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Your search keyword '"Khoury, Richard G."' showing total 49 results
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49 results on '"Khoury, Richard G."'

1. Dynamic devices. Shape switching and substrate binding in ion-controlled nanomechanical molecular tweezers

Author

Petitjean, Anne, Khoury, Richard G., Kyritsakas, Nathalie, and Lehn, Jean-Marie

Subjects
Allosteric proteins -- Chemical properties, Switches -- Research, Chemistry
Abstract

Two molecular conformational switches are described, which display cation-controlled nanomechanical motion coupled to substrate binding and release. The systems represent effector-triggered supramolecular switching devices leading toward multistate nanomechanical chemical systems and illustrate the use of simple conformational switches in the binding site and allosteric regulation of substrate affinity.

Published
2004

2. Synthesis and functionalization of meso-aryl-substituted corroles

Author

Paolesse, Roberto, Nardis, Sara, Sagone, Francesco, and Khoury, Richard G.

Subjects
Porphyrins -- Research, Condensation products (Chemistry) -- Analysis, Organic compounds -- Synthesis, Structure-activity relationships (Biochemistry) -- Analysis, Biological sciences, Chemistry
Abstract

Research examines the Rothemund synthesis of corroles via pyrrole and aldehydes and functionalization of the macrocycle through bromination. The condensation reaction of pyrrole and aldehydes, in the presence of an excess of pyrrole, leads to the formation of meso-triaryl-substituted corroles. Characterization of the brominated triarylcorrole is discussed.

Published
2001

3. Interconversion of single and double helices formed from synthetic molecular strands

Author

Berl, Volker, Huc, Ivan, Khoury, Richard G., Krische, Michael J., and Lehn, Jean-Marie

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Volker Berl [1, 2]; Ivan Huc (corresponding author) [3, 1]; Richard G. Khoury [1]; Michael J. Krische [1, 4]; Jean-Marie Lehn (corresponding author) [1] Synthetic single-helical conformations are quite [...]

Published
2000
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4. Metal dependence of the contributions of low-frequency normal coordinates to the sterically induced distortions of meso-dialkyl-substituted porphyrins

Author

Song, Xing-Zhi, Jaquinod, Laurent, Jentzen, Walter, Nurco, Daniel J., Jia, Song-Ling, Khoury, Richard G., Ma, Jian-Guo, Medforth, Craig J., Smith, Kevin M., and Shelnutt, John A.

Subjects
Porphyrins -- Research, Conformational analysis -- Research, Coordination compounds -- Research, Crystals -- Structure, Chemistry
Abstract

Research was conducted to study the influence of central metals of various sizes on the macrocyclic structure of a series of 5,15-disubstituted metallophorphyrins. Methodologies used included X-ray crystallography, resonance Raman spectroscopy and molecular mechanics. The contributions of the ruf and dom deformations in the crystal structures of several metal complexes of the phorphyrins were found to be metal-dependent. Results indicate the quantitative validity of normal-coordinate structural decomposition.

Published
1998

5. A novel synthetic route to sapphyrins

Author

Paolesse, Robert, Licoccia, Silvia, Spagnoli, Mariangela, Boschi, Tristano, Khoury, Richard G., and Smith, Kevin M.

Subjects
Porphyrins -- Analysis, Cyclic compounds -- Analysis, Biological sciences, Chemistry
Abstract

A novel methodology of synthesizing pentapyrrolic expanded porphyrins, sapphyrins, was developed. The approach was characterized by acid-catalyzed condensation of 1,19-diunsubstituted a,c-biladienes and 3,4-dialkylpyrrole-2-carbaldehydes which eliminated the preparation of bipyrrolic intermediates. The approach also involved the preparation of sapphyrins with symmetrical distribution of the peripheral substituents.

Published
1997

6. Metal-catalyzed oxidative cyclizations of a,c-biladiene salts bearing 1- and/or 19-arylmethyl substituents: macrocyclic products and their chemistry

Author

Lin, Jack J., Gerzevske,Kevin R., Liddell, Paul A., Senge, Mathias O., Olmstead, Marilyn M., Khoury, Richard G., Weeth, Brent E., Tsao, Stephanie A., and Smith, Kevin M.

Subjects
Ring formation (Chemistry) -- Analysis, Crown ethers -- Analysis, Oxidation-reduction reaction -- Analysis, Biological sciences, Chemistry
Abstract

Copper(II) oxidation procedure was utilized to cyclize a,c-biladienes containing 1- and/or 19-(para-tolylmethyl) substituents yielding numerous products wherein 1- or 19-substituents had modified positions in the tetrapyrrole macrocycle. a,c-Biladiene coordinates rendered copper(II) 1-(para-tolylmethyl)-20-para-tolyl macrocyclic compounds, copper(II) 2-methylidenechlorin and copper(II) porphyrins upon copper(II)-assisted cyclization. para-Tolyl-methyl group displayed more stable contributions of methylene both as macrocyclic bridging carbon and interpyrrolic carbon atom.

Published
1997

12. Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Author

Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, and Xu, Wei

Published
2012
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13. Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

Author

Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, and Rice, Kenneth D.

Published
2012
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18. Cover Picture

Author

Berl, Volker, primary, Huc, Ivan, additional, Khoury, Richard G., additional, and Lehn, Jean-Marie, additional

Published
2001
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32. Phosphorus complex of corrole

Author

Paolesse, Roberto, primary, Boschi, Tristano, additional, Licoccia, Silvia, additional, Khoury, Richard G., additional, and Smith, Kevin M., additional

Published
1998
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34. A Calix[4]arenoporphyrin

Author

Khoury, Richard G., primary, Jaquinod, Laurent, additional, Aoyagi, Katsuhiro, additional, Olmstead, Marilyn M., additional, Fisher, Andrew J., additional, and Smith, Kevin M., additional

Published
1997
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35. Ein Calix[4]arenoporphyrin

Author

Khoury, Richard G., primary, Jaquinod, Laurent, additional, Aoyagi, Katsuhiro, additional, Olmstead, Marilyn M., additional, Fisher, Andrew J., additional, and Smith, Kevin M., additional

Published
1997
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