional, Lee, KiHong, additional, Kim, Kye Hun, additional, Kim, Seong Hwan, additional, Saharudin, Sahrin, additional, Beh, Boon Cong, additional, Lee, Yu Wei, additional, Yen, Chia How, additional, Othman, Mohd Khairi, additional, Augustine, Amie‐Anne, additional, Asnawi, Mohd Hariz Mohd, additional, Mojolou, Roberto Angelo, additional, Tan, You Zhuan, additional, Arbain, Aida Nurbaini, additional, Wong, Chii Koh, additional, Ghazi, Azmee Mohd, additional, Khelae, Surinder Kaur, additional, Chew, David S.P., additional, Yap, Lok Bin, additional, Hussin, Azlan, additional, Muhammad, Zulkeflee, additional, Abidin, Imran Zainal, additional, Zhudi, Ahmad Syadi Bin Mahmood, additional, Sari, Nor Ashikin Md, additional, Sridhar, Ganiga Srinivasaiah, additional, Zuhdi, Ahmad Syadi Mahmood, additional, Ismail, Muhammad Dzafir, additional, Ong, Tiong Kiam, additional, Cham, Yee Ling, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Fong, Alan Yean Yip, additional, Amin, Nor Hanim Mohd, additional, Seng, Keong Chua, additional, Tan, Sian Kong, additional, Yew, Kuan Leong, additional, Santos, Jones, additional, Lim, Allan, additional, Lapitan, Raul, additional, Andal, Ryan, additional, Lopez, Eleanor, additional, Sim, Kheng Leng David, additional, Tan, Boon Yew, additional, Lim, Choon Pin, additional, Teo, Louis L.Y., additional, Chan, Laura L. H., additional, Chai, Ping, additional, Wong, Ching Chiew Raymond, additional, Poh, Kian Keong, additional, Yeo, Poh Shuan Daniel, additional, Lee, Evelyn M., additional, Loh, Seet Yong, additional, Ching, Min Er, additional, Khoo, Deanna Z.L., additional, Yew, Min Sen, additional, Huang, Wenjie, additional, See, Jia Hao Jason, additional, Lim, Yaozong Benji, additional, Tan, Svenszeat, additional, Yeo, Colin, additional, Chai, Siang Chew, additional, Jaufeerally, Fazlur Rehman, additional, Tulsidas, Haresh, additional, Aung, Than, additional, Ong, Hean Yee, additional, Ling, Lee Fong, additional, Soon, Dinna Kar Nee, additional, Yeh, Hung‐I, additional, Kuo, Jen‐Yuan, additional, Yen, Chih‐Hsuan, additional, Hwang, Juey‐Jen, additional, Chien, Kuo‐Liong, additional, Su, Ta‐Chen, additional, Lin, Lian‐Yu, additional, Juang, Jyh‐Ming, additional, Lin, Yen‐Hung, additional, Chiang, Fu‐Tien, additional, Lin, Jiunn‐Lee, additional, Ho, Yi‐Lwun, additional, Lee, Chii‐Ming, additional, Lin, Po‐Chih, additional, Hung, Chi‐Sheng, additional, Chang, Sheng‐Nan, additional, Lin, Jou‐Wei, additional, Hsu, Chih‐Neng, additional, Yu, Wen‐Chung, additional, Chao, Tze‐Fan, additional, Sung, Shih‐Hsien, additional, Wang, Kang‐Ling, additional, Leu, Hsin‐Bang, additional, Lin, Yenn‐Jiang, additional, Chang, Shih‐Lin, additional, Huang, Po‐Hsun, additional, Lo, Li‐Wei, additional, Wu, Cheng‐Hsueh, additional, Liang, Hsin‐Yueh, additional, Chang, Shih‐Sheng, additional, Hsiao, Lien‐Cheng, additional, Wang, Yu‐Chen, additional, Lu, Chiung‐Ray, additional, Wu, Hung‐Pin, additional, Lin, Yen‐Nien, additional, Chen, Ke‐Wei, additional, Lo, Ping‐Han, additional, Hsu, Chung‐Ho, additional, Hsieh, Li‐Chuan, additional, Chandavimol, Mann, additional, Yingchoncharoen, Teerapat, additional, Laothavorn, Prasart, additional, Wongcharoen, Wanwarang, additional, and Phrommintikul, Arintaya, additional

Published
2020
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21. Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker

Author

Steinwender, Clemens, primary, Khelae, Surinder Kaur, additional, Garweg, Christophe, additional, Chan, Joseph Yat Sun, additional, Ritter, Philippe, additional, Johansen, Jens Brock, additional, Sagi, Venkata, additional, Epstein, Laurence M., additional, Piccini, Jonathan P., additional, Pascual, Mario, additional, Mont, Lluis, additional, Sheldon, Todd, additional, Splett, Vincent, additional, Stromberg, Kurt, additional, Wood, Nicole, additional, and Chinitz, Larry, additional

Published
2020
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22. Beta-blocker use and risk of symptomatic bradyarrhythmias: a hospital-based case-control study

Author

Lu, Hou Tee, Kam, Jiyen, Nordin, Rusli Bin, Khelae, Surinder Kaur, Wang, Jing Mein, Choy, Chun Ngok, and Lee, Chuey Yan

Subjects
Bradyarrhythmias, Adverse drug reaction, Beta-blocker, Case-control, Research Article
Abstract

Objective To investigate the risk factors of symptomatic bradyarrhythmias in relation to β-blockers use. Methods A hospital-based case-control study [228 patients: 108 with symptomatic bradyarrhythmias (cases) and 120 controls] was conducted in Sultanah Aminah Hospital, Malaysia between January 2011 and January 2014. Results The mean age was 61.1 ± 13.3 years with a majority of men (68.9%). Cases were likely than control to be older, hypertensive, lower body mass index and concomitant use of rate-controlling drugs (such as digoxin, verapamil, diltiazem, ivabradine or amiodarone). Significantly higher level of serum potassium, urea, creatinine and lower level of estimated glomerular filtration rate (eGFR) were observed among cases as compared to controls. On univariate analysis among patients on β-blockers, older age (crude OR: 1.07; 95% CI: 1.03–1.11, P = 0.000), hypertension (crude OR: 5.6; 95% CI: 1.51–20.72, P = 0.010), lower sodium (crude OR: 0.04; 95% CI: 0.81–0.99, P = 0.036), higher potassium (crude OR: 2.36; 95% CI: 1.31–4.26, P = 0.004) and higher urea (crude OR: 1.23; 95% CI: 1.11–1.38, P = 0.000) were associated with increased risk of symptomatic bradyarrhythmias; eGFR was inversely and significantly associated with symptomatic bradyarrhythmias in both ‘β-blockers’ (crude OR: 0.97; 95% CI: 0.96–0.98, P = 0.000) and ‘non-β-blockers’ (crude OR: 0.99; 95% CI: 0.97–0.99, P = 0.023) arms. However, eGFR was not significantly associated with symptomatic bradyarrhythmias in the final model of both ‘β-blockers’ (adjusted OR: 0.98; 95% CI: 0.96–0.98, P = 0.103) and ‘non-β-blockers’ (adjusted OR: 0.99; 95% CI: 0.97–1.01, P = 0.328) arms. Importantly, older age was a significant predictor of symptomatic bradyarrhythmias in the ‘β-blockers’ as compared to the ‘non-β-blockers’ arms (adjusted OR: 1.09; 95% CI: 1.03–1.15, P = 0.003 vs. adjusted OR: 1.03; 95% CI: 0.98–1.09, P = 0.232, respectively). Conclusion Older age was a significant predictor of symptomatic bradyarrhythmias in patients on β-blockers than those without β-blockers.

Published
2016

23. Abstract 10580: Health Care Utilization After First-Line Cryoablation for Atrial Fibrillation

Author

Zucchelli, Giulio, Chun, Julian K, Khelae, Surinder Kaur, Földesi, Csaba, Kueffer, Fred, van Bragt, Kelly, Scazzuso, Fernando, On, Young-Keun, Al-Kandari, Fawzia, and Okumura, Ken

Abstract

Background:Cryoablation is superior to antiarrhythmic drugs (AAD) for the prevention of arrhythmia recurrence in drug naïve (first-line) patients with paroxysmal atrial fibrillation (AF). The adoption and outcomes of first-line cryoablation in a real-world setting are unknown.Purpose:To describe global usage, safety, efficacy, and healthcare utilization outcomes in patients treated with cryoablation for first-line management of AF.Methods:Cryo Global Registry (NCT02752737) is an ongoing, prospective, multicenter registry. AF patients with an index cryoballoon ablation performed according to local standards of care at 58 centers in 26 global countries were included. Subjects undergoing first-line cryoablation were compared to patients with prior failed AAD usage and/or taking AADs at baseline. Serious procedure-related complication rates, 12-month freedom from a ≥30sec AF/atrial flutter (AFL)/atrial tachycardia (AT) recurrence after a 90-day blanking period, and healthcare utilization were compared.Results:Of 1,394 total patients, 433 (31.1%) were treated with first-line cryoablation. The proportion of first-line enrollments varied widely by world region and country. AAD-refractory patients failed a mean of 1.2 ± 0.5 AADs prior to cryoablation. Freedom from AF/AFL/AT after cryoablation in first-line and AAD-refractory was 90.0% (95% CI: 86.4-92.7%) vs 84.4% (95% CI: 81.5-86.8%) in paroxysmal AF and 72.9% (95% CI: 58.6-83.0%) vs 70.2% (95% CI: 62.9-76.4%) in persistent AF (overall p=0.02), respectively. Serious adverse event rates were not statistically different between first-line and AAD-refractory patients (2.3% vs 3.4%; p=0.32), with highest rates being groin-site complications (0.7% vs 0.5%), respectively. Freedom from repeat ablations in first-line vs AAD-refractory was 95.5% (95% CI: 92.7 - 97.2%) vs 93.1% (95% CI: 91.0 - 94.7%) in paroxysmal AF and 84.7% (95% CI: 71.8 - 92.1%) vs 88.2% (95% CI: 82.5 - 92.2%) in persistent AF (overall p=0.35), respectively.Conclusion:The current data support cryoablation as an early intervention strategy for treatment of patients with AF.

Published
2021
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24. Practical considerations, indications, and future perspectives for leadless and extravascular cardiac implantable electronic devices: a position paper by EHRA/HRS/LAHRS/APHRS.

Author

Boersma LV, El-Chami M, Steinwender C, Lambiase P, Murgatroyd F, Mela T, Theuns DAMJ, Khelae SK, Kalil C, Zabala F, Stuehlinger M, Lenarczyk R, Clementy N, Tamirisa KP, Rinaldi CA, Knops R, Lau CP, Crozier I, Boveda S, Defaye P, Deharo JC, Botto GL, Vassilikos V, Oliveira MM, Tse HF, Figueroa J, Stambler BS, Guerra JM, Stiles M, and Marques M

Subjects
Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac therapy, Electronics, Heart, Humans, Defibrillators, Implantable
Abstract

Competing Interests: Conflict of interest: The authors have provided declaration of interest information for all relationships that might be perceived as real or potential sources of conflicts of interest. The full disclosures can be viewed in the supplementary material for this article, available online at http://academic.oup.com/europace/article-lookup/doi/10.1093/europace/euac066#supplementary-data.

Published
2022
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